GREMLIN Database
Q97Y76 - Amino acid transporter
UniProt: Q97Y76 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 417 (400)
Sequences: 24161 (15700)
Seq/√Len: 785.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_L316_G4.6121.00
351_I355_K3.4701.00
48_A230_S3.4071.00
216_K220_R3.1651.00
343_M374_I3.0411.00
8_T212_K2.9451.00
211_T217_V2.8721.00
73_Y302_D2.8631.00
89_G299_L2.7491.00
213_N216_K2.6841.00
165_I239_S2.6731.00
163_L167_I2.5381.00
13_L224_M2.5241.00
209_P301_R2.5151.00
268_W272_I2.5001.00
60_E353_R2.4811.00
210_S294_R2.4771.00
9_F224_M2.4671.00
77_L85_G2.3191.00
258_L261_S2.3131.00
134_V138_F2.2951.00
297_R301_R2.2871.00
371_V375_I2.2211.00
9_F217_V2.2131.00
313_V317_I2.1911.00
137_Y309_H2.1811.00
12_A211_T2.1541.00
9_F13_L2.1461.00
126_V323_L2.1281.00
346_G373_A2.1131.00
220_R224_M2.0921.00
248_Y262_Q2.0921.00
141_G145_E2.0911.00
133_L312_L2.0541.00
80_L351_I2.0531.00
57_N346_G2.0401.00
8_T11_Q2.0241.00
152_I156_S2.0171.00
93_V315_G2.0051.00
401_L405_T1.9931.00
77_L82_E1.9801.00
49_I53_S1.9701.00
368_V372_F1.9431.00
32_T40_A1.8981.00
76_T88_V1.8971.00
80_L347_L1.8781.00
11_Q148_T1.8731.00
172_K175_N1.8611.00
393_V397_F1.8581.00
245_P248_Y1.8541.00
213_N217_V1.8211.00
385_G388_S1.8151.00
223_V227_I1.8101.00
258_L262_Q1.8021.00
117_P120_L1.7971.00
136_D286_L1.7721.00
130_V316_G1.7551.00
172_K176_F1.7531.00
375_I379_L1.7481.00
88_V344_L1.7431.00
13_L228_I1.7381.00
43_A190_T1.7361.00
156_S160_L1.7301.00
39_G187_V1.7111.00
7_L11_Q1.6911.00
104_A285_T1.6891.00
111_L124_L1.6871.00
81_G84_S1.6841.00
16_G225_S1.6811.00
137_Y313_V1.6741.00
207_L290_V1.6411.00
252_T258_L1.6291.00
90_W399_G1.6171.00
227_I231_I1.6001.00
310_E314_V1.5811.00
126_V320_A1.5781.00
55_G226_L1.5561.00
155_I159_I1.5361.00
351_I354_R1.5351.00
49_I372_F1.5281.00
252_T255_P1.5271.00
366_F370_Q1.5201.00
261_S270_F1.5161.00
356_G359_G1.5111.00
104_A129_I1.5091.00
166_P239_S1.5081.00
296_L311_L1.5031.00
175_N178_P1.5001.00
395_T399_G1.4991.00
50_F376_L1.4981.00
80_L84_S1.4981.00
174_H177_V1.4931.00
76_T344_L1.4871.00
120_L123_T1.4801.00
53_S372_F1.4761.00
157_S276_S1.4721.00
126_V130_V1.4651.00
214_G219_P1.4651.00
213_N220_R1.4591.00
292_S315_G1.4581.00
394_V398_I1.4561.00
107_F128_L1.4531.00
347_L374_I1.4501.00
47_T194_A1.4431.00
129_I316_G1.4431.00
347_L351_I1.4411.00
11_Q144_A1.4361.00
107_F278_I1.4311.00
133_L313_V1.4281.00
69_E209_P1.4151.00
54_I346_G1.3691.00
64_I359_G1.3671.00
271_L275_I1.3601.00
378_A382_I1.3591.00
65_F78_K1.3581.00
293_E312_L1.3571.00
264_H269_L1.3521.00
55_G222_I1.3461.00
217_V220_R1.3451.00
400_I404_E1.3391.00
132_L285_T1.3381.00
137_Y307_V1.3331.00
231_I235_S1.3321.00
162_S235_S1.3281.00
68_V74_S1.3171.00
56_L223_V1.3141.00
171_I175_N1.3111.00
318_M322_L1.3101.00
20_I229_T1.2981.00
9_F220_R1.2931.00
129_I319_L1.2891.00
41_I238_F1.2871.00
261_S267_T1.2841.00
74_S78_K1.2831.00
122_Y126_V1.2801.00
7_L12_A1.2781.00
125_A323_L1.2771.00
27_V106_G1.2671.00
310_E313_V1.2651.00
377_S380_F1.2551.00
394_V397_F1.2501.00
296_L305_L1.2491.00
246_W249_Y1.2451.00
7_L144_A1.2441.00
103_T284_V1.2371.00
79_T348_E1.2361.00
391_I394_V1.2331.00
68_V78_K1.2331.00
39_G180_F1.2311.00
386_L389_L1.2291.00
212_K217_V1.2281.00
161_F165_I1.2171.00
165_I243_A1.2161.00
171_I174_H1.2111.00
135_L146_V1.2101.00
57_N370_Q1.2091.00
365_A369_I1.2081.00
368_V371_V1.2051.00
6_L212_K1.2041.00
166_P170_G1.2021.00
160_L164_T1.1981.00
58_S72_V1.1881.00
83_M406_L1.1831.00
76_T84_S1.1821.00
379_L383_S1.1801.00
119_T123_T1.1771.00
62_S75_F1.1701.00
16_G204_I1.1661.00
17_L228_I1.1511.00
86_F90_W1.1471.00
12_A221_A1.1431.00
15_I207_L1.1421.00
350_I371_V1.1361.00
10_W14_F1.1271.00
130_V320_A1.1271.00
389_L393_V1.1231.00
146_V150_F1.1211.00
365_A368_V1.1191.00
60_E63_S1.1161.00
127_I131_I1.1151.00
367_P371_V1.1131.00
357_L360_S1.1011.00
390_E394_V1.0971.00
386_L390_E1.0871.00
64_I357_L1.0871.00
73_Y298_Q1.0831.00
147_D286_L1.0821.00
123_T127_I1.0801.00
373_A377_S1.0651.00
379_L382_I1.0611.00
183_G186_G1.0601.00
111_L278_I1.0581.00
100_G319_L1.0581.00
93_V296_L1.0571.00
145_E149_I1.0561.00
172_K178_P1.0541.00
392_G396_L1.0461.00
133_L137_Y1.0451.00
161_F260_L1.0431.00
343_M378_A1.0411.00
108_S124_L1.0391.00
159_I163_L1.0371.00
17_L229_T1.0361.00
130_V134_V1.0331.00
140_I290_V1.0291.00
374_I378_A1.0291.00
250_G255_P1.0251.00
397_F401_L1.0221.00
389_L392_G1.0221.00
402_V405_T1.0221.00
70_G73_Y1.0031.00
150_F283_S0.9971.00
83_M400_I0.9951.00
243_A259_A0.9921.00
370_Q374_I0.9911.00
174_H178_P0.9861.00
343_M347_L0.9851.00
162_S239_S0.9841.00
83_M87_L0.9811.00
33_I40_A0.9801.00
336_F392_G0.9791.00
208_T218_I0.9781.00
41_I241_V0.9781.00
402_V406_L0.9781.00
202_N206_T0.9741.00
45_I234_I0.9691.00
108_S125_A0.9671.00
370_Q377_S0.9661.00
48_A198_Y0.9661.00
180_F187_V0.9641.00
238_F242_D0.9601.00
267_T271_L0.9571.00
132_L286_L0.9571.00
230_S234_I0.9571.00
131_I282_I0.9541.00
173_V177_V0.9511.00
224_M228_I0.9441.00
349_V370_Q0.9371.00
377_S381_M0.9341.00
188_L379_L0.9311.00
199_S338_I0.9301.00
245_P262_Q0.9291.00
309_H313_V0.9211.00
354_R367_P0.9111.00
390_E393_V0.9091.00
77_L302_D0.9081.00
162_S166_P0.9081.00
70_G74_S0.9061.00
124_L127_I0.9041.00
116_L120_L0.9031.00
381_M384_L0.9011.00
102_A331_A0.9001.00
134_V137_Y0.8951.00
388_S391_I0.8941.00
294_R297_R0.8931.00
11_Q145_E0.8931.00
155_I232_I0.8921.00
102_A196_F0.8911.00
399_G402_V0.8901.00
63_S360_S0.8831.00
84_S344_L0.8761.00
154_N280_A0.8751.00
385_G389_L0.8741.00
6_L141_G0.8731.00
289_I316_G0.8711.00
169_V242_D0.8691.00
254_A258_L0.8681.00
184_I188_L0.8651.00
21_I24_G0.8631.00
9_F221_A0.8631.00
14_F148_T0.8551.00
61_L349_V0.8471.00
361_F364_P0.8461.00
42_I187_V0.8411.00
184_I187_V0.8391.00
308_K311_L0.8381.00
398_I402_V0.8381.00
203_T291_A0.8371.00
64_I360_S0.8351.00
333_A337_G0.8351.00
92_R96_Y0.8341.00
107_F282_I0.8341.00
189_T193_L0.8331.00
343_M377_S0.8311.00
387_N391_I0.8251.00
171_I176_F0.8251.00
90_W305_L0.8241.00
108_S121_Y0.8241.00
10_W148_T0.8221.00
13_L221_A0.8171.00
366_F369_I0.8131.00
199_S342_Y0.8121.00
132_L289_I0.8111.00
52_M56_L0.8081.00
52_M223_V0.8071.00
388_S392_G0.8041.00
145_E148_T0.7991.00
64_I67_D0.7901.00
138_F142_T0.7891.00
76_T348_E0.7881.00
53_S57_N0.7851.00
173_V178_P0.7841.00
317_I321_S0.7831.00
394_V401_L0.7811.00
81_G407_R0.7781.00
162_S236_V0.7711.00
98_I333_A0.7701.00
25_I236_V0.7681.00
365_A370_Q0.7651.00
167_I170_G0.7641.00
61_L75_F0.7581.00
136_D290_V0.7571.00
42_I45_I0.7551.00
32_T36_A0.7551.00
21_I154_N0.7541.00
45_I49_I0.7531.00
316_G320_A0.7531.00
358_R362_R0.7521.00
350_I354_R0.7511.00
268_W271_L0.7511.00
348_E352_V0.7501.00
73_Y77_L0.7491.00
318_M321_S0.7491.00
19_N287_S0.7481.00
107_F281_T0.7461.00
20_I225_S0.7441.00
69_E297_R0.7401.00
213_N219_P0.7391.00
166_P235_S0.7391.00
260_L264_H0.7381.00
346_G374_I0.7371.00
132_L282_I0.7371.00
374_I377_S0.7351.00
296_L314_V0.7321.00
81_G85_G0.7321.00
122_Y125_A0.7301.00
255_P260_L0.7281.00
390_E395_T0.7261.00
38_P241_V0.7241.00
337_G341_S0.7241.00
209_P297_R0.7231.00
39_G179_L0.7221.00
219_P222_I0.7211.00
110_Y277_A0.7211.00
370_Q373_A0.7211.00
10_W145_E0.7211.00
42_I46_F0.7201.00
79_T351_I0.7191.00
373_A376_L0.7191.00
144_A148_T0.7191.00
387_N392_G0.7181.00
395_T398_I0.7161.00
322_L325_G0.7161.00
319_L322_L0.7131.00
40_A237_I0.7131.00
18_G151_V0.7111.00
375_I382_I0.7111.00
228_I232_I0.7091.00
350_I367_P0.7081.00
112_L115_G0.7071.00
401_L404_E0.7051.00
164_T264_H0.7051.00
111_L114_F0.7041.00
105_L330_I0.7021.00
99_G334_S0.7011.00
6_L140_I0.7001.00
387_N390_E0.6991.00
326_N329_A0.6981.00
13_L16_G0.6971.00
398_I401_L0.6971.00
399_G403_Y0.6961.00
173_V176_F0.6931.00
54_I377_S0.6911.00
289_I293_E0.6901.00
51_A201_F0.6891.00
357_L362_R0.6891.00
137_Y312_L0.6871.00
46_F191_S0.6861.00
104_A108_S0.6861.00
395_T402_V0.6841.00
369_I373_A0.6841.00
96_Y288_I0.6831.00
392_G401_L0.6821.00
319_L325_G0.6811.00
349_V353_R0.6811.00
385_G392_G0.6801.00
108_S111_L0.6791.00
389_L394_V0.6791.00
359_G362_R0.6781.00
53_S369_I0.6771.00
392_G395_T0.6761.00
318_M325_G0.6761.00
380_F384_L0.6761.00
294_R308_K0.6761.00
60_E364_P0.6751.00
392_G397_F0.6731.00
293_E311_L0.6721.00
101_A330_I0.6721.00
41_I45_I0.6721.00
130_V133_L0.6721.00
58_S345_T0.6711.00
44_F197_S0.6701.00
55_G201_F0.6691.00
62_S218_I0.6671.00
350_I370_Q0.6671.00
140_I207_L0.6671.00
41_I234_I0.6671.00
362_R365_A0.6651.00
366_F371_V0.6651.00
95_S338_I0.6641.00
363_S366_F0.6631.00
235_S239_S0.6621.00
215_E360_S0.6621.00
375_I378_A0.6621.00
236_V240_M0.6601.00
6_L10_W0.6591.00
403_Y407_R0.6591.00
19_N288_I0.6571.00
136_D312_L0.6571.00
139_G142_T0.6531.00
224_M227_I0.6531.00
57_N373_A0.6521.00
367_P370_Q0.6511.00
122_Y323_L0.6491.00
142_T145_E0.6481.00
73_Y89_G0.6471.00
240_M256_L0.6461.00
210_S297_R0.6451.00
21_I232_I0.6441.00
28_M331_A0.6411.00
99_G102_A0.6401.00
205_V222_I0.6391.00
25_I28_M0.6391.00
113_L275_I0.6381.00
211_T218_I0.6381.00
133_L289_I0.6381.00
31_S328_E0.6381.00
280_A283_S0.6381.00
22_G233_Y0.6371.00
35_V189_T0.6361.00
390_E397_F0.6361.00
376_L380_F0.6351.00
29_A237_I0.6341.00
153_I276_S0.6341.00
110_Y257_S0.6311.00
111_L128_L0.6301.00
292_S296_L0.6301.00
393_V396_L0.6301.00
97_V315_G0.6291.00
320_A324_L0.6281.00
272_I276_S0.6281.00
59_A63_S0.6271.00
328_E331_A0.6261.00
56_L361_F0.6231.00
128_L285_T0.6231.00
103_T285_T0.6231.00
55_G59_A0.6221.00
79_T352_V0.6201.00
73_Y85_G0.6181.00
80_L348_E0.6161.00
61_L79_T0.6151.00
386_L393_V0.6151.00
62_S205_V0.6141.00
385_G391_I0.6141.00
386_L392_G0.6131.00
370_Q384_L0.6111.00
17_L20_I0.6111.00
186_G189_T0.6101.00
180_F184_I0.6101.00
239_S242_D0.6091.00
216_K219_P0.6081.00
393_V399_G0.6051.00
171_I178_P0.6051.00
188_L383_S0.6041.00
129_I323_L0.6041.00
392_G402_V0.6031.00
374_I384_L0.6031.00
256_L264_H0.6031.00
199_S202_N0.6011.00
53_S373_A0.6001.00
144_A286_L0.5991.00
336_F381_M0.5971.00
176_F241_V0.5971.00
228_I231_I0.5971.00
116_L119_T0.5951.00
10_W13_L0.5941.00
403_Y406_L0.5921.00
91_F341_S0.5901.00
126_V324_L0.5891.00
391_I395_T0.5891.00
321_S324_L0.5891.00
206_T291_A0.5871.00
153_I157_S0.5871.00
164_T168_I0.5841.00
47_T198_Y0.5841.00
103_T281_T0.5791.00
143_V290_V0.5781.00
356_G362_R0.5771.00
236_V256_L0.5761.00
105_L325_G0.5761.00
72_V206_T0.5741.00
250_G253_S0.5731.00
5_K212_K0.5721.00
260_L269_L0.5721.00
218_I222_I0.5711.00
380_F383_S0.5701.00
275_I279_L0.5691.00
370_Q381_M0.5691.00
19_N203_T0.5681.00
289_I312_L0.5681.00
385_G390_E0.5671.00
50_F53_S0.5671.00
47_T195_F0.5671.00
17_L151_V0.5661.00
97_V318_M0.5651.00
214_G217_V0.5631.00
338_I341_S0.5621.00
251_Q255_P0.5621.00
142_T146_V0.5621.00
210_S308_K0.5611.00
255_P259_A0.5611.00
56_L364_P0.5601.00
394_V399_G0.5571.00
370_Q376_L0.5571.00
314_V318_M0.5571.00
244_M258_L0.5561.00
76_T85_G0.5551.00
131_I135_L0.5541.00
60_E64_I0.5531.00
91_F95_S0.5531.00
171_I177_V0.5491.00
356_G360_S0.5481.00
88_V341_S0.5471.00
72_V345_T0.5471.00
25_I158_L0.5461.00
31_S34_S0.5441.00
72_V202_N0.5441.00
32_T194_A0.5421.00
99_G103_T0.5421.00
393_V400_I0.5401.00
386_L399_G0.5391.00
352_V359_G0.5381.00
309_H312_L0.5381.00
169_V239_S0.5381.00
36_A43_A0.5371.00
377_S384_L0.5371.00
27_V30_G0.5361.00
71_G205_V0.5351.00
404_E407_R0.5341.00
38_P41_I0.5331.00
57_N363_S0.5321.00
91_F340_F0.5321.00
228_I235_S0.5301.00
321_S325_G0.5291.00
149_I152_I0.5291.00
148_T152_I0.5281.00
293_E315_G0.5271.00
156_S159_I0.5261.00
25_I29_A0.5261.00
396_L400_I0.5261.00
227_I230_S0.5261.00
32_T190_T0.5261.00
197_S233_Y0.5221.00
397_F400_I0.5221.00
243_A263_I0.5221.00
311_L315_G0.5211.00
171_I242_D0.5211.00
214_G218_I0.5201.00
127_I130_V0.5201.00
211_T221_A0.5181.00
388_S395_T0.5171.00
56_L369_I0.5171.00
95_S337_G0.5171.00
149_I153_I0.5161.00
29_A33_I0.5151.00
118_K121_Y0.5141.00
386_L403_Y0.5131.00
320_A323_L0.5131.00
389_L406_L0.5131.00
16_G221_A0.5131.00
367_P382_I0.5121.00
385_G395_T0.5121.00
8_T141_G0.5101.00
151_V154_N0.5091.00
130_V313_V0.5091.00
106_G110_Y0.5091.00
44_F237_I0.5081.00
204_I218_I0.5081.00
296_L300_S0.5081.00
206_T295_T0.5071.00
311_L314_V0.5051.00
27_V281_T0.5041.00
64_I352_V0.5041.00
54_I202_N0.5031.00
153_I279_L0.5031.00
148_T151_V0.5031.00
244_M248_Y0.5031.00
113_L271_L0.5021.00
16_G20_I0.5021.00
43_A187_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9568 100 0.277 Contact Map
3giaA 1 0.9784 100 0.322 Contact Map
4djkA 2 0.9281 100 0.375 Contact Map
3dh4A 3 0.9496 98.6 0.86 Contact Map
2jlnA 1 0.9544 98.5 0.863 Contact Map
2xq2A 2 0.9448 98.4 0.867 Contact Map
4wgvA 2 0.8537 97.9 0.884 Contact Map
2a65A 2 0.9688 97.6 0.89 Contact Map
4xp4A 1 0.976 95.8 0.913 Contact Map
4us3A 1 0.9161 95.7 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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