GREMLIN Database
Q97YC0 - Uncharacterized protein
UniProt: Q97YC0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 261 (228)
Sequences: 341 (293)
Seq/√Len: 19.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_R82_N5.3261.00
161_L217_F4.6821.00
165_I243_V3.9301.00
243_V254_V3.4681.00
144_R245_K2.9730.99
132_F136_T2.8720.99
26_R49_L2.8500.99
238_V254_V2.8300.99
7_F81_V2.8060.99
41_E138_L2.7860.99
14_D73_A2.6570.98
25_S79_F2.4330.97
237_Y241_F2.4250.96
56_D77_Y2.2920.95
165_I241_F2.2900.95
27_T41_E2.2640.95
244_G252_G2.1730.93
9_L54_V2.1710.93
194_Y211_F2.1670.93
168_H247_R2.1540.93
26_R41_E2.1420.93
132_F164_S2.1270.93
7_F50_R2.0940.92
26_R247_R2.0520.91
247_R251_F2.0410.91
246_S249_I2.0320.91
74_E104_N1.9500.89
246_S251_F1.9410.89
244_G250_G1.8590.86
197_R205_N1.8010.85
17_I229_E1.7530.83
129_R216_V1.7250.82
92_V168_H1.6550.79
24_L134_T1.6550.79
28_L47_K1.6450.79
54_V74_E1.6260.78
22_S53_V1.5970.77
82_N253_E1.5460.74
30_L54_V1.5330.74
136_T211_F1.5260.73
77_Y85_L1.5110.72
41_E164_S1.4680.70
80_I217_F1.4660.70
110_E181_T1.4660.70
160_L217_F1.4620.70
138_L246_S1.4570.70
242_G246_S1.4520.69
83_T197_R1.4420.69
213_G252_G1.4190.67
213_G244_G1.4190.67
26_R246_S1.4170.67
37_S219_L1.4130.67
239_N243_V1.3950.66
159_P163_Y1.3950.66
101_E107_F1.3950.66
47_K251_F1.3900.66
233_R254_V1.3800.65
82_N238_V1.3470.63
154_L158_V1.3320.62
130_V235_L1.3290.62
26_R138_L1.3190.62
11_P14_D1.3050.61
21_S26_R1.3010.61
242_G252_G1.2790.59
192_V218_E1.2730.59
108_H117_K1.2470.57
137_L251_F1.2430.57
83_T89_V1.2410.57
165_I237_Y1.2300.56
111_L114_V1.2120.55
201_A251_F1.2120.55
137_L246_S1.2110.55
154_L194_Y1.2080.55
155_F194_Y1.1970.54
160_L241_F1.1880.53
52_T253_E1.1740.53
33_S92_V1.1720.52
227_I231_I1.1660.52
34_P37_S1.1630.52
160_L237_Y1.1620.52
202_Y207_P1.1610.52
73_A201_A1.1580.52
82_N255_E1.1410.50
127_F216_V1.1390.50
17_I243_V1.1360.50
16_I98_V1.1330.50
242_G247_R1.1120.49
81_V98_V1.1040.48
154_L209_K1.1030.48
213_G250_G1.1030.48
56_D173_M1.1000.48
245_K249_I1.0970.48
137_L154_L1.0930.47
84_L241_F1.0810.47
234_L237_Y1.0720.46
110_E240_Y1.0700.46
170_N234_L1.0690.46
7_F79_F1.0650.46
138_L164_S1.0640.46
47_K248_N1.0520.45
18_P23_K1.0480.45
26_R249_I1.0480.45
170_N210_G1.0350.44
7_F10_K1.0320.44
11_P175_K1.0200.43
57_Q129_R1.0150.42
111_L240_Y1.0090.42
139_Q219_L1.0060.42
238_V243_V0.9960.41
228_R232_R0.9910.41
26_R242_G0.9890.41
7_F57_Q0.9870.41
109_V172_Y0.9870.41
8_R133_K0.9760.40
238_V247_R0.9730.40
52_T238_V0.9700.40
233_R248_N0.9680.40
134_T221_A0.9660.39
16_I19_P0.9610.39
137_L245_K0.9490.38
145_M157_Y0.9480.38
142_R180_V0.9470.38
165_I234_L0.9470.38
144_R251_F0.9460.38
33_S36_Y0.9440.38
134_T208_N0.9430.38
41_E198_P0.9410.38
23_K26_R0.9410.38
31_S218_E0.9370.38
103_Y117_K0.9350.38
40_I49_L0.9290.37
45_P51_I0.9280.37
128_Y232_R0.9260.37
27_T138_L0.9250.37
30_L34_P0.9250.37
26_R169_W0.9210.37
170_N182_G0.9180.37
169_W234_L0.9170.36
86_E90_K0.9130.36
160_L165_I0.9090.36
241_F254_V0.9050.36
164_S243_V0.9040.36
86_E115_S0.9040.36
130_V238_V0.9030.36
100_R119_N0.9020.36
42_S154_L0.8970.35
48_P205_N0.8910.35
78_T128_Y0.8820.34
29_F248_N0.8810.34
26_R139_Q0.8800.34
8_R11_P0.8770.34
38_K142_R0.8760.34
145_M160_L0.8700.34
128_Y235_L0.8690.34
108_H114_V0.8690.34
25_S208_N0.8500.33
104_N122_A0.8450.32
14_D17_I0.8440.32
163_Y183_S0.8420.32
10_K14_D0.8400.32
242_G250_G0.8400.32
167_S177_I0.8380.32
234_L240_Y0.8320.32
134_T184_K0.8300.32
23_K204_G0.8240.31
89_V134_T0.8230.31
145_M154_L0.8190.31
156_P244_G0.8180.31
156_P252_G0.8180.31
113_N175_K0.8170.31
41_E246_S0.8100.30
156_P213_G0.8090.30
212_V255_E0.8040.30
50_R93_I0.8000.30
164_S238_V0.7990.30
83_T88_V0.7960.30
26_R251_F0.7950.30
130_V254_V0.7940.30
41_E139_Q0.7920.29
29_F43_K0.7900.29
114_V118_E0.7880.29
130_V239_N0.7860.29
76_T125_A0.7840.29
35_T216_V0.7770.29
166_A254_V0.7750.29
41_E168_H0.7700.28
30_L37_S0.7700.28
10_K16_I0.7650.28
156_P242_G0.7550.28
29_F171_R0.7530.27
203_Y245_K0.7530.27
193_N216_V0.7470.27
33_S118_E0.7350.27
41_E247_R0.7330.26
43_K171_R0.7320.26
51_I144_R0.7310.26
75_N238_V0.7290.26
16_I106_S0.7220.26
161_L165_I0.7210.26
32_F91_E0.7200.26
37_S181_T0.7150.26
169_W173_M0.7100.25
111_L182_G0.7090.25
165_I169_W0.7050.25
26_R137_L0.7050.25
8_R205_N0.7030.25
131_H137_L0.7020.25
145_M158_V0.7000.25
190_R228_R0.7000.25
194_Y254_V0.7000.25
113_N220_S0.6940.25
116_V191_E0.6900.24
40_I253_E0.6890.24
229_E248_N0.6890.24
108_H199_M0.6880.24
131_H171_R0.6880.24
132_F211_F0.6870.24
200_T209_K0.6870.24
71_L77_Y0.6850.24
226_K230_N0.6840.24
102_I116_V0.6830.24
196_I246_S0.6790.24
168_H246_S0.6760.24
123_E133_K0.6740.24
117_K212_V0.6730.24
133_K212_V0.6700.23
9_L203_Y0.6690.23
189_F219_L0.6670.23
21_S30_L0.6660.23
128_Y256_V0.6660.23
85_L92_V0.6660.23
88_V240_Y0.6620.23
57_Q112_V0.6610.23
128_Y231_I0.6610.23
50_R84_L0.6590.23
122_A256_V0.6560.23
32_F45_P0.6550.23
184_K187_Y0.6530.23
9_L15_V0.6510.23
74_E77_Y0.6490.22
208_N249_I0.6480.22
81_V229_E0.6470.22
195_R221_A0.6450.22
81_V92_V0.6450.22
108_H111_L0.6410.22
39_I197_R0.6400.22
79_F202_Y0.6400.22
27_T181_T0.6380.22
33_S222_R0.6380.22
130_V231_I0.6360.22
23_K251_F0.6340.22
138_L226_K0.6340.22
26_R30_L0.6310.22
20_F140_P0.6300.22
100_R197_R0.6290.22
166_A234_L0.6290.22
139_Q251_F0.6260.21
88_V225_S0.6250.21
27_T245_K0.6250.21
194_Y249_I0.6250.21
86_E112_V0.6240.21
21_S24_L0.6240.21
20_F104_N0.6240.21
100_R104_N0.6230.21
75_N85_L0.6210.21
168_H241_F0.6180.21
185_T242_G0.6180.21
13_N125_A0.6120.21
114_V174_D0.6090.21
41_E137_L0.6080.21
23_K245_K0.6070.21
33_S127_F0.6020.20
71_L190_R0.5990.20
167_S222_R0.5990.20
34_P204_G0.5950.20
23_K201_A0.5950.20
71_L211_F0.5910.20
154_L196_I0.5890.20
107_F111_L0.5860.20
20_F193_N0.5860.20
243_V249_I0.5850.20
119_N233_R0.5810.20
183_S189_F0.5800.20
98_V243_V0.5800.20
174_D217_F0.5790.20
6_T16_I0.5790.20
209_K241_F0.5770.19
22_S192_V0.5770.19
30_L249_I0.5740.19
13_N19_P0.5730.19
97_S111_L0.5720.19
77_Y166_A0.5710.19
44_E101_E0.5710.19
111_L190_R0.5700.19
194_Y243_V0.5680.19
9_L110_E0.5660.19
81_V115_S0.5640.19
211_F234_L0.5630.19
57_Q126_R0.5630.19
14_D72_K0.5610.19
154_L211_F0.5590.19
5_L13_N0.5580.19
138_L198_P0.5560.19
160_L245_K0.5550.19
204_G216_V0.5550.19
22_S228_R0.5530.18
6_T80_I0.5510.18
27_T49_L0.5510.18
165_I254_V0.5500.18
30_L161_L0.5470.18
234_L244_G0.5460.18
234_L252_G0.5460.18
93_I113_N0.5460.18
76_T94_R0.5450.18
119_N215_V0.5440.18
164_S221_A0.5410.18
169_W172_Y0.5410.18
90_K198_P0.5400.18
22_S89_V0.5370.18
141_P229_E0.5370.18
83_T92_V0.5340.18
79_F102_I0.5300.18
8_R15_V0.5290.18
93_I175_K0.5290.18
112_V219_L0.5290.18
84_L138_L0.5270.18
213_G242_G0.5260.17
11_P127_F0.5250.17
155_F193_N0.5240.17
139_Q246_S0.5220.17
7_F75_N0.5180.17
23_K30_L0.5170.17
11_P17_I0.5150.17
96_E113_N0.5120.17
39_I42_S0.5100.17
56_D254_V0.5080.17
23_K203_Y0.5080.17
74_E117_K0.5060.17
200_T249_I0.5040.17
108_H134_T0.5040.17
47_K219_L0.5010.17
26_R168_H0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4illA 2 0.9617 100 0.379 Contact Map
4c98A 2 0.8161 100 0.449 Contact Map
4c97A 1 0.8352 100 0.459 Contact Map
3i4hX 1 0.8276 100 0.556 Contact Map
3ufcX 1 0.8812 100 0.561 Contact Map
4w8zA 1 0.4981 85.9 0.927 Contact Map
4l6uA 1 0.4904 74.8 0.935 Contact Map
4qtsA 1 0.613 29.9 0.951 Contact Map
4qtsC 1 0.4828 22.7 0.954 Contact Map
3x1lH 1 0.6973 13.8 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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