GREMLIN Database
Q97YA0 - Uncharacterized protein
UniProt: Q97YA0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 252 (214)
Sequences: 437 (404)
Seq/√Len: 27.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_C130_E5.3721.00
158_T176_S5.2311.00
180_I185_I5.0231.00
179_I220_I3.6951.00
127_C134_G2.9381.00
163_E170_S2.9371.00
162_I167_K2.8681.00
32_L42_P2.7721.00
12_L16_F2.7471.00
160_V169_A2.7091.00
21_G33_R2.5430.99
8_L187_V2.5410.99
19_G214_G2.4250.99
159_H175_F2.3910.99
31_Q185_I2.2130.98
155_M181_D2.2080.98
159_H220_I2.2040.98
33_R178_E2.1830.98
18_V42_P2.1570.98
47_K217_S2.0600.97
127_C131_R2.0540.97
55_E164_R1.9990.96
18_V185_I1.9200.95
19_G181_D1.9180.95
16_F212_I1.8150.93
19_G178_E1.8130.93
158_T174_L1.7970.93
159_H177_E1.7920.93
19_G31_Q1.7890.93
79_A82_K1.7670.93
139_A225_L1.7270.92
13_R224_V1.6980.91
122_Y125_Y1.6710.90
169_A172_K1.6370.89
158_T175_F1.6240.89
15_G179_I1.6170.89
34_I149_I1.5970.88
30_R181_D1.5290.86
174_L214_G1.4710.83
159_H218_R1.4550.83
14_T30_R1.4350.82
211_F222_Y1.4330.82
147_S187_V1.4260.81
28_V33_R1.4030.80
157_R160_V1.3900.80
211_F215_S1.3790.79
101_T106_N1.3760.79
41_I212_I1.3580.78
75_R78_N1.3480.78
77_I81_L1.3440.77
48_G213_G1.3360.77
213_G221_G1.3360.77
48_G221_G1.3360.77
42_P49_M1.3260.76
103_N106_N1.3190.76
171_E174_L1.3130.76
90_I93_S1.3050.75
179_I222_Y1.2870.74
31_Q39_V1.2740.73
49_M210_Y1.2670.73
51_R55_E1.2670.73
16_F180_I1.2550.72
126_N135_S1.2370.71
45_S218_R1.2310.71
181_D214_G1.2130.70
17_R214_G1.2030.69
50_F144_I1.2010.69
54_S201_S1.1950.68
17_R215_S1.1930.68
31_Q180_I1.1930.68
102_Q111_D1.1870.68
18_V180_I1.1860.68
158_T162_I1.1840.68
42_P157_R1.1690.67
132_L135_S1.1620.66
12_L214_G1.1620.66
156_E178_E1.1560.66
130_E134_G1.1460.65
11_R226_D1.0970.62
94_K97_K1.0870.61
77_I82_K1.0850.61
83_S86_K1.0840.61
175_F218_R1.0820.61
163_E166_S1.0740.60
115_L118_L1.0740.60
50_F151_N1.0720.60
160_V220_I1.0700.60
37_E46_W1.0610.59
119_R122_Y1.0580.59
102_Q106_N1.0560.59
179_I215_S1.0560.59
119_R123_N1.0540.59
98_E102_Q1.0540.59
53_V167_K1.0520.58
21_G174_L1.0420.58
14_T194_E1.0410.58
159_H179_I1.0280.57
85_E89_R1.0260.56
20_G32_L1.0080.55
155_M169_A1.0070.55
162_I218_R1.0020.55
168_K214_G1.0010.55
87_F132_L0.9940.54
41_I205_L0.9900.54
106_N111_D0.9890.54
201_S204_L0.9880.54
46_W155_M0.9870.53
17_R181_D0.9820.53
29_I177_E0.9810.53
100_I103_N0.9770.53
162_I175_F0.9730.52
213_G219_G0.9690.52
48_G219_G0.9690.52
78_N81_L0.9580.51
26_D175_F0.9570.51
158_T215_S0.9420.50
15_G220_I0.9310.49
160_V173_H0.9260.49
42_P45_S0.9240.49
157_R218_R0.9200.48
21_G28_V0.9200.48
15_G167_K0.9180.48
131_R135_S0.9170.48
85_E88_R0.9150.48
160_V175_F0.9120.48
185_I189_V0.9070.47
42_P218_R0.9020.47
28_V32_L0.8910.46
74_T78_N0.8880.46
127_C133_Y0.8850.46
89_R94_K0.8800.45
15_G49_M0.8780.45
93_S96_G0.8750.45
130_E133_Y0.8720.45
102_Q105_I0.8720.45
32_L40_M0.8690.45
72_V75_R0.8680.44
28_V181_D0.8630.44
15_G211_F0.8620.44
15_G176_S0.8580.44
17_R39_V0.8570.44
11_R184_K0.8570.44
97_K100_I0.8540.43
24_V149_I0.8510.43
121_I125_Y0.8350.42
41_I52_R0.8320.42
15_G157_R0.8320.42
46_W141_G0.8270.41
46_W147_S0.8260.41
37_E191_V0.8210.41
146_D166_S0.8150.41
17_R33_R0.8140.40
11_R224_V0.8130.40
16_F26_D0.8130.40
160_V172_K0.8090.40
40_M43_A0.8060.40
139_A220_I0.8050.40
95_V98_E0.8020.40
43_A123_N0.7910.39
27_N33_R0.7890.39
165_K168_K0.7880.39
7_R186_E0.7830.38
89_R98_E0.7830.38
35_G154_I0.7820.38
27_N176_S0.7810.38
31_Q178_E0.7760.38
44_S47_K0.7760.38
169_A216_K0.7740.38
14_T218_R0.7680.37
10_F223_I0.7670.37
100_I111_D0.7670.37
214_G217_S0.7650.37
99_V106_N0.7630.37
75_R81_L0.7620.37
161_T169_A0.7610.37
77_I83_S0.7590.36
17_R27_N0.7570.36
138_F198_W0.7570.36
42_P216_K0.7530.36
17_R178_E0.7520.36
54_S199_K0.7510.36
99_V104_G0.7490.36
76_T83_S0.7480.36
167_K175_F0.7470.36
163_E189_V0.7470.36
159_H211_F0.7460.36
51_R219_G0.7460.36
32_L218_R0.7450.35
175_F215_S0.7390.35
124_E135_S0.7370.35
174_L211_F0.7370.35
99_V103_N0.7350.35
47_K178_E0.7340.35
178_E181_D0.7320.35
77_I80_L0.7320.35
90_I98_E0.7310.35
32_L222_Y0.7280.34
94_K106_N0.7270.34
194_E197_L0.7220.34
162_I166_S0.7200.34
25_G39_V0.7200.34
6_F113_E0.7180.34
37_E152_A0.7160.34
52_R187_V0.7050.33
56_I200_N0.7050.33
94_K101_T0.7010.32
15_G24_V0.7010.32
100_I105_I0.6990.32
125_Y129_I0.6980.32
115_L119_R0.6980.32
169_A173_H0.6930.32
15_G155_M0.6930.32
144_I148_V0.6900.32
21_G181_D0.6880.32
158_T220_I0.6850.31
196_E203_K0.6850.31
94_K98_E0.6830.31
157_R179_I0.6810.31
27_N158_T0.6800.31
173_H220_I0.6800.31
11_R183_E0.6800.31
24_V31_Q0.6690.30
101_T112_S0.6680.30
157_R220_I0.6670.30
141_G149_I0.6620.30
125_Y224_V0.6610.30
14_T181_D0.6540.29
18_V183_E0.6490.29
155_M182_A0.6480.29
62_D114_S0.6460.29
17_R31_Q0.6460.29
10_F187_V0.6380.28
15_G159_H0.6340.28
118_L121_I0.6330.28
161_T215_S0.6320.28
12_L223_I0.6310.28
167_K216_K0.6310.28
115_L132_L0.6280.28
89_R95_V0.6240.28
161_T170_S0.6240.28
95_V99_V0.6230.28
72_V130_E0.6220.27
92_I97_K0.6180.27
12_L215_S0.6100.27
9_N227_E0.6080.27
96_G99_V0.6030.26
45_S183_E0.6020.26
216_K222_Y0.6010.26
117_D151_N0.6010.26
96_G106_N0.6010.26
47_K174_L0.6000.26
95_V101_T0.5960.26
10_F40_M0.5960.26
19_G215_S0.5960.26
161_T167_K0.5940.26
169_A174_L0.5910.26
39_V51_R0.5890.25
87_F93_S0.5890.25
157_R175_F0.5860.25
174_L219_G0.5850.25
72_V77_I0.5820.25
43_A166_S0.5810.25
45_S49_M0.5790.25
174_L177_E0.5780.25
139_A159_H0.5750.25
7_R188_K0.5730.25
98_E101_T0.5690.24
161_T172_K0.5660.24
49_M52_R0.5660.24
121_I124_E0.5630.24
77_I84_D0.5630.24
52_R141_G0.5590.24
183_E223_I0.5580.24
17_R34_I0.5580.24
18_V157_R0.5560.24
27_N171_E0.5550.24
199_K227_E0.5550.24
15_G225_L0.5540.24
22_Q29_I0.5540.24
187_V192_R0.5540.24
13_R140_G0.5520.23
10_F81_L0.5500.23
53_V171_E0.5500.23
13_R192_R0.5500.23
168_K220_I0.5490.23
16_F55_E0.5450.23
178_E214_G0.5420.23
10_F13_R0.5390.23
149_I181_D0.5370.23
179_I210_Y0.5350.22
27_N30_R0.5330.22
22_Q33_R0.5330.22
12_L29_I0.5320.22
63_H75_R0.5310.22
154_I178_E0.5300.22
52_R147_S0.5270.22
6_F20_G0.5270.22
6_F64_F0.5260.22
97_K104_G0.5240.22
143_T149_I0.5240.22
137_Y140_G0.5240.22
31_Q149_I0.5230.22
146_D214_G0.5200.22
101_T104_G0.5200.22
84_D90_I0.5190.22
153_S179_I0.5180.22
18_V154_I0.5160.22
54_S225_L0.5150.21
177_E181_D0.5120.21
114_S118_L0.5100.21
130_E144_I0.5080.21
14_T187_V0.5070.21
148_V203_K0.5070.21
143_T192_R0.5060.21
10_F133_Y0.5060.21
129_I134_G0.5040.21
24_V155_M0.5040.21
158_T177_E0.5030.21
142_I197_L0.5030.21
26_D218_R0.5000.21
35_G216_K0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qtsC 1 0.6151 100 0.407 Contact Map
3x1lC 3 0.8849 100 0.411 Contact Map
4w8wA 1 0.7579 100 0.434 Contact Map
4n0lA 1 0.8413 100 0.442 Contact Map
4w8vA 1 0.8333 100 0.542 Contact Map
3x1lH 1 0.7619 100 0.544 Contact Map
4txdA 1 0.8849 99 0.799 Contact Map
4qtsA 1 0.8135 99 0.804 Contact Map
4w8zA 1 0.6905 98.1 0.852 Contact Map
4l6uA 1 0.6944 97.9 0.858 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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