GREMLIN Database
Q97Y81 - Glutamate dehydrogenase
UniProt: Q97Y81 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 419 (366)
Sequences: 5273 (2550)
Seq/√Len: 133.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
232_L237_A4.2511.00
286_I308_K3.7681.00
218_I229_A3.7281.00
289_C311_A3.3091.00
217_I289_C3.3061.00
262_E266_S3.0091.00
200_A315_V2.9981.00
288_D310_R2.9181.00
256_D259_R2.8591.00
328_E332_Q2.7801.00
114_D117_K2.5391.00
97_N348_V2.5111.00
104_Y352_Y2.4961.00
132_Q162_E2.4621.00
215_R238_K2.4081.00
121_K125_D2.4051.00
202_D205_N2.3871.00
229_A242_V2.3471.00
331_K396_D2.3441.00
387_F391_K2.3351.00
149_I297_V2.2921.00
202_D378_I2.2891.00
209_G214_S2.2521.00
49_S55_R2.2481.00
280_T283_E2.1961.00
199_I343_A2.1821.00
196_V317_G2.1301.00
216_V232_L2.1291.00
230_K234_E2.1291.00
64_H90_S2.1271.00
381_F385_Y2.1231.00
206_K389_K2.1121.00
396_D399_T2.0831.00
152_N155_T2.0771.00
315_V343_A2.0191.00
303_K325_D2.0111.00
387_F407_D1.9981.00
216_V237_A1.9981.00
407_D411_G1.9931.00
46_Q129_K1.9921.00
132_Q165_K1.9561.00
202_D382_N1.9531.00
322_L330_M1.9381.00
386_D390_R1.9361.00
330_M335_V1.9341.00
206_K385_Y1.9161.00
261_L265_Q1.9121.00
338_I343_A1.9091.00
241_G284_L1.9071.00
75_V159_F1.9011.00
368_E372_L1.8551.00
187_V366_D1.8531.00
113_V118_L1.8421.00
197_A235_M1.8071.00
306_A329_I1.8041.00
62_S90_S1.7891.00
252_E277_K1.7821.00
285_L292_L1.7751.00
203_A313_L1.7711.00
68_L101_L1.7521.00
71_Y107_G1.7511.00
211_I237_A1.7491.00
302_N305_N1.7331.00
341_I402_M1.7151.00
181_E411_G1.7121.00
131_V159_F1.6461.00
324_A327_D1.6431.00
329_I333_R1.6361.00
99_L342_L1.6321.00
201_R235_M1.6181.00
206_K381_F1.6051.00
201_R374_V1.6041.00
395_Q400_V1.6001.00
217_I241_G1.5991.00
242_V260_A1.5921.00
157_A179_P1.5831.00
389_K394_D1.5811.00
395_Q403_A1.5681.00
50_S119_T1.5671.00
135_H167_T1.5661.00
198_T201_R1.5431.00
366_D370_K1.4941.00
301_I322_L1.4891.00
59_G130_Y1.4751.00
301_I309_V1.4721.00
203_A338_I1.4581.00
318_A321_P1.4511.00
82_T85_E1.4461.00
198_T374_V1.4451.00
204_A291_I1.3981.00
216_V293_I1.3941.00
210_G213_G1.3931.00
228_T293_I1.3871.00
162_E165_K1.3861.00
119_T122_E1.3731.00
245_I264_V1.3651.00
315_V338_I1.3621.00
248_G279_V1.3611.00
303_K329_I1.3581.00
78_G297_V1.3561.00
196_V315_V1.3521.00
66_S71_Y1.3481.00
206_K382_N1.3381.00
382_N386_D1.3361.00
153_P189_L1.3351.00
48_R121_K1.3281.00
375_D379_N1.3271.00
374_V378_I1.3181.00
241_G287_S1.3131.00
64_H94_T1.2971.00
135_H166_I1.2751.00
381_F397_L1.2691.00
246_G269_S1.2671.00
129_K132_Q1.2661.00
358_N363_I1.2541.00
370_K374_V1.2451.00
201_R205_N1.2451.00
224_V317_G1.2421.00
120_L154_Q1.2371.00
215_R236_G1.2341.00
307_P329_I1.2341.00
390_R407_D1.2301.00
198_T370_K1.2281.00
342_L384_L1.2271.00
228_T295_A1.2231.00
204_A211_I1.2231.00
216_V239_I1.2211.00
294_P318_A1.2071.00
292_L309_V1.2051.00
232_L239_I1.1991.00
94_T409_V1.1860.99
217_I287_S1.1850.99
328_E331_K1.1820.99
124_E128_R1.1810.99
263_V267_T1.1810.99
113_V126_L1.1790.99
95_W341_I1.1760.99
118_L126_L1.1760.99
209_G312_K1.1720.99
248_G281_N1.1720.99
379_N383_T1.1700.99
301_I330_M1.1660.99
207_F312_K1.1570.99
215_R252_E1.1570.99
329_I332_Q1.1550.99
260_A264_V1.1510.99
60_W112_R1.1510.99
62_S83_Q1.1490.99
215_R288_D1.1480.99
391_K403_A1.1460.99
134_I137_Y1.1430.99
240_I289_C1.1390.99
58_I112_R1.1380.99
215_R290_D1.1360.99
200_A293_I1.1360.99
281_N285_L1.1290.99
95_W409_V1.1250.99
194_L231_F1.1240.99
46_Q56_T1.1240.99
367_E371_K1.1220.99
257_V261_L1.1200.99
216_V291_I1.1190.99
230_K261_L1.1110.99
233_S258_N1.1100.99
79_P114_D1.0990.99
100_L349_V1.0920.99
387_F404_L1.0920.99
197_A232_L1.0910.99
251_N259_R1.0870.99
259_R262_E1.0830.99
313_L336_I1.0810.99
151_T156_M1.0780.99
158_W161_D1.0770.99
200_A291_I1.0720.99
123_L126_L1.0710.99
194_L370_K1.0650.99
77_Y151_T1.0570.99
281_N284_L1.0550.99
259_R273_Y1.0540.99
221_F242_V1.0490.99
227_F230_K1.0490.99
365_S368_E1.0480.99
100_L345_A1.0430.99
411_G414_K1.0410.99
303_K307_P1.0400.99
283_E286_I1.0390.99
207_F336_I1.0390.99
280_T284_L1.0370.99
327_D398_R1.0350.99
240_I250_I1.0350.99
217_I240_I1.0300.98
203_A315_V1.0290.98
65_N413_M1.0280.98
142_V168_G1.0180.98
136_K168_G1.0170.98
196_V293_I1.0140.98
196_V295_A1.0140.98
179_P182_L1.0110.98
314_I330_M1.0070.98
78_G149_I1.0030.98
196_V200_A0.9910.98
260_A273_Y0.9820.98
122_E126_L0.9760.98
226_F261_L0.9730.98
229_A239_I0.9700.98
129_K162_E0.9700.98
80_N85_E0.9690.98
268_G272_N0.9680.98
365_S375_D0.9570.98
75_V130_Y0.9560.98
301_I306_A0.9560.98
406_V409_V0.9540.97
292_L300_V0.9500.97
194_L374_V0.9470.97
201_R211_I0.9460.97
189_L227_F0.9450.97
371_K375_D0.9440.97
77_Y127_S0.9430.97
228_T232_L0.9380.97
282_E286_I0.9330.97
67_A409_V0.9330.97
387_F403_A0.9320.97
49_S57_F0.9320.97
293_I315_V0.9310.97
196_V228_T0.9310.97
348_V351_S0.9310.97
129_K133_L0.9270.97
251_N273_Y0.9260.97
395_Q399_T0.9260.97
200_A313_L0.9210.97
156_M159_F0.9190.97
206_K386_D0.9190.97
101_L376_R0.9170.97
84_D87_I0.9170.97
263_V273_Y0.9170.97
385_Y389_K0.9160.97
371_K374_V0.9150.97
233_S257_V0.9120.97
303_K326_A0.9080.97
309_V314_I0.8980.96
391_K395_Q0.8720.96
129_K165_K0.8720.96
128_R162_E0.8700.96
304_F307_P0.8630.95
263_V272_N0.8630.95
215_R240_I0.8600.95
72_K348_V0.8570.95
127_S131_V0.8560.95
271_V275_E0.8560.95
327_D331_K0.8550.95
255_I260_A0.8540.95
233_S239_I0.8450.95
288_D311_A0.8440.95
261_L264_V0.8400.95
233_S256_D0.8390.95
262_E265_Q0.8380.95
48_R55_R0.8360.95
386_D389_K0.8340.95
162_E166_I0.8320.94
77_Y111_I0.8290.94
240_I287_S0.8260.94
185_I364_I0.8220.94
120_L124_E0.8200.94
199_I384_L0.8110.94
108_K319_N0.8090.94
75_V145_P0.8050.93
116_K245_I0.8010.93
373_I377_M0.8010.93
250_I287_S0.7970.93
68_L98_S0.7930.93
227_F231_F0.7920.93
141_D359_R0.7910.93
131_V175_F0.7870.93
108_K192_T0.7870.93
307_P333_R0.7860.93
109_G130_Y0.7840.93
301_I314_I0.7830.92
160_L170_V0.7830.92
120_L123_L0.7800.92
394_D399_T0.7760.92
351_S354_E0.7740.92
244_D247_G0.7660.92
128_R161_D0.7660.92
269_S272_N0.7650.92
90_S94_T0.7650.92
232_L293_I0.7620.91
249_V270_V0.7600.91
301_I340_D0.7580.91
249_V260_A0.7550.91
314_I322_L0.7550.91
267_T270_V0.7540.91
211_I216_V0.7540.91
120_L126_L0.7540.91
207_F313_L0.7510.91
263_V268_G0.7510.91
244_D264_V0.7500.91
109_G127_S0.7490.91
131_V162_E0.7480.91
388_H395_Q0.7470.91
191_S373_I0.7380.90
387_F400_V0.7380.90
250_I277_K0.7370.90
132_Q166_I0.7370.90
133_L136_K0.7340.90
231_F370_K0.7340.90
166_I175_F0.7320.90
226_F265_Q0.7310.90
356_A362_G0.7300.90
55_R117_K0.7290.90
49_S53_K0.7280.89
241_G248_G0.7250.89
388_H391_K0.7230.89
72_K104_Y0.7210.89
192_T347_G0.7210.89
96_K319_N0.7190.89
150_N224_V0.7180.89
311_A314_I0.7120.88
244_D269_S0.7110.88
291_I313_L0.7080.88
270_V273_Y0.7070.88
131_V134_I0.7060.88
159_F175_F0.7060.88
309_V330_M0.7040.88
160_L164_I0.7020.88
154_Q157_A0.7020.88
238_K253_N0.7010.88
380_A384_L0.7010.88
381_F384_L0.7000.88
388_H397_L0.7000.88
267_T272_N0.6970.87
345_A349_V0.6920.87
279_V287_S0.6880.87
336_I397_L0.6880.87
405_A409_V0.6870.87
372_L375_D0.6870.87
199_I315_V0.6840.86
50_S125_D0.6840.86
218_I242_V0.6840.86
140_S169_K0.6830.86
167_T171_D0.6830.86
248_G286_I0.6830.86
311_A335_V0.6820.86
263_V274_L0.6800.86
47_I57_F0.6800.86
391_K394_D0.6790.86
197_A231_F0.6790.86
378_I382_N0.6760.86
81_V110_G0.6740.86
156_M182_L0.6740.86
376_R379_N0.6730.85
264_V278_K0.6730.85
193_G228_T0.6720.85
322_L326_A0.6720.85
350_G364_I0.6710.85
114_D119_T0.6710.85
229_A257_V0.6680.85
330_M337_V0.6680.85
101_L379_N0.6660.85
337_V340_D0.6650.85
349_V353_V0.6650.85
322_L337_V0.6640.85
224_V245_I0.6640.85
293_I317_G0.6630.85
260_A263_V0.6620.85
387_F390_R0.6600.84
303_K327_D0.6590.84
349_V377_M0.6590.84
92_I320_G0.6560.84
385_Y388_H0.6560.84
199_I338_I0.6510.84
290_D312_K0.6490.83
116_K119_T0.6490.83
247_G270_V0.6490.83
352_Y356_A0.6460.83
406_V410_V0.6420.83
357_N364_I0.6410.83
283_E305_N0.6400.83
67_A413_M0.6390.82
138_L159_F0.6380.82
63_Q142_V0.6380.82
159_F162_E0.6380.82
177_G351_S0.6370.82
205_N382_N0.6350.82
188_R350_G0.6350.82
276_G281_N0.6330.82
251_N276_G0.6320.82
140_S171_D0.6300.82
116_K264_V0.6300.82
86_V90_S0.6280.81
404_L408_R0.6270.81
55_R118_L0.6260.81
196_V343_A0.6260.81
48_R54_L0.6240.81
202_D206_K0.6240.81
194_L230_K0.6230.81
191_S223_N0.6220.81
260_A270_V0.6220.81
217_I284_L0.6220.81
272_N278_K0.6210.81
248_G287_S0.6200.80
204_A208_I0.6190.80
260_A278_K0.6190.80
203_A336_I0.6180.80
204_A214_S0.6170.80
317_G343_A0.6170.80
63_Q71_Y0.6150.80
247_G271_V0.6140.80
77_Y113_V0.6110.80
67_A412_A0.6060.79
197_A228_T0.6060.79
203_A385_Y0.6050.79
391_K407_D0.6040.79
314_I335_V0.6040.79
372_L376_R0.6040.79
190_Y227_F0.6030.79
302_N322_L0.6030.79
188_R223_N0.6030.79
338_I397_L0.6020.79
205_N378_I0.6000.78
68_L408_R0.5990.78
327_D330_M0.5990.78
219_Q300_V0.5980.78
124_E158_W0.5970.78
88_A320_G0.5960.78
246_G271_V0.5950.78
126_L129_K0.5930.77
197_A201_R0.5930.77
47_I50_S0.5930.77
273_Y276_G0.5920.77
86_V110_G0.5910.77
221_F260_A0.5910.77
229_A260_A0.5910.77
286_I305_N0.5910.77
387_F395_Q0.5890.77
199_I342_L0.5880.77
349_V376_R0.5860.77
298_E320_G0.5860.77
385_Y397_L0.5850.77
147_P223_N0.5820.76
302_N323_T0.5820.76
91_M95_W0.5810.76
403_A406_V0.5810.76
208_I214_S0.5810.76
292_L314_I0.5800.76
398_R402_M0.5800.76
127_S159_F0.5790.76
118_L122_E0.5770.76
96_K108_K0.5770.76
82_T112_R0.5770.76
228_T317_G0.5760.75
282_E304_F0.5760.75
370_K377_M0.5750.75
327_D337_V0.5750.75
185_I350_G0.5740.75
204_A209_G0.5740.75
147_P188_R0.5730.75
258_N261_L0.5720.75
307_P332_Q0.5710.75
303_K330_M0.5710.75
350_G369_A0.5700.75
400_V403_A0.5700.75
157_A161_D0.5700.75
248_G280_T0.5690.75
123_L267_T0.5690.75
62_S107_G0.5670.74
221_F257_V0.5660.74
278_K281_N0.5650.74
369_A372_L0.5650.74
87_I90_S0.5640.74
264_V270_V0.5630.74
241_G255_I0.5630.74
213_G236_G0.5600.73
217_I311_A0.5580.73
191_S350_G0.5580.73
232_L291_I0.5570.73
192_T223_N0.5560.73
192_T344_N0.5550.73
217_I288_D0.5550.73
95_W406_V0.5540.73
271_V278_K0.5530.72
206_K336_I0.5530.72
215_R250_I0.5520.72
338_I381_F0.5520.72
99_L383_T0.5520.72
217_I248_G0.5500.72
379_N382_N0.5490.72
243_S285_L0.5480.72
188_R351_S0.5480.72
156_M175_F0.5480.72
108_K146_A0.5470.72
104_Y355_W0.5460.72
203_A381_F0.5450.71
151_T191_S0.5440.71
79_P115_P0.5440.71
383_T386_D0.5410.71
388_H394_D0.5410.71
154_Q158_W0.5390.71
204_A313_L0.5380.70
226_F257_V0.5380.70
322_L327_D0.5380.70
301_I337_V0.5350.70
377_M380_A0.5350.70
218_I232_L0.5330.70
72_K97_N0.5330.70
141_D361_G0.5330.70
334_G394_D0.5320.70
57_F113_V0.5310.69
127_S155_T0.5310.69
180_S186_G0.5300.69
65_N94_T0.5300.69
306_A330_M0.5300.69
301_I305_N0.5290.69
384_L388_H0.5290.69
226_F263_V0.5290.69
377_M381_F0.5280.69
68_L105_G0.5240.68
176_T351_S0.5220.68
384_L387_F0.5220.68
53_K56_T0.5220.68
226_F230_K0.5210.68
295_A317_G0.5210.68
146_A223_N0.5210.68
128_R131_V0.5210.68
301_I329_I0.5200.68
374_V377_M0.5190.68
356_A360_S0.5190.68
200_A317_G0.5180.68
201_R378_I0.5180.68
378_I381_F0.5160.67
214_S291_I0.5160.67
72_K355_W0.5140.67
248_G284_L0.5130.67
353_V368_E0.5110.67
272_N275_E0.5110.67
98_S405_A0.5100.66
251_N275_E0.5100.66
147_P351_S0.5100.66
297_V300_V0.5090.66
72_K351_S0.5090.66
304_F308_K0.5090.66
285_L300_V0.5060.66
131_V137_Y0.5050.66
314_I326_A0.5040.65
193_G317_G0.5030.65
231_F234_E0.5020.65
259_R263_V0.5020.65
125_D161_D0.5020.65
251_N255_I0.5010.65
193_G224_V0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yfqA 5 0.9332 100 0.07 Contact Map
4xgiA 6 0.9809 100 0.07 Contact Map
2tmgA 5 0.9714 100 0.084 Contact Map
1v9lA 4 0.9833 100 0.088 Contact Map
3aogA 8 0.9905 100 0.09 Contact Map
3aoeE 3 0.9833 100 0.092 Contact Map
3k92A 5 0.9881 100 0.093 Contact Map
3r3jA 5 0.9928 100 0.093 Contact Map
4fccA 5 0.9857 100 0.096 Contact Map
2bmaA 5 0.9928 100 0.097 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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