Q97YA6 - SULSO - GREMLIN Contacts

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Q97YA6 - Uncharacterized protein

UniProt:	Q97YA6	Sequences: MVLMVNYTFIDKRVIKRTTMIEGDVETVSPLKIGGGKDNFDPSSLAKDSILKDVEGRPIIPGSSWKGIFRSTGERILRLRNIEVCSGIGKDYCLNNNRKERDFNSALKENVDQALEIFWDYTCLNCKVFGTMSVIGAVRFLDSLPISYSLNTRSMIAISRTEGAVARRALVTVEYVDVGSKFSFKMMGYNLPNYAIGYLITIMKNIHDGFTQVGGHKSRGFGFVKFGKVKFTDLGEKRIGDEDIQVKDVGDLVEGNGDEFFGRMKPFMEAFNNAKIPYPKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	281 (216)
Sequences:	378 (345)
Seq/√Len:	23.5

SULSO - Q97YA6 Q97YA7 Q97YA0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
123_C	126_C	8.887	1.00
69_F	140_F	6.493	1.00
23_G	184_F	5.986	1.00
26_E	181_K	3.539	1.00
26_E	227_G	3.226	1.00
62_G	142_D	2.923	1.00
31_L	213_V	2.779	0.99
212_Q	223_F	2.702	0.99
73_G	77_L	2.618	0.99
143_S	184_F	2.406	0.98
168_R	171_V	2.332	0.98
135_I	221_F	2.307	0.97
73_G	198_Y	2.277	0.97
25_V	224_V	2.275	0.97
153_R	156_I	2.244	0.97
28_V	225_K	2.158	0.96
63_S	142_D	1.961	0.93
20_M	185_K	1.954	0.93
123_C	127_K	1.910	0.92
190_N	197_G	1.895	0.92
188_G	195_A	1.870	0.92
156_I	165_V	1.836	0.91
154_S	172_T	1.810	0.90
27_T	31_L	1.730	0.88
25_V	184_F	1.677	0.86
194_Y	197_G	1.623	0.84
27_T	180_S	1.615	0.84
165_V	217_K	1.587	0.83
80_R	126_C	1.557	0.82
162_E	165_V	1.530	0.81
127_K	195_A	1.523	0.80
22_E	185_K	1.522	0.80
15_I	69_F	1.519	0.80
70_R	130_G	1.500	0.79
214_G	222_G	1.477	0.78
248_D	251_D	1.472	0.78
47_K	50_I	1.453	0.77
65_W	143_S	1.440	0.76
19_T	191_L	1.412	0.75
70_R	129_F	1.405	0.74
30_P	221_F	1.385	0.73
59_I	144_L	1.381	0.73
21_I	186_M	1.365	0.72
24_D	181_K	1.355	0.72
15_I	19_T	1.341	0.71
64_S	68_I	1.336	0.71
22_E	183_S	1.331	0.70
71_S	74_E	1.329	0.70
25_V	211_T	1.329	0.70
67_G	222_G	1.321	0.70
67_G	214_G	1.321	0.70
18_T	189_Y	1.308	0.69
250_G	253_V	1.300	0.68
182_F	190_N	1.300	0.68
25_V	60_I	1.273	0.67
151_N	177_D	1.263	0.66
19_T	216_H	1.257	0.66
68_I	209_G	1.252	0.65
21_I	194_Y	1.251	0.65
67_G	129_F	1.246	0.65
125_N	233_D	1.237	0.64
83_E	125_N	1.225	0.64
138_V	203_M	1.221	0.63
23_G	76_I	1.221	0.63
33_I	172_T	1.214	0.63
73_G	124_L	1.213	0.63
150_L	153_R	1.209	0.63
154_S	170_L	1.209	0.63
145_P	180_S	1.206	0.62
70_R	142_D	1.202	0.62
47_K	51_L	1.193	0.62
58_P	167_R	1.174	0.60
66_K	187_M	1.143	0.58
21_I	237_K	1.137	0.58
191_L	195_A	1.126	0.57
36_G	179_G	1.125	0.57
69_F	162_E	1.125	0.57
138_V	233_D	1.124	0.57
64_S	215_G	1.107	0.56
161_T	164_A	1.102	0.55
213_V	224_V	1.101	0.55
188_G	191_L	1.086	0.54
75_R	80_R	1.081	0.54
245_Q	250_G	1.070	0.53
24_D	228_K	1.062	0.53
130_G	222_G	1.036	0.51
130_G	214_G	1.036	0.51
247_K	252_L	1.032	0.51
26_E	225_K	1.031	0.50
144_L	163_G	1.030	0.50
183_S	227_G	1.026	0.50
145_P	149_S	1.026	0.50
138_V	141_L	1.026	0.50
53_D	56_G	1.025	0.50
74_E	126_C	1.018	0.50
181_K	230_K	1.018	0.50
212_Q	221_F	1.008	0.49
242_E	245_Q	0.997	0.48
179_G	185_K	0.985	0.47
128_V	191_L	0.984	0.47
153_R	219_R	0.983	0.47
141_L	177_D	0.965	0.46
153_R	175_Y	0.960	0.45
191_L	197_G	0.957	0.45
50_I	215_G	0.947	0.45
157_A	176_V	0.947	0.45
155_M	221_F	0.943	0.44
19_T	188_G	0.940	0.44
245_Q	248_D	0.939	0.44
58_P	138_V	0.937	0.44
245_Q	249_V	0.935	0.44
22_E	237_K	0.930	0.43
72_T	188_G	0.930	0.43
74_E	123_C	0.929	0.43
243_D	246_V	0.928	0.43
172_T	216_H	0.927	0.43
125_N	198_Y	0.926	0.43
151_N	155_M	0.924	0.43
66_K	174_E	0.924	0.43
50_I	66_K	0.924	0.43
207_H	226_F	0.923	0.43
16_K	134_V	0.922	0.43
27_T	179_G	0.920	0.43
23_G	143_S	0.906	0.42
133_S	142_D	0.905	0.42
129_F	220_G	0.905	0.42
159_S	162_E	0.905	0.42
19_T	79_L	0.904	0.42
58_P	176_V	0.898	0.41
175_Y	221_F	0.893	0.41
47_K	52_K	0.892	0.41
29_S	127_K	0.890	0.41
196_I	228_K	0.887	0.40
216_H	221_F	0.883	0.40
80_R	128_V	0.882	0.40
30_P	177_D	0.869	0.39
159_S	166_A	0.867	0.39
87_G	148_Y	0.859	0.39
128_V	193_N	0.857	0.38
67_G	130_G	0.857	0.38
143_S	182_F	0.857	0.38
77_L	198_Y	0.854	0.38
219_R	224_V	0.847	0.38
50_I	137_A	0.844	0.38
184_F	236_E	0.842	0.37
214_G	220_G	0.841	0.37
186_M	237_K	0.837	0.37
33_I	58_P	0.837	0.37
121_Y	227_G	0.830	0.37
80_R	123_C	0.830	0.37
64_S	124_L	0.825	0.36
66_K	135_I	0.821	0.36
112_D	230_K	0.819	0.36
136_G	142_D	0.814	0.36
159_S	213_V	0.813	0.36
73_G	202_I	0.809	0.35
21_I	247_K	0.804	0.35
86_S	179_G	0.797	0.35
155_M	170_L	0.792	0.34
137_A	143_S	0.789	0.34
23_G	164_A	0.784	0.34
207_H	221_F	0.783	0.34
142_D	219_R	0.783	0.34
76_I	205_N	0.780	0.33
60_I	238_R	0.779	0.33
237_K	251_D	0.778	0.33
174_E	219_R	0.774	0.33
24_D	230_K	0.773	0.33
77_L	80_R	0.772	0.33
136_G	156_I	0.770	0.33
155_M	226_F	0.758	0.32
14_V	85_C	0.758	0.32
201_T	205_N	0.756	0.32
243_D	252_L	0.755	0.32
66_K	218_S	0.755	0.32
34_G	215_G	0.754	0.32
72_T	205_N	0.752	0.32
247_K	253_V	0.752	0.32
116_E	186_M	0.751	0.32
113_Q	116_E	0.751	0.32
19_T	23_G	0.748	0.31
34_G	64_S	0.747	0.31
82_I	86_S	0.745	0.31
236_E	239_I	0.745	0.31
52_K	174_E	0.742	0.31
136_G	140_F	0.741	0.31
136_G	195_A	0.741	0.31
67_G	70_R	0.740	0.31
136_G	148_Y	0.740	0.31
27_T	58_P	0.739	0.31
24_D	146_I	0.738	0.31
151_N	178_V	0.736	0.31
241_D	247_K	0.735	0.31
19_T	77_L	0.729	0.30
158_I	163_G	0.727	0.30
131_T	173_V	0.724	0.30
15_I	18_T	0.724	0.30
52_K	123_C	0.723	0.30
141_L	187_M	0.723	0.30
32_K	174_E	0.722	0.30
126_C	138_V	0.717	0.30
237_K	249_V	0.716	0.30
140_F	147_S	0.715	0.30
34_G	218_S	0.715	0.30
249_V	253_V	0.715	0.30
144_L	213_V	0.710	0.29
70_R	74_E	0.710	0.29
21_I	26_E	0.705	0.29
66_K	230_K	0.705	0.29
31_L	176_V	0.704	0.29
69_F	202_I	0.703	0.29
60_I	229_V	0.701	0.29
30_P	175_Y	0.701	0.29
244_I	250_G	0.698	0.29
30_P	219_R	0.697	0.28
19_T	195_A	0.696	0.28
23_G	73_G	0.690	0.28
23_G	65_W	0.685	0.28
188_G	233_D	0.684	0.28
147_S	243_D	0.683	0.28
140_F	198_Y	0.681	0.28
140_F	162_E	0.681	0.28
29_S	49_S	0.681	0.28
138_V	162_E	0.677	0.27
77_L	164_A	0.676	0.27
32_K	139_R	0.676	0.27
33_I	232_T	0.674	0.27
155_M	161_T	0.671	0.27
27_T	34_G	0.669	0.27
40_F	229_V	0.668	0.27
135_I	218_S	0.667	0.27
45_L	128_V	0.666	0.27
247_K	250_G	0.665	0.27
120_D	144_L	0.664	0.27
142_D	158_I	0.663	0.27
139_R	187_M	0.662	0.27
24_D	246_V	0.661	0.26
54_V	57_R	0.661	0.26
79_L	217_K	0.659	0.26
183_S	196_I	0.657	0.26
55_E	128_V	0.656	0.26
160_R	165_V	0.656	0.26
155_M	175_Y	0.650	0.26
20_M	174_E	0.649	0.26
24_D	229_V	0.648	0.26
199_L	208_D	0.642	0.25
206_I	218_S	0.642	0.25
66_K	191_L	0.634	0.25
236_E	241_D	0.629	0.25
183_S	241_D	0.628	0.25
213_V	217_K	0.627	0.25
42_P	221_F	0.626	0.25
21_I	164_A	0.625	0.25
44_S	202_I	0.623	0.24
66_K	70_R	0.622	0.24
158_I	165_V	0.619	0.24
37_K	56_G	0.618	0.24
22_E	230_K	0.617	0.24
76_I	173_V	0.616	0.24
30_P	155_M	0.616	0.24
54_V	164_A	0.614	0.24
67_G	220_G	0.612	0.24
206_I	221_F	0.611	0.24
68_I	217_K	0.609	0.24
26_E	179_G	0.609	0.24
217_K	223_F	0.607	0.24
25_V	125_N	0.606	0.24
17_R	190_N	0.605	0.24
84_V	87_G	0.603	0.23
19_T	196_I	0.603	0.23
68_I	211_T	0.601	0.23
70_R	80_R	0.600	0.23
24_D	243_D	0.600	0.23
246_V	253_V	0.599	0.23
121_Y	241_D	0.597	0.23
163_G	189_Y	0.592	0.23
80_R	191_L	0.590	0.23
79_L	218_S	0.585	0.23
249_V	252_L	0.584	0.22
141_L	185_K	0.581	0.22
25_V	30_P	0.580	0.22
194_Y	224_V	0.577	0.22
18_T	211_T	0.577	0.22
246_V	250_G	0.568	0.22
245_Q	253_V	0.567	0.22
29_S	182_F	0.567	0.22
176_V	179_G	0.566	0.22
242_E	248_D	0.565	0.22
146_I	183_S	0.563	0.21
70_R	123_C	0.563	0.21
37_K	143_S	0.563	0.21
190_N	195_A	0.560	0.21
170_L	173_V	0.559	0.21
129_F	214_G	0.558	0.21
129_F	222_G	0.558	0.21
239_I	243_D	0.558	0.21
51_L	141_L	0.557	0.21
47_K	220_G	0.557	0.21
212_Q	217_K	0.556	0.21
247_K	251_D	0.555	0.21
29_S	207_H	0.551	0.21
28_V	64_S	0.545	0.21
44_S	49_S	0.545	0.21
26_E	146_I	0.544	0.21
21_I	193_N	0.541	0.20
240_G	247_K	0.539	0.20
162_E	168_R	0.538	0.20
50_I	178_V	0.537	0.20
138_V	186_M	0.534	0.20
68_I	175_Y	0.533	0.20
170_L	215_G	0.532	0.20
36_G	211_T	0.532	0.20
225_K	246_V	0.531	0.20
234_L	246_V	0.527	0.20
74_E	176_V	0.523	0.20
238_R	242_E	0.522	0.20
32_K	215_G	0.519	0.19
22_E	252_L	0.513	0.19
205_N	209_G	0.507	0.19
147_S	181_K	0.507	0.19
114_A	203_M	0.506	0.19
68_I	204_K	0.505	0.19
22_E	147_S	0.505	0.19
19_T	233_D	0.500	0.19

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qtsC	1	0.6335	100	0.45	Contact Map
4n0lA	1	0.8648	100	0.468	Contact Map
4w8wA	1	0.5267	100	0.532	Contact Map
3x1lC	3	0.7331	100	0.533	Contact Map
4w8vA	1	0.6975	100	0.553	Contact Map
3x1lH	1	0.6904	100	0.555	Contact Map
4txdA	1	0.8826	99.4	0.783	Contact Map
4w8zA	1	0.7082	98.9	0.827	Contact Map
4l6uA	1	0.7331	98.9	0.827	Contact Map
4qtsA	1	0.7295	97.2	0.887	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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