GREMLIN Database
Q97YB2 - Acylaminoacyl-peptidase, putative (ApeH-1)
UniProt: Q97YB2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 536 (473)
Sequences: 10053 (8378)
Seq/√Len: 385.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
412_T422_A4.4851.00
304_D309_R3.8841.00
389_K418_L3.7741.00
299_K316_E3.4941.00
508_Y523_D3.2561.00
408_T422_A3.2351.00
237_F241_H3.1491.00
392_G395_K3.0051.00
227_I230_V2.9691.00
302_S309_R2.9381.00
321_D352_K2.7771.00
232_D235_G2.7251.00
455_N459_D2.5831.00
243_K246_V2.5691.00
401_A425_V2.4861.00
375_D378_G2.4731.00
155_D158_G2.4581.00
398_I411_A2.4041.00
523_D527_E2.3451.00
267_K270_R2.3451.00
117_E120_Y2.3441.00
110_L113_Y2.3011.00
397_A532_I2.2961.00
504_K527_E2.2631.00
303_Y387_S2.2351.00
312_A387_S2.1691.00
303_Y312_A2.1371.00
314_L354_I2.1031.00
394_K420_C2.1011.00
201_N204_K2.0751.00
397_A421_S2.0721.00
238_V241_H2.0621.00
134_C139_Y2.0351.00
417_D470_K2.0301.00
486_A507_I1.9731.00
453_D456_L1.9621.00
108_K111_H1.9571.00
93_R98_G1.9511.00
236_N239_L1.9501.00
388_V396_I1.9491.00
114_L117_E1.9341.00
260_Y276_R1.9301.00
163_V166_I1.9171.00
366_R370_H1.8711.00
423_V532_I1.8501.00
111_H122_K1.8491.00
412_T473_L1.8351.00
458_R464_F1.8331.00
217_I220_A1.8211.00
315_Y347_M1.8061.00
185_F189_S1.8061.00
301_V312_A1.7861.00
312_A354_I1.7691.00
260_Y278_G1.7611.00
465_F468_R1.7421.00
286_D289_N1.7351.00
389_K415_F1.7271.00
56_K75_D1.7251.00
385_I419_W1.7251.00
451_G455_N1.7211.00
199_E208_R1.7121.00
323_G354_I1.6981.00
469_I492_V1.6981.00
475_L493_V1.6911.00
186_I189_S1.6871.00
292_K295_F1.6851.00
450_V453_D1.6591.00
100_L133_Y1.6591.00
134_C138_K1.6311.00
325_V384_V1.6311.00
151_I154_M1.5851.00
303_Y356_P1.5841.00
118_G121_I1.5841.00
511_E520_N1.5771.00
287_S290_D1.5751.00
354_I387_S1.5541.00
83_I86_E1.5521.00
79_I82_I1.5491.00
165_N168_N1.5441.00
398_I422_A1.5421.00
58_F92_P1.5421.00
441_I445_Y1.5281.00
467_D499_L1.5211.00
325_V388_V1.5211.00
477_A486_A1.5211.00
117_E122_K1.5101.00
236_N240_I1.4971.00
231_E235_G1.4971.00
107_K110_L1.4961.00
111_H116_N1.4911.00
409_M424_A1.4871.00
111_H114_L1.4801.00
113_Y116_N1.4781.00
423_V528_A1.4751.00
354_I391_L1.4711.00
93_R97_E1.4521.00
109_T113_Y1.4471.00
187_F190_N1.4341.00
231_E234_H1.4341.00
323_G396_I1.4031.00
237_F240_I1.3971.00
490_L507_I1.3921.00
316_E352_K1.3861.00
110_L114_L1.3821.00
93_R96_N1.3821.00
87_F90_L1.3811.00
193_D196_K1.3781.00
327_I407_L1.3771.00
186_I190_N1.3751.00
476_L524_S1.3721.00
375_D379_G1.3691.00
382_L386_N1.3661.00
345_F529_V1.3631.00
430_N491_Q1.3601.00
410_M414_K1.3591.00
236_N241_H1.3591.00
81_K84_D1.3571.00
175_N179_F1.3571.00
349_R529_V1.3491.00
320_E392_G1.3491.00
98_G114_L1.3481.00
506_K527_E1.3441.00
325_V419_W1.3431.00
378_G382_L1.3421.00
117_E121_I1.3391.00
386_N389_K1.3381.00
75_D78_K1.3331.00
433_T491_Q1.3221.00
401_A426_V1.3201.00
412_T471_T1.3161.00
454_E458_R1.3151.00
378_G459_D1.3091.00
118_G122_K1.3011.00
58_F71_I1.3011.00
81_K85_N1.3001.00
323_G352_K1.2881.00
288_M291_A1.2861.00
385_I389_K1.2851.00
110_L116_N1.2801.00
486_A490_L1.2761.00
163_V167_P1.2751.00
382_L414_K1.2701.00
70_K81_K1.2681.00
385_I418_L1.2681.00
114_L121_I1.2631.00
475_L492_V1.2631.00
227_I232_D1.2601.00
185_F190_N1.2591.00
359_R383_D1.2591.00
161_I166_I1.2581.00
381_L411_A1.2561.00
192_E196_K1.2511.00
395_K420_C1.2501.00
388_V419_W1.2491.00
152_H163_V1.2471.00
94_E133_Y1.2471.00
262_Y276_R1.2431.00
56_K73_L1.2371.00
324_I532_I1.2331.00
243_K247_N1.2321.00
495_E498_K1.2291.00
138_K157_S1.2281.00
185_F188_L1.2241.00
413_T469_I1.2231.00
123_L126_G1.2221.00
306_N359_R1.2211.00
139_Y153_V1.2181.00
367_R371_L1.2121.00
53_N96_N1.2081.00
300_V311_Y1.2041.00
107_K111_H1.2031.00
308_L367_R1.1991.00
374_K453_D1.1971.00
526_K530_E1.1941.00
432_F458_R1.1841.00
380_E403_Y1.1801.00
296_I344_Q1.1771.00
324_I346_F1.1771.00
251_T254_L1.1761.00
52_I92_P1.1701.00
422_A473_L1.1641.00
150_N154_M1.1631.00
413_T492_V1.1621.00
245_I250_F1.1601.00
376_P431_W1.1561.00
442_L445_Y1.1551.00
95_T98_G1.1551.00
154_M159_N1.1541.00
71_I74_Y1.1531.00
301_V390_V1.1481.00
52_I55_N1.1471.00
112_L115_Y1.1461.00
58_F90_L1.1441.00
134_C141_V1.1441.00
479_E507_I1.1411.00
315_Y355_C1.1381.00
207_I211_R1.1341.00
439_R442_L1.1321.00
201_N205_G1.1301.00
283_R286_D1.1291.00
455_N458_R1.1251.00
423_V474_L1.1211.00
497_R503_V1.1181.00
223_Y226_S1.1181.00
263_F277_Y1.1181.00
414_K465_F1.1161.00
111_H115_Y1.1121.00
422_A471_T1.1121.00
424_A427_P1.1111.00
237_F242_E1.1111.00
222_P225_G1.1091.00
324_I399_T1.1051.00
298_P315_Y1.1041.00
164_I168_N1.1021.00
456_L459_D1.0961.00
409_M429_V1.0961.00
495_E499_L1.0951.00
162_N165_N1.0931.00
141_V153_V1.0911.00
229_Y232_D1.0911.00
239_L242_E1.0901.00
510_D517_K1.0871.00
124_S128_G1.0861.00
470_K501_R1.0851.00
181_S184_S1.0821.00
409_M492_V1.0811.00
133_Y137_G1.0811.00
379_G382_L1.0801.00
317_K321_D1.0791.00
189_S192_E1.0731.00
343_I347_M1.0711.00
227_I231_E1.0601.00
424_A475_L1.0591.00
98_G101_V1.0561.00
153_V162_N1.0551.00
378_G414_K1.0541.00
180_T183_S1.0531.00
466_I492_V1.0511.00
119_K122_K1.0461.00
92_P98_G1.0451.00
493_V503_V1.0421.00
494_E498_K1.0381.00
162_N166_I1.0381.00
359_R371_L1.0341.00
176_E179_F1.0341.00
334_E363_G1.0281.00
79_I83_I1.0271.00
194_L198_Y1.0241.00
466_I469_I1.0231.00
527_E530_E1.0201.00
164_I167_P1.0131.00
287_S291_A1.0081.00
108_K113_Y1.0081.00
493_V505_Y1.0051.00
343_I353_V1.0051.00
489_T505_Y1.0041.00
179_F183_S1.0041.00
385_I415_F1.0011.00
325_V354_I1.0001.00
72_Y81_K0.9991.00
153_V179_F0.9981.00
213_S218_F0.9961.00
134_C137_G0.9931.00
327_I398_I0.9881.00
196_K209_K0.9871.00
466_I495_E0.9851.00
138_K155_D0.9841.00
406_Y410_M0.9831.00
496_L501_R0.9831.00
432_F454_E0.9821.00
110_L115_Y0.9801.00
112_L116_N0.9791.00
323_G388_V0.9771.00
476_L506_K0.9731.00
429_V492_V0.9711.00
517_K520_N0.9671.00
107_K112_L0.9661.00
426_V515_F0.9641.00
504_K509_K0.9631.00
156_L159_N0.9621.00
480_N510_D0.9611.00
503_V506_K0.9581.00
154_M161_I0.9571.00
136_N139_Y0.9571.00
399_T425_V0.9501.00
317_K352_K0.9491.00
80_E83_I0.9491.00
375_D453_D0.9461.00
282_E285_T0.9431.00
109_T122_K0.9411.00
377_G380_E0.9391.00
441_I446_D0.9381.00
152_H156_L0.9361.00
389_K393_V0.9341.00
438_E441_I0.9341.00
227_I233_R0.9311.00
51_W57_M0.9291.00
356_P387_S0.9261.00
314_L352_K0.9241.00
70_K74_Y0.9191.00
475_L489_T0.9181.00
73_L99_I0.9171.00
161_I167_P0.9161.00
228_A231_E0.9131.00
370_H373_D0.9131.00
188_L191_H0.9121.00
147_Y150_N0.9111.00
275_Y283_R0.9081.00
194_L197_V0.9031.00
255_K259_D0.9031.00
55_N75_D0.9001.00
163_V168_N0.9001.00
522_V526_K0.8951.00
228_A232_D0.8941.00
273_D285_T0.8901.00
139_Y155_D0.8871.00
107_K114_L0.8861.00
506_K509_K0.8841.00
428_F431_W0.8841.00
479_E486_A0.8841.00
304_D390_V0.8831.00
108_K114_L0.8831.00
109_T115_Y0.8831.00
440_E443_Q0.8781.00
152_H161_I0.8771.00
305_S308_L0.8761.00
198_Y209_K0.8751.00
488_E491_Q0.8751.00
161_I165_N0.8711.00
311_Y364_Y0.8691.00
95_T137_G0.8661.00
53_N56_K0.8661.00
80_E86_E0.8641.00
271_S339_F0.8641.00
93_R133_Y0.8641.00
264_V272_A0.8621.00
167_P172_E0.8621.00
424_A429_V0.8601.00
326_Y335_C0.8601.00
188_L192_E0.8591.00
426_V514_G0.8591.00
216_E219_E0.8571.00
139_Y142_Y0.8571.00
246_V249_G0.8561.00
247_N250_F0.8551.00
442_L446_D0.8541.00
305_S382_L0.8481.00
115_Y120_Y0.8481.00
504_K531_F0.8441.00
92_P99_I0.8441.00
310_I368_F0.8441.00
213_S216_E0.8431.00
439_R445_Y0.8431.00
92_P96_N0.8411.00
113_Y122_K0.8371.00
461_S464_F0.8351.00
259_D278_G0.8331.00
504_K508_Y0.8331.00
281_V287_S0.8331.00
100_L131_N0.8311.00
162_N167_P0.8291.00
345_F349_R0.8281.00
340_N343_I0.8271.00
473_L501_R0.8271.00
442_L447_E0.8251.00
76_N79_I0.8251.00
421_S531_F0.8231.00
327_I384_V0.8211.00
281_V285_T0.8211.00
82_I85_N0.8201.00
173_L177_N0.8191.00
109_T114_L0.8171.00
371_L376_P0.8141.00
504_K507_I0.8141.00
265_N270_R0.8091.00
479_E509_K0.8071.00
185_F191_H0.8061.00
174_A177_N0.8041.00
229_Y233_R0.8031.00
149_N152_H0.8031.00
244_E247_N0.8021.00
195_S198_Y0.8011.00
243_K250_F0.7991.00
172_E175_N0.7981.00
421_S532_I0.7981.00
141_V179_F0.7981.00
297_K316_E0.7971.00
421_S472_S0.7971.00
72_Y75_D0.7951.00
413_T465_F0.7951.00
335_C355_C0.7951.00
399_T528_A0.7941.00
482_P512_G0.7931.00
74_Y77_G0.7921.00
52_I56_K0.7921.00
108_K115_Y0.7911.00
149_N153_V0.7911.00
162_N168_N0.7911.00
109_T112_L0.7911.00
439_R443_Q0.7891.00
81_K86_E0.7891.00
438_E442_L0.7841.00
79_I84_D0.7831.00
134_C142_Y0.7811.00
424_A473_L0.7791.00
415_F418_L0.7781.00
245_I248_E0.7781.00
173_L179_F0.7781.00
378_G460_R0.7771.00
508_Y511_E0.7761.00
213_S219_E0.7761.00
358_Y384_V0.7751.00
58_F99_I0.7751.00
108_K112_L0.7731.00
177_N183_S0.7721.00
201_N206_E0.7721.00
113_Y120_Y0.7711.00
388_V418_L0.7711.00
212_E218_F0.7701.00
473_L492_V0.7671.00
107_K116_N0.7661.00
238_V242_E0.7661.00
214_D219_E0.7661.00
123_L128_G0.7661.00
305_S386_N0.7661.00
263_F281_V0.7651.00
209_K212_E0.7641.00
222_P226_S0.7641.00
500_G503_V0.7641.00
114_L120_Y0.7631.00
358_Y380_E0.7601.00
213_S217_I0.7591.00
93_R100_L0.7591.00
171_Q174_A0.7571.00
385_I388_V0.7561.00
80_E84_D0.7551.00
403_Y407_L0.7541.00
303_Y386_N0.7531.00
377_G406_Y0.7531.00
59_I79_I0.7521.00
167_P173_L0.7511.00
82_I86_E0.7511.00
212_E216_E0.7511.00
282_E288_M0.7491.00
230_V233_R0.7481.00
153_V159_N0.7481.00
493_V497_R0.7471.00
212_E217_I0.7461.00
433_T488_E0.7451.00
306_N382_L0.7421.00
273_D287_S0.7381.00
74_Y79_I0.7361.00
273_D283_R0.7361.00
130_V143_S0.7331.00
263_F275_Y0.7231.00
270_R273_D0.7221.00
196_K199_E0.7181.00
476_L508_Y0.7171.00
73_L92_P0.7161.00
107_K113_Y0.7151.00
409_M427_P0.7141.00
177_N180_T0.7131.00
423_V476_L0.7091.00
113_Y118_G0.7091.00
235_G239_L0.7091.00
97_E116_N0.7091.00
109_T116_N0.7081.00
367_R370_H0.7071.00
71_I90_L0.7071.00
473_L496_L0.7061.00
195_S199_E0.7051.00
216_E220_A0.7051.00
233_R236_N0.7051.00
79_I85_N0.7041.00
402_S513_H0.7031.00
282_E287_S0.7021.00
326_Y355_C0.7021.00
268_H337_N0.7021.00
396_I418_L0.7011.00
438_E445_Y0.6991.00
315_Y343_I0.6991.00
200_F205_G0.6970.99
252_Y256_V0.6960.99
373_D444_L0.6960.99
87_F103_S0.6950.99
180_T184_S0.6940.99
58_F73_L0.6910.99
51_W54_R0.6910.99
151_I159_N0.6900.99
312_A390_V0.6900.99
212_E215_Y0.6840.99
173_L176_E0.6840.99
283_R287_S0.6810.99
94_E137_G0.6800.99
214_D218_F0.6790.99
443_Q447_E0.6770.99
477_A489_T0.6770.99
403_Y406_Y0.6760.99
66_S69_R0.6760.99
385_I414_K0.6750.99
221_I225_G0.6740.99
227_I235_G0.6740.99
508_Y527_E0.6730.99
59_I72_Y0.6720.99
424_A492_V0.6720.99
246_V250_F0.6720.99
430_N461_S0.6710.99
184_S201_N0.6710.99
80_E85_N0.6700.99
486_A505_Y0.6700.99
133_Y141_V0.6690.99
199_E210_I0.6690.99
236_N242_E0.6680.99
101_V104_N0.6680.99
161_I168_N0.6670.99
60_T90_L0.6660.99
450_V454_E0.6660.99
375_D456_L0.6660.99
50_D91_S0.6650.99
326_Y343_I0.6640.99
426_V477_A0.6640.99
425_V476_L0.6630.99
100_L140_I0.6610.99
129_P133_Y0.6600.99
142_Y154_M0.6590.99
101_V120_Y0.6580.99
466_I499_L0.6580.99
231_E240_I0.6580.99
345_F348_E0.6570.99
343_I355_C0.6540.99
408_T412_T0.6540.99
134_C140_I0.6540.99
503_V507_I0.6520.99
125_K128_G0.6510.99
285_T288_M0.6510.99
215_Y218_F0.6500.99
296_I347_M0.6500.99
525_I528_A0.6480.99
184_S203_L0.6470.99
212_E220_A0.6460.99
296_I348_E0.6460.99
385_I411_A0.6450.99
328_H361_S0.6440.99
284_L287_S0.6440.99
266_S272_A0.6420.99
114_L122_K0.6410.99
434_E485_P0.6390.99
441_I444_L0.6380.99
302_S311_Y0.6370.99
156_L161_I0.6370.99
490_L505_Y0.6370.99
60_T87_F0.6360.99
279_K282_E0.6350.99
323_G391_L0.6340.99
114_L118_G0.6300.99
175_N180_T0.6280.99
322_K392_G0.6280.99
324_I397_A0.6270.99
172_E179_F0.6260.99
432_F457_L0.6260.99
473_L503_V0.6260.99
124_S127_E0.6250.99
399_T532_I0.6250.99
175_N178_C0.6230.99
243_K249_G0.6230.99
316_E321_D0.6220.99
409_M473_L0.6220.99
98_G137_G0.6200.99
133_Y140_I0.6200.99
137_G142_Y0.6200.99
303_Y390_V0.6190.99
115_Y121_I0.6180.99
326_Y399_T0.6180.99
155_D161_I0.6170.99
411_A419_W0.6170.99
149_N154_M0.6170.99
440_E444_L0.6160.99
193_D198_Y0.6160.99
213_S220_A0.6160.99
154_M158_G0.6150.99
375_D459_D0.6140.99
474_L506_K0.6130.99
301_V354_I0.6130.99
399_T423_V0.6120.99
61_V72_Y0.6120.99
381_L410_M0.6120.99
49_V57_M0.6120.99
328_H358_Y0.6100.99
180_T221_I0.6100.99
141_V177_N0.6100.99
100_L103_S0.6090.99
83_I87_F0.6070.99
276_R282_E0.6070.99
261_I277_Y0.6060.99
381_L407_L0.6050.99
318_G321_D0.6030.99
158_G161_I0.6000.98
329_G402_S0.5990.98
100_L114_L0.5980.98
313_L357_N0.5970.98
172_E177_N0.5960.98
431_W461_S0.5960.98
157_S160_E0.5960.98
193_D197_V0.5950.98
503_V508_Y0.5940.98
401_A514_G0.5920.98
410_M413_T0.5920.98
151_I156_L0.5910.98
384_V398_I0.5910.98
374_K456_L0.5910.98
325_V356_P0.5900.98
155_D159_N0.5900.98
524_S528_A0.5880.98
479_E510_D0.5870.98
133_Y156_L0.5870.98
430_N488_E0.5850.98
410_M465_F0.5850.98
60_T69_R0.5840.98
456_L460_R0.5840.98
155_D160_E0.5830.98
195_S200_F0.5830.98
381_L385_I0.5830.98
90_L96_N0.5830.98
230_V235_G0.5820.98
207_I210_I0.5810.98
305_S310_I0.5810.98
233_R238_V0.5810.98
228_A235_G0.5810.98
328_H402_S0.5810.98
503_V509_K0.5800.98
93_R99_I0.5790.98
469_I501_R0.5780.98
68_I72_Y0.5780.98
474_L504_K0.5760.98
100_L104_N0.5740.98
284_L288_M0.5740.98
98_G104_N0.5730.98
438_E444_L0.5730.98
279_K287_S0.5720.98
280_K287_S0.5710.98
94_E100_L0.5710.98
286_D290_D0.5690.98
320_E395_K0.5680.98
417_D471_T0.5650.98
440_E445_Y0.5650.98
438_E443_Q0.5640.98
378_G456_L0.5610.98
269_D297_K0.5590.98
92_P101_V0.5580.98
71_I75_D0.5560.98
334_E362_I0.5550.98
254_L261_I0.5530.97
428_F434_E0.5530.97
430_N464_F0.5530.97
221_I224_K0.5530.97
434_E441_I0.5530.97
372_N379_G0.5520.97
444_L447_E0.5510.97
204_K207_I0.5510.97
357_N361_S0.5500.97
50_D60_T0.5490.97
371_L379_G0.5480.97
152_H155_D0.5470.97
408_T424_A0.5470.97
115_Y118_G0.5460.97
449_K454_E0.5430.97
103_S120_Y0.5420.97
357_N364_Y0.5400.97
161_I164_I0.5390.97
115_Y122_K0.5390.97
427_P484_C0.5390.97
176_E181_S0.5380.97
176_E180_T0.5370.97
150_N153_V0.5360.97
427_P489_T0.5350.97
434_E488_E0.5350.97
311_Y368_F0.5340.97
93_R101_V0.5340.97
80_E118_G0.5340.97
69_R72_Y0.5320.97
279_K290_D0.5320.97
208_R211_R0.5320.97
450_V457_L0.5260.97
426_V512_G0.5260.97
431_W434_E0.5260.97
449_K452_N0.5260.97
49_V60_T0.5250.97
57_M74_Y0.5230.96
132_N135_F0.5220.96
184_S199_E0.5220.96
262_Y274_L0.5200.96
392_G420_C0.5190.96
346_F351_F0.5190.96
129_P134_C0.5170.96
312_A356_P0.5160.96
416_S471_T0.5160.96
166_I173_L0.5150.96
153_V156_L0.5150.96
360_G383_D0.5150.96
376_P403_Y0.5140.96
511_E517_K0.5120.96
515_F524_S0.5100.96
401_A524_S0.5080.96
190_N194_L0.5070.96
442_L449_K0.5060.96
281_V291_A0.5040.96
329_G407_L0.5040.96
187_F191_H0.5030.96
308_L371_L0.5010.95
179_F185_F0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hxfB 4 0.9104 100 0.425 Contact Map
2z3zA 2 0.959 100 0.437 Contact Map
1xfdA 2 0.9757 100 0.443 Contact Map
3azoA 1 0.9757 100 0.445 Contact Map
4bp8A 1 0.9925 100 0.447 Contact Map
3iujA 1 0.9795 100 0.447 Contact Map
4q1vA 2 0.9646 100 0.452 Contact Map
4wjlA 2 0.9757 100 0.453 Contact Map
1yr2A 1 0.9701 100 0.453 Contact Map
4a5sA 2 0.9701 100 0.453 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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