GREMLIN Database
Q97YE1 - Second ORF in transposon ISC1190
UniProt: Q97YE1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 248 (241)
Sequences: 4635 (3448)
Seq/√Len: 222.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_I108_E2.9281.00
95_S117_E2.8211.00
158_F231_A2.7161.00
9_L28_A2.7121.00
213_H216_N2.7021.00
127_L243_P2.7011.00
146_V158_F2.4491.00
99_F110_R2.3791.00
56_S59_R2.3741.00
162_C188_L2.3431.00
142_I234_T2.2811.00
130_T243_P2.2681.00
207_K211_V2.2461.00
102_D110_R2.2051.00
153_G157_R2.1601.00
50_W54_T2.1261.00
180_I224_T2.0821.00
56_S63_R2.0191.00
228_R232_V2.0161.00
106_R110_R2.0021.00
20_S168_V1.9951.00
154_D157_R1.9471.00
170_F175_V1.9281.00
162_C231_A1.8901.00
103_E106_R1.8871.00
57_I111_K1.8561.00
48_S145_R1.8551.00
164_L227_A1.8491.00
127_L237_V1.8191.00
58_V62_N1.8181.00
115_E118_L1.8061.00
128_I234_T1.8041.00
218_K221_K1.7891.00
131_I234_T1.7721.00
50_W115_E1.7681.00
51_D190_R1.7521.00
30_L34_M1.7271.00
242_K245_D1.7261.00
56_S103_E1.7231.00
134_I139_G1.7211.00
212_E216_N1.7171.00
206_I226_C1.7041.00
117_E120_D1.6881.00
103_E110_R1.6701.00
152_F161_Y1.6641.00
236_A240_Y1.6421.00
237_V243_P1.6061.00
64_L104_L1.6051.00
217_L221_K1.5711.00
138_L191_A1.5611.00
53_I111_K1.5581.00
141_I191_A1.5491.00
131_I237_V1.5311.00
54_T57_I1.5301.00
129_F136_R1.5231.00
194_L197_L1.5161.00
127_L130_T1.5001.00
211_V215_E1.4891.00
206_I233_I1.4661.00
112_R115_E1.4301.00
57_I104_L1.4281.00
82_L85_V1.4261.00
209_F229_K1.4081.00
196_A230_L1.4021.00
200_I210_Y1.3951.00
57_I61_K1.3791.00
159_V165_D1.3791.00
51_D187_V1.3761.00
210_Y226_C1.3621.00
196_A227_A1.3481.00
78_S89_E1.3421.00
145_R185_D1.3381.00
193_Y227_A1.3341.00
196_A226_C1.3251.00
159_V228_R1.3221.00
18_K168_V1.3191.00
7_L11_K1.3161.00
85_V89_E1.3071.00
210_Y222_L1.3051.00
102_D109_V1.2911.00
138_L195_A1.2851.00
131_I230_L1.2801.00
235_W239_Y1.2761.00
99_F113_E1.2661.00
115_E119_E1.2661.00
104_L108_E1.2651.00
122_V129_F1.2641.00
190_R194_L1.2621.00
50_W137_T1.2611.00
56_S60_V1.2611.00
120_D124_K1.2581.00
83_N87_R1.2571.00
60_V63_R1.2381.00
101_L105_E1.2361.00
49_Q53_I1.2291.00
78_S85_V1.2271.00
54_T111_K1.2231.00
102_D106_R1.2171.00
209_F213_H1.2081.00
195_A230_L1.1721.00
81_N84_E1.1671.00
64_L97_V1.1511.00
52_F63_R1.1441.00
213_H222_L1.1361.00
78_S84_E1.1331.00
59_R62_N1.1311.00
204_P208_R1.1301.00
214_K222_L1.1261.00
75_D78_S1.1221.00
4_I9_L1.1181.00
77_L81_N1.1171.00
214_K219_G1.1161.00
85_V88_G1.1071.00
19_K24_D1.0991.00
55_R59_R1.0881.00
26_K30_L1.0871.00
76_S81_N1.0671.00
79_K83_N1.0671.00
99_F117_E1.0621.00
119_E136_R1.0591.00
75_D79_K1.0441.00
149_V238_L1.0391.00
77_L84_E1.0391.00
171_S175_V1.0371.00
233_I237_V1.0321.00
134_I234_T1.0321.00
236_A239_Y1.0011.00
110_R113_E0.9991.00
50_W111_K0.9991.00
134_I138_L0.9991.00
78_S81_N0.9901.00
108_E112_R0.9901.00
209_F226_C0.9891.00
196_A223_I0.9811.00
128_I139_G0.9801.00
128_I238_L0.9761.00
80_K84_E0.9711.00
193_Y224_T0.9701.00
77_L85_V0.9681.00
106_R109_V0.9641.00
37_E40_T0.9621.00
80_K83_N0.9611.00
47_T187_V0.9601.00
146_V149_V0.9591.00
78_S88_G0.9451.00
209_F212_E0.9411.00
60_V64_L0.9371.00
209_F225_A0.9371.00
28_A31_V0.9321.00
193_Y197_L0.9321.00
180_I189_R0.9291.00
77_L87_R0.9291.00
83_N86_L0.9271.00
220_K223_I0.9190.99
77_L82_L0.9190.99
78_S82_L0.9170.99
86_L89_E0.9170.99
44_K145_R0.9150.99
82_L89_E0.9150.99
47_T140_C0.9080.99
78_S87_R0.9020.99
134_I230_L0.9020.99
42_E90_D0.8940.99
145_R187_V0.8890.99
237_V242_K0.8850.99
182_R189_R0.8820.99
77_L88_G0.8750.99
192_F231_A0.8670.99
78_S83_N0.8660.99
81_N89_E0.8650.99
208_R212_E0.8620.99
80_K87_R0.8480.99
54_T58_V0.8450.99
197_L220_K0.8400.99
47_T144_A0.8360.99
197_L200_I0.8350.99
61_K104_L0.8340.99
39_T124_K0.8330.99
94_L98_R0.8320.99
82_L86_L0.8280.99
118_L122_V0.8280.99
109_V113_E0.8270.99
224_T227_A0.8250.99
96_E99_F0.8140.99
213_H217_L0.8140.99
18_K23_N0.8130.99
46_L114_I0.8100.99
119_E123_P0.8060.99
122_V125_D0.8010.99
161_Y185_D0.7980.99
81_N85_V0.7930.98
17_G160_A0.7910.98
170_F176_V0.7870.98
5_N8_V0.7860.98
157_R160_A0.7780.98
78_S86_L0.7750.98
213_H218_K0.7740.98
49_Q96_E0.7740.98
205_I244_F0.7740.98
79_K82_L0.7710.98
37_E41_S0.7670.98
51_D55_R0.7620.98
49_Q114_I0.7610.98
129_F139_G0.7600.98
79_K86_L0.7600.98
21_D171_S0.7600.98
47_T141_I0.7580.98
92_I95_S0.7570.98
81_N88_G0.7560.98
213_H225_A0.7470.98
200_I214_K0.7450.98
99_F103_E0.7440.98
113_E117_E0.7370.98
107_L110_R0.7340.97
206_I230_L0.7320.97
95_S98_R0.7320.97
117_E121_L0.7310.97
204_P207_K0.7270.97
199_A206_I0.7260.97
168_V175_V0.7260.97
52_F56_S0.7220.97
4_I31_V0.7190.97
91_N117_E0.7170.97
115_E122_V0.7160.97
154_D235_W0.7160.97
193_Y220_K0.7110.97
77_L86_L0.7110.97
31_V35_G0.7060.97
208_R211_V0.7030.97
197_L223_I0.7030.97
47_T118_L0.7030.97
77_L89_E0.7020.97
75_D88_G0.7020.97
60_V103_E0.7020.97
75_D89_E0.6980.97
79_K85_V0.6970.97
75_D81_N0.6960.97
95_S99_F0.6950.96
83_N88_G0.6860.96
131_I134_I0.6860.96
100_L103_E0.6850.96
165_D182_R0.6840.96
93_V96_E0.6830.96
53_I114_I0.6800.96
232_V235_W0.6800.96
76_S80_K0.6750.96
127_L241_N0.6750.96
165_D181_S0.6720.96
17_G183_R0.6660.96
141_I145_R0.6660.96
155_K232_V0.6660.96
62_N66_R0.6650.96
76_S79_K0.6640.95
79_K87_R0.6630.95
205_I233_I0.6630.95
60_V100_L0.6630.95
49_Q99_F0.6490.95
165_D168_V0.6480.95
84_E88_G0.6480.95
105_E109_V0.6470.95
60_V104_L0.6450.95
12_F31_V0.6430.95
234_T237_V0.6420.95
194_L198_T0.6410.95
160_A165_D0.6390.94
41_S45_E0.6390.94
48_S187_V0.6390.94
164_L228_R0.6340.94
194_L220_K0.6330.94
210_Y214_K0.6320.94
77_L83_N0.6320.94
148_D151_R0.6320.94
8_V11_K0.6310.94
192_F227_A0.6290.94
134_I142_I0.6270.94
156_K228_R0.6250.94
184_G189_R0.6250.94
167_L181_S0.6240.94
108_E111_K0.6220.94
197_L227_A0.6210.94
180_I225_A0.6130.93
81_N86_L0.6090.93
76_S87_R0.6090.93
165_D189_R0.6090.93
9_L31_V0.6080.93
142_I188_L0.6080.93
212_E215_E0.6040.93
12_F34_M0.6040.93
53_I110_R0.6010.92
9_L27_L0.6000.92
200_I223_I0.5980.92
99_F102_D0.5970.92
77_L80_K0.5970.92
92_I96_E0.5970.92
58_V61_K0.5960.92
125_D129_F0.5960.92
82_L88_G0.5950.92
202_V207_K0.5930.92
221_K225_A0.5910.92
198_T202_V0.5900.92
121_L124_K0.5890.92
9_L35_G0.5870.92
39_T42_E0.5870.92
200_I226_C0.5830.91
92_I117_E0.5820.91
211_V214_K0.5810.91
191_A195_A0.5780.91
30_L33_S0.5730.91
95_S106_R0.5730.91
36_S44_K0.5730.91
103_E107_L0.5710.90
38_F42_E0.5700.90
111_K115_E0.5680.90
218_K222_L0.5660.90
7_L17_G0.5640.90
76_S82_L0.5620.90
63_R66_R0.5610.90
63_R100_L0.5570.89
48_S185_D0.5570.89
10_K15_I0.5570.89
199_A203_N0.5560.89
141_I187_V0.5550.89
60_V107_L0.5520.89
4_I12_F0.5520.89
149_V235_W0.5520.89
114_I118_L0.5490.89
23_N27_L0.5480.89
6_P145_R0.5470.88
165_D183_R0.5410.88
159_V232_V0.5370.88
125_D139_G0.5360.87
28_A32_I0.5340.87
20_S170_F0.5320.87
107_L111_K0.5310.87
233_I236_A0.5300.87
80_K85_V0.5290.87
98_R102_D0.5280.87
36_S41_S0.5270.87
105_E108_E0.5240.86
54_T115_E0.5230.86
42_E91_N0.5230.86
75_D87_R0.5210.86
52_F59_R0.5180.86
119_E122_V0.5160.85
12_F30_L0.5140.85
146_V162_C0.5120.85
95_S113_E0.5110.85
65_R69_I0.5100.85
42_E121_L0.5080.85
127_L131_I0.5060.84
52_F55_R0.5060.84
49_Q60_V0.5030.84
109_V112_R0.5030.84
203_N207_K0.5030.84
203_N233_I0.5030.84
45_E67_D0.5020.84
79_K89_E0.5020.84
169_E178_R0.5020.84
57_I107_L0.5010.84
203_N244_F0.5010.84
53_I57_I0.5000.84
49_Q52_F0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c1yA 5 0.7339 91.3 0.917 Contact Map
3fhfA 1 0.7742 87.4 0.923 Contact Map
1keaA 2 0.7661 84.9 0.926 Contact Map
2a1jA 1 0.2419 79.7 0.93 Contact Map
2a1jB 2 0.3105 79.2 0.93 Contact Map
3c65A 1 0.3831 78.5 0.931 Contact Map
1z00B 1 0.2944 76.6 0.932 Contact Map
1kftA 1 0.2177 74.2 0.933 Contact Map
3n0uA 1 0.7419 74.1 0.933 Contact Map
4glxA 1 0.5685 72.9 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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