GREMLIN Database
Q97YA6 - Uncharacterized protein
UniProt: Q97YA6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (216)
Sequences: 378 (345)
Seq/√Len: 23.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_C126_C8.8871.00
69_F140_F6.4931.00
23_G184_F5.9861.00
26_E181_K3.5391.00
26_E227_G3.2261.00
62_G142_D2.9231.00
31_L213_V2.7790.99
212_Q223_F2.7020.99
73_G77_L2.6180.99
143_S184_F2.4060.98
168_R171_V2.3320.98
135_I221_F2.3070.97
73_G198_Y2.2770.97
25_V224_V2.2750.97
153_R156_I2.2440.97
28_V225_K2.1580.96
63_S142_D1.9610.93
20_M185_K1.9540.93
123_C127_K1.9100.92
190_N197_G1.8950.92
188_G195_A1.8700.92
156_I165_V1.8360.91
154_S172_T1.8100.90
27_T31_L1.7300.88
25_V184_F1.6770.86
194_Y197_G1.6230.84
27_T180_S1.6150.84
165_V217_K1.5870.83
80_R126_C1.5570.82
162_E165_V1.5300.81
127_K195_A1.5230.80
22_E185_K1.5220.80
15_I69_F1.5190.80
70_R130_G1.5000.79
214_G222_G1.4770.78
248_D251_D1.4720.78
47_K50_I1.4530.77
65_W143_S1.4400.76
19_T191_L1.4120.75
70_R129_F1.4050.74
30_P221_F1.3850.73
59_I144_L1.3810.73
21_I186_M1.3650.72
24_D181_K1.3550.72
15_I19_T1.3410.71
64_S68_I1.3360.71
22_E183_S1.3310.70
71_S74_E1.3290.70
25_V211_T1.3290.70
67_G222_G1.3210.70
67_G214_G1.3210.70
18_T189_Y1.3080.69
250_G253_V1.3000.68
182_F190_N1.3000.68
25_V60_I1.2730.67
151_N177_D1.2630.66
19_T216_H1.2570.66
68_I209_G1.2520.65
21_I194_Y1.2510.65
67_G129_F1.2460.65
125_N233_D1.2370.64
83_E125_N1.2250.64
138_V203_M1.2210.63
23_G76_I1.2210.63
33_I172_T1.2140.63
73_G124_L1.2130.63
150_L153_R1.2090.63
154_S170_L1.2090.63
145_P180_S1.2060.62
70_R142_D1.2020.62
47_K51_L1.1930.62
58_P167_R1.1740.60
66_K187_M1.1430.58
21_I237_K1.1370.58
191_L195_A1.1260.57
36_G179_G1.1250.57
69_F162_E1.1250.57
138_V233_D1.1240.57
64_S215_G1.1070.56
161_T164_A1.1020.55
213_V224_V1.1010.55
188_G191_L1.0860.54
75_R80_R1.0810.54
245_Q250_G1.0700.53
24_D228_K1.0620.53
130_G222_G1.0360.51
130_G214_G1.0360.51
247_K252_L1.0320.51
26_E225_K1.0310.50
144_L163_G1.0300.50
183_S227_G1.0260.50
145_P149_S1.0260.50
138_V141_L1.0260.50
53_D56_G1.0250.50
74_E126_C1.0180.50
181_K230_K1.0180.50
212_Q221_F1.0080.49
242_E245_Q0.9970.48
179_G185_K0.9850.47
128_V191_L0.9840.47
153_R219_R0.9830.47
141_L177_D0.9650.46
153_R175_Y0.9600.45
191_L197_G0.9570.45
50_I215_G0.9470.45
157_A176_V0.9470.45
155_M221_F0.9430.44
19_T188_G0.9400.44
245_Q248_D0.9390.44
58_P138_V0.9370.44
245_Q249_V0.9350.44
22_E237_K0.9300.43
72_T188_G0.9300.43
74_E123_C0.9290.43
243_D246_V0.9280.43
172_T216_H0.9270.43
125_N198_Y0.9260.43
151_N155_M0.9240.43
66_K174_E0.9240.43
50_I66_K0.9240.43
207_H226_F0.9230.43
16_K134_V0.9220.43
27_T179_G0.9200.43
23_G143_S0.9060.42
133_S142_D0.9050.42
129_F220_G0.9050.42
159_S162_E0.9050.42
19_T79_L0.9040.42
58_P176_V0.8980.41
175_Y221_F0.8930.41
47_K52_K0.8920.41
29_S127_K0.8900.41
196_I228_K0.8870.40
216_H221_F0.8830.40
80_R128_V0.8820.40
30_P177_D0.8690.39
159_S166_A0.8670.39
87_G148_Y0.8590.39
128_V193_N0.8570.38
67_G130_G0.8570.38
143_S182_F0.8570.38
77_L198_Y0.8540.38
219_R224_V0.8470.38
50_I137_A0.8440.38
184_F236_E0.8420.37
214_G220_G0.8410.37
186_M237_K0.8370.37
33_I58_P0.8370.37
121_Y227_G0.8300.37
80_R123_C0.8300.37
64_S124_L0.8250.36
66_K135_I0.8210.36
112_D230_K0.8190.36
136_G142_D0.8140.36
159_S213_V0.8130.36
73_G202_I0.8090.35
21_I247_K0.8040.35
86_S179_G0.7970.35
155_M170_L0.7920.34
137_A143_S0.7890.34
23_G164_A0.7840.34
207_H221_F0.7830.34
142_D219_R0.7830.34
76_I205_N0.7800.33
60_I238_R0.7790.33
237_K251_D0.7780.33
174_E219_R0.7740.33
24_D230_K0.7730.33
77_L80_R0.7720.33
136_G156_I0.7700.33
155_M226_F0.7580.32
14_V85_C0.7580.32
201_T205_N0.7560.32
243_D252_L0.7550.32
66_K218_S0.7550.32
34_G215_G0.7540.32
72_T205_N0.7520.32
247_K253_V0.7520.32
116_E186_M0.7510.32
113_Q116_E0.7510.32
19_T23_G0.7480.31
34_G64_S0.7470.31
82_I86_S0.7450.31
236_E239_I0.7450.31
52_K174_E0.7420.31
136_G140_F0.7410.31
136_G195_A0.7410.31
67_G70_R0.7400.31
136_G148_Y0.7400.31
27_T58_P0.7390.31
24_D146_I0.7380.31
151_N178_V0.7360.31
241_D247_K0.7350.31
19_T77_L0.7290.30
158_I163_G0.7270.30
131_T173_V0.7240.30
15_I18_T0.7240.30
52_K123_C0.7230.30
141_L187_M0.7230.30
32_K174_E0.7220.30
126_C138_V0.7170.30
237_K249_V0.7160.30
140_F147_S0.7150.30
34_G218_S0.7150.30
249_V253_V0.7150.30
144_L213_V0.7100.29
70_R74_E0.7100.29
21_I26_E0.7050.29
66_K230_K0.7050.29
31_L176_V0.7040.29
69_F202_I0.7030.29
60_I229_V0.7010.29
30_P175_Y0.7010.29
244_I250_G0.6980.29
30_P219_R0.6970.28
19_T195_A0.6960.28
23_G73_G0.6900.28
23_G65_W0.6850.28
188_G233_D0.6840.28
147_S243_D0.6830.28
140_F198_Y0.6810.28
140_F162_E0.6810.28
29_S49_S0.6810.28
138_V162_E0.6770.27
77_L164_A0.6760.27
32_K139_R0.6760.27
33_I232_T0.6740.27
155_M161_T0.6710.27
27_T34_G0.6690.27
40_F229_V0.6680.27
135_I218_S0.6670.27
45_L128_V0.6660.27
247_K250_G0.6650.27
120_D144_L0.6640.27
142_D158_I0.6630.27
139_R187_M0.6620.27
24_D246_V0.6610.26
54_V57_R0.6610.26
79_L217_K0.6590.26
183_S196_I0.6570.26
55_E128_V0.6560.26
160_R165_V0.6560.26
155_M175_Y0.6500.26
20_M174_E0.6490.26
24_D229_V0.6480.26
199_L208_D0.6420.25
206_I218_S0.6420.25
66_K191_L0.6340.25
236_E241_D0.6290.25
183_S241_D0.6280.25
213_V217_K0.6270.25
42_P221_F0.6260.25
21_I164_A0.6250.25
44_S202_I0.6230.24
66_K70_R0.6220.24
158_I165_V0.6190.24
37_K56_G0.6180.24
22_E230_K0.6170.24
76_I173_V0.6160.24
30_P155_M0.6160.24
54_V164_A0.6140.24
67_G220_G0.6120.24
206_I221_F0.6110.24
68_I217_K0.6090.24
26_E179_G0.6090.24
217_K223_F0.6070.24
25_V125_N0.6060.24
17_R190_N0.6050.24
84_V87_G0.6030.23
19_T196_I0.6030.23
68_I211_T0.6010.23
70_R80_R0.6000.23
24_D243_D0.6000.23
246_V253_V0.5990.23
121_Y241_D0.5970.23
163_G189_Y0.5920.23
80_R191_L0.5900.23
79_L218_S0.5850.23
249_V252_L0.5840.22
141_L185_K0.5810.22
25_V30_P0.5800.22
194_Y224_V0.5770.22
18_T211_T0.5770.22
246_V250_G0.5680.22
245_Q253_V0.5670.22
29_S182_F0.5670.22
176_V179_G0.5660.22
242_E248_D0.5650.22
146_I183_S0.5630.21
70_R123_C0.5630.21
37_K143_S0.5630.21
190_N195_A0.5600.21
170_L173_V0.5590.21
129_F214_G0.5580.21
129_F222_G0.5580.21
239_I243_D0.5580.21
51_L141_L0.5570.21
47_K220_G0.5570.21
212_Q217_K0.5560.21
247_K251_D0.5550.21
29_S207_H0.5510.21
28_V64_S0.5450.21
44_S49_S0.5450.21
26_E146_I0.5440.21
21_I193_N0.5410.20
240_G247_K0.5390.20
162_E168_R0.5380.20
50_I178_V0.5370.20
138_V186_M0.5340.20
68_I175_Y0.5330.20
170_L215_G0.5320.20
36_G211_T0.5320.20
225_K246_V0.5310.20
234_L246_V0.5270.20
74_E176_V0.5230.20
238_R242_E0.5220.20
32_K215_G0.5190.19
22_E252_L0.5130.19
205_N209_G0.5070.19
147_S181_K0.5070.19
114_A203_M0.5060.19
68_I204_K0.5050.19
22_E147_S0.5050.19
19_T233_D0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qtsC 1 0.6335 100 0.45 Contact Map
4n0lA 1 0.8648 100 0.468 Contact Map
4w8wA 1 0.5267 100 0.532 Contact Map
3x1lC 3 0.7331 100 0.533 Contact Map
4w8vA 1 0.6975 100 0.553 Contact Map
3x1lH 1 0.6904 100 0.555 Contact Map
4txdA 1 0.8826 99.4 0.783 Contact Map
4w8zA 1 0.7082 98.9 0.827 Contact Map
4l6uA 1 0.7331 98.9 0.827 Contact Map
4qtsA 1 0.7295 97.2 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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