GREMLIN Database
Q97YD2 - Uncharacterized protein
UniProt: Q97YD2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 321 (274)
Sequences: 125 (113)
Seq/√Len: 6.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_A168_K3.7090.93
75_S162_N3.5210.91
96_S106_G3.4930.91
170_E173_F3.4200.90
74_D163_A2.7380.76
110_R114_I2.6910.75
94_L113_L2.5430.71
255_L259_V2.5380.70
13_L105_A2.4860.69
11_S168_K2.4160.66
128_I162_N2.4090.66
163_A186_I2.2610.61
79_T145_V2.2370.60
134_F141_L2.2230.60
130_S204_I2.1870.58
11_S71_A2.1790.58
7_S165_P2.1730.58
167_L179_L2.1570.57
74_D167_L2.1450.57
74_D258_W2.1160.56
95_Y164_T2.1070.55
167_L258_W2.0810.54
134_F203_P1.9580.50
8_V169_P1.9450.49
106_G109_I1.9290.48
169_P197_V1.9170.48
75_S163_A1.8860.47
188_Y191_Q1.8740.46
99_T102_S1.8680.46
163_A172_I1.8590.46
172_I175_T1.8510.46
73_L179_L1.8430.45
5_V169_P1.7940.43
185_L198_I1.7780.43
138_I186_I1.7740.43
161_I199_L1.7720.43
128_I142_F1.7670.42
5_V127_T1.7410.41
6_C97_T1.7120.40
56_K119_R1.6950.40
97_T233_G1.6900.40
8_V12_L1.6730.39
162_N190_Y1.6020.36
130_S250_E1.5950.36
72_E166_G1.5940.36
109_I174_L1.5660.35
145_V160_Y1.5660.35
12_L165_P1.5330.34
171_S258_W1.5310.34
178_G197_V1.5270.34
101_N178_G1.5210.34
102_S262_L1.5170.33
171_S179_L1.5070.33
78_S164_T1.4890.33
168_K188_Y1.4810.32
170_E190_Y1.4730.32
9_G168_K1.4660.32
199_L219_I1.4610.32
256_K259_V1.4600.32
76_L204_I1.4480.31
10_T15_N1.4310.31
13_L58_L1.4270.31
161_I178_G1.4230.30
128_I173_F1.4210.30
238_L263_L1.4190.30
9_G72_E1.4110.30
72_E188_Y1.3850.29
170_E193_F1.3760.29
279_I284_G1.3730.29
163_A171_S1.3700.29
196_V206_I1.3630.28
12_L180_L1.3480.28
33_D149_I1.3470.28
70_S189_K1.3380.28
177_A190_Y1.3350.28
97_T191_Q1.3270.27
186_I197_V1.3210.27
13_L258_W1.3140.27
163_A180_L1.3060.27
73_L167_L1.3010.27
134_F137_G1.2890.26
38_K107_E1.2870.26
75_S172_I1.2830.26
37_L223_T1.2770.26
94_L191_Q1.2770.26
97_T206_I1.2640.26
70_S161_I1.2610.25
161_I196_V1.2600.25
178_G255_L1.2600.25
97_T174_L1.2550.25
75_S175_T1.2520.25
172_I193_F1.2480.25
280_V284_G1.2470.25
9_G71_A1.2400.25
187_Y198_I1.2350.25
92_V113_L1.2320.25
6_C175_T1.2290.25
71_A188_Y1.2270.24
195_D207_R1.2210.24
128_I171_S1.2200.24
163_A170_E1.2110.24
118_I190_Y1.2070.24
15_N167_L1.2060.24
97_T165_P1.1920.24
168_K191_Q1.1840.23
63_R177_A1.1830.23
97_T188_Y1.1790.23
163_A199_L1.1770.23
58_L261_K1.1750.23
73_L276_Y1.1710.23
66_G138_I1.1590.23
141_L205_T1.1570.23
4_H68_R1.1430.22
65_K82_K1.1400.22
103_Q107_E1.1370.22
98_N165_P1.1360.22
11_S72_E1.1360.22
9_G166_G1.1350.22
141_L195_D1.1330.22
137_G140_D1.1320.22
283_E286_R1.1250.22
72_E168_K1.1220.22
3_V93_F1.1160.22
8_V175_T1.1070.21
33_D64_S1.1050.21
231_E246_E1.1020.21
74_D189_K1.0890.21
70_S196_V1.0870.21
4_H167_L1.0840.21
218_A232_L1.0800.21
58_L266_Y1.0790.21
69_A196_V1.0740.20
282_G286_R1.0670.20
12_L69_A1.0670.20
74_D172_I1.0660.20
150_L178_G1.0650.20
97_T173_F1.0650.20
137_G197_V1.0520.20
71_A165_P1.0410.20
162_N173_F1.0410.20
67_R78_S1.0350.19
24_K47_I1.0310.19
7_S174_L1.0300.19
96_S172_I1.0270.19
161_I170_E1.0220.19
180_L199_L1.0110.19
15_N218_A1.0080.19
8_V112_Y1.0060.19
69_A175_T1.0040.19
166_G188_Y0.9940.19
134_F173_F0.9940.19
189_K198_I0.9930.19
203_P259_V0.9910.18
172_I190_Y0.9910.18
161_I193_F0.9890.18
278_V286_R0.9880.18
75_S171_S0.9860.18
63_R82_K0.9820.18
169_P251_D0.9760.18
7_S109_I0.9760.18
70_S106_G0.9750.18
92_V145_V0.9740.18
174_L194_N0.9700.18
61_F81_E0.9700.18
96_S124_T0.9630.18
122_L243_M0.9630.18
128_I137_G0.9560.18
102_S185_L0.9450.17
72_E191_Q0.9440.17
131_E173_F0.9330.17
96_S119_R0.9330.17
9_G188_Y0.9310.17
11_S99_T0.9230.17
47_I129_S0.9230.17
12_L215_I0.9190.17
195_D283_E0.9180.17
102_S175_T0.9180.17
281_E284_G0.9170.17
106_G189_K0.9170.17
12_L15_N0.9140.17
10_T200_P0.9090.17
134_F162_N0.9050.17
71_A191_Q0.9010.17
64_S149_I0.9000.16
231_E250_E0.8980.16
128_I170_E0.8960.16
109_I141_L0.8940.16
73_L162_N0.8940.16
32_K39_F0.8920.16
4_H12_L0.8920.16
102_S128_I0.8850.16
6_C163_A0.8850.16
15_N141_L0.8810.16
173_F179_L0.8760.16
125_V182_G0.8750.16
194_N208_P0.8750.16
161_I169_P0.8700.16
105_A143_D0.8570.16
163_A265_I0.8460.15
13_L73_L0.8430.15
130_S173_F0.8420.15
276_Y279_I0.8390.15
164_T188_Y0.8370.15
229_A239_L0.8330.15
15_N109_I0.8300.15
193_F197_V0.8270.15
7_S142_F0.8260.15
167_L183_A0.8250.15
114_I253_Y0.8240.15
134_F259_V0.8230.15
148_R190_Y0.8210.15
130_S133_N0.8170.15
11_S203_P0.8140.15
6_C76_L0.8130.15
58_L163_A0.8130.15
95_Y207_R0.8120.15
189_K196_V0.8070.15
66_G177_A0.8070.15
80_F172_I0.8040.15
73_L171_S0.8040.15
170_E174_L0.8030.15
95_Y161_I0.7990.14
166_G217_F0.7990.14
217_F264_G0.7980.14
9_G165_P0.7980.14
75_S129_S0.7960.14
11_S166_G0.7960.14
218_A256_K0.7940.14
97_T109_I0.7940.14
57_M91_Y0.7860.14
135_Y175_T0.7850.14
10_T71_A0.7810.14
95_Y133_N0.7800.14
58_L213_W0.7800.14
7_S11_S0.7740.14
185_L202_P0.7700.14
183_A200_P0.7700.14
74_D98_N0.7700.14
73_L169_P0.7690.14
209_K250_E0.7690.14
203_P245_V0.7690.14
73_L183_A0.7650.14
13_L97_T0.7630.14
68_R97_T0.7630.14
4_H214_L0.7630.14
68_R154_E0.7610.14
97_T204_I0.7610.14
74_D78_S0.7520.14
167_L172_I0.7520.14
15_N134_F0.7440.13
26_I213_W0.7430.13
107_E110_R0.7400.13
4_H250_E0.7390.13
77_F97_T0.7340.13
54_L103_Q0.7310.13
196_V199_L0.7300.13
173_F206_I0.7290.13
97_T136_E0.7270.13
145_V167_L0.7250.13
6_C162_N0.7210.13
118_I134_F0.7180.13
134_F190_Y0.7180.13
70_S258_W0.7180.13
162_N263_L0.7180.13
120_S253_Y0.7150.13
70_S99_T0.7150.13
108_V248_K0.7120.13
12_L204_I0.7110.13
173_F199_L0.7060.13
5_V95_Y0.7030.13
10_T141_L0.7030.13
56_K103_Q0.6980.13
84_K242_K0.6980.13
112_Y122_L0.6950.13
174_L244_L0.6940.13
69_A149_I0.6920.13
149_I198_I0.6920.13
117_G207_R0.6910.13
176_L180_L0.6900.13
76_L82_K0.6890.13
77_F224_L0.6880.13
98_N140_D0.6850.12
162_N172_I0.6840.12
6_C171_S0.6760.12
167_L189_K0.6750.12
58_L74_D0.6750.12
103_Q285_E0.6740.12
95_Y214_L0.6730.12
50_N54_L0.6720.12
178_G188_Y0.6670.12
32_K79_T0.6660.12
178_G192_E0.6660.12
8_V220_S0.6640.12
103_Q135_Y0.6630.12
73_L128_I0.6630.12
202_P258_W0.6610.12
71_A94_L0.6570.12
74_D200_P0.6560.12
137_G162_N0.6550.12
168_K178_G0.6500.12
137_G141_L0.6490.12
6_C261_K0.6490.12
133_N267_L0.6490.12
29_L114_I0.6470.12
38_K52_D0.6460.12
276_Y280_V0.6460.12
181_A196_V0.6430.12
88_S113_L0.6410.12
15_N159_V0.6390.12
6_C180_L0.6380.12
193_F196_V0.6380.12
18_D232_L0.6370.12
165_P261_K0.6350.12
156_D258_W0.6320.12
275_Y286_R0.6320.12
102_S165_P0.6300.12
75_S164_T0.6270.12
78_S125_V0.6260.12
139_V201_S0.6250.12
29_L89_E0.6240.11
99_T168_K0.6210.11
99_T138_I0.6200.11
128_I160_Y0.6170.11
175_T180_L0.6130.11
279_I282_G0.6110.11
11_S188_Y0.6090.11
175_T261_K0.6090.11
42_D178_G0.6040.11
7_S31_L0.6040.11
72_E203_P0.6030.11
16_S190_Y0.6020.11
163_A175_T0.6010.11
156_D204_I0.6000.11
83_L147_Y0.5980.11
98_N207_R0.5970.11
4_H237_R0.5940.11
5_V8_V0.5920.11
147_Y159_V0.5920.11
239_L247_R0.5900.11
163_A193_F0.5870.11
4_H140_D0.5850.11
144_K261_K0.5850.11
231_E235_P0.5840.11
31_L49_E0.5820.11
142_F163_A0.5810.11
149_I186_I0.5800.11
99_T203_P0.5800.11
164_T170_E0.5790.11
78_S172_I0.5790.11
239_L245_V0.5740.11
79_T118_I0.5740.11
275_Y278_V0.5730.11
153_K245_V0.5730.11
30_G246_E0.5700.11
101_N164_T0.5670.11
125_V145_V0.5650.11
127_T207_R0.5630.11
120_S217_F0.5600.11
139_V186_I0.5600.11
72_E165_P0.5580.11
53_S95_Y0.5550.10
113_L117_G0.5550.10
162_N189_K0.5540.10
29_L166_G0.5540.10
93_F229_A0.5530.10
10_T189_K0.5520.10
133_N148_R0.5520.10
144_K258_W0.5510.10
183_A258_W0.5500.10
181_A211_L0.5500.10
5_V245_V0.5390.10
200_P255_L0.5380.10
280_V286_R0.5370.10
8_V245_V0.5360.10
179_L254_R0.5360.10
5_V17_L0.5360.10
102_S109_I0.5310.10
280_V283_E0.5310.10
78_S245_V0.5300.10
171_S177_A0.5300.10
5_V155_Q0.5300.10
68_R219_I0.5290.10
76_L94_L0.5290.10
207_R256_K0.5290.10
25_E28_R0.5290.10
163_A190_Y0.5280.10
72_E99_T0.5270.10
62_I281_E0.5260.10
129_S172_I0.5250.10
139_V199_L0.5230.10
168_K203_P0.5220.10
50_N58_L0.5220.10
212_D260_R0.5210.10
233_G244_L0.5210.10
68_R75_S0.5190.10
203_P256_K0.5180.10
74_D183_A0.5170.10
181_A265_I0.5150.10
141_L187_Y0.5110.10
180_L271_A0.5110.10
218_A259_V0.5090.10
75_S187_Y0.5090.10
69_A94_L0.5080.10
92_V171_S0.5080.10
15_N197_V0.5070.10
94_L186_I0.5070.10
97_T268_P0.5050.10
90_I167_L0.5040.10
109_I197_V0.5030.10
7_S67_R0.5000.10
273_N284_G0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qyfA 2 0.8318 100 0.209 Contact Map
1xmxA 2 0.7103 98.6 0.879 Contact Map
2wteA 2 0.6106 97.9 0.9 Contact Map
4eogA 2 0.7601 79.4 0.947 Contact Map
4n82B 1 0.3894 29.6 0.962 Contact Map
5nulA 1 0.3645 22.5 0.964 Contact Map
3l82B 1 0.4237 18.5 0.966 Contact Map
2m6rA 1 0.3863 15.2 0.967 Contact Map
1bjaA 1 0.2928 13 0.968 Contact Map
3oq2A 3 0.3146 11.6 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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