GREMLIN Database
Q97YA7 - Uncharacterized protein
UniProt: Q97YA7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 250 (195)
Sequences: 816 (708)
Seq/√Len: 50.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_C110_C8.9691.00
63_F124_I5.1041.00
19_G168_F4.3771.00
24_E218_K4.3221.00
138_T156_T3.7351.00
20_K165_E3.5781.00
127_A168_F3.5731.00
48_Y51_R3.1201.00
22_R165_E3.0301.00
21_L217_I2.8901.00
47_K158_D2.6941.00
22_R220_V2.6471.00
140_V149_Q2.5961.00
16_K169_M2.5781.00
59_L127_A2.3731.00
67_V195_L2.1151.00
27_L206_V2.0701.00
143_N150_M2.0121.00
18_E169_M1.9901.00
14_V173_Y1.9731.00
152_G155_Y1.9300.99
57_S126_D1.9170.99
111_I188_S1.9030.99
66_L198_T1.6940.98
209_R214_Y1.6480.98
67_V191_A1.6210.98
130_E167_S1.5940.98
63_F195_L1.5770.98
68_E107_C1.5670.97
22_R218_K1.5570.97
67_V71_T1.5530.97
26_L214_Y1.5400.97
139_M212_V1.4980.97
112_L172_I1.4770.96
205_F210_K1.4650.96
18_E223_K1.4610.96
73_S197_A1.4230.96
141_A144_R1.4090.95
187_K190_E1.4080.95
62_A204_I1.3650.94
23_N27_L1.3590.94
172_I188_S1.3570.94
26_L159_Y1.3570.94
95_K98_D1.3540.94
20_K221_D1.3120.93
205_F216_L1.3000.93
52_P160_V1.2970.93
138_T154_L1.2930.93
125_L169_M1.2910.93
70_Y194_F1.2830.92
119_A214_Y1.2800.92
18_E167_S1.2690.92
172_I175_L1.2580.92
28_R208_A1.2410.91
149_Q210_K1.2400.91
23_N164_S1.2320.91
143_N148_G1.2100.90
122_V170_M1.1930.89
191_A195_L1.1840.89
16_K171_M1.1700.88
63_F192_L1.1660.88
30_G208_A1.1650.88
28_R158_D1.1590.88
26_L137_R1.1540.88
129_A164_S1.1490.87
42_D46_I1.1290.86
139_M155_Y1.1230.86
68_E110_C1.1220.86
229_A232_H1.1190.86
161_D195_L1.1140.86
154_L208_A1.0980.85
97_K100_G1.0930.85
60_K171_M1.0930.85
195_L198_T1.0870.84
66_L204_I1.0770.84
53_L128_I1.0670.83
175_L188_S1.0630.83
137_R140_V1.0280.81
18_E225_S1.0240.80
131_K167_S1.0230.80
119_A219_L1.0180.80
43_N157_L1.0120.80
61_G207_G1.0070.79
29_V166_F1.0060.79
21_L168_F0.9990.79
57_S60_K0.9890.78
45_I52_P0.9850.78
139_M154_L0.9670.76
63_F199_L0.9650.76
137_R214_Y0.9590.76
58_S62_A0.9550.76
101_I105_R0.9550.76
31_K60_K0.9530.75
98_D101_I0.9510.75
45_I134_I0.9460.75
212_V217_I0.9370.74
19_G170_M0.9330.74
51_R129_A0.9280.73
74_L110_C0.9250.73
137_R159_Y0.9150.72
225_S232_H0.9100.72
65_S68_E0.9090.72
61_G215_G0.9070.72
207_G215_G0.9070.72
228_K231_D0.8980.71
47_K50_D0.8940.71
146_F152_G0.8930.71
108_I187_K0.8930.71
17_I224_V0.8830.70
125_L171_M0.8770.69
130_E165_E0.8760.69
143_N146_F0.8730.69
142_I147_G0.8680.68
101_I104_G0.8640.68
21_L166_F0.8600.68
42_D47_K0.8550.67
154_L157_L0.8520.67
16_K225_S0.8450.66
51_R133_S0.8420.66
190_E218_K0.8410.66
139_M214_Y0.8390.66
107_C111_I0.8380.66
140_V155_Y0.8350.65
139_M159_Y0.8350.65
70_Y191_A0.8350.65
145_V148_G0.8340.65
56_G126_D0.8340.65
17_I193_K0.8330.65
33_K50_D0.8320.65
176_N187_K0.8310.65
165_E220_V0.8290.65
186_A190_E0.8160.64
206_V217_I0.8140.63
174_N190_E0.8140.63
15_V224_V0.8130.63
135_S161_D0.8070.63
227_Y232_H0.8060.63
24_E216_L0.8020.62
203_G227_Y0.7990.62
149_Q154_L0.7880.61
54_I199_L0.7810.60
117_D170_M0.7780.60
97_K102_V0.7730.59
26_L139_M0.7690.59
26_L62_A0.7690.59
26_L208_A0.7640.58
147_G152_G0.7630.58
66_L154_L0.7620.58
58_S135_S0.7600.58
146_F155_Y0.7600.58
159_Y214_Y0.7530.57
30_G158_D0.7530.57
156_T209_R0.7520.57
102_V110_C0.7510.57
118_L121_R0.7480.57
135_S139_M0.7470.57
41_T136_Q0.7420.56
74_L100_G0.7400.56
142_I155_Y0.7370.56
74_L77_S0.7320.55
106_Y190_E0.7310.55
27_L162_P0.7230.54
56_G59_L0.7210.54
174_N188_S0.7120.53
124_I172_I0.7110.53
51_R130_E0.7000.52
15_V175_L0.6970.52
64_R68_E0.6970.52
175_L210_K0.6940.51
131_K220_V0.6930.51
28_R170_M0.6920.51
77_S220_V0.6910.51
23_N162_P0.6910.51
159_Y212_V0.6900.51
148_G152_G0.6850.50
188_S196_L0.6830.50
166_F174_N0.6790.50
18_E230_P0.6710.49
161_D208_A0.6700.49
71_T191_A0.6680.49
176_N186_A0.6630.48
197_A211_S0.6620.48
20_K167_S0.6620.48
190_E193_K0.6620.48
47_K164_S0.6600.48
59_L168_F0.6590.48
17_I222_A0.6540.47
68_E71_T0.6520.47
112_L188_S0.6520.47
70_Y193_K0.6450.46
38_A42_D0.6450.46
26_L212_V0.6430.46
122_V196_L0.6420.46
42_D57_S0.6410.46
49_R131_K0.6370.45
124_I170_M0.6360.45
62_A206_V0.6350.45
160_V216_L0.6330.45
207_G213_G0.6330.45
61_G213_G0.6330.45
99_N105_R0.6320.45
114_G207_G0.6280.44
61_G114_G0.6280.44
54_I206_V0.6280.44
135_S162_P0.6240.44
227_Y231_D0.6230.44
109_P226_L0.6220.44
64_R113_F0.6210.44
225_S228_K0.6210.44
223_K226_L0.6190.44
17_I186_A0.6170.43
60_K159_Y0.6170.43
39_E45_I0.6150.43
41_T44_P0.6150.43
22_R130_E0.6140.43
228_K232_H0.6120.43
13_T175_L0.6090.43
137_R212_V0.6070.42
157_L214_Y0.6050.42
20_K222_A0.6040.42
56_G219_L0.6020.42
43_N50_D0.6020.42
15_V189_V0.6010.42
196_L205_F0.6000.42
41_T47_K0.5980.41
55_P126_D0.5890.41
77_S167_S0.5880.40
123_Y163_G0.5870.40
45_I158_D0.5850.40
141_A150_M0.5850.40
67_V166_F0.5840.40
186_A189_V0.5800.40
148_G186_A0.5800.40
97_K101_I0.5800.40
23_N217_I0.5770.39
163_G166_F0.5730.39
79_Y110_C0.5700.39
13_T174_N0.5700.39
67_V112_L0.5680.38
74_L148_G0.5670.38
96_K99_N0.5650.38
224_V229_A0.5640.38
18_E186_A0.5610.38
51_R220_V0.5600.38
58_S65_S0.5600.38
21_L127_A0.5590.38
28_R124_I0.5590.38
57_S127_A0.5590.38
73_S210_K0.5580.38
144_R211_S0.5580.38
75_N186_A0.5580.38
65_S123_Y0.5550.37
53_L164_S0.5540.37
35_Q44_P0.5520.37
65_S191_A0.5520.37
52_P129_A0.5510.37
66_L195_L0.5500.37
142_I158_D0.5460.36
47_K208_A0.5450.36
57_S113_F0.5430.36
175_L211_S0.5430.36
157_L161_D0.5430.36
71_T109_P0.5420.36
17_I187_K0.5410.36
70_Y189_V0.5410.36
139_M157_L0.5390.36
73_S192_L0.5390.36
140_V154_L0.5370.35
103_E106_Y0.5360.35
149_Q152_G0.5330.35
123_Y173_Y0.5300.35
67_V188_S0.5270.35
75_N79_Y0.5260.34
74_L107_C0.5250.34
137_R155_Y0.5250.34
120_S147_G0.5240.34
25_T112_L0.5220.34
114_G215_G0.5200.34
147_G155_Y0.5200.34
112_L217_I0.5180.34
196_L219_L0.5150.33
30_G161_D0.5100.33
134_I158_D0.5080.33
102_V105_R0.5070.33
119_A191_A0.5060.33
151_P155_Y0.5060.33
137_R157_L0.5050.33
133_S170_M0.5030.32
69_S192_L0.5020.32
15_V172_I0.5020.32
150_M160_V0.5000.32
25_T111_I0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qtsC 1 0.676 100 0.37 Contact Map
4n0lA 1 0.864 100 0.391 Contact Map
3x1lC 3 0.828 100 0.451 Contact Map
4w8wA 1 0.592 100 0.458 Contact Map
3x1lH 1 0.776 100 0.5 Contact Map
4w8vA 1 0.772 100 0.5 Contact Map
4txdA 1 0.92 99.4 0.742 Contact Map
4w8zA 1 0.72 98.9 0.791 Contact Map
4l6uA 1 0.736 98.8 0.796 Contact Map
4qtsA 1 0.752 98.3 0.828 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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