GREMLIN Database
Q97YB8 - Transposase ISC1058
UniProt: Q97YB8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 262 (252)
Sequences: 285 (174)
Seq/√Len: 10.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
170_V191_V3.6210.98
246_S249_R3.3910.97
24_M27_F2.9570.94
17_V20_R2.8000.92
238_R242_E2.7780.92
236_G239_W2.7380.91
235_Y242_E2.6730.90
41_N46_T2.5960.88
235_Y238_R2.5930.88
14_D89_Y2.5830.88
187_D214_R2.5160.87
121_T139_K2.4100.84
209_K212_L2.3550.83
10_W13_Y2.3280.82
244_L247_V2.2680.80
17_V21_Y2.2410.79
114_A174_Q2.1060.75
140_F144_E2.0510.73
63_I83_I2.0420.73
123_T126_Q1.9740.70
244_L248_K1.9690.70
65_L189_N1.8960.67
88_D198_V1.8640.65
169_T172_D1.8430.64
88_D91_T1.8430.64
184_K203_K1.8410.64
119_I159_V1.7710.61
119_I255_V1.7710.61
125_G203_K1.7700.61
146_V150_N1.7680.61
202_P206_A1.7620.61
130_A135_T1.7430.60
116_A166_S1.7350.59
248_K255_V1.7180.59
156_N196_V1.7030.58
239_W245_F1.6620.56
15_E19_T1.6390.55
147_M241_V1.6350.55
144_E166_S1.6320.55
51_P54_F1.6160.54
114_A139_K1.6130.54
204_K207_S1.6010.53
58_L74_L1.5990.53
122_N139_K1.5770.52
26_P29_V1.5770.52
227_D230_R1.5720.52
187_D203_K1.5700.52
214_R229_W1.5630.51
90_S228_R1.5500.51
144_E160_T1.5450.50
24_M29_V1.5420.50
92_I181_Y1.5410.50
159_V255_V1.5370.50
145_I245_F1.5350.50
69_A160_T1.5330.50
81_K143_I1.5310.50
94_E160_T1.5310.50
95_R214_R1.4850.48
57_F255_V1.4800.47
52_K145_I1.4310.45
112_V155_V1.4230.45
134_K254_S1.4220.45
92_I175_D1.4200.44
133_G141_L1.4120.44
111_E245_F1.3830.43
66_P69_A1.3750.42
139_K162_N1.3740.42
95_R229_W1.3660.42
161_S241_V1.3620.42
72_G95_R1.3350.40
202_P217_A1.3250.40
115_D186_Y1.3210.40
111_E149_N1.3190.40
17_V187_D1.3120.39
148_D185_A1.3070.39
30_F92_I1.2950.39
6_Y155_V1.2940.39
243_S246_S1.2740.38
49_K154_V1.2730.38
29_V57_F1.2670.37
67_Y80_L1.2530.37
46_T246_S1.2480.37
198_V217_A1.2460.36
86_S133_G1.2390.36
244_L251_F1.2380.36
142_K166_S1.2380.36
40_E46_T1.2300.36
92_I116_A1.2250.36
28_Y154_V1.2220.35
120_G126_Q1.2190.35
32_H49_K1.2130.35
93_W145_I1.2060.35
122_N136_R1.2030.35
230_R236_G1.1990.34
113_I149_N1.1950.34
182_G186_Y1.1850.34
95_R187_D1.1830.34
130_A136_R1.1770.33
50_A121_T1.1750.33
161_S164_V1.1740.33
187_D229_W1.1710.33
62_H151_E1.1710.33
71_E89_Y1.1630.33
129_V135_T1.1610.33
61_L136_R1.1550.33
22_K51_P1.1420.32
25_F61_L1.1400.32
115_D118_G1.1400.32
28_Y58_L1.1350.32
209_K236_G1.1280.31
247_V251_F1.1280.31
13_Y17_V1.1270.31
237_V243_S1.1160.31
13_Y115_D1.1150.31
163_E221_F1.1040.30
62_H198_V1.0900.30
140_F186_Y1.0890.30
77_L155_V1.0830.30
16_N117_T1.0810.29
73_V259_L1.0790.29
13_Y20_R1.0730.29
240_R244_L1.0670.29
35_D47_K1.0620.29
124_G236_G1.0510.28
16_N62_H1.0480.28
123_T154_V1.0460.28
248_K251_F1.0420.28
11_S25_F1.0360.28
23_L168_K1.0360.28
152_F244_L1.0250.27
120_G132_W1.0250.27
18_I75_R1.0210.27
25_F216_K1.0200.27
19_T90_S1.0180.27
117_T245_F1.0160.27
170_V192_Y1.0150.27
6_Y14_D1.0070.27
117_T241_V1.0050.27
10_W133_G0.9950.26
100_N198_V0.9940.26
191_V209_K0.9920.26
42_R92_I0.9860.26
61_L65_L0.9830.26
80_L124_G0.9800.26
188_A191_V0.9760.25
61_L167_V0.9630.25
34_W85_T0.9630.25
181_Y199_V0.9530.25
24_M28_Y0.9520.25
137_D141_L0.9510.25
70_I92_I0.9490.24
26_P30_F0.9470.24
20_R229_W0.9430.24
79_Q257_Q0.9330.24
66_P234_G0.9320.24
8_R103_F0.9320.24
195_G220_E0.9290.24
231_E249_R0.9270.24
27_F255_V0.9230.24
65_L149_N0.9180.23
6_Y16_N0.9080.23
124_G128_I0.9070.23
32_H36_L0.9070.23
128_I240_R0.9070.23
127_Y140_F0.9050.23
24_M202_P0.9020.23
227_D233_K0.9010.23
12_K31_E0.8970.23
242_E248_K0.8920.23
134_K138_S0.8880.22
127_Y144_E0.8860.22
20_R33_W0.8850.22
74_L155_V0.8840.22
156_N173_L0.8820.22
68_R201_P0.8820.22
177_G194_T0.8780.22
111_E121_T0.8750.22
170_V245_F0.8670.22
148_D239_W0.8580.21
111_E124_G0.8570.21
115_D131_K0.8540.21
35_D254_S0.8490.21
180_F196_V0.8480.21
165_E239_W0.8480.21
227_D231_E0.8470.21
132_W191_V0.8450.21
54_F67_Y0.8410.21
50_A108_D0.8410.21
15_E196_V0.8400.21
135_T204_K0.8370.21
57_F114_A0.8350.21
162_N219_R0.8330.21
224_L232_E0.8280.20
5_K231_E0.8230.20
59_A67_Y0.8230.20
145_I179_K0.8200.20
159_V220_E0.8190.20
213_A253_E0.8170.20
113_I196_V0.8150.20
56_E96_V0.8150.20
5_K8_R0.8090.20
71_E75_R0.8050.20
56_E104_P0.8050.20
11_S19_T0.8010.20
33_W54_F0.7990.20
183_D186_Y0.7960.19
55_N95_R0.7950.19
223_K259_L0.7910.19
233_K236_G0.7900.19
99_M104_P0.7900.19
153_N165_E0.7860.19
121_T143_I0.7770.19
11_S85_T0.7730.19
51_P55_N0.7710.19
140_F201_P0.7700.19
228_R232_E0.7690.19
91_T94_E0.7680.19
43_N72_G0.7670.19
132_W140_F0.7660.19
193_K203_K0.7580.18
50_A111_E0.7550.18
121_T248_K0.7540.18
174_Q257_Q0.7530.18
25_F34_W0.7400.18
93_W111_E0.7380.18
225_G229_W0.7360.18
40_E180_F0.7320.18
95_R126_Q0.7310.18
102_T231_E0.7290.18
77_L102_T0.7280.18
18_I71_E0.7270.17
65_L158_E0.7250.17
161_S257_Q0.7240.17
198_V213_A0.7180.17
43_N125_G0.7160.17
99_M237_V0.7150.17
167_V254_S0.7130.17
35_D39_E0.7130.17
162_N204_K0.7110.17
73_V215_R0.7080.17
9_D21_Y0.7070.17
66_P257_Q0.7060.17
85_T89_Y0.7000.17
143_I202_P0.7000.17
72_G88_D0.6970.17
14_D71_E0.6950.17
128_I135_T0.6940.17
8_R58_L0.6900.16
74_L256_R0.6880.16
67_Y171_K0.6880.16
72_G126_Q0.6870.16
33_W214_R0.6860.16
112_V126_Q0.6860.16
208_T218_V0.6850.16
46_T83_I0.6810.16
128_I230_R0.6790.16
191_V236_G0.6770.16
33_W229_W0.6770.16
100_N163_E0.6720.16
76_A95_R0.6710.16
51_P59_A0.6700.16
189_N215_R0.6680.16
23_L83_I0.6680.16
220_E232_E0.6660.16
28_Y196_V0.6650.16
101_I106_A0.6650.16
16_N162_N0.6650.16
245_F249_R0.6610.16
109_E255_V0.6600.16
82_I92_I0.6590.16
55_N137_D0.6590.16
49_K172_D0.6580.16
147_M240_R0.6550.16
56_E247_V0.6540.16
72_G125_G0.6510.15
18_I69_A0.6470.15
62_H192_Y0.6460.15
158_E182_G0.6400.15
73_V206_A0.6380.15
174_Q196_V0.6380.15
35_D59_A0.6370.15
77_L107_S0.6370.15
27_F122_N0.6360.15
59_A111_E0.6360.15
169_T180_F0.6350.15
113_I181_Y0.6340.15
15_E91_T0.6340.15
113_I246_S0.6330.15
157_A240_R0.6290.15
136_R236_G0.6260.15
182_G233_K0.6240.15
131_K193_K0.6230.15
153_N158_E0.6210.15
93_W210_R0.6210.15
49_K90_S0.6200.15
184_K187_D0.6190.15
185_A198_V0.6190.15
220_E224_L0.6180.15
7_K114_A0.6170.15
196_V240_R0.6160.15
79_Q106_A0.6160.15
46_T147_M0.6130.15
91_T152_F0.6130.15
246_S253_E0.6110.14
167_V225_G0.6110.14
11_S15_E0.6100.14
180_F198_V0.6090.14
52_K95_R0.6070.14
19_T34_W0.6070.14
75_R160_T0.6040.14
128_I181_Y0.6030.14
76_A127_Y0.6020.14
20_R187_D0.6010.14
6_Y18_I0.5960.14
63_I157_A0.5960.14
138_S148_D0.5930.14
80_L112_V0.5920.14
85_T97_R0.5900.14
85_T175_D0.5880.14
86_S165_E0.5830.14
152_F251_F0.5810.14
232_E248_K0.5780.14
156_N254_S0.5770.14
5_K36_L0.5750.14
203_K230_R0.5740.14
130_A209_K0.5730.14
181_Y196_V0.5720.14
62_H128_I0.5710.14
11_S29_V0.5700.14
224_L228_R0.5690.14
121_T137_D0.5690.14
166_S183_D0.5690.14
136_R248_K0.5680.14
35_D38_A0.5670.13
48_Y237_V0.5660.13
111_E123_T0.5660.13
193_K196_V0.5590.13
73_V97_R0.5570.13
123_T245_F0.5530.13
102_T232_E0.5530.13
125_G136_R0.5510.13
38_A197_E0.5500.13
85_T110_L0.5500.13
17_V183_D0.5500.13
24_M30_F0.5490.13
180_F191_V0.5470.13
96_V247_V0.5440.13
175_D199_V0.5420.13
96_V256_R0.5410.13
236_G245_F0.5410.13
113_I200_V0.5400.13
81_K250_T0.5390.13
19_T82_I0.5370.13
5_K11_S0.5360.13
8_R29_V0.5350.13
91_T173_L0.5350.13
145_I185_A0.5320.13
67_Y93_W0.5310.13
228_R248_K0.5300.13
14_D17_V0.5270.13
102_T220_E0.5270.13
78_E113_I0.5270.13
120_G187_D0.5250.13
135_T169_T0.5240.13
39_E48_Y0.5240.13
202_P255_V0.5210.12
25_F52_K0.5210.12
55_N144_E0.5180.12
92_I222_R0.5150.12
68_R200_V0.5110.12
65_L73_V0.5110.12
238_R252_G0.5090.12
86_S141_L0.5070.12
33_W95_R0.5070.12
9_D17_V0.5040.12
56_E90_S0.5030.12
12_K100_N0.5010.12
203_K209_K0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8855 74.5 0.956 Contact Map
4fcyA 4 0.7023 57.5 0.961 Contact Map
4u7bA 2 0.8282 37.5 0.965 Contact Map
2gloA 1 0.2252 15.4 0.971 Contact Map
1k78A 1 0.3626 11.8 0.973 Contact Map
1pdnC 1 0.3511 10 0.973 Contact Map
1u78A 1 0.3435 8.6 0.974 Contact Map
2cobA 1 0.2557 6.4 0.976 Contact Map
1jkoC 1 0.1756 5.3 0.977 Contact Map
4l5eA 2 0.1756 4.2 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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