GREMLIN Database
Q97YD0 - Transposase ISC1225
UniProt: Q97YD0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 364 (317)
Sequences: 185 (125)
Seq/√Len: 7.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_T284_Y6.4951.00
110_I165_V4.5430.98
184_L283_S4.4500.98
179_V203_V3.6250.93
74_R301_F3.2790.89
113_T288_K3.0410.84
260_T296_S3.0050.84
186_A205_G2.9480.82
149_L284_Y2.8270.79
127_S133_S2.8020.79
260_T313_Y2.6490.75
304_L308_L2.6380.74
185_D277_R2.6320.74
179_V284_Y2.6040.73
172_I182_V2.5740.72
27_V203_V2.5250.71
260_T278_S2.5180.71
139_A151_A2.3580.65
36_S179_V2.3570.65
260_T308_L2.1740.59
138_T307_V2.0750.55
111_D281_E2.0670.55
336_F340_L2.0340.53
168_L261_N2.0020.52
112_W179_V1.9930.52
117_W297_T1.9930.52
114_T135_N1.9800.51
66_Y169_M1.9620.51
172_I202_F1.9570.50
306_F313_Y1.8960.48
282_T285_R1.8890.48
53_C73_V1.8780.47
113_T126_G1.8150.45
21_Q179_V1.7870.44
134_W284_Y1.7630.43
312_F323_M1.7600.43
147_V285_R1.7430.42
336_F341_S1.7310.42
145_N195_K1.7170.41
108_I172_I1.7150.41
290_F313_Y1.6880.40
47_R61_S1.6620.39
179_V287_I1.6610.39
111_D185_D1.6570.39
185_D281_E1.6570.39
159_M203_V1.6510.39
108_I142_K1.6330.38
188_F294_T1.6090.37
126_G306_F1.5820.36
165_V168_L1.5410.35
277_R281_E1.5400.35
111_D277_R1.5400.35
128_S293_F1.5390.35
181_L289_A1.5270.34
52_A187_G1.5180.34
260_T290_F1.5150.34
166_K296_S1.5010.34
117_W314_S1.4940.33
126_G261_N1.4820.33
81_G85_I1.4760.33
68_V119_G1.4720.33
301_F305_I1.4660.32
269_V315_L1.4620.32
273_Y280_I1.4430.32
320_K324_T1.4420.32
231_E255_Y1.4400.32
260_T288_K1.4400.32
214_Y217_F1.4290.31
336_F343_L1.4170.31
68_V138_T1.4040.30
261_N306_F1.3910.30
284_Y294_T1.3860.30
132_N197_I1.3860.30
110_I261_N1.3820.30
19_P22_N1.3730.29
45_V53_C1.3610.29
291_L303_E1.3500.29
208_V211_V1.3450.28
83_E208_V1.3370.28
335_C339_D1.3210.28
187_G207_P1.3170.28
168_L202_F1.3150.28
149_L310_M1.3140.27
91_S193_V1.3040.27
177_L222_T1.3000.27
111_D273_Y1.2950.27
273_Y281_E1.2950.27
76_Y298_K1.2880.27
126_G288_K1.2850.27
139_A172_I1.2830.27
302_R316_Y1.2830.27
134_W290_F1.2810.27
147_V180_G1.2770.26
209_G343_L1.2750.26
129_A285_R1.2730.26
274_N314_S1.2710.26
72_T224_N1.2630.26
86_E90_E1.2620.26
183_T205_G1.2610.26
177_L182_V1.2570.26
333_I343_L1.2570.26
288_K313_Y1.2460.25
169_M194_L1.2450.25
49_L73_V1.2410.25
93_R290_F1.2400.25
146_M180_G1.2370.25
189_Y206_V1.2320.25
77_V151_A1.2270.25
155_Q183_T1.2220.25
52_A329_R1.2140.25
49_L189_Y1.2130.25
329_R334_L1.2100.24
109_S125_L1.2060.24
336_F339_D1.2050.24
189_Y282_T1.1970.24
133_S278_S1.1900.24
137_A168_L1.1880.24
149_L283_S1.1770.24
296_S313_Y1.1730.23
75_N298_K1.1700.23
139_A323_M1.1680.23
242_G301_F1.1620.23
168_L287_I1.1620.23
82_T155_Q1.1530.23
61_S115_K1.1470.23
317_T320_K1.1330.22
261_N288_K1.1290.22
126_G143_Y1.1180.22
90_E125_L1.1180.22
137_A202_F1.1130.22
138_T280_I1.1110.22
131_G239_L1.1110.22
35_L285_R1.1100.22
296_S302_R1.1040.22
102_G134_W1.1030.22
293_F314_S1.1030.22
113_T147_V1.1000.21
43_E292_P1.1000.21
94_R133_S1.0940.21
312_F316_Y1.0860.21
180_G278_S1.0810.21
215_E218_D1.0730.21
53_C309_A1.0710.21
138_T306_F1.0640.21
198_S326_E1.0630.21
83_E155_Q1.0540.20
51_S60_E1.0450.20
127_S308_L1.0420.20
139_A169_M1.0410.20
327_E340_L1.0350.20
37_F161_K1.0340.20
106_V253_V1.0320.20
53_C104_K1.0300.20
197_I200_F1.0300.20
145_N152_F1.0300.20
109_S193_V1.0280.20
111_D188_F1.0260.20
188_F281_E1.0260.20
92_M304_L1.0250.20
339_D343_L1.0200.19
138_T168_L1.0170.19
160_S190_T1.0120.19
69_S206_V1.0090.19
44_E64_K1.0070.19
72_T288_K1.0030.19
281_E302_R1.0020.19
111_D302_R1.0020.19
288_K306_F1.0010.19
184_L197_I0.9990.19
73_V189_Y0.9970.19
119_G189_Y0.9960.19
169_M218_D0.9950.19
194_L202_F0.9900.19
53_C312_F0.9880.19
70_P273_Y0.9880.19
63_S201_K0.9810.19
287_I306_F0.9810.19
53_C60_E0.9730.18
62_K66_Y0.9650.18
288_K296_S0.9650.18
231_E298_K0.9650.18
20_H23_N0.9610.18
125_L296_S0.9610.18
204_I262_L0.9590.18
25_Q28_G0.9580.18
328_F331_L0.9570.18
113_T305_I0.9540.18
125_L151_A0.9490.18
202_F261_N0.9440.18
35_L220_E0.9430.18
112_W155_Q0.9410.18
133_S317_T0.9400.18
27_V134_W0.9390.18
173_V203_V0.9360.18
77_V186_A0.9340.17
328_F340_L0.9340.17
117_W122_V0.9320.17
213_I237_R0.9290.17
184_L189_Y0.9250.17
77_V132_N0.9210.17
324_T330_L0.9140.17
162_D196_F0.9110.17
194_L282_T0.9100.17
284_Y295_S0.9090.17
221_Y226_K0.9060.17
100_L266_K0.9040.17
46_S124_G0.9040.17
104_K178_K0.9030.17
213_I267_R0.8990.17
113_T287_I0.8960.17
52_A194_L0.8950.17
187_G315_L0.8880.16
144_Q198_S0.8850.16
114_T133_S0.8840.16
75_N124_G0.8840.16
109_S142_K0.8820.16
163_E186_A0.8780.16
111_D280_I0.8780.16
34_M214_Y0.8770.16
133_S290_F0.8750.16
172_I179_V0.8740.16
197_I255_Y0.8710.16
165_V172_I0.8700.16
27_V275_K0.8660.16
35_L84_V0.8640.16
22_N231_E0.8630.16
119_G136_Y0.8620.16
125_L236_F0.8550.16
258_R304_L0.8520.16
278_S290_F0.8520.16
50_V202_F0.8490.16
278_S296_S0.8490.16
88_L304_L0.8480.16
128_S207_P0.8470.16
42_A298_K0.8470.16
24_I29_Y0.8450.16
70_P298_K0.8380.15
304_L312_F0.8350.15
261_N287_I0.8320.15
27_V157_N0.8300.15
331_L335_C0.8290.15
24_I145_N0.8280.15
204_I215_E0.8270.15
77_V244_E0.8260.15
124_G299_F0.8230.15
62_K149_L0.8220.15
90_E151_A0.8150.15
339_D342_D0.8150.15
261_N296_S0.8130.15
282_T318_V0.8100.15
59_V169_M0.8100.15
193_V248_K0.8080.15
71_Q241_Y0.8070.15
333_I340_L0.8060.15
100_L318_V0.8050.15
215_E271_K0.7950.15
296_S306_F0.7910.15
278_S313_Y0.7910.15
165_V261_N0.7890.14
119_G148_L0.7880.14
75_N300_I0.7850.14
45_V73_V0.7840.14
185_D273_Y0.7840.14
136_Y189_Y0.7810.14
92_M309_A0.7790.14
141_T235_K0.7790.14
94_R125_L0.7790.14
91_S214_Y0.7730.14
56_N169_M0.7710.14
135_N287_I0.7680.14
85_I119_G0.7660.14
52_A131_G0.7660.14
36_S134_W0.7660.14
204_I271_K0.7630.14
38_K326_E0.7530.14
51_S161_K0.7510.14
282_T315_L0.7470.14
215_E341_S0.7410.14
110_I137_A0.7410.14
297_T304_L0.7400.14
128_S148_L0.7360.14
292_P305_I0.7360.14
146_M325_R0.7330.13
335_C343_L0.7320.13
143_Y154_P0.7310.13
133_S292_P0.7300.13
119_G297_T0.7270.13
21_Q159_M0.7250.13
80_Q304_L0.7250.13
94_R175_M0.7180.13
71_Q204_I0.7130.13
113_T202_F0.7120.13
78_E109_S0.7110.13
282_T286_N0.7110.13
188_F273_Y0.7080.13
203_V273_Y0.7070.13
121_P211_V0.7070.13
147_V206_V0.7030.13
154_P327_E0.7030.13
96_S253_V0.7010.13
203_V226_K0.7000.13
295_S307_V0.7000.13
113_T296_S0.6990.13
51_S189_Y0.6980.13
232_E301_F0.6980.13
145_N312_F0.6960.13
39_G172_I0.6920.13
131_G280_I0.6920.13
229_K267_R0.6920.13
130_K160_S0.6900.13
151_A169_M0.6880.13
125_L263_D0.6870.13
182_V250_K0.6850.13
21_Q105_E0.6840.13
203_V241_Y0.6800.13
184_L259_A0.6780.12
52_A324_T0.6780.12
188_F280_I0.6750.12
184_L278_S0.6750.12
156_V315_L0.6710.12
95_I301_F0.6650.12
27_V186_A0.6650.12
148_L234_V0.6620.12
176_G304_L0.6610.12
79_E314_S0.6600.12
260_T282_T0.6580.12
273_Y277_R0.6560.12
26_Q183_T0.6560.12
21_Q97_M0.6550.12
194_L204_I0.6530.12
279_P285_R0.6530.12
134_W257_A0.6490.12
101_K267_R0.6490.12
42_A46_S0.6470.12
183_T292_P0.6450.12
274_N279_P0.6430.12
35_L40_R0.6430.12
57_D220_E0.6430.12
32_L264_L0.6420.12
24_I169_M0.6400.12
149_L173_V0.6400.12
194_L238_L0.6390.12
23_N323_M0.6390.12
48_V77_V0.6380.12
157_N222_T0.6350.12
36_S241_Y0.6340.12
52_A236_F0.6310.12
105_E232_E0.6310.12
169_M304_L0.6290.12
132_N147_V0.6290.12
152_F208_V0.6280.12
36_S131_G0.6270.12
140_T169_M0.6260.12
180_G331_L0.6250.12
190_T282_T0.6220.12
45_V203_V0.6210.12
195_K274_N0.6200.12
148_L219_G0.6200.12
189_Y207_P0.6200.12
62_K279_P0.6180.12
115_K197_I0.6170.12
321_N325_R0.6160.11
24_I32_L0.6150.11
135_N187_G0.6150.11
172_I177_L0.6130.11
277_R294_T0.6130.11
27_V293_F0.6130.11
138_T258_R0.6120.11
75_N283_S0.6080.11
76_Y285_R0.6070.11
54_L57_D0.6060.11
115_K204_I0.6030.11
262_L269_V0.6030.11
261_N290_F0.6030.11
82_T167_L0.6020.11
82_T168_L0.6010.11
74_R283_S0.5990.11
302_R314_S0.5990.11
177_L200_F0.5960.11
217_F221_Y0.5950.11
136_Y273_Y0.5950.11
72_T126_G0.5930.11
116_T312_F0.5900.11
117_W144_Q0.5900.11
240_V319_F0.5890.11
25_Q63_S0.5880.11
274_N316_Y0.5880.11
139_A163_E0.5870.11
51_S64_K0.5870.11
92_M97_M0.5850.11
89_L289_A0.5820.11
151_A212_K0.5770.11
100_L296_S0.5770.11
281_E314_S0.5770.11
111_D314_S0.5770.11
134_W138_T0.5760.11
148_L285_R0.5740.11
46_S100_L0.5730.11
143_Y307_V0.5730.11
172_I322_V0.5720.11
42_A186_A0.5720.11
216_E219_G0.5700.11
137_A164_I0.5690.11
170_E182_V0.5680.11
75_N184_L0.5680.11
70_P290_F0.5670.11
23_N29_Y0.5670.11
150_L168_L0.5670.11
147_V278_S0.5670.11
114_T315_L0.5660.11
304_L310_M0.5660.11
91_S267_R0.5650.11
274_N326_E0.5640.11
53_C289_A0.5630.11
319_F322_V0.5630.11
29_Y32_L0.5620.11
117_W125_L0.5550.11
240_V300_I0.5540.11
199_Q243_K0.5540.11
96_S142_K0.5510.11
26_Q30_K0.5490.10
81_G182_V0.5480.10
74_R242_G0.5480.10
156_V250_K0.5480.10
78_E152_F0.5470.10
194_L259_A0.5470.10
155_Q165_V0.5460.10
117_W134_W0.5410.10
110_I193_V0.5410.10
108_I179_V0.5400.10
31_L46_S0.5390.10
333_I336_F0.5390.10
152_F297_T0.5380.10
131_G238_L0.5380.10
123_E144_Q0.5370.10
173_V207_P0.5360.10
138_T149_L0.5360.10
114_T187_G0.5350.10
101_K264_L0.5350.10
325_R329_R0.5340.10
241_Y266_K0.5340.10
257_A266_K0.5330.10
71_Q161_K0.5330.10
48_V203_V0.5300.10
335_C340_L0.5300.10
123_E203_V0.5280.10
131_G291_L0.5280.10
25_Q29_Y0.5270.10
153_V167_L0.5260.10
193_V280_I0.5250.10
26_Q107_D0.5230.10
182_V264_L0.5220.10
209_G263_D0.5210.10
110_I181_L0.5210.10
179_V210_D0.5200.10
31_L80_Q0.5180.10
139_A224_N0.5150.10
203_V269_V0.5150.10
220_E290_F0.5150.10
93_R285_R0.5140.10
274_N285_R0.5140.10
91_S150_L0.5130.10
67_N218_D0.5120.10
306_F322_V0.5110.10
78_E221_Y0.5100.10
243_K329_R0.5100.10
132_N282_T0.5070.10
210_D285_R0.5060.10
69_S311_I0.5060.10
283_S299_F0.5050.10
141_T293_F0.5040.10
141_T316_Y0.5040.10
33_S117_W0.5040.10
168_L284_Y0.5020.10
197_I294_T0.5000.10
196_F213_I0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8874 99.3 0.866 Contact Map
1f6yA 2 0.6181 14.9 0.973 Contact Map
2vxzA 1 0.3901 13.4 0.973 Contact Map
2yciX 2 0.6291 11.6 0.974 Contact Map
1jkoC 1 0.1209 7.5 0.976 Contact Map
4mq3A 1 0.3379 7 0.977 Contact Map
4jp0A 1 0.261 6.9 0.977 Contact Map
4emtA 3 0.1841 6.8 0.977 Contact Map
2m8eA 1 0.1566 6.8 0.977 Contact Map
1qgpA 1 0.206 6.6 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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