GREMLIN Database
Q97YD3 - Uncharacterized protein
UniProt: Q97YD3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 201 (181)
Sequences: 925 (746)
Seq/√Len: 55.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_E145_R4.9001.00
78_I88_P4.3231.00
124_D153_K3.6961.00
81_Y157_E3.6331.00
27_F31_P3.0671.00
117_K148_Y2.9741.00
110_Y155_Y2.9151.00
34_V163_I2.7141.00
31_P162_K2.6821.00
112_H137_Y2.5091.00
83_D164_R2.4651.00
19_I163_I2.2701.00
121_Y156_V2.2151.00
99_V134_L2.1501.00
59_K90_Y2.1401.00
171_V174_V2.1241.00
113_K144_V2.0601.00
25_K33_I1.9711.00
108_K140_L1.9481.00
51_E105_S1.9401.00
18_T80_R1.9191.00
47_E51_E1.9121.00
133_G148_Y1.9111.00
48_A105_S1.8991.00
154_R158_K1.8961.00
100_P133_G1.8891.00
93_I98_W1.8831.00
110_Y113_K1.7620.99
21_G122_L1.7290.99
55_V138_V1.6670.99
27_F166_A1.5810.98
117_K152_E1.5680.98
84_L160_L1.5670.98
33_I37_E1.5440.98
60_V75_G1.5230.98
117_K156_V1.5180.98
73_V76_K1.5090.98
120_L148_Y1.4940.97
158_K162_K1.4740.97
75_G87_S1.4640.97
35_R39_M1.4450.97
50_I54_Q1.4410.97
73_V93_I1.4360.97
171_V177_A1.4300.97
77_P87_S1.3960.96
26_H33_I1.3810.96
28_A114_L1.3700.96
25_K112_H1.3630.96
99_V132_E1.3600.96
42_T188_Y1.3470.95
20_S41_F1.3250.95
99_V145_R1.3180.95
27_F162_K1.3110.95
27_F163_I1.2900.94
35_R38_S1.2710.94
60_V87_S1.2530.93
24_I118_Y1.2220.92
116_M133_G1.2170.92
81_Y125_M1.2110.92
156_V160_L1.2080.92
92_L143_M1.2040.92
161_S165_E1.2040.92
186_F192_K1.1970.91
122_L126_N1.1950.91
84_L118_Y1.1490.90
46_S49_M1.1480.90
44_R188_Y1.1410.89
15_V18_T1.1330.89
113_K155_Y1.1250.89
174_V177_A1.1200.88
18_T83_D1.1060.88
43_E49_M1.1030.88
171_V176_D1.1020.88
56_E115_Q1.0920.87
76_K93_I1.0910.87
91_V130_V1.0880.87
171_V175_Q1.0810.87
20_S38_S1.0680.86
134_L145_R1.0510.85
76_K91_V1.0430.85
118_Y156_V1.0370.84
44_R187_V1.0360.84
48_A182_N1.0330.84
45_V53_E1.0250.83
150_Y154_R1.0010.82
52_G56_E0.9970.82
23_T38_S0.9930.81
180_C189_C0.9890.81
82_G121_Y0.9850.81
23_T34_V0.9790.81
184_G191_P0.9700.80
26_H37_E0.9680.80
180_C183_C0.9650.80
74_V77_P0.9650.80
117_K135_L0.9590.79
114_L155_Y0.9580.79
24_I114_L0.9500.79
89_D115_Q0.9440.78
154_R168_N0.9430.78
55_V105_S0.9390.78
105_S139_S0.9390.78
18_T79_F0.9380.78
147_E150_Y0.9370.78
183_C189_C0.9190.76
157_E161_S0.9100.75
29_Y179_K0.9080.75
104_K115_Q0.9060.75
50_I53_E0.9030.75
160_L164_R0.8950.74
120_L130_V0.8940.74
23_T163_I0.8780.73
29_Y48_A0.8730.72
90_Y136_Y0.8710.72
27_F167_I0.8680.72
159_V162_K0.8630.72
162_K165_E0.8600.71
34_V112_H0.8570.71
133_G146_L0.8550.71
80_R160_L0.8510.70
53_E57_K0.8490.70
28_A155_Y0.8480.70
72_N90_Y0.8470.70
86_G124_D0.8410.70
21_G86_G0.8400.69
51_E55_V0.8360.69
66_A70_P0.8300.69
108_K112_H0.8300.69
158_K161_S0.8290.68
34_V166_A0.8260.68
132_E147_E0.8250.68
121_Y160_L0.8200.68
102_D115_Q0.8110.67
94_Y97_H0.8110.67
174_V194_K0.8080.66
154_R157_E0.8070.66
25_K37_E0.8000.66
100_P120_L0.8000.66
52_G115_Q0.7900.65
57_K81_Y0.7860.64
62_N75_G0.7820.64
123_M133_G0.7670.62
120_L133_G0.7660.62
154_R161_S0.7640.62
49_M184_G0.7640.62
81_Y165_E0.7600.62
20_S23_T0.7600.62
21_G156_V0.7570.61
46_S112_H0.7490.61
121_Y181_Y0.7470.60
165_E168_N0.7430.60
88_P91_V0.7400.60
140_L144_V0.7370.59
41_F87_S0.7370.59
26_H35_R0.7330.59
29_Y171_V0.7320.59
185_F191_P0.7300.59
108_K113_K0.7290.58
157_E160_L0.7280.58
46_S143_M0.7270.58
121_Y153_K0.7230.58
178_R181_Y0.7190.57
116_M135_L0.7170.57
26_H184_G0.7160.57
78_I122_L0.7140.57
32_Q40_G0.7110.57
18_T85_I0.7110.57
21_G118_Y0.7080.56
76_K110_Y0.7070.56
33_I184_G0.7040.56
37_E49_M0.7010.55
15_V83_D0.6930.55
28_A111_D0.6890.54
33_I122_L0.6870.54
141_K146_L0.6830.54
177_A192_K0.6810.53
123_M130_V0.6770.53
54_Q57_K0.6740.53
38_S41_F0.6680.52
74_V103_V0.6610.51
176_D179_K0.6590.51
135_L140_L0.6580.51
155_Y159_V0.6570.51
158_K165_E0.6550.51
98_W130_V0.6540.50
147_E161_S0.6520.50
56_E102_D0.6420.49
36_I134_L0.6400.49
55_V137_Y0.6390.49
176_D186_F0.6380.49
19_I23_T0.6370.49
102_D119_Y0.6360.48
25_K109_R0.6320.48
98_W128_I0.6260.47
19_I34_V0.6250.47
65_Y194_K0.6240.47
124_D130_V0.6200.47
16_L169_G0.6180.47
39_M167_I0.6130.46
132_E158_K0.6130.46
29_Y66_A0.6080.45
24_I34_V0.6040.45
117_K153_K0.6040.45
25_K46_S0.5990.45
45_V122_L0.5990.45
181_Y186_F0.5970.44
52_G89_D0.5950.44
94_Y99_V0.5950.44
17_M194_K0.5940.44
81_Y129_N0.5900.44
82_G157_E0.5860.43
138_V141_K0.5840.43
156_V163_I0.5840.43
49_M56_E0.5770.42
31_P100_P0.5760.42
163_I167_I0.5750.42
148_Y192_K0.5740.42
115_Q119_Y0.5720.42
87_S166_A0.5690.41
30_C180_C0.5680.41
132_E148_Y0.5650.41
75_G78_I0.5640.41
165_E169_G0.5630.41
99_V131_K0.5620.41
56_E103_V0.5600.40
15_V113_K0.5600.40
190_K193_I0.5580.40
49_M106_G0.5580.40
22_I33_I0.5550.40
45_V49_M0.5550.40
29_Y102_D0.5550.40
86_G122_L0.5540.40
15_V48_A0.5540.40
80_R83_D0.5530.40
30_C189_C0.5520.40
84_L111_D0.5510.39
59_K103_V0.5480.39
61_M74_V0.5460.39
70_P94_Y0.5450.39
130_V195_G0.5440.39
16_L20_S0.5410.38
79_F164_R0.5380.38
117_K120_L0.5370.38
43_E184_G0.5350.38
96_N162_K0.5330.38
21_G126_N0.5310.37
81_Y150_Y0.5300.37
15_V168_N0.5270.37
97_H168_N0.5250.37
114_L156_V0.5240.37
97_H161_S0.5230.37
178_R182_N0.5230.37
136_Y142_E0.5220.37
55_V108_K0.5210.36
23_T26_H0.5190.36
91_V123_M0.5190.36
31_P34_V0.5160.36
38_S102_D0.5150.36
52_G104_K0.5150.36
152_E156_V0.5140.36
18_T31_P0.5120.36
134_L142_E0.5110.35
88_P122_L0.5090.35
131_K157_E0.5070.35
108_K137_Y0.5060.35
24_I163_I0.5050.35
118_Y160_L0.5050.35
52_G102_D0.5030.35
30_C183_C0.5030.35
26_H122_L0.5030.35
98_W136_Y0.5020.35
29_Y182_N0.5010.34
120_L153_K0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r5qA 1 0.8657 99.9 0.579 Contact Map
4ic1A 5 0.9005 99.9 0.586 Contact Map
3u4qB 1 0.9652 99.7 0.701 Contact Map
3l0aA 3 0.9204 99.4 0.753 Contact Map
3h4rA 3 0.796 99.1 0.788 Contact Map
3u4qA 1 0.602 97.6 0.862 Contact Map
1w36C 1 0.9602 96.9 0.876 Contact Map
3sm4A 3 0.8756 81.6 0.922 Contact Map
3k93A 3 0.7861 72.2 0.928 Contact Map
3syyA 3 0.7861 67 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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