GREMLIN Database
CSA2A - CRISPR-associated protein Cas7/Csa2 1
UniProt: Q97YC7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 318 (280)
Sequences: 100 (85)
Seq/√Len: 5.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_D84_A7.2691.00
186_I241_K3.0690.73
81_D120_D3.0140.72
65_Y126_A2.8540.67
25_N60_M2.6760.62
81_D123_E2.6750.62
205_G240_A2.6240.60
92_R123_E2.6050.60
25_N120_D2.5360.58
82_S85_K2.4060.53
280_N284_D2.3810.53
69_L121_I2.3710.52
84_A120_D2.3660.52
40_L85_K2.3180.50
23_L247_P2.2750.49
21_E91_K2.2710.49
84_A123_E2.2070.47
74_L85_K2.1620.45
277_D281_S2.0810.43
129_M195_L2.0530.42
54_P244_R2.0240.41
193_Y218_K2.0090.40
21_E191_A2.0070.40
116_V132_N1.9900.40
24_N240_A1.9260.38
69_L78_L1.9240.38
91_K253_A1.8900.37
187_E244_R1.8770.36
28_S146_M1.8440.35
66_Q91_K1.8130.34
10_I275_Y1.7480.33
143_F160_S1.7170.32
63_H247_P1.6810.31
206_K251_I1.6690.30
54_P148_P1.6600.30
69_L122_V1.6410.30
13_S151_D1.6160.29
61_I146_M1.5960.28
235_Q262_P1.5890.28
62_A65_Y1.5820.28
148_P244_R1.5740.28
189_A226_L1.5690.28
117_I212_V1.5590.27
80_V191_A1.5580.27
25_N207_T1.5570.27
25_N145_Y1.5240.26
72_L224_A1.5210.26
27_E62_A1.5070.26
141_V197_G1.4940.26
117_I207_T1.4810.25
59_E126_A1.4730.25
27_E91_K1.4690.25
27_E34_R1.4620.25
13_S43_K1.4480.25
217_K220_D1.4470.25
135_V258_A1.4400.24
35_H191_A1.4330.24
84_A141_V1.4300.24
22_D241_K1.4250.24
145_Y187_E1.4250.24
22_D25_N1.4240.24
70_V136_K1.4130.24
120_D240_A1.4110.24
73_A79_P1.4110.24
32_Y248_I1.4090.24
15_R244_R1.3970.23
91_K184_Y1.3640.23
38_A120_D1.3540.22
187_E241_K1.3530.22
55_A255_F1.3120.21
56_V77_N1.3110.21
131_P286_F1.3060.21
128_F241_K1.3040.21
220_D223_K1.3010.21
21_E145_Y1.3010.21
266_P279_V1.2920.21
91_K196_T1.2890.21
133_K219_K1.2870.21
26_V191_A1.2870.21
40_L217_K1.2840.21
69_L191_A1.2640.20
128_F165_R1.2580.20
21_E27_E1.2550.20
242_L246_K1.2480.20
218_K222_E1.2480.20
54_P113_E1.2460.20
113_E148_P1.2460.20
27_E186_I1.2370.20
23_L63_H1.2330.20
10_I201_V1.2290.20
28_S164_V1.2280.20
222_E255_F1.2270.20
131_P200_N1.2230.20
294_R300_Y1.2170.19
27_E60_M1.2150.19
59_E245_F1.2100.19
36_R57_S1.1920.19
50_V248_I1.1880.19
91_K264_N1.1880.19
137_R247_P1.1870.19
27_E66_Q1.1870.19
44_D280_N1.1790.19
223_K227_D1.1750.19
164_V182_S1.1730.19
38_A81_D1.1720.19
39_P91_K1.1700.18
26_V145_Y1.1690.18
18_V270_G1.1620.18
56_V146_M1.1500.18
111_D257_S1.1480.18
39_P145_Y1.1380.18
13_S270_G1.1330.18
91_K145_Y1.1320.18
212_V226_L1.1320.18
126_A141_V1.1300.18
91_K126_A1.1180.17
14_V252_E1.1180.17
21_E60_M1.1170.17
24_N56_V1.1140.17
181_Q185_N1.1140.17
35_H54_P1.1050.17
225_A228_A1.0970.17
145_Y186_I1.0950.17
161_Q165_R1.0910.17
163_H193_Y1.0900.17
21_E62_A1.0870.17
161_Q166_Y1.0740.17
131_P256_V1.0720.17
69_L133_K1.0690.17
188_T245_F1.0680.17
25_N240_A1.0670.17
89_L145_Y1.0640.16
136_K200_N1.0590.16
117_I259_S1.0550.16
240_A265_L1.0530.16
56_V144_S1.0490.16
162_F190_S1.0360.16
87_G229_L1.0300.16
34_R270_G1.0280.16
30_G124_D1.0270.16
30_G127_G1.0270.16
30_G221_R1.0270.16
58_G221_R1.0270.16
58_G124_D1.0270.16
30_G58_G1.0270.16
127_G221_R1.0270.16
58_G127_G1.0270.16
124_D127_G1.0270.16
124_D221_R1.0270.16
25_N160_S1.0270.16
9_W20_V1.0240.16
116_V130_N1.0200.16
76_R79_P1.0170.16
62_A194_V1.0140.16
10_I73_A1.0070.15
214_E226_L1.0040.15
21_E264_N0.9920.15
89_L164_V0.9890.15
293_K296_V0.9850.15
69_L275_Y0.9850.15
70_V87_G0.9810.15
138_T186_I0.9800.15
296_V299_Y0.9770.15
32_Y187_E0.9770.15
35_H148_P0.9760.15
145_Y244_R0.9740.15
137_R163_H0.9670.15
62_A80_V0.9670.15
200_N257_S0.9640.15
24_N57_S0.9560.15
42_F248_I0.9550.15
74_L283_T0.9550.15
199_L225_A0.9480.14
263_F267_P0.9470.14
187_E248_I0.9440.14
65_Y225_A0.9430.14
37_R153_V0.9420.14
35_H60_M0.9360.14
85_K125_V0.9340.14
109_G219_K0.9340.14
107_E274_K0.9330.14
148_P187_E0.9330.14
21_E196_T0.9230.14
205_G226_L0.9210.14
65_Y228_A0.9200.14
202_N216_D0.9180.14
63_H226_L0.9130.14
41_V95_D0.9120.14
107_E216_D0.9090.14
62_A145_Y0.9090.14
214_E273_K0.9080.14
96_D106_D0.9000.14
259_S266_P0.8990.14
35_H187_E0.8970.14
24_N120_D0.8950.14
62_A91_K0.8940.14
57_S73_A0.8930.14
12_F274_K0.8920.14
60_M282_T0.8900.14
55_A181_Q0.8890.14
138_T181_Q0.8890.14
226_L252_E0.8880.14
53_V63_H0.8870.14
218_K248_I0.8730.13
35_H59_E0.8720.13
73_A122_V0.8710.13
108_K183_L0.8660.13
16_Y170_E0.8660.13
36_R145_Y0.8600.13
27_E65_Y0.8570.13
126_A242_L0.8570.13
167_A201_V0.8540.13
145_Y181_Q0.8520.13
77_N111_D0.8510.13
27_E145_Y0.8490.13
62_A126_A0.8480.13
76_R227_D0.8450.13
16_Y263_F0.8430.13
19_N63_H0.8380.13
164_V267_P0.8370.13
64_G279_V0.8350.13
56_V108_K0.8340.13
11_S36_R0.8290.13
57_S240_A0.8280.13
52_Y64_G0.8280.13
31_N193_Y0.8250.13
117_I200_N0.8230.13
33_V184_Y0.8190.13
35_H244_R0.8190.13
59_E66_Q0.8180.13
113_E254_L0.8150.12
136_K241_K0.8130.12
65_Y89_L0.8080.12
90_I136_K0.8040.12
38_A55_A0.8010.12
36_R73_A0.8000.12
65_Y242_L0.8000.12
84_A208_Q0.7980.12
11_S72_L0.7970.12
80_V146_M0.7950.12
295_P300_Y0.7910.12
54_P187_E0.7900.12
81_D92_R0.7900.12
49_T258_A0.7890.12
62_A247_P0.7890.12
33_V199_L0.7890.12
243_T279_V0.7870.12
65_Y232_T0.7870.12
167_A202_N0.7850.12
61_I77_N0.7840.12
62_A186_I0.7790.12
22_D125_V0.7770.12
91_K122_V0.7770.12
29_A34_R0.7670.12
80_V177_N0.7650.12
45_K129_M0.7560.12
26_V60_M0.7530.12
56_V111_D0.7490.12
194_V272_I0.7480.12
135_V206_K0.7420.11
72_L77_N0.7420.11
21_E26_V0.7380.11
75_Q299_Y0.7380.11
120_D123_E0.7370.11
186_I242_L0.7300.11
22_D186_I0.7290.11
30_G137_R0.7270.11
58_G137_R0.7270.11
137_R221_R0.7270.11
127_G137_R0.7270.11
124_D137_R0.7270.11
37_R233_L0.7240.11
188_T242_L0.7240.11
205_G259_S0.7230.11
217_K283_T0.7210.11
120_D207_T0.7200.11
203_S206_K0.7200.11
39_P52_Y0.7190.11
34_R56_V0.7180.11
38_A84_A0.7120.11
204_V270_G0.7120.11
141_V231_L0.7110.11
139_S247_P0.7090.11
135_V190_S0.7080.11
138_T145_Y0.7050.11
100_E104_C0.7030.11
22_D60_M0.7010.11
16_Y68_N0.7000.11
38_A234_T0.6990.11
145_Y241_K0.6980.11
95_D163_H0.6970.11
100_E106_D0.6970.11
24_N36_R0.6930.11
42_F50_V0.6900.11
164_V195_L0.6880.11
19_N113_E0.6870.11
203_S254_L0.6840.11
147_V246_K0.6810.11
92_R228_A0.6790.11
208_Q219_K0.6780.11
65_Y145_Y0.6780.11
100_E103_K0.6760.11
138_T187_E0.6730.11
10_I51_T0.6710.11
21_E65_Y0.6710.11
100_E293_K0.6700.11
96_D214_E0.6700.11
61_I284_D0.6690.11
109_G300_Y0.6690.11
25_N55_A0.6680.11
87_G150_I0.6670.10
228_A287_A0.6660.10
93_G166_Y0.6620.10
147_V190_S0.6590.10
117_I189_A0.6560.10
184_Y188_T0.6540.10
144_S272_I0.6540.10
10_I117_I0.6540.10
14_V195_L0.6510.10
122_V229_L0.6510.10
169_K218_K0.6500.10
103_K110_S0.6500.10
99_H253_A0.6430.10
14_V254_L0.6420.10
59_E161_Q0.6410.10
276_I288_K0.6390.10
21_E35_H0.6370.10
113_E244_R0.6360.10
59_E91_K0.6360.10
215_V273_K0.6350.10
62_A264_N0.6310.10
22_D185_N0.6290.10
132_N274_K0.6260.10
84_A109_G0.6240.10
176_K183_L0.6240.10
194_V264_N0.6210.10
241_K244_R0.6180.10
192_S219_K0.6140.10
89_L243_T0.6120.10
190_S232_T0.6090.10
167_A184_Y0.6080.10
80_V233_L0.6080.10
61_I202_N0.6050.10
159_S183_L0.6040.10
211_P214_E0.5990.10
274_K288_K0.5970.10
13_S168_N0.5960.10
110_S118_N0.5930.10
96_D229_L0.5910.10
140_N217_K0.5870.10
197_G229_L0.5820.09
78_L193_Y0.5820.09
91_K186_I0.5810.09
103_K132_N0.5810.09
129_M254_L0.5810.09
135_V154_K0.5790.09
104_C114_L0.5780.09
295_P298_K0.5780.09
253_A275_Y0.5780.09
59_E145_Y0.5770.09
200_N233_L0.5760.09
35_H145_Y0.5760.09
78_L224_A0.5740.09
90_I178_E0.5730.09
129_M232_T0.5720.09
240_A248_I0.5710.09
43_K179_N0.5680.09
136_K168_N0.5660.09
15_R241_K0.5650.09
36_R181_Q0.5620.09
109_G296_V0.5600.09
24_N205_G0.5590.09
10_I289_I0.5590.09
104_C109_G0.5570.09
183_L281_S0.5500.09
65_Y191_A0.5480.09
24_N55_A0.5430.09
11_S224_A0.5420.09
77_N281_S0.5410.09
52_Y241_K0.5410.09
254_L296_V0.5390.09
259_S283_T0.5370.09
23_L137_R0.5360.09
101_G298_K0.5340.09
52_Y166_Y0.5320.09
145_Y161_Q0.5320.09
117_I225_A0.5320.09
14_V61_I0.5310.09
210_Y216_D0.5310.09
54_P87_G0.5300.09
31_N228_A0.5300.09
120_D162_F0.5250.09
242_L265_L0.5230.09
91_K181_Q0.5230.09
296_V300_Y0.5220.09
72_L231_L0.5210.09
52_Y279_V0.5190.09
66_Q126_A0.5180.09
101_G110_S0.5150.09
35_H69_L0.5150.09
207_T237_L0.5150.09
77_N110_S0.5120.09
25_N185_N0.5110.09
21_E69_L0.5110.09
41_V190_S0.5100.09
27_E80_V0.5080.09
71_E212_V0.5080.09
40_L262_P0.5060.09
15_R56_V0.5050.09
35_H241_K0.5050.09
66_Q130_N0.5050.09
36_R122_V0.5030.09
65_Y91_K0.5020.09
144_S159_S0.5010.09
31_N58_G0.5010.09
31_N124_D0.5010.09
31_N127_G0.5010.09
31_N221_R0.5010.09
49_T254_L0.5000.09
9_W265_L0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ps0A 1 0.8836 100 0.403 Contact Map
4u7uE 3 0.8333 39.4 0.97 Contact Map
4txdA 1 0.8616 15.5 0.975 Contact Map
1tifA 1 0.2327 8.4 0.978 Contact Map
2ve7C 1 0.2201 7.9 0.978 Contact Map
3wwvA 2 0.1667 6.9 0.979 Contact Map
1xmbA 1 0.1384 6.7 0.979 Contact Map
1lxjA 4 0.2013 6.4 0.979 Contact Map
2iboA 4 0.1887 5.4 0.98 Contact Map
4bt9A 2 0.2264 5.3 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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