GREMLIN Database
Q97Y86 - Uncharacterized protein
UniProt: Q97Y86 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 175 (165)
Sequences: 899 (715)
Seq/√Len: 55.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_N123_N4.3491.00
58_L69_V4.0191.00
62_D135_G3.3381.00
103_E131_V3.3301.00
60_D104_R3.1211.00
10_Y14_K3.0351.00
89_N133_Y2.9201.00
96_L126_V2.8871.00
17_P141_L2.5971.00
14_K140_E2.4671.00
156_S159_L2.3641.00
91_F116_M2.2131.00
36_A44_I2.2111.00
76_S113_V2.1881.00
64_G142_V2.1851.00
92_R122_I2.1281.00
36_A43_E2.0701.00
36_A42_K2.0501.00
100_Y134_I2.0341.00
77_V112_T1.9531.00
8_K16_I1.9151.00
36_A40_N1.8781.00
36_A39_V1.8761.00
85_R119_E1.7600.99
89_N92_R1.7260.99
112_T126_V1.6790.99
132_E136_K1.6780.99
31_N82_A1.6300.99
65_L138_V1.5920.98
10_Y144_S1.5710.98
52_K71_V1.5600.98
4_V101_L1.5580.98
16_I20_R1.5480.98
136_K140_E1.4990.98
35_I39_V1.4910.97
12_L31_N1.4880.97
18_W22_K1.4670.97
55_E68_I1.4560.97
96_L130_H1.4370.97
11_S93_I1.4240.97
10_Y140_E1.4200.97
99_A126_V1.4190.97
53_Y74_E1.4080.96
8_K91_F1.3960.96
27_E168_V1.3810.96
96_L134_I1.3800.96
25_W168_V1.3720.96
10_Y141_L1.3680.96
39_V42_K1.3680.96
9_D16_I1.3260.95
97_A134_I1.2910.94
134_I138_V1.2770.94
56_V74_E1.2720.94
57_H68_I1.2710.94
53_Y56_V1.2380.93
65_L97_A1.2030.92
26_K32_S1.1990.92
36_A41_L1.1950.91
35_I38_N1.1790.91
3_S24_G1.1790.91
76_S123_N1.1680.90
76_S111_N1.1380.89
56_V72_L1.1330.89
18_W21_K1.1280.89
101_L105_N1.1100.88
7_L93_I1.0840.87
160_C163_C1.0840.87
28_P37_K1.0830.87
160_C169_C1.0830.87
6_D17_P1.0810.87
40_N44_I1.0760.86
138_V142_V1.0650.86
82_A118_K1.0590.85
36_A46_R1.0460.85
12_L159_L1.0410.85
95_L112_T1.0400.84
35_I42_K1.0330.84
163_C169_C1.0150.83
3_S21_K1.0130.83
35_I43_E1.0120.83
40_N43_E1.0090.83
36_A47_D1.0020.82
128_K132_E0.9980.82
28_P32_S0.9910.81
27_E167_R0.9840.81
139_N143_E0.9830.81
11_S133_Y0.9720.80
9_D20_R0.9710.80
62_D143_E0.9620.79
95_L114_L0.9500.79
92_R133_Y0.9400.78
85_R91_F0.9350.78
62_D104_R0.9240.77
17_P91_F0.9210.76
31_N162_A0.9150.76
113_V123_N0.9140.76
43_E71_V0.9100.76
72_L109_V0.9070.75
6_D141_L0.9050.75
6_D21_K0.9040.75
112_T124_I0.9000.75
7_L17_P0.8940.74
140_E143_E0.8940.74
125_E128_K0.8900.74
71_V115_L0.8870.74
137_V140_E0.8840.73
96_L114_L0.8810.73
30_T33_Q0.8810.73
143_E146_E0.8810.73
7_L97_A0.8810.73
61_K138_V0.8700.72
111_N125_E0.8640.72
38_N41_L0.8520.71
17_P144_S0.8410.70
63_S100_Y0.8250.68
54_Y80_I0.8190.68
35_I82_A0.8100.67
44_I55_E0.8090.67
99_A109_V0.8050.66
61_K64_G0.8040.66
38_N44_I0.7980.66
81_K94_Q0.7910.65
93_I133_Y0.7890.65
119_E122_I0.7890.65
87_F92_R0.7870.65
41_L44_I0.7800.64
16_I164_Q0.7770.64
102_A109_V0.7730.63
39_V71_V0.7660.62
9_D18_W0.7650.62
10_Y145_L0.7630.62
155_P166_R0.7540.61
8_K20_R0.7500.61
135_G139_N0.7490.61
10_Y149_S0.7380.60
132_E135_G0.7290.59
136_K139_N0.7280.58
40_N94_Q0.7260.58
135_G138_V0.7250.58
136_K143_E0.7160.57
132_E146_E0.7140.57
86_R91_F0.7140.57
12_L162_A0.7060.56
158_L162_A0.7050.56
4_V67_G0.7000.55
77_V99_A0.6980.55
11_S90_H0.6960.55
21_K24_G0.6940.55
102_A112_T0.6930.55
9_D164_Q0.6920.55
79_E94_Q0.6900.54
35_I47_D0.6860.54
132_E139_N0.6860.54
74_E106_G0.6820.54
133_Y137_V0.6780.53
16_I101_L0.6650.52
8_K88_Y0.6650.52
18_W150_P0.6650.52
60_D64_G0.6640.52
22_K145_L0.6600.51
141_L145_L0.6600.51
38_N42_K0.6600.51
58_L101_L0.6590.51
69_V72_L0.6560.51
35_I44_I0.6550.51
18_W151_P0.6480.50
56_V106_G0.6470.50
63_S135_G0.6450.50
143_E147_D0.6410.49
67_G103_E0.6380.49
4_V134_I0.6280.48
3_S6_D0.6160.46
96_L131_V0.6160.46
84_Y118_K0.6150.46
100_Y138_V0.6140.46
154_N159_L0.6100.46
5_T109_V0.6100.46
43_E46_R0.6090.46
35_I53_Y0.6090.46
134_I141_L0.6070.45
4_V97_A0.6060.45
32_S164_Q0.6060.45
85_R92_R0.6050.45
137_V143_E0.6020.45
99_A112_T0.5960.44
83_F91_F0.5950.44
45_V54_Y0.5950.44
100_Y131_V0.5910.44
24_G68_I0.5910.44
110_R135_G0.5850.43
19_I26_K0.5780.42
117_N120_R0.5760.42
11_S137_V0.5760.42
86_R116_M0.5720.42
52_K60_D0.5690.41
23_M150_P0.5690.41
108_R146_E0.5630.41
149_S153_V0.5610.41
161_K166_R0.5610.41
114_L146_E0.5600.40
65_L90_H0.5600.40
70_D94_Q0.5570.40
153_V156_S0.5540.40
79_E101_L0.5540.40
4_V31_N0.5520.40
120_R124_I0.5510.40
42_K55_E0.5500.39
88_Y133_Y0.5490.39
90_H116_M0.5480.39
67_G101_L0.5470.39
128_K146_E0.5460.39
111_N136_K0.5440.39
83_F165_Y0.5390.38
158_L161_K0.5360.38
97_A138_V0.5340.38
73_T83_F0.5340.38
62_D128_K0.5340.38
6_D9_D0.5330.38
110_R146_E0.5330.38
145_L148_D0.5300.37
139_N152_V0.5290.37
85_R88_Y0.5290.37
155_P159_L0.5280.37
100_Y161_K0.5220.37
107_F132_E0.5220.37
86_R90_H0.5210.37
5_T16_I0.5200.36
113_V121_K0.5200.36
106_G111_N0.5190.36
8_K116_M0.5170.36
109_V131_V0.5170.36
79_E98_Y0.5170.36
136_K146_E0.5160.36
111_N126_V0.5160.36
8_K164_Q0.5150.36
141_L144_S0.5120.36
43_E68_I0.5100.35
103_E109_V0.5080.35
6_D23_M0.5070.35
18_W23_M0.5070.35
93_I134_I0.5060.35
16_I21_K0.5050.35
13_C169_C0.5050.35
89_N127_R0.5040.35
32_S83_F0.5020.35
147_D156_S0.5010.35
43_E47_D0.5000.34
40_N68_I0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r5qA 1 0.8743 99.9 0.552 Contact Map
4ic1A 5 0.9371 99.9 0.568 Contact Map
3u4qB 1 0.9657 99.7 0.674 Contact Map
3l0aA 3 0.9486 99.5 0.726 Contact Map
3h4rA 3 0.8629 99.2 0.758 Contact Map
1w36C 1 0.9543 97.3 0.86 Contact Map
3u4qA 1 0.5771 97.1 0.865 Contact Map
1w36B 1 0.8343 40.3 0.937 Contact Map
3sm4A 3 0.8971 26.5 0.942 Contact Map
3syyA 3 0.8686 16.9 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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