GREMLIN Database
Q97Y77 - Uncharacterized protein
UniProt: Q97Y77 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 107 (93)
Sequences: 144 (122)
Seq/√Len: 12.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_I85_V3.1670.97
8_Y11_E3.1080.97
63_T68_L3.0290.96
71_N79_F2.4300.89
13_L16_V2.3640.87
27_S34_T2.1520.82
38_S76_I2.0390.78
52_V63_T1.9740.76
14_I18_K1.9190.73
67_I89_V1.8910.72
27_S97_L1.8460.70
81_F89_V1.8300.70
11_E15_G1.8260.70
47_F99_L1.7420.66
44_G96_V1.7300.65
14_I43_L1.6950.64
67_I81_F1.6510.61
53_L60_N1.5980.59
33_E98_R1.5810.58
81_F85_V1.5710.57
68_L79_F1.5520.56
26_K98_R1.5500.56
42_F63_T1.5210.55
15_G80_A1.4650.52
28_L83_I1.4540.51
93_L97_L1.3350.45
37_Y40_L1.3100.44
72_L79_F1.2950.43
30_E41_F1.2760.42
49_A60_N1.2740.42
75_V87_L1.2710.42
79_F91_I1.2610.42
42_F53_L1.2510.41
24_V78_S1.2370.40
56_A66_H1.1780.38
63_T85_V1.1550.36
15_G18_K1.1500.36
35_E40_L1.1130.34
53_L58_I1.1020.34
14_I39_L1.0860.33
60_N68_L1.0710.33
10_S58_I1.0700.32
26_K80_A1.0690.32
19_C96_V1.0520.32
92_T99_L1.0480.32
46_F53_L1.0440.31
11_E18_K1.0360.31
27_S41_F0.9950.29
50_F53_L0.9850.29
46_F77_S0.9810.29
74_M85_V0.9710.28
45_A75_V0.9670.28
63_T82_L0.9480.27
60_N74_M0.9340.27
58_I84_A0.9210.26
12_V21_N0.9090.26
17_R90_W0.9080.26
8_Y15_G0.8980.25
22_V95_L0.8870.25
90_W93_L0.8830.25
75_V94_S0.8820.25
84_A87_L0.8680.24
24_V83_I0.8650.24
92_T95_L0.8620.24
23_L95_L0.8620.24
24_V39_L0.8570.24
77_S94_S0.8400.23
17_R47_F0.8350.23
12_V43_L0.8260.23
63_T67_I0.8180.22
36_D40_L0.8180.22
58_I78_S0.8140.22
55_E70_G0.8130.22
67_I74_M0.8100.22
75_V96_V0.7950.21
55_E66_H0.7900.21
31_V39_L0.7850.21
19_C67_I0.7850.21
34_T93_L0.7840.21
52_V74_M0.7800.21
16_V19_C0.7710.21
60_N80_A0.7610.20
66_H70_G0.7550.20
11_E19_C0.7470.20
7_P10_S0.7440.20
43_L95_L0.7420.20
8_Y12_V0.7300.19
15_G19_C0.7280.19
7_P12_V0.7260.19
21_N53_L0.7110.19
55_E61_C0.7080.19
27_S33_E0.6920.18
46_F68_L0.6860.18
19_C72_L0.6850.18
78_S94_S0.6840.18
26_K36_D0.6830.18
20_M83_I0.6770.18
43_L51_L0.6760.18
29_V71_N0.6730.18
63_T74_M0.6670.17
7_P16_V0.6570.17
68_L91_I0.6400.17
54_F91_I0.6230.16
26_K97_L0.6220.16
32_R51_L0.6180.16
68_L74_M0.6150.16
34_T97_L0.6150.16
26_K44_G0.6100.16
31_V54_F0.6060.16
30_E37_Y0.5960.15
55_E64_F0.5960.15
72_L82_L0.5920.15
78_S98_R0.5900.15
17_R53_L0.5880.15
52_V77_S0.5850.15
52_V60_N0.5820.15
11_E16_V0.5820.15
63_T89_V0.5810.15
86_M93_L0.5770.15
26_K31_V0.5730.15
63_T81_F0.5700.15
76_I91_I0.5630.14
68_L94_S0.5580.14
82_L91_I0.5480.14
8_Y89_V0.5450.14
45_A98_R0.5450.14
28_L43_L0.5450.14
17_R21_N0.5430.14
41_F75_V0.5410.14
31_V51_L0.5320.14
89_V93_L0.5290.14
76_I80_A0.5250.14
92_T96_V0.5250.14
31_V37_Y0.5200.13
42_F76_I0.5170.13
60_N79_F0.5170.13
82_L89_V0.5160.13
32_R80_A0.5100.13
9_Y13_L0.5100.13
93_L96_V0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.8972 13.5 0.939 Contact Map
3dh4A 3 0.8972 12.4 0.94 Contact Map
1fftB 1 0.4112 10.5 0.942 Contact Map
2k1kA 2 0.3458 7.6 0.946 Contact Map
4qi1A 3 0.271 5.1 0.95 Contact Map
2ks1B 1 0.4112 4.4 0.951 Contact Map
1q90G 1 0.2617 3.8 0.953 Contact Map
3dwlA 1 0.4112 3.3 0.955 Contact Map
4b1yB 1 0.4112 2.5 0.957 Contact Map
2llmA 1 0.4019 2.4 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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