Q97YD2 - SULSO - GREMLIN Contacts

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Q97YD2 - Uncharacterized protein

UniProt:	Q97YD2	Sequences: MEVHVCSVGTSLLKNSLDDDNVRKEIERLGLKDWDRLKFDDDRQNRIKENFDSLRKMLLKFIRSKGRRASAELDSLFSTFEKLKHNKSEIYVFLYSTNTSNSQLAGEVIRDYLIEEGIRSELVTVKTISSEENFYEGIVDLFDKVIYRILKFKEQDNEVYINATPGLKPESIFLTLAGLLAGADLIYYKYQEFNDVVILPSPPITIRPKYLDWLIRFAISGYTLSEKRAEELGIPVRLLEAKMLVERKGEDAYRLKDWVRKLLGIYLPIGAQNKYYRVIVEGEGERTFDNEVEAYNYMESKRKEGKNVRVEVPDRVYFLGL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	321 (274)
Sequences:	125 (113)
Seq/√Len:	6.9

SULSO - Q97YD2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
71_A	168_K	3.709	0.93
75_S	162_N	3.521	0.91
96_S	106_G	3.493	0.91
170_E	173_F	3.420	0.90
74_D	163_A	2.738	0.76
110_R	114_I	2.691	0.75
94_L	113_L	2.543	0.71
255_L	259_V	2.538	0.70
13_L	105_A	2.486	0.69
11_S	168_K	2.416	0.66
128_I	162_N	2.409	0.66
163_A	186_I	2.261	0.61
79_T	145_V	2.237	0.60
134_F	141_L	2.223	0.60
130_S	204_I	2.187	0.58
11_S	71_A	2.179	0.58
7_S	165_P	2.173	0.58
167_L	179_L	2.157	0.57
74_D	167_L	2.145	0.57
74_D	258_W	2.116	0.56
95_Y	164_T	2.107	0.55
167_L	258_W	2.081	0.54
134_F	203_P	1.958	0.50
8_V	169_P	1.945	0.49
106_G	109_I	1.929	0.48
169_P	197_V	1.917	0.48
75_S	163_A	1.886	0.47
188_Y	191_Q	1.874	0.46
99_T	102_S	1.868	0.46
163_A	172_I	1.859	0.46
172_I	175_T	1.851	0.46
73_L	179_L	1.843	0.45
5_V	169_P	1.794	0.43
185_L	198_I	1.778	0.43
138_I	186_I	1.774	0.43
161_I	199_L	1.772	0.43
128_I	142_F	1.767	0.42
5_V	127_T	1.741	0.41
6_C	97_T	1.712	0.40
56_K	119_R	1.695	0.40
97_T	233_G	1.690	0.40
8_V	12_L	1.673	0.39
162_N	190_Y	1.602	0.36
130_S	250_E	1.595	0.36
72_E	166_G	1.594	0.36
109_I	174_L	1.566	0.35
145_V	160_Y	1.566	0.35
12_L	165_P	1.533	0.34
171_S	258_W	1.531	0.34
178_G	197_V	1.527	0.34
101_N	178_G	1.521	0.34
102_S	262_L	1.517	0.33
171_S	179_L	1.507	0.33
78_S	164_T	1.489	0.33
168_K	188_Y	1.481	0.32
170_E	190_Y	1.473	0.32
9_G	168_K	1.466	0.32
199_L	219_I	1.461	0.32
256_K	259_V	1.460	0.32
76_L	204_I	1.448	0.31
10_T	15_N	1.431	0.31
13_L	58_L	1.427	0.31
161_I	178_G	1.423	0.30
128_I	173_F	1.421	0.30
238_L	263_L	1.419	0.30
9_G	72_E	1.411	0.30
72_E	188_Y	1.385	0.29
170_E	193_F	1.376	0.29
279_I	284_G	1.373	0.29
163_A	171_S	1.370	0.29
196_V	206_I	1.363	0.28
12_L	180_L	1.348	0.28
33_D	149_I	1.347	0.28
70_S	189_K	1.338	0.28
177_A	190_Y	1.335	0.28
97_T	191_Q	1.327	0.27
186_I	197_V	1.321	0.27
13_L	258_W	1.314	0.27
163_A	180_L	1.306	0.27
73_L	167_L	1.301	0.27
134_F	137_G	1.289	0.26
38_K	107_E	1.287	0.26
75_S	172_I	1.283	0.26
37_L	223_T	1.277	0.26
94_L	191_Q	1.277	0.26
97_T	206_I	1.264	0.26
70_S	161_I	1.261	0.25
161_I	196_V	1.260	0.25
178_G	255_L	1.260	0.25
97_T	174_L	1.255	0.25
75_S	175_T	1.252	0.25
172_I	193_F	1.248	0.25
280_V	284_G	1.247	0.25
9_G	71_A	1.240	0.25
187_Y	198_I	1.235	0.25
92_V	113_L	1.232	0.25
6_C	175_T	1.229	0.25
71_A	188_Y	1.227	0.24
195_D	207_R	1.221	0.24
128_I	171_S	1.220	0.24
163_A	170_E	1.211	0.24
118_I	190_Y	1.207	0.24
15_N	167_L	1.206	0.24
97_T	165_P	1.192	0.24
168_K	191_Q	1.184	0.23
63_R	177_A	1.183	0.23
97_T	188_Y	1.179	0.23
163_A	199_L	1.177	0.23
58_L	261_K	1.175	0.23
73_L	276_Y	1.171	0.23
66_G	138_I	1.159	0.23
141_L	205_T	1.157	0.23
4_H	68_R	1.143	0.22
65_K	82_K	1.140	0.22
103_Q	107_E	1.137	0.22
98_N	165_P	1.136	0.22
11_S	72_E	1.136	0.22
9_G	166_G	1.135	0.22
141_L	195_D	1.133	0.22
137_G	140_D	1.132	0.22
283_E	286_R	1.125	0.22
72_E	168_K	1.122	0.22
3_V	93_F	1.116	0.22
8_V	175_T	1.107	0.21
33_D	64_S	1.105	0.21
231_E	246_E	1.102	0.21
74_D	189_K	1.089	0.21
70_S	196_V	1.087	0.21
4_H	167_L	1.084	0.21
218_A	232_L	1.080	0.21
58_L	266_Y	1.079	0.21
69_A	196_V	1.074	0.20
282_G	286_R	1.067	0.20
12_L	69_A	1.067	0.20
74_D	172_I	1.066	0.20
150_L	178_G	1.065	0.20
97_T	173_F	1.065	0.20
137_G	197_V	1.052	0.20
71_A	165_P	1.041	0.20
162_N	173_F	1.041	0.20
67_R	78_S	1.035	0.19
24_K	47_I	1.031	0.19
7_S	174_L	1.030	0.19
96_S	172_I	1.027	0.19
161_I	170_E	1.022	0.19
180_L	199_L	1.011	0.19
15_N	218_A	1.008	0.19
8_V	112_Y	1.006	0.19
69_A	175_T	1.004	0.19
166_G	188_Y	0.994	0.19
134_F	173_F	0.994	0.19
189_K	198_I	0.993	0.19
203_P	259_V	0.991	0.18
172_I	190_Y	0.991	0.18
161_I	193_F	0.989	0.18
278_V	286_R	0.988	0.18
75_S	171_S	0.986	0.18
63_R	82_K	0.982	0.18
169_P	251_D	0.976	0.18
7_S	109_I	0.976	0.18
70_S	106_G	0.975	0.18
92_V	145_V	0.974	0.18
174_L	194_N	0.970	0.18
61_F	81_E	0.970	0.18
96_S	124_T	0.963	0.18
122_L	243_M	0.963	0.18
128_I	137_G	0.956	0.18
102_S	185_L	0.945	0.17
72_E	191_Q	0.944	0.17
131_E	173_F	0.933	0.17
96_S	119_R	0.933	0.17
9_G	188_Y	0.931	0.17
11_S	99_T	0.923	0.17
47_I	129_S	0.923	0.17
12_L	215_I	0.919	0.17
195_D	283_E	0.918	0.17
102_S	175_T	0.918	0.17
281_E	284_G	0.917	0.17
106_G	189_K	0.917	0.17
12_L	15_N	0.914	0.17
10_T	200_P	0.909	0.17
134_F	162_N	0.905	0.17
71_A	191_Q	0.901	0.17
64_S	149_I	0.900	0.16
231_E	250_E	0.898	0.16
128_I	170_E	0.896	0.16
109_I	141_L	0.894	0.16
73_L	162_N	0.894	0.16
32_K	39_F	0.892	0.16
4_H	12_L	0.892	0.16
102_S	128_I	0.885	0.16
6_C	163_A	0.885	0.16
15_N	141_L	0.881	0.16
173_F	179_L	0.876	0.16
125_V	182_G	0.875	0.16
194_N	208_P	0.875	0.16
161_I	169_P	0.870	0.16
105_A	143_D	0.857	0.16
163_A	265_I	0.846	0.15
13_L	73_L	0.843	0.15
130_S	173_F	0.842	0.15
276_Y	279_I	0.839	0.15
164_T	188_Y	0.837	0.15
229_A	239_L	0.833	0.15
15_N	109_I	0.830	0.15
193_F	197_V	0.827	0.15
7_S	142_F	0.826	0.15
167_L	183_A	0.825	0.15
114_I	253_Y	0.824	0.15
134_F	259_V	0.823	0.15
148_R	190_Y	0.821	0.15
130_S	133_N	0.817	0.15
11_S	203_P	0.814	0.15
6_C	76_L	0.813	0.15
58_L	163_A	0.813	0.15
95_Y	207_R	0.812	0.15
189_K	196_V	0.807	0.15
66_G	177_A	0.807	0.15
80_F	172_I	0.804	0.15
73_L	171_S	0.804	0.15
170_E	174_L	0.803	0.15
95_Y	161_I	0.799	0.14
166_G	217_F	0.799	0.14
217_F	264_G	0.798	0.14
9_G	165_P	0.798	0.14
75_S	129_S	0.796	0.14
11_S	166_G	0.796	0.14
218_A	256_K	0.794	0.14
97_T	109_I	0.794	0.14
57_M	91_Y	0.786	0.14
135_Y	175_T	0.785	0.14
10_T	71_A	0.781	0.14
95_Y	133_N	0.780	0.14
58_L	213_W	0.780	0.14
7_S	11_S	0.774	0.14
185_L	202_P	0.770	0.14
183_A	200_P	0.770	0.14
74_D	98_N	0.770	0.14
73_L	169_P	0.769	0.14
209_K	250_E	0.769	0.14
203_P	245_V	0.769	0.14
73_L	183_A	0.765	0.14
13_L	97_T	0.763	0.14
68_R	97_T	0.763	0.14
4_H	214_L	0.763	0.14
68_R	154_E	0.761	0.14
97_T	204_I	0.761	0.14
74_D	78_S	0.752	0.14
167_L	172_I	0.752	0.14
15_N	134_F	0.744	0.13
26_I	213_W	0.743	0.13
107_E	110_R	0.740	0.13
4_H	250_E	0.739	0.13
77_F	97_T	0.734	0.13
54_L	103_Q	0.731	0.13
196_V	199_L	0.730	0.13
173_F	206_I	0.729	0.13
97_T	136_E	0.727	0.13
145_V	167_L	0.725	0.13
6_C	162_N	0.721	0.13
118_I	134_F	0.718	0.13
134_F	190_Y	0.718	0.13
70_S	258_W	0.718	0.13
162_N	263_L	0.718	0.13
120_S	253_Y	0.715	0.13
70_S	99_T	0.715	0.13
108_V	248_K	0.712	0.13
12_L	204_I	0.711	0.13
173_F	199_L	0.706	0.13
5_V	95_Y	0.703	0.13
10_T	141_L	0.703	0.13
56_K	103_Q	0.698	0.13
84_K	242_K	0.698	0.13
112_Y	122_L	0.695	0.13
174_L	244_L	0.694	0.13
69_A	149_I	0.692	0.13
149_I	198_I	0.692	0.13
117_G	207_R	0.691	0.13
176_L	180_L	0.690	0.13
76_L	82_K	0.689	0.13
77_F	224_L	0.688	0.13
98_N	140_D	0.685	0.12
162_N	172_I	0.684	0.12
6_C	171_S	0.676	0.12
167_L	189_K	0.675	0.12
58_L	74_D	0.675	0.12
103_Q	285_E	0.674	0.12
95_Y	214_L	0.673	0.12
50_N	54_L	0.672	0.12
178_G	188_Y	0.667	0.12
32_K	79_T	0.666	0.12
178_G	192_E	0.666	0.12
8_V	220_S	0.664	0.12
103_Q	135_Y	0.663	0.12
73_L	128_I	0.663	0.12
202_P	258_W	0.661	0.12
71_A	94_L	0.657	0.12
74_D	200_P	0.656	0.12
137_G	162_N	0.655	0.12
168_K	178_G	0.650	0.12
137_G	141_L	0.649	0.12
6_C	261_K	0.649	0.12
133_N	267_L	0.649	0.12
29_L	114_I	0.647	0.12
38_K	52_D	0.646	0.12
276_Y	280_V	0.646	0.12
181_A	196_V	0.643	0.12
88_S	113_L	0.641	0.12
15_N	159_V	0.639	0.12
6_C	180_L	0.638	0.12
193_F	196_V	0.638	0.12
18_D	232_L	0.637	0.12
165_P	261_K	0.635	0.12
156_D	258_W	0.632	0.12
275_Y	286_R	0.632	0.12
102_S	165_P	0.630	0.12
75_S	164_T	0.627	0.12
78_S	125_V	0.626	0.12
139_V	201_S	0.625	0.12
29_L	89_E	0.624	0.11
99_T	168_K	0.621	0.11
99_T	138_I	0.620	0.11
128_I	160_Y	0.617	0.11
175_T	180_L	0.613	0.11
279_I	282_G	0.611	0.11
11_S	188_Y	0.609	0.11
175_T	261_K	0.609	0.11
42_D	178_G	0.604	0.11
7_S	31_L	0.604	0.11
72_E	203_P	0.603	0.11
16_S	190_Y	0.602	0.11
163_A	175_T	0.601	0.11
156_D	204_I	0.600	0.11
83_L	147_Y	0.598	0.11
98_N	207_R	0.597	0.11
4_H	237_R	0.594	0.11
5_V	8_V	0.592	0.11
147_Y	159_V	0.592	0.11
239_L	247_R	0.590	0.11
163_A	193_F	0.587	0.11
4_H	140_D	0.585	0.11
144_K	261_K	0.585	0.11
231_E	235_P	0.584	0.11
31_L	49_E	0.582	0.11
142_F	163_A	0.581	0.11
149_I	186_I	0.580	0.11
99_T	203_P	0.580	0.11
164_T	170_E	0.579	0.11
78_S	172_I	0.579	0.11
239_L	245_V	0.574	0.11
79_T	118_I	0.574	0.11
275_Y	278_V	0.573	0.11
153_K	245_V	0.573	0.11
30_G	246_E	0.570	0.11
101_N	164_T	0.567	0.11
125_V	145_V	0.565	0.11
127_T	207_R	0.563	0.11
120_S	217_F	0.560	0.11
139_V	186_I	0.560	0.11
72_E	165_P	0.558	0.11
53_S	95_Y	0.555	0.10
113_L	117_G	0.555	0.10
162_N	189_K	0.554	0.10
29_L	166_G	0.554	0.10
93_F	229_A	0.553	0.10
10_T	189_K	0.552	0.10
133_N	148_R	0.552	0.10
144_K	258_W	0.551	0.10
183_A	258_W	0.550	0.10
181_A	211_L	0.550	0.10
5_V	245_V	0.539	0.10
200_P	255_L	0.538	0.10
280_V	286_R	0.537	0.10
8_V	245_V	0.536	0.10
179_L	254_R	0.536	0.10
5_V	17_L	0.536	0.10
102_S	109_I	0.531	0.10
280_V	283_E	0.531	0.10
78_S	245_V	0.530	0.10
171_S	177_A	0.530	0.10
5_V	155_Q	0.530	0.10
68_R	219_I	0.529	0.10
76_L	94_L	0.529	0.10
207_R	256_K	0.529	0.10
25_E	28_R	0.529	0.10
163_A	190_Y	0.528	0.10
72_E	99_T	0.527	0.10
62_I	281_E	0.526	0.10
129_S	172_I	0.525	0.10
139_V	199_L	0.523	0.10
168_K	203_P	0.522	0.10
50_N	58_L	0.522	0.10
212_D	260_R	0.521	0.10
233_G	244_L	0.521	0.10
68_R	75_S	0.519	0.10
203_P	256_K	0.518	0.10
74_D	183_A	0.517	0.10
181_A	265_I	0.515	0.10
141_L	187_Y	0.511	0.10
180_L	271_A	0.511	0.10
218_A	259_V	0.509	0.10
75_S	187_Y	0.509	0.10
69_A	94_L	0.508	0.10
92_V	171_S	0.508	0.10
15_N	197_V	0.507	0.10
94_L	186_I	0.507	0.10
97_T	268_P	0.505	0.10
90_I	167_L	0.504	0.10
109_I	197_V	0.503	0.10
7_S	67_R	0.500	0.10
273_N	284_G	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3qyfA	2	0.8318	100	0.209	Contact Map
1xmxA	2	0.7103	98.6	0.879	Contact Map
2wteA	2	0.6106	97.9	0.9	Contact Map
4eogA	2	0.7601	79.4	0.947	Contact Map
4n82B	1	0.3894	29.6	0.962	Contact Map
5nulA	1	0.3645	22.5	0.964	Contact Map
3l82B	1	0.4237	18.5	0.966	Contact Map
2m6rA	1	0.3863	15.2	0.967	Contact Map
1bjaA	1	0.2928	13	0.968	Contact Map
3oq2A	3	0.3146	11.6	0.969	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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