GREMLIN Database
Q97Y93 - ATP-dependent RNA helicase homolog
UniProt: Q97Y93 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 515 (409)
Sequences: 13695 (9419)
Seq/√Len: 465.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_M98_L4.8951.00
124_F127_K4.3571.00
373_N377_V4.0341.00
64_T173_I3.9241.00
55_P58_Y3.6651.00
132_T137_F3.6171.00
85_L94_L3.5931.00
44_L205_V3.3241.00
28_R104_K3.1331.00
36_G52_L3.0991.00
372_Y376_E2.9831.00
306_K311_K2.9421.00
67_L81_V2.9371.00
271_R294_K2.8891.00
268_Y274_A2.8781.00
212_D215_L2.8241.00
268_Y277_A2.7751.00
286_L312_L2.7471.00
305_N309_D2.7041.00
335_C363_Y2.5871.00
236_K239_R2.5591.00
215_L218_V2.4611.00
278_Y288_P2.3361.00
188_G192_S2.3061.00
250_E257_K2.2891.00
238_D242_Y2.2851.00
384_V388_K2.2571.00
380_T384_V2.2561.00
289_I306_K2.2001.00
45_E70_A2.1991.00
302_D306_K2.1561.00
262_K328_D2.0861.00
238_D241_I2.0741.00
95_Y99_K2.0691.00
373_N376_E2.0321.00
215_L219_L1.9681.00
49_N206_V1.9611.00
213_K217_R1.9561.00
253_I256_E1.9551.00
251_I257_K1.9471.00
48_H227_G1.9461.00
250_E258_V1.9321.00
253_I257_K1.9041.00
268_Y314_V1.9011.00
31_F62_T1.8991.00
370_K373_N1.8981.00
275_I290_L1.8961.00
250_E253_I1.8961.00
344_A361_E1.8891.00
184_G188_G1.8731.00
363_Y366_P1.8671.00
97_K100_K1.8551.00
67_L70_A1.8451.00
364_I367_F1.8421.00
67_L72_S1.8001.00
372_Y375_G1.7811.00
28_R103_D1.7761.00
250_E254_A1.7751.00
81_V171_I1.7241.00
64_T207_T1.7171.00
42_R46_N1.7061.00
319_I323_I1.6901.00
237_I240_K1.6761.00
326_S352_K1.6571.00
366_P369_G1.6521.00
216_E219_L1.6451.00
64_T94_L1.6371.00
255_D259_K1.6261.00
377_V380_T1.6251.00
403_E407_I1.5791.00
400_Y404_I1.5781.00
98_L129_V1.5721.00
44_L50_V1.5651.00
277_A314_V1.5601.00
140_N161_E1.5561.00
372_Y377_V1.5511.00
238_D245_E1.5421.00
251_I255_D1.5391.00
239_R245_E1.5231.00
262_K352_K1.5211.00
214_G218_V1.5141.00
453_V456_A1.5021.00
218_V222_K1.5001.00
66_I69_N1.4921.00
278_Y282_K1.4841.00
380_T383_R1.4741.00
255_D284_R1.4511.00
43_Y46_N1.4501.00
82_I167_I1.4481.00
274_A292_H1.4371.00
218_V221_D1.4331.00
236_K240_K1.4191.00
315_S319_I1.4071.00
67_L173_I1.3991.00
365_F369_G1.3941.00
382_K390_I1.3811.00
69_N73_S1.3781.00
251_I258_V1.3761.00
363_Y369_G1.3731.00
52_L207_T1.3651.00
332_T335_C1.3591.00
187_L191_L1.3591.00
442_I446_F1.3521.00
384_V387_L1.3481.00
164_R167_I1.3351.00
403_E408_L1.3351.00
163_P166_L1.3271.00
281_L314_V1.3271.00
113_G120_H1.3251.00
400_Y403_E1.3231.00
289_I303_K1.3221.00
98_L131_V1.3121.00
432_N435_S1.3071.00
364_I369_G1.2841.00
363_Y367_F1.2811.00
384_V390_I1.2741.00
395_L399_D1.2731.00
332_T344_A1.2711.00
278_Y290_L1.2701.00
192_S196_V1.2671.00
362_V365_F1.2611.00
246_L249_D1.2491.00
80_R168_Y1.2481.00
172_V204_I1.2361.00
177_F206_V1.2261.00
42_R70_A1.2231.00
39_E42_R1.2201.00
371_V376_E1.2191.00
256_E259_K1.2111.00
351_G399_D1.2111.00
382_K385_R1.2051.00
376_E380_T1.2041.00
243_V246_L1.2001.00
81_V173_I1.1991.00
69_N78_G1.1971.00
213_K216_E1.1821.00
212_D218_V1.1821.00
295_F303_K1.1771.00
39_E43_Y1.1761.00
215_L221_D1.1681.00
385_R390_I1.1641.00
84_V137_F1.1641.00
240_K245_E1.1641.00
273_G334_A1.1611.00
451_D454_D1.1601.00
456_A459_L1.1601.00
159_H162_F1.1541.00
362_V366_P1.1461.00
267_V343_R1.1451.00
69_N72_S1.1451.00
361_E366_P1.1391.00
178_H321_A1.1381.00
447_P450_S1.1291.00
403_E406_S1.1251.00
132_T162_F1.1241.00
391_D395_L1.1231.00
426_V430_Y1.1221.00
425_K428_S1.1181.00
455_D458_P1.1181.00
449_N452_N1.1171.00
98_L109_T1.1081.00
96_L100_K1.1071.00
117_M120_H1.1071.00
239_R242_Y1.1041.00
142_F192_S1.1011.00
387_L390_I1.0981.00
84_V132_T1.0951.00
216_E220_M1.0941.00
400_Y408_L1.0921.00
92_Q301_I1.0881.00
257_K260_E1.0721.00
296_S299_D1.0661.00
395_L403_E1.0651.00
237_I241_I1.0611.00
80_R128_K1.0581.00
375_G378_K1.0521.00
404_I407_I1.0501.00
399_D403_E1.0491.00
301_I305_N1.0471.00
95_Y109_T1.0441.00
371_V377_V1.0391.00
255_D258_V1.0371.00
371_V375_G1.0371.00
252_S284_R1.0351.00
232_A235_F1.0341.00
252_S255_D1.0331.00
332_T336_P1.0321.00
398_R401_T1.0311.00
441_S445_G1.0261.00
400_Y405_D1.0241.00
376_E379_E1.0231.00
216_E228_K1.0191.00
266_L312_L1.0161.00
436_I439_E1.0131.00
253_I258_V1.0111.00
162_F165_A1.0101.00
231_Y234_D1.0041.00
62_T66_I1.0031.00
458_P461_E1.0031.00
236_K241_I1.0021.00
405_D408_L1.0011.00
43_Y229_V0.9981.00
241_I244_N0.9971.00
43_Y227_G0.9941.00
361_E364_I0.9861.00
387_L391_D0.9861.00
377_V384_V0.9831.00
425_K432_N0.9811.00
382_K387_L0.9801.00
388_K392_E0.9741.00
361_E365_F0.9701.00
264_V329_V0.9681.00
396_I399_D0.9671.00
302_D305_N0.9671.00
250_E255_D0.9661.00
299_D303_K0.9661.00
453_V457_I0.9651.00
443_I447_P0.9631.00
138_I192_S0.9611.00
187_L190_G0.9601.00
245_E249_D0.9571.00
113_G116_D0.9541.00
164_R168_Y0.9531.00
394_L398_R0.9521.00
455_D459_L0.9501.00
291_I319_I0.9461.00
430_Y434_C0.9451.00
385_R389_T0.9451.00
420_F424_K0.9441.00
378_K381_M0.9431.00
179_L183_D0.9351.00
383_R387_L0.9311.00
264_V312_L0.9311.00
362_V369_G0.9261.00
264_V331_I0.9251.00
421_V424_K0.9161.00
173_I205_V0.9161.00
384_V389_T0.9101.00
391_D394_L0.9021.00
373_N380_T0.9011.00
417_N421_V0.8971.00
430_Y433_I0.8941.00
370_K374_E0.8941.00
452_N456_A0.8911.00
274_A278_Y0.8901.00
256_E260_E0.8891.00
424_K428_S0.8891.00
174_F181_G0.8861.00
70_A168_Y0.8831.00
51_I219_L0.8811.00
213_K218_V0.8801.00
240_K354_G0.8781.00
374_E378_K0.8781.00
304_V325_T0.8781.00
254_A257_K0.8761.00
397_E406_S0.8751.00
394_L397_E0.8721.00
278_Y314_V0.8721.00
380_T387_L0.8691.00
380_T388_K0.8691.00
274_A290_L0.8681.00
451_D455_D0.8671.00
459_L463_E0.8621.00
270_T273_G0.8621.00
456_A460_T0.8601.00
237_I245_E0.8591.00
383_R388_K0.8591.00
454_D458_P0.8581.00
449_N453_V0.8581.00
259_K286_L0.8571.00
280_K284_R0.8551.00
379_E384_V0.8541.00
432_N436_I0.8531.00
380_T390_I0.8481.00
433_I436_I0.8481.00
261_G264_V0.8471.00
120_H123_P0.8461.00
364_I368_S0.8461.00
327_F331_I0.8451.00
462_E465_I0.8431.00
336_P343_R0.8421.00
444_L448_P0.8421.00
328_D331_I0.8421.00
83_H98_L0.8421.00
399_D405_D0.8411.00
299_D302_D0.8391.00
386_K390_I0.8381.00
201_G204_I0.8361.00
241_I245_E0.8361.00
382_K388_K0.8351.00
380_T385_R0.8351.00
214_G217_R0.8341.00
160_Y163_P0.8311.00
192_S195_E0.8311.00
435_S439_E0.8301.00
459_L462_E0.8281.00
460_T463_E0.8271.00
445_G448_P0.8261.00
41_L66_I0.8231.00
230_V233_S0.8221.00
396_I403_E0.8211.00
461_E465_I0.8171.00
332_T363_Y0.8151.00
443_I446_F0.8151.00
227_G234_D0.8151.00
112_I297_K0.8131.00
448_P452_N0.8131.00
160_Y167_I0.8121.00
236_K242_Y0.8091.00
263_R310_A0.8091.00
448_P451_D0.8071.00
275_I292_H0.8061.00
219_L222_K0.8061.00
395_L404_I0.8041.00
412_L415_I0.8031.00
397_E403_E0.8031.00
40_T63_L0.8011.00
457_I461_E0.7991.00
162_F167_I0.7991.00
383_R386_K0.7971.00
64_T205_V0.7941.00
365_F368_S0.7941.00
266_L331_I0.7941.00
47_G203_P0.7931.00
385_R388_K0.7911.00
452_N455_D0.7901.00
67_L171_I0.7871.00
61_T94_L0.7871.00
212_D219_L0.7831.00
118_D122_S0.7821.00
218_V223_L0.7821.00
393_S396_I0.7811.00
395_L398_R0.7791.00
225_K228_K0.7771.00
251_I284_R0.7761.00
227_G231_Y0.7751.00
379_E382_K0.7731.00
291_I295_F0.7721.00
110_K123_P0.7721.00
138_I142_F0.7711.00
295_F299_D0.7701.00
188_G191_L0.7681.00
397_E408_L0.7661.00
446_F449_N0.7661.00
78_G166_L0.7651.00
432_N439_E0.7641.00
49_N204_I0.7601.00
240_K244_N0.7591.00
219_L223_L0.7581.00
72_S75_I0.7561.00
363_Y368_S0.7551.00
460_T464_A0.7511.00
391_D399_D0.7511.00
215_L222_K0.7511.00
161_E164_R0.7501.00
240_K246_L0.7501.00
35_K39_E0.7481.00
242_Y246_L0.7481.00
394_L408_L0.7471.00
362_V367_F0.7471.00
113_G118_D0.7451.00
254_A331_I0.7451.00
428_S432_N0.7441.00
447_P452_N0.7431.00
381_M384_V0.7411.00
85_L91_V0.7401.00
381_M389_T0.7391.00
431_E435_S0.7381.00
51_I206_V0.7381.00
370_K376_E0.7371.00
418_S423_Y0.7361.00
70_A171_I0.7351.00
405_D409_A0.7341.00
423_Y426_V0.7321.00
119_Y122_S0.7301.00
447_P451_D0.7301.00
226_S234_D0.7301.00
410_R413_S0.7301.00
230_V234_D0.7271.00
398_R403_E0.7261.00
461_E464_A0.7261.00
455_D461_E0.7251.00
395_L400_Y0.7241.00
380_T386_K0.7241.00
454_D457_I0.7221.00
159_H167_I0.7221.00
381_M385_R0.7211.00
392_E397_E0.7201.00
40_T44_L0.7201.00
378_K383_R0.7181.00
451_D458_P0.7181.00
383_R390_I0.7161.00
172_V201_G0.7161.00
36_G40_T0.7151.00
422_D433_I0.7141.00
392_E398_R0.7131.00
263_R326_S0.7111.00
401_T405_D0.7101.00
442_I448_P0.7091.00
424_K437_T0.7041.00
433_I437_T0.6991.00
402_K408_L0.6981.00
426_V429_L0.6971.00
431_E434_C0.6961.00
125_F189_A0.6931.00
237_I242_Y0.6921.00
70_A74_N0.6921.00
392_E399_D0.6901.00
111_S114_A0.6891.00
29_H100_K0.6881.00
172_V194_I0.6881.00
374_E377_V0.6871.00
51_I211_I0.6871.00
422_D425_K0.6851.00
113_G117_M0.6851.00
194_I198_S0.6841.00
332_T343_R0.6841.00
400_Y407_I0.6831.00
228_K231_Y0.6821.00
239_R243_V0.6821.00
444_L447_P0.6811.00
231_Y235_F0.6801.00
160_Y165_A0.6781.00
424_K432_N0.6771.00
450_S457_I0.6771.00
238_D243_V0.6741.00
243_V248_K0.6721.00
441_S444_L0.6721.00
391_D397_E0.6711.00
102_A105_G0.6711.00
67_L71_V0.6701.00
336_P340_L0.6681.00
40_T52_L0.6681.00
178_H342_Q0.6671.00
446_F450_S0.6671.00
456_A463_E0.6661.00
251_I280_K0.6661.00
39_E227_G0.6651.00
449_N454_D0.6631.00
456_A461_E0.6631.00
391_D403_E0.6621.00
421_V425_K0.6621.00
395_L401_T0.6611.00
244_N249_D0.6591.00
160_Y166_L0.6561.00
435_S443_I0.6551.00
404_I408_L0.6541.00
419_V422_D0.6541.00
118_D121_D0.6531.00
375_G388_K0.6511.00
31_F101_Y0.6501.00
326_S330_L0.6481.00
325_T328_D0.6481.00
252_S256_E0.6451.00
191_L221_D0.6451.00
279_W282_K0.6451.00
87_Y321_A0.6441.00
381_M386_K0.6431.00
251_I277_A0.6371.00
418_S422_D0.6371.00
245_E248_K0.6371.00
423_Y427_K0.6341.00
351_G354_G0.6310.99
398_R404_I0.6290.99
373_N381_M0.6290.99
425_K430_Y0.6250.99
223_L226_S0.6230.99
402_K406_S0.6230.99
423_Y429_L0.6210.99
442_I449_N0.6200.99
42_R45_E0.6180.99
377_V381_M0.6180.99
381_M390_I0.6180.99
459_L464_A0.6170.99
330_L347_V0.6170.99
329_V332_T0.6150.99
396_I406_S0.6150.99
392_E395_L0.6150.99
243_V247_E0.6130.99
424_K427_K0.6130.99
361_E368_S0.6130.99
427_K433_I0.6100.99
307_I313_V0.6090.99
392_E396_I0.6060.99
453_V464_A0.6030.99
424_K429_L0.6020.99
41_L45_E0.6020.99
37_I40_T0.5990.99
381_M388_K0.5980.99
419_V424_K0.5970.99
399_D408_L0.5960.99
116_D119_Y0.5960.99
41_L44_L0.5960.99
450_S453_V0.5950.99
227_G233_S0.5930.99
455_D462_E0.5910.99
162_F166_L0.5890.99
252_S258_V0.5890.99
393_S403_E0.5880.99
242_Y354_G0.5870.99
443_I451_D0.5860.99
392_E403_E0.5840.99
449_N463_E0.5840.99
406_S409_A0.5820.99
438_R441_S0.5820.99
279_W283_E0.5810.99
378_K387_L0.5790.99
458_P463_E0.5780.99
223_L228_K0.5770.99
398_R408_L0.5770.99
228_K233_S0.5760.99
273_G276_E0.5730.99
424_K434_C0.5730.99
38_E42_R0.5720.99
373_N379_E0.5710.99
162_F168_Y0.5680.99
401_T404_I0.5650.99
457_I460_T0.5650.99
198_S202_V0.5650.99
443_I455_D0.5640.99
96_L99_K0.5640.99
84_V174_F0.5640.99
422_D427_K0.5620.99
277_A333_E0.5620.99
450_S456_A0.5620.99
90_I322_G0.5610.99
454_D459_L0.5610.99
450_S455_D0.5610.99
433_I439_E0.5600.99
168_Y202_V0.5590.99
379_E383_R0.5590.99
254_A258_V0.5580.99
213_K219_L0.5570.99
438_R442_I0.5570.99
440_T445_G0.5570.99
34_R37_I0.5570.99
395_L405_D0.5540.99
40_T43_Y0.5520.99
224_G231_Y0.5520.99
457_I465_I0.5510.99
86_P180_L0.5500.99
397_E402_K0.5480.99
68_A105_G0.5460.99
397_E405_D0.5450.99
400_Y406_S0.5450.99
53_K230_V0.5440.98
282_K288_P0.5430.98
429_L433_I0.5430.98
397_E404_I0.5430.98
371_V380_T0.5430.98
446_F452_N0.5420.98
393_S399_D0.5420.98
391_D396_I0.5410.98
440_T443_I0.5410.98
238_D246_L0.5400.98
439_E443_I0.5400.98
446_F451_D0.5400.98
452_N457_I0.5390.98
456_A462_E0.5390.98
427_K431_E0.5370.98
242_Y247_E0.5360.98
327_F330_L0.5360.98
428_S433_I0.5360.98
439_E451_D0.5340.98
168_Y171_I0.5330.98
393_S397_E0.5320.98
436_I440_T0.5320.98
460_T465_I0.5310.98
425_K429_L0.5300.98
422_D426_V0.5290.98
451_D459_L0.5290.98
95_Y131_V0.5270.98
397_E400_Y0.5250.98
426_V432_N0.5250.98
399_D407_I0.5240.98
391_D400_Y0.5240.98
274_A314_V0.5240.98
441_S446_F0.5230.98
422_D429_L0.5230.98
444_L450_S0.5220.98
443_I448_P0.5210.98
226_S232_A0.5210.98
327_F332_T0.5200.98
425_K437_T0.5200.98
240_K243_V0.5200.98
360_G363_Y0.5200.98
281_L312_L0.5190.98
436_I442_I0.5180.98
320_E339_N0.5180.98
419_V423_Y0.5180.98
445_G453_V0.5180.98
97_K101_Y0.5180.98
434_C437_T0.5170.98
253_I260_E0.5170.98
361_E367_F0.5160.98
276_E280_K0.5160.98
440_T447_P0.5150.98
446_F454_D0.5140.98
114_A117_M0.5140.98
227_G232_A0.5130.98
439_E446_F0.5120.98
395_L406_S0.5120.98
265_L315_S0.5120.98
93_D324_D0.5110.98
449_N457_I0.5110.98
239_R246_L0.5100.98
293_S319_I0.5080.98
373_N383_R0.5080.98
43_Y50_V0.5080.98
321_A342_Q0.5050.98
33_E37_I0.5040.98
216_E221_D0.5030.97
370_K375_G0.5010.97
442_I445_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pxaA 1 0.7223 100 0.406 Contact Map
4ljyA 1 0.7495 100 0.41 Contact Map
4nhoA 1 0.7126 100 0.413 Contact Map
2db3A 1 0.7146 100 0.415 Contact Map
4d25A 1 0.7146 100 0.419 Contact Map
4c9bA 1 0.7146 100 0.422 Contact Map
3peyA 1 0.7204 100 0.423 Contact Map
3fmpB 1 0.4136 100 0.425 Contact Map
4ct4B 1 0.7087 100 0.425 Contact Map
1s2mA 1 0.7087 100 0.426 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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