GREMLIN Database
Q97YB3 - Uncharacterized protein
UniProt: Q97YB3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 409 (334)
Sequences: 4743 (3858)
Seq/√Len: 211.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_C113_L3.9541.00
58_L169_L3.3461.00
44_L130_I3.3201.00
278_N285_T3.2981.00
61_L64_K3.2881.00
50_P53_V3.2081.00
257_N261_K3.1411.00
126_V142_V3.1111.00
59_I143_S3.0891.00
250_T332_G2.7321.00
338_L356_V2.5991.00
60_K78_Y2.5611.00
47_I59_I2.5121.00
59_I141_T2.5041.00
335_A356_V2.3871.00
63_I112_F2.2731.00
59_I112_F2.2281.00
334_V367_V2.1831.00
173_S340_R2.1481.00
44_L126_V2.1461.00
127_K131_D2.1151.00
43_S210_P2.0931.00
275_K278_N2.0451.00
265_V270_V1.9771.00
275_K279_D1.9431.00
278_N283_T1.9321.00
247_L306_F1.9201.00
94_T98_L1.8401.00
172_L180_V1.8251.00
246_V283_T1.8221.00
181_I201_S1.7901.00
28_K32_K1.7841.00
256_Y271_A1.7831.00
203_L333_I1.7791.00
31_P65_K1.7731.00
284_L339_S1.7571.00
178_I198_L1.7171.00
87_Y90_L1.6981.00
337_H341_I1.6861.00
285_T302_I1.6771.00
42_F130_I1.6741.00
222_T226_I1.6721.00
289_I357_V1.6601.00
286_L305_H1.6541.00
284_L307_V1.6521.00
305_H332_G1.6441.00
382_K387_I1.6211.00
57_T61_L1.6151.00
274_I304_I1.6071.00
50_P208_L1.6011.00
382_K385_K1.5931.00
83_L132_T1.5801.00
50_P307_V1.5771.00
257_N260_A1.5691.00
320_G325_D1.5611.00
174_F202_Y1.5491.00
382_K386_V1.5451.00
370_R373_T1.5391.00
177_Y212_I1.5291.00
28_K31_P1.5231.00
210_P214_G1.5201.00
53_V169_L1.5171.00
75_S107_K1.5131.00
96_D99_K1.5061.00
242_I273_Y1.5021.00
93_R98_L1.5021.00
356_V367_V1.4951.00
96_D100_I1.4931.00
376_V380_A1.4901.00
337_H340_R1.4831.00
46_F161_R1.4761.00
237_M241_Q1.4541.00
60_K132_T1.4471.00
119_V122_W1.4431.00
34_I62_L1.4431.00
285_T304_I1.4421.00
258_S261_K1.4421.00
381_G385_K1.4391.00
216_S219_K1.4351.00
335_A344_I1.4331.00
174_F177_Y1.4321.00
78_Y112_F1.4251.00
263_I270_V1.4211.00
89_E93_R1.4141.00
286_L335_A1.4061.00
347_T352_E1.4031.00
66_L110_F1.4021.00
225_I228_E1.4001.00
63_I110_F1.3901.00
385_K388_T1.3831.00
267_H271_A1.3561.00
238_L265_V1.3521.00
243_L277_F1.3481.00
345_G359_L1.3441.00
168_I281_F1.3401.00
229_I233_G1.3381.00
131_D160_R1.3351.00
118_F124_R1.3091.00
48_V281_F1.3071.00
357_V364_G1.3001.00
349_V352_E1.2941.00
199_F333_I1.2891.00
235_D238_L1.2761.00
63_I76_I1.2701.00
380_A383_M1.2681.00
203_L329_I1.2671.00
336_S340_R1.2431.00
211_S218_L1.2401.00
245_A249_T1.2391.00
39_L43_S1.2371.00
29_W32_K1.2331.00
61_L65_K1.2301.00
256_Y274_I1.2261.00
90_L93_R1.2241.00
174_F195_I1.2231.00
47_I169_L1.2201.00
126_V140_V1.2121.00
226_I230_N1.2071.00
332_G336_S1.2071.00
94_T101_R1.2051.00
242_I270_V1.2041.00
117_T144_G1.1901.00
115_E160_R1.1831.00
381_G386_V1.1751.00
95_R98_L1.1741.00
228_E233_G1.1701.00
241_Q244_S1.1691.00
183_P198_L1.1631.00
115_E145_S1.1571.00
253_K301_Q1.1541.00
260_A270_V1.1431.00
196_E200_E1.1401.00
197_E201_S1.1351.00
252_S328_I1.1301.00
159_G353_E1.1281.00
380_A384_K1.1271.00
334_V369_Y1.1201.00
161_R166_D1.1201.00
170_Y284_L1.1111.00
172_L177_Y1.1111.00
239_A277_F1.1031.00
91_L94_T1.1011.00
75_S105_G1.0971.00
269_T273_Y1.0961.00
174_F178_I1.0961.00
205_V211_S1.0951.00
111_I140_V1.0931.00
284_L336_S1.0821.00
327_P331_E1.0801.00
246_V274_I1.0801.00
296_Y299_R1.0761.00
93_R96_D1.0751.00
335_A339_S1.0741.00
219_K222_T1.0731.00
233_G276_L1.0621.00
360_P363_I1.0601.00
354_I389_L1.0561.00
217_P220_T1.0541.00
286_L346_Y1.0511.00
144_G160_R1.0421.00
338_L344_I1.0401.00
202_Y207_G1.0361.00
44_L142_V1.0351.00
171_P307_V1.0351.00
93_R101_R1.0321.00
84_V90_L1.0321.00
30_I33_E1.0321.00
173_S176_G1.0291.00
171_P207_G1.0291.00
386_V389_L1.0281.00
177_Y201_S1.0271.00
112_F141_T1.0191.00
203_L326_D1.0181.00
144_G159_G1.0121.00
303_K331_E1.0091.00
194_E198_L1.0071.00
199_F203_L1.0061.00
152_K279_D1.0051.00
89_E92_K1.0021.00
381_G384_K1.0011.00
221_Y243_L0.9981.00
174_F198_L0.9971.00
75_S109_S0.9971.00
383_M386_V0.9961.00
90_L98_L0.9961.00
354_I364_G0.9961.00
312_Y329_I0.9951.00
219_K223_E0.9951.00
385_K389_L0.9901.00
48_V166_D0.9841.00
381_G388_T0.9841.00
353_E368_K0.9821.00
210_P213_N0.9801.00
52_Q159_G0.9781.00
93_R97_Y0.9761.00
177_Y198_L0.9741.00
30_I34_I0.9741.00
116_V123_Y0.9701.00
144_G327_P0.9691.00
200_E326_D0.9651.00
218_L310_L0.9611.00
175_S179_N0.9591.00
95_R99_K0.9551.00
170_Y340_R0.9460.99
366_E369_Y0.9450.99
242_I259_I0.9430.99
245_A262_E0.9430.99
284_L335_A0.9380.99
380_A388_T0.9350.99
257_N267_H0.9340.99
86_D89_E0.9250.99
375_Q378_V0.9250.99
83_L131_D0.9240.99
90_L97_Y0.9210.99
121_E124_R0.9180.99
250_T312_Y0.9120.99
81_C119_V0.9070.99
82_D127_K0.9070.99
266_N269_T0.9050.99
27_F31_P0.9030.99
93_R102_K0.9020.99
82_D128_H0.9010.99
129_L133_G0.8990.99
272_E276_L0.8980.99
333_I337_H0.8960.99
178_I195_I0.8940.99
383_M387_I0.8870.99
294_G297_N0.8850.99
268_R271_A0.8830.99
30_I62_L0.8780.99
260_A267_H0.8770.99
27_F34_I0.8770.99
115_E327_P0.8760.99
365_Y368_K0.8760.99
200_E204_K0.8760.99
240_K244_S0.8750.99
305_H356_V0.8750.99
115_E144_G0.8750.99
247_L315_M0.8740.99
27_F58_L0.8740.99
159_G368_K0.8740.99
29_W167_V0.8700.99
222_T240_K0.8680.99
230_N236_E0.8670.99
115_E366_E0.8620.99
92_K95_R0.8590.99
53_V208_L0.8580.99
76_I110_F0.8570.99
259_I263_I0.8560.99
48_V168_I0.8560.99
113_L140_V0.8530.99
112_F143_S0.8480.99
306_F332_G0.8470.99
47_I58_L0.8400.99
194_E197_E0.8350.99
384_K387_I0.8320.99
330_V369_Y0.8310.99
239_A273_Y0.8300.99
313_D329_I0.8260.99
181_I198_L0.8250.99
288_F300_K0.8230.99
256_Y267_H0.8220.99
368_K371_E0.8190.99
326_D369_Y0.8180.99
236_E240_K0.8170.99
51_R115_E0.8150.98
211_S217_P0.8150.98
59_I63_I0.8100.98
373_T378_V0.8070.98
193_S196_E0.8070.98
177_Y180_V0.8070.98
46_F142_V0.8070.98
45_N141_T0.8030.98
83_L128_H0.8020.98
225_I230_N0.7990.98
379_I383_M0.7960.98
34_I66_L0.7940.98
124_R127_K0.7930.98
158_P161_R0.7920.98
202_Y333_I0.7920.98
243_L306_F0.7920.98
158_P231_R0.7900.98
373_T377_K0.7890.98
29_W33_E0.7890.98
258_S262_E0.7870.98
205_V212_I0.7860.98
76_I112_F0.7850.98
309_P313_D0.7830.98
289_I359_L0.7830.98
205_V215_L0.7810.98
254_V257_N0.7790.98
239_A242_I0.7790.98
225_I229_I0.7740.98
258_S295_Y0.7720.98
226_I229_I0.7720.98
254_V259_I0.7710.98
84_V87_Y0.7700.98
354_I385_K0.7700.98
98_L101_R0.7700.98
131_D156_S0.7700.98
221_Y315_M0.7690.98
244_S315_M0.7690.98
274_I285_T0.7610.98
162_G219_K0.7570.98
198_L201_S0.7570.98
383_M388_T0.7540.97
373_T379_I0.7510.97
309_P336_S0.7500.97
383_M389_L0.7500.97
33_E39_L0.7490.97
158_P223_E0.7480.97
195_I198_L0.7460.97
286_L344_I0.7460.97
52_Q353_E0.7410.97
31_P66_L0.7400.97
309_P329_I0.7380.97
31_P38_S0.7370.97
94_T97_Y0.7370.97
113_L126_V0.7350.97
245_A263_I0.7350.97
220_T224_W0.7320.97
160_R355_D0.7300.97
60_K63_I0.7280.97
303_K346_Y0.7280.97
31_P34_I0.7270.97
168_I339_S0.7230.97
50_P170_Y0.7200.97
226_I233_G0.7200.97
208_L211_S0.7180.97
229_I276_L0.7180.97
352_E384_K0.7170.97
309_P332_G0.7150.97
353_E366_E0.7130.96
97_Y100_I0.7130.96
42_F162_G0.7100.96
331_E353_E0.7080.96
253_K346_Y0.7040.96
329_I333_I0.7030.96
44_L140_V0.7030.96
27_F61_L0.7030.96
246_V306_F0.6980.96
84_V88_E0.6930.96
227_Y231_R0.6920.96
66_L76_I0.6920.96
193_S197_E0.6920.96
307_V336_S0.6920.96
86_D90_L0.6920.96
46_F166_D0.6900.96
88_E92_K0.6850.96
89_E94_T0.6850.96
230_N233_G0.6850.96
63_I78_Y0.6840.96
171_P308_D0.6830.96
249_T252_S0.6780.95
99_K102_K0.6750.95
128_H132_T0.6730.95
52_Q144_G0.6730.95
50_P56_T0.6720.95
83_L86_D0.6710.95
53_V171_P0.6710.95
355_D366_E0.6700.95
153_Q232_V0.6680.95
180_V212_I0.6650.95
246_V304_I0.6650.95
201_S215_L0.6650.95
277_F283_T0.6650.95
374_K378_V0.6640.95
238_L263_I0.6630.95
241_Q271_A0.6630.95
249_T262_E0.6590.95
239_A276_L0.6590.95
378_V381_G0.6590.95
82_D118_F0.6580.95
27_F65_K0.6530.94
287_H302_I0.6500.94
87_Y91_L0.6500.94
181_I215_L0.6460.94
115_E353_E0.6450.94
251_P305_H0.6420.94
30_I167_V0.6400.94
45_N167_V0.6390.94
49_G54_G0.6380.94
171_P336_S0.6380.94
381_G389_L0.6370.94
311_F315_M0.6360.93
253_K256_Y0.6360.93
170_Y339_S0.6360.93
84_V128_H0.6350.93
81_C122_W0.6340.93
80_S131_D0.6330.93
51_R144_G0.6310.93
375_Q379_I0.6260.93
245_A259_I0.6220.93
242_I274_I0.6220.93
193_S198_L0.6210.93
80_S132_T0.6210.93
172_L176_G0.6190.93
217_P223_E0.6160.92
86_D100_I0.6160.92
174_F333_I0.6150.92
80_S83_L0.6140.92
269_T272_E0.6140.92
127_K148_L0.6130.92
123_Y155_E0.6110.92
335_A367_V0.6110.92
33_E45_N0.6070.92
339_S343_S0.6030.92
330_V367_V0.6030.92
305_H335_A0.6020.92
250_T306_F0.6020.92
90_L94_T0.6010.91
144_G355_D0.6010.91
43_S130_I0.6000.91
290_D296_Y0.6000.91
62_L167_V0.5980.91
244_S248_S0.5970.91
166_D223_E0.5950.91
364_G368_K0.5920.91
171_P208_L0.5900.91
347_T354_I0.5890.91
368_K373_T0.5880.91
345_G348_E0.5880.91
133_G138_D0.5880.91
331_E366_E0.5880.91
88_E121_E0.5870.90
176_G179_N0.5860.90
172_L209_P0.5850.90
344_I356_V0.5820.90
102_K106_I0.5790.90
115_E331_E0.5770.90
249_T258_S0.5740.89
242_I265_V0.5700.89
260_A263_I0.5700.89
116_V255_S0.5700.89
201_S205_V0.5690.89
262_E295_Y0.5690.89
173_S177_Y0.5660.89
367_V378_V0.5640.89
179_N182_N0.5610.88
52_Q180_V0.5600.88
146_S150_I0.5590.88
57_T60_K0.5580.88
309_P333_I0.5550.88
225_I243_L0.5550.88
122_W126_V0.5540.88
116_V122_W0.5540.88
354_I357_V0.5530.88
384_K388_T0.5530.88
240_K315_M0.5520.88
170_Y307_V0.5520.88
230_N234_R0.5520.88
366_E385_K0.5500.87
261_K267_H0.5490.87
162_G167_V0.5490.87
327_P368_K0.5460.87
355_D368_K0.5450.87
89_E97_Y0.5450.87
133_G139_V0.5450.87
105_G108_S0.5450.87
242_I263_I0.5450.87
228_E234_R0.5440.87
126_V129_L0.5440.87
251_P254_V0.5430.87
178_I202_Y0.5430.87
27_F62_L0.5420.87
226_I231_R0.5410.87
255_S258_S0.5380.86
225_I231_R0.5350.86
47_I141_T0.5340.86
207_G308_D0.5310.86
58_L172_L0.5310.86
369_Y373_T0.5310.86
334_V338_L0.5280.85
384_K389_L0.5280.85
244_S297_N0.5280.85
156_S159_G0.5270.85
283_T304_I0.5260.85
228_E231_R0.5250.85
310_L313_D0.5250.85
208_L309_P0.5240.85
145_S159_G0.5210.84
179_N183_P0.5200.84
93_R119_V0.5190.84
382_K388_T0.5180.84
380_A385_K0.5170.84
77_F109_S0.5150.84
162_G166_D0.5140.84
260_A265_V0.5140.84
376_V383_M0.5140.84
118_F127_K0.5130.84
124_R357_V0.5130.84
359_L362_V0.5110.83
131_D366_E0.5110.83
327_P355_D0.5110.83
115_E368_K0.5070.83
199_F326_D0.5070.83
91_L95_R0.5020.82
28_K34_I0.5020.82
229_I234_R0.5010.82
217_P222_T0.5010.82
225_I233_G0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qenA 1 0.6699 100 0.662 Contact Map
2fnaA 1 0.665 100 0.664 Contact Map
3pfiA 3 0.6675 99.8 0.771 Contact Map
1w5sA 1 0.7555 99.7 0.805 Contact Map
1hqcA 1 0.6748 99.7 0.806 Contact Map
1fnnA 1 0.7457 99.6 0.808 Contact Map
1in4A 1 0.6724 99.5 0.832 Contact Map
2qbyA 1 0.7384 99.4 0.832 Contact Map
2v1uA 1 0.7604 99.4 0.833 Contact Map
1iqpA 5 0.7384 99.4 0.835 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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