GREMLIN Database
Q97YC4 - ATP-dependent RNA helicase related protein
UniProt: Q97YC4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 572 (460)
Sequences: 5456 (4633)
Seq/√Len: 216.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_L101_A5.0381.00
382_G386_I3.9151.00
382_G387_W3.9061.00
131_T136_F3.6211.00
160_F164_T3.5841.00
88_V97_I3.1321.00
70_V84_L3.0121.00
298_V307_L2.9601.00
38_C54_L2.8231.00
298_V304_A2.6801.00
380_D387_W2.6601.00
396_D403_T2.6481.00
46_E199_I2.4661.00
422_Y425_I2.4651.00
212_E217_M2.4431.00
396_D400_V2.3981.00
399_E403_T2.3111.00
423_G427_D2.2971.00
403_T406_E2.2771.00
101_A130_I2.2311.00
345_I349_V2.2211.00
101_A128_F2.1801.00
400_V403_T2.1451.00
301_V322_R2.1281.00
382_G385_Y2.1211.00
430_I433_P2.0621.00
212_E220_R2.0421.00
406_E409_S2.0411.00
218_E221_K2.0411.00
311_L340_I2.0331.00
298_V340_I2.0231.00
307_L340_I1.9351.00
487_I491_G1.9001.00
509_V513_K1.8971.00
160_F163_Y1.8911.00
425_I430_I1.8881.00
456_D461_L1.8761.00
426_V429_V1.8761.00
425_I428_R1.8691.00
223_V226_A1.8661.00
305_I318_L1.8651.00
463_K467_L1.8571.00
393_Y397_K1.8471.00
428_R432_P1.8441.00
184_L188_V1.8421.00
116_P119_I1.8171.00
522_K525_V1.8111.00
457_L461_L1.8111.00
447_A450_L1.8091.00
274_N277_D1.8041.00
317_C336_C1.7751.00
424_E427_D1.7741.00
512_Y516_R1.7651.00
430_I434_R1.7551.00
415_S418_V1.7491.00
425_I429_V1.7481.00
525_V528_T1.7451.00
213_L218_E1.7351.00
275_F278_K1.7091.00
380_D386_I1.7001.00
518_V521_D1.7001.00
517_K520_V1.6971.00
530_V533_A1.6941.00
403_T410_K1.6891.00
527_E530_V1.6691.00
296_V338_I1.6581.00
429_V433_P1.6561.00
172_F200_L1.6291.00
213_L220_R1.6201.00
400_V404_I1.5851.00
401_E404_I1.5821.00
66_S97_I1.5791.00
421_S425_I1.5751.00
528_T531_E1.5621.00
525_V529_C1.5571.00
181_W185_L1.5561.00
213_L217_M1.5451.00
395_Y400_V1.5441.00
212_E218_E1.5251.00
427_D431_K1.5201.00
529_C533_A1.4881.00
468_T474_N1.4751.00
414_I417_K1.4711.00
412_N416_L1.4671.00
425_I435_G1.4571.00
395_Y398_D1.4541.00
521_D524_N1.4511.00
402_N406_E1.4511.00
471_Y475_V1.4491.00
483_E487_I1.4451.00
432_P435_G1.4441.00
406_E410_K1.4411.00
70_V168_H1.4381.00
407_L410_K1.4361.00
447_A451_F1.4361.00
396_D406_E1.4361.00
483_E486_L1.4321.00
443_L447_A1.4241.00
393_Y396_D1.4091.00
529_C532_I1.3971.00
422_Y429_V1.3821.00
44_Y47_C1.3811.00
380_D383_E1.3781.00
400_V411_K1.3751.00
478_D481_A1.3701.00
394_P403_T1.3661.00
49_D197_N1.3601.00
54_L201_S1.3601.00
431_K435_G1.3571.00
461_L464_Y1.3531.00
70_V166_L1.3491.00
468_T473_I1.3481.00
471_Y474_N1.3421.00
485_D489_L1.3381.00
217_M220_R1.3371.00
463_K466_T1.3321.00
278_K285_V1.3201.00
464_Y468_T1.3191.00
66_S201_S1.3171.00
465_C469_N1.3161.00
486_L490_D1.3131.00
523_V527_E1.3091.00
213_L219_N1.3041.00
505_V508_Y1.2941.00
214_I218_E1.2851.00
514_P517_K1.2851.00
464_Y467_L1.2791.00
384_L387_W1.2781.00
515_E518_V1.2781.00
404_I408_E1.2731.00
394_P399_E1.2681.00
482_S486_L1.2671.00
358_T370_V1.2641.00
498_A501_G1.2591.00
468_T471_Y1.2561.00
426_V432_P1.2531.00
500_K503_D1.2521.00
395_Y401_E1.2451.00
526_R531_E1.2441.00
285_V355_V1.2441.00
523_V526_R1.2381.00
509_V516_R1.2311.00
46_E49_D1.2271.00
458_E461_L1.2241.00
394_P400_V1.2241.00
263_E266_I1.2231.00
402_N407_L1.2221.00
403_T407_L1.2201.00
447_A452_A1.2181.00
397_K404_I1.2131.00
173_H347_V1.2111.00
517_K521_D1.2071.00
470_S473_I1.2051.00
510_E513_K1.2041.00
441_R452_A1.2011.00
501_G508_Y1.2001.00
402_N405_K1.2001.00
87_V136_F1.1961.00
456_D460_L1.1931.00
399_E406_E1.1921.00
396_D399_E1.1911.00
181_W184_L1.1841.00
414_I418_V1.1821.00
422_Y432_P1.1811.00
501_G505_V1.1741.00
468_T472_V1.1711.00
380_D384_L1.1701.00
439_L442_E1.1631.00
423_G426_V1.1601.00
500_K504_C1.1581.00
394_P406_E1.1561.00
510_E516_R1.1561.00
459_K470_S1.1561.00
527_E531_E1.1521.00
181_W187_A1.1521.00
341_A345_I1.1441.00
469_N472_V1.1411.00
506_Y510_E1.1331.00
212_E219_N1.1321.00
486_L489_L1.1281.00
442_E446_I1.1251.00
98_Q110_V1.1211.00
404_I411_K1.1201.00
463_K469_N1.1191.00
443_L446_I1.1191.00
422_Y426_V1.1181.00
526_R529_C1.1121.00
426_V431_K1.1061.00
182_T185_L1.1051.00
113_S139_N1.1031.00
236_K240_C1.1031.00
213_L216_M1.1011.00
399_E404_I1.1011.00
212_E216_M1.0961.00
508_Y513_K1.0951.00
438_D441_R1.0951.00
427_D435_G1.0931.00
499_I503_D1.0921.00
432_P436_D1.0921.00
508_Y511_E1.0901.00
87_V131_T1.0891.00
438_D442_E1.0871.00
476_A480_P1.0851.00
83_R165_S1.0831.00
45_Y52_F1.0821.00
422_Y433_P1.0811.00
400_V406_E1.0811.00
407_L411_K1.0781.00
519_A523_V1.0781.00
522_K526_R1.0771.00
532_I535_P1.0751.00
524_N527_E1.0681.00
427_D432_P1.0641.00
446_I450_L1.0641.00
412_N417_K1.0621.00
501_G504_C1.0621.00
405_K409_S1.0601.00
380_D385_Y1.0601.00
444_D449_N1.0601.00
467_L473_I1.0591.00
308_Y316_P1.0571.00
426_V430_I1.0571.00
381_K387_W1.0571.00
513_K516_R1.0571.00
121_S124_F1.0561.00
465_C470_S1.0551.00
273_I276_L1.0491.00
421_S430_I1.0481.00
397_K400_V1.0471.00
182_T187_A1.0451.00
487_I490_D1.0441.00
422_Y428_R1.0431.00
442_E447_A1.0421.00
443_L451_F1.0401.00
421_S429_V1.0371.00
425_I434_R1.0341.00
425_I432_P1.0301.00
525_V531_E1.0291.00
423_G428_R1.0281.00
511_E514_P1.0281.00
424_E429_V1.0271.00
429_V434_R1.0271.00
226_A229_N1.0271.00
184_L187_A1.0231.00
394_P402_N1.0221.00
424_E430_I1.0211.00
292_K354_E1.0211.00
32_V64_T1.0201.00
476_A481_A1.0171.00
423_G430_I1.0171.00
126_A129_I1.0161.00
423_G431_K1.0131.00
460_L463_K1.0121.00
425_I433_P1.0111.00
450_L453_T1.0111.00
393_Y400_V1.0081.00
472_V475_V1.0041.00
464_Y473_I1.0021.00
459_K463_K1.0011.00
524_N531_E0.9961.00
280_D283_L0.9961.00
515_E523_V0.9941.00
216_M219_N0.9941.00
429_V435_G0.9881.00
428_R434_R0.9881.00
513_K517_K0.9871.00
446_I452_A0.9851.00
395_Y403_T0.9851.00
388_K393_Y0.9811.00
27_K30_Q0.9801.00
512_Y521_D0.9791.00
327_D331_K0.9781.00
100_S103_E0.9771.00
482_S489_L0.9751.00
503_D507_A0.9731.00
497_I500_K0.9731.00
456_D459_K0.9731.00
397_K403_T0.9721.00
513_K519_A0.9711.00
397_K410_K0.9691.00
507_A512_Y0.9671.00
476_A479_T0.9661.00
394_P397_K0.9661.00
461_L474_N0.9631.00
319_I345_I0.9621.00
422_Y430_I0.9601.00
498_A504_C0.9581.00
428_R431_K0.9541.00
512_Y525_V0.9511.00
498_A503_D0.9511.00
512_Y515_E0.9481.00
422_Y427_D0.9451.00
88_V132_T0.9441.00
448_E452_A0.9401.00
413_D416_L0.9391.00
525_V530_V0.9360.99
466_T470_S0.9330.99
503_D512_Y0.9320.99
430_I435_G0.9320.99
445_N448_E0.9310.99
86_H101_A0.9290.99
488_P495_L0.9280.99
315_S337_N0.9280.99
484_R488_P0.9270.99
98_Q102_C0.9250.99
362_P369_R0.9240.99
317_C331_K0.9200.99
482_S485_D0.9200.99
260_V265_K0.9190.99
296_V357_I0.9180.99
466_T469_N0.9140.99
520_V525_V0.9130.99
412_N415_S0.9120.99
502_N505_V0.9070.99
406_E411_K0.9070.99
214_I217_M0.9050.99
513_K518_V0.9050.99
531_E534_K0.9040.99
383_E387_W0.9040.99
404_I407_L0.9010.99
74_D108_F0.9010.99
526_R530_V0.8990.99
427_D430_I0.8990.99
442_E449_N0.8980.99
426_V434_R0.8920.99
518_V525_V0.8900.99
422_Y431_K0.8890.99
460_L469_N0.8890.99
393_Y398_D0.8890.99
26_R30_Q0.8880.99
236_K239_N0.8880.99
398_D406_E0.8880.99
509_V514_P0.8830.99
469_N474_N0.8780.99
413_D418_V0.8770.99
531_E535_P0.8760.99
464_Y471_Y0.8750.99
173_H368_Q0.8740.99
295_M341_A0.8730.99
212_E215_R0.8710.99
440_L443_L0.8710.99
356_M373_L0.8710.99
484_R489_L0.8700.99
397_K409_S0.8700.99
101_A110_V0.8680.99
496_K500_K0.8670.99
461_L468_T0.8630.99
509_V512_Y0.8580.99
423_G433_P0.8570.99
467_L475_V0.8570.99
167_V188_V0.8560.99
504_C508_Y0.8550.99
456_D462_D0.8530.99
500_K509_V0.8520.99
414_I419_P0.8510.99
224_R227_V0.8500.99
466_T471_Y0.8470.99
495_L503_D0.8470.99
217_M221_K0.8460.99
262_V265_K0.8440.99
398_D401_E0.8440.99
393_Y403_T0.8420.99
444_D447_A0.8420.99
469_N475_V0.8410.99
503_D511_E0.8400.99
484_R487_I0.8380.99
405_K411_K0.8370.99
90_T134_D0.8360.99
441_R447_A0.8360.99
513_K523_V0.8340.99
525_V533_A0.8310.99
511_E517_K0.8300.99
463_K468_T0.8290.99
455_E469_N0.8270.99
294_I355_V0.8260.99
423_G429_V0.8240.99
421_S432_P0.8220.99
462_D466_T0.8220.99
424_E432_P0.8210.99
182_T188_V0.8200.99
510_E520_V0.8180.99
463_K470_S0.8170.99
438_D446_I0.8160.99
395_Y406_E0.8160.99
522_K529_C0.8120.99
441_R446_I0.8110.99
495_L499_I0.8100.99
404_I410_K0.8090.99
507_A511_E0.8080.99
522_K527_E0.8080.99
449_N454_R0.8080.99
440_L452_A0.8070.98
429_V432_P0.8050.98
65_L69_I0.8050.98
459_K471_Y0.8030.98
272_N275_F0.8030.98
461_L465_C0.8020.98
494_A504_C0.8000.98
511_E515_E0.8000.98
516_R519_A0.7990.98
520_V524_N0.7980.98
283_L314_L0.7970.98
388_K394_P0.7930.98
319_I323_F0.7920.98
515_E519_A0.7910.98
456_D466_T0.7900.98
498_A502_N0.7890.98
311_L338_I0.7890.98
472_V480_P0.7860.98
461_L471_Y0.7860.98
118_H122_P0.7840.98
93_L348_G0.7830.98
100_S104_R0.7830.98
399_E409_S0.7830.98
446_I451_F0.7820.98
308_Y312_R0.7800.98
117_S120_K0.7790.98
27_K32_V0.7780.98
398_D403_T0.7780.98
361_A384_L0.7770.98
303_K360_Q0.7750.98
457_L464_Y0.7730.98
450_L461_L0.7720.98
459_K467_L0.7720.98
276_L285_V0.7700.98
45_Y48_E0.7680.98
397_K402_N0.7680.98
184_L190_H0.7670.98
408_E411_K0.7650.98
494_A501_G0.7630.98
497_I508_Y0.7600.98
463_K472_V0.7580.98
90_T347_V0.7570.98
442_E445_N0.7550.98
493_L497_I0.7550.98
402_N409_S0.7550.98
423_G435_G0.7530.98
440_L451_F0.7470.98
477_Y481_A0.7460.98
395_Y410_K0.7460.98
521_D528_T0.7450.97
57_P60_Y0.7450.97
416_L419_P0.7430.97
430_I436_D0.7420.97
498_A507_A0.7420.97
95_K329_D0.7410.97
213_L221_K0.7400.97
66_S69_I0.7380.97
421_S424_E0.7370.97
528_T532_I0.7360.97
501_G509_V0.7360.97
440_L444_D0.7340.97
483_E491_G0.7330.97
397_K401_E0.7310.97
400_V410_K0.7310.97
421_S431_K0.7290.97
399_E402_N0.7280.97
442_E450_L0.7270.97
448_E451_F0.7250.97
511_E523_V0.7250.97
506_Y509_V0.7240.97
523_V529_C0.7220.97
477_Y480_P0.7210.97
505_V511_E0.7210.97
182_T186_G0.7210.97
44_Y48_E0.7200.97
479_T488_P0.7190.97
468_T475_V0.7190.97
395_Y399_E0.7180.97
421_S427_D0.7170.97
352_S378_K0.7160.97
505_V512_Y0.7150.97
514_P521_D0.7140.97
404_I409_S0.7130.97
403_T409_S0.7120.97
437_P444_D0.7110.97
116_P120_K0.7090.97
214_I220_R0.7090.97
401_E405_K0.7070.97
492_D497_I0.7070.97
467_L470_S0.7070.97
493_L500_K0.7030.96
464_Y475_V0.7010.96
293_K352_S0.7000.96
110_V130_I0.6990.96
440_L447_A0.6970.96
93_L96_D0.6970.96
427_D433_P0.6960.96
424_E428_R0.6950.96
494_A497_I0.6930.96
273_I277_D0.6910.96
85_I129_I0.6890.96
444_D454_R0.6890.96
212_E221_K0.6860.96
456_D468_T0.6860.96
420_S423_G0.6860.96
92_S96_D0.6860.96
278_K360_Q0.6850.96
530_V534_K0.6840.96
507_A517_K0.6830.96
507_A510_E0.6820.96
471_Y481_A0.6810.96
528_T534_K0.6810.96
510_E514_P0.6790.96
521_D525_V0.6780.96
510_E517_K0.6780.96
470_S474_N0.6770.96
492_D495_L0.6760.96
469_N473_I0.6750.96
482_S487_I0.6740.95
454_R457_L0.6710.95
423_G434_R0.6690.95
143_A160_F0.6690.95
494_A511_E0.6660.95
497_I503_D0.6620.95
438_D444_D0.6610.95
420_S434_R0.6610.95
499_I505_V0.6600.95
449_N452_A0.6600.95
526_R534_K0.6580.95
519_A532_I0.6580.95
465_C472_V0.6580.95
467_L472_V0.6560.95
491_G495_L0.6550.95
186_G189_R0.6550.95
273_I278_K0.6550.95
431_K434_R0.6550.95
104_R353_S0.6500.95
509_V515_E0.6490.94
388_K395_Y0.6480.94
433_P436_D0.6480.94
441_R451_F0.6480.94
514_P518_V0.6470.94
410_K415_S0.6460.94
453_T457_L0.6450.94
225_L228_V0.6440.94
517_K524_N0.6440.94
507_A514_P0.6430.94
396_D404_I0.6420.94
503_D527_E0.6420.94
399_E410_K0.6420.94
494_A500_K0.6410.94
415_S419_P0.6390.94
499_I514_P0.6390.94
279_E359_E0.6370.94
422_Y436_D0.6360.94
395_Y405_K0.6360.94
83_R127_K0.6350.94
519_A522_K0.6330.94
455_E461_L0.6330.94
402_N408_E0.6330.94
500_K513_K0.6280.93
515_E528_T0.6270.93
471_Y477_Y0.6270.93
527_E532_I0.6240.93
444_D452_A0.6230.93
485_D490_D0.6220.93
508_Y512_Y0.6220.93
525_V532_I0.6210.93
465_C471_Y0.6210.93
487_I495_L0.6200.93
441_R448_E0.6180.93
503_D506_Y0.6180.93
477_Y485_D0.6180.93
498_A512_Y0.6170.93
399_E408_E0.6170.93
458_E464_Y0.6160.93
462_D470_S0.6150.93
347_V368_Q0.6140.93
516_R528_T0.6120.93
506_Y512_Y0.6100.92
480_P491_G0.6100.92
456_D464_Y0.6080.92
502_N530_V0.6080.92
459_K465_C0.6060.92
223_V227_V0.5990.92
504_C510_E0.5970.92
464_Y472_V0.5970.92
457_L460_L0.5950.92
429_V436_D0.5950.92
497_I511_E0.5950.92
405_K408_E0.5950.92
498_A509_V0.5920.91
513_K520_V0.5920.91
499_I529_C0.5910.91
395_Y409_S0.5880.91
516_R520_V0.5880.91
502_N506_Y0.5880.91
161_G164_T0.5880.91
400_V405_K0.5870.91
119_I122_P0.5860.91
488_P491_G0.5850.91
398_D405_K0.5840.91
308_Y318_L0.5830.91
111_Q126_A0.5810.91
299_N360_Q0.5810.91
512_Y519_A0.5810.91
507_A516_R0.5810.91
27_K64_T0.5800.90
437_P441_R0.5780.90
388_K401_E0.5780.90
520_V527_E0.5770.90
455_E458_E0.5770.90
401_E408_E0.5770.90
396_D402_N0.5740.90
500_K508_Y0.5730.90
305_I320_H0.5730.90
205_P374_L0.5720.90
216_M220_R0.5690.90
520_V530_V0.5680.90
183_S187_A0.5670.89
528_T533_A0.5650.89
523_V530_V0.5610.89
403_T408_E0.5600.89
308_Y340_I0.5590.89
454_R469_N0.5580.89
30_Q33_L0.5580.89
503_D516_R0.5570.89
439_L443_L0.5560.89
459_K469_N0.5550.88
513_K522_K0.5540.88
293_K354_E0.5530.88
508_Y514_P0.5510.88
55_T206_S0.5500.88
388_K396_D0.5490.88
436_D441_R0.5490.88
280_D314_L0.5460.88
203_A371_G0.5450.88
280_D284_G0.5440.87
321_S345_I0.5430.87
441_R445_N0.5430.87
282_V357_I0.5420.87
493_L534_K0.5400.87
505_V518_V0.5400.87
520_V523_V0.5400.87
398_D402_N0.5390.87
428_R435_G0.5390.87
27_K33_L0.5380.87
27_K31_K0.5380.87
466_T473_I0.5380.87
137_L186_G0.5370.87
358_T361_A0.5370.87
282_V359_E0.5370.87
397_K406_E0.5360.87
493_L501_G0.5360.87
71_R105_G0.5350.87
423_G432_P0.5340.86
514_P525_V0.5330.86
439_L448_E0.5330.86
517_K531_E0.5330.86
442_E451_F0.5330.86
443_L450_L0.5330.86
88_V94_A0.5320.86
422_Y434_R0.5320.86
398_D410_K0.5310.86
413_D417_K0.5310.86
485_D488_P0.5310.86
522_K530_V0.5300.86
508_Y518_V0.5280.86
400_V408_E0.5280.86
521_D531_E0.5280.86
425_I436_D0.5260.86
45_Y50_V0.5260.86
185_L188_V0.5250.86
512_Y527_E0.5250.86
457_L473_I0.5250.86
437_P442_E0.5240.85
398_D409_S0.5230.85
489_L502_N0.5230.85
497_I505_V0.5220.85
512_Y520_V0.5210.85
483_E488_P0.5200.85
498_A505_V0.5180.85
465_C477_Y0.5150.84
459_K462_D0.5140.84
508_Y530_V0.5140.84
426_V435_G0.5140.84
456_D472_V0.5130.84
462_D485_D0.5110.84
425_I431_K0.5100.84
38_C42_S0.5090.84
505_V509_V0.5090.84
358_T369_R0.5080.84
488_P497_I0.5060.83
451_F454_R0.5050.83
277_D281_D0.5040.83
506_Y517_K0.5030.83
501_G507_A0.5020.83
437_P450_L0.5000.83
515_E522_K0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pxaA 1 0.6503 100 0.477 Contact Map
3fmpB 1 0.3689 100 0.478 Contact Map
4nhoA 1 0.6416 100 0.483 Contact Map
2db3A 1 0.6434 100 0.484 Contact Map
4d25A 1 0.6451 100 0.485 Contact Map
3eiqA 1 0.5979 100 0.489 Contact Map
3i5xA 1 0.7937 100 0.491 Contact Map
4ljyA 1 0.6731 100 0.493 Contact Map
4ct4B 1 0.6329 100 0.494 Contact Map
3peyA 1 0.6469 100 0.494 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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