GREMLIN Database
Q97Y74 - Uncharacterized protein
UniProt: Q97Y74 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 410 (356)
Sequences: 4969 (4126)
Seq/√Len: 218.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_A121_R3.7011.00
267_R274_F3.6061.00
59_L62_K3.5551.00
246_S250_K3.4221.00
239_Y316_N3.3301.00
57_S129_T3.1751.00
48_V51_S3.1631.00
71_F104_L3.1391.00
56_L153_L3.0011.00
117_V128_I2.9991.00
322_L343_F2.7661.00
45_I57_S2.5701.00
57_S127_I2.5181.00
34_L63_R2.4661.00
319_A343_F2.4621.00
58_L68_Y2.4491.00
380_K400_E2.4481.00
61_L103_V2.3761.00
118_S122_D2.3681.00
31_P35_K2.2841.00
157_S324_R2.2761.00
30_V56_L2.2691.00
64_K99_V2.2121.00
318_V356_Y2.1941.00
41_N195_E2.1741.00
245_L260_E2.1081.00
42_A117_V2.0631.00
264_S267_R2.0441.00
330_E346_E1.9501.00
254_L259_V1.9451.00
73_D123_V1.9401.00
27_E31_P1.9081.00
57_S103_V1.9051.00
236_I294_V1.8821.00
264_S268_E1.8341.00
363_N367_R1.8321.00
235_V272_T1.8281.00
267_R272_T1.7971.00
204_V298_G1.7881.00
293_Y316_N1.7751.00
273_F323_L1.7631.00
207_I211_I1.7531.00
31_P34_L1.7381.00
274_F290_K1.7351.00
353_Q381_L1.7131.00
188_T317_L1.7091.00
278_Y344_Y1.7061.00
165_K186_K1.7021.00
195_E199_L1.6751.00
343_F356_Y1.6671.00
55_T59_L1.6571.00
32_N35_K1.6251.00
48_V295_V1.6241.00
273_F295_V1.6151.00
162_L183_E1.5941.00
332_L346_E1.5881.00
209_N213_F1.5801.00
321_K325_E1.5781.00
48_V193_F1.5771.00
252_L259_V1.5681.00
366_I370_I1.5661.00
263_A292_V1.5631.00
51_S153_L1.5561.00
161_Y197_L1.5371.00
226_E230_E1.5321.00
61_L101_Y1.5201.00
205_N209_N1.5141.00
275_I319_A1.5131.00
158_F187_Y1.5061.00
383_I401_V1.5061.00
275_I293_Y1.4901.00
29_D159_Q1.4751.00
27_E163_K1.4721.00
44_A148_H1.4701.00
33_L151_Y1.4621.00
156_F164_Y1.4621.00
205_N302_N1.4581.00
83_D86_K1.4431.00
274_F292_V1.4331.00
46_L270_Y1.4281.00
36_Y149_S1.4271.00
68_Y71_F1.3881.00
316_N320_I1.3831.00
158_F180_L1.3811.00
321_K324_R1.3751.00
231_F262_W1.3691.00
206_V210_D1.3671.00
29_D157_S1.3601.00
319_A331_K1.3471.00
232_A266_L1.3431.00
247_S250_K1.3381.00
370_I397_V1.3251.00
242_E289_N1.3241.00
152_I270_Y1.3231.00
110_V113_W1.3201.00
146_G340_E1.3201.00
184_L317_L1.3091.00
59_L63_R1.3061.00
358_S361_I1.3061.00
320_I324_R1.3041.00
35_K201_K1.2971.00
188_T313_I1.2941.00
224_E227_K1.2931.00
339_Y371_E1.2921.00
208_Y211_I1.2921.00
347_K350_R1.2921.00
256_K260_E1.2801.00
58_L123_V1.2791.00
334_Y339_Y1.2791.00
61_L66_F1.2741.00
284_Q287_T1.2531.00
106_E131_S1.2501.00
273_F320_I1.2441.00
300_V313_I1.2431.00
217_V220_Y1.2411.00
207_I212_L1.2361.00
65_K98_D1.2361.00
90_A94_L1.2351.00
344_Y353_Q1.2281.00
109_N115_L1.2231.00
230_E233_R1.2231.00
206_V209_N1.2141.00
227_K254_L1.2141.00
385_T388_L1.2021.00
318_V354_V1.1941.00
122_D147_R1.1921.00
158_F161_Y1.1911.00
181_K185_E1.1901.00
117_V126_L1.1881.00
34_L38_E1.1841.00
239_Y300_V1.1751.00
391_K400_E1.1621.00
73_D119_R1.1521.00
107_I114_E1.1481.00
155_P192_G1.1471.00
246_S256_K1.1441.00
234_T238_Y1.1441.00
190_V196_A1.1421.00
149_S206_V1.1371.00
108_H130_G1.1341.00
115_L118_S1.1341.00
156_F161_Y1.1321.00
378_A381_L1.1311.00
161_Y186_K1.1311.00
45_I153_L1.1301.00
187_Y192_G1.1281.00
182_N186_K1.1261.00
231_F248_I1.1221.00
311_G357_T1.1221.00
204_V207_I1.1211.00
241_N312_R1.1201.00
235_V263_A1.1131.00
76_F79_L1.1131.00
51_S193_F1.1081.00
196_A204_V1.1051.00
258_T262_W1.1021.00
208_Y212_L1.1001.00
157_S160_E1.0951.00
158_F183_E1.0921.00
249_A256_K1.0881.00
245_L263_A1.0881.00
68_Y103_V1.0861.00
42_A128_I1.0841.00
130_G147_R1.0791.00
207_I213_F1.0781.00
370_I381_L1.0751.00
106_E147_R1.0751.00
300_V309_D1.0721.00
37_L60_L1.0711.00
352_I382_L1.0691.00
154_F273_F1.0661.00
66_F101_Y1.0591.00
161_Y183_E1.0591.00
185_E189_E1.0561.00
130_G311_G1.0541.00
362_E366_I1.0521.00
208_Y303_L1.0521.00
228_F231_F1.0471.00
33_L60_L1.0431.00
392_I401_V1.0391.00
102_I126_L1.0381.00
88_L92_Y1.0321.00
187_Y317_L1.0271.00
319_A323_L1.0181.00
158_F162_L1.0171.00
46_L150_D1.0121.00
350_R379_K1.0121.00
255_N258_T1.0111.00
44_A128_I1.0091.00
43_L127_I1.0061.00
183_E186_K1.0051.00
229_R233_R1.0041.00
339_Y367_R1.0001.00
215_D219_R0.9911.00
359_D363_N0.9901.00
65_K100_D0.9871.00
209_N229_R0.9871.00
30_V153_L0.9871.00
235_V292_V0.9861.00
188_T310_K0.9811.00
103_V127_I0.9801.00
85_N89_Q0.9791.00
74_E77_Y0.9781.00
33_L37_L0.9761.00
385_T389_E0.9721.00
382_L400_E0.9711.00
242_E333_Y0.9701.00
275_I331_K0.9671.00
154_F324_R0.9671.00
50_R146_G0.9661.00
257_R260_E0.9661.00
231_F259_V0.9581.00
340_E357_T0.9551.00
138_G268_E0.9521.00
167_V183_E0.9461.00
365_E368_G0.9451.00
236_I303_L0.9451.00
354_V384_I0.9331.00
346_E349_S0.9321.00
301_S313_I0.9321.00
345_D352_I0.9310.99
234_T251_I0.9300.99
208_Y232_A0.9250.99
247_S251_I0.9230.99
329_E347_K0.9210.99
37_L125_K0.9180.99
294_V316_N0.9180.99
69_V76_F0.9160.99
317_L321_K0.9150.99
220_Y265_G0.9140.99
106_E130_G0.9100.99
341_V353_Q0.9090.99
90_A93_E0.9070.99
263_A274_F0.9050.99
66_F103_V0.9030.99
34_L60_L0.9020.99
130_G146_G0.8980.99
340_E355_T0.8980.99
120_L124_K0.8960.99
291_K315_E0.8930.99
228_F266_L0.8910.99
190_V200_G0.8900.99
103_V129_T0.8890.99
34_L37_L0.8840.99
235_V294_V0.8810.99
106_E311_G0.8810.99
45_I56_L0.8780.99
159_Q163_K0.8780.99
297_V320_I0.8760.99
275_I333_Y0.8750.99
328_G331_K0.8710.99
147_R342_D0.8710.99
48_V154_F0.8650.99
84_L91_I0.8550.99
365_E369_L0.8550.99
245_L256_K0.8550.99
155_P295_V0.8530.99
46_L152_I0.8500.99
57_S61_L0.8500.99
145_T210_D0.8490.99
293_Y343_F0.8470.99
180_L183_E0.8470.99
74_E78_N0.8450.99
81_I112_G0.8370.99
195_E198_M0.8370.99
184_L188_T0.8370.99
228_F262_W0.8360.99
122_D143_Y0.8360.99
322_L331_K0.8350.99
185_E310_K0.8320.99
33_L43_L0.8280.99
318_V384_I0.8260.99
261_K265_G0.8230.99
88_L91_I0.8230.99
392_I400_E0.8220.99
311_G315_E0.8210.99
152_I323_L0.8190.99
376_T379_K0.8180.99
71_F110_V0.8170.99
361_I365_E0.8170.99
232_A294_V0.8170.99
72_D118_S0.8170.99
341_V369_L0.8140.99
368_G371_E0.8130.99
73_D122_D0.8100.99
278_Y346_E0.8100.99
138_G141_A0.8090.99
297_V316_N0.8080.99
50_R340_E0.8060.99
49_R106_E0.8060.99
227_K252_L0.8040.99
313_I317_L0.8020.98
93_E96_G0.8000.98
362_E365_E0.7990.98
297_V301_S0.7990.98
101_Y127_I0.7980.98
246_S249_A0.7980.98
277_R288_Y0.7960.98
131_S146_G0.7940.98
40_P206_V0.7940.98
381_L398_N0.7930.98
201_K330_E0.7930.98
388_L391_K0.7900.98
74_E119_R0.7880.98
205_N208_Y0.7860.98
249_A259_V0.7850.98
104_L126_L0.7820.98
240_S293_Y0.7760.98
233_R303_L0.7750.98
67_A70_N0.7750.98
238_Y241_N0.7730.98
234_T248_I0.7710.98
71_F113_W0.7680.98
155_P296_D0.7650.98
315_E355_T0.7650.98
390_E401_V0.7590.98
315_E340_E0.7590.98
51_S155_P0.7570.98
297_V313_I0.7570.98
161_Y164_Y0.7560.98
42_A126_L0.7560.98
299_I303_L0.7550.98
205_N212_L0.7550.98
112_G115_L0.7540.98
385_T401_V0.7520.98
190_V197_L0.7520.98
273_F319_A0.7500.98
106_E355_T0.7450.98
238_Y251_I0.7440.98
165_K183_E0.7430.98
295_V320_I0.7430.98
365_E370_I0.7420.98
297_V317_L0.7400.97
33_L56_L0.7390.97
217_V225_I0.7390.97
130_G342_D0.7380.97
215_D218_S0.7370.97
87_V91_I0.7360.97
332_L335_M0.7350.97
86_K89_Q0.7350.97
36_Y41_N0.7310.97
311_G342_D0.7310.97
243_I248_I0.7300.97
238_Y247_S0.7300.97
162_L180_L0.7280.97
361_I364_R0.7280.97
29_D163_K0.7260.97
84_L88_L0.7260.97
228_F265_G0.7250.97
361_I385_T0.7200.97
50_R130_G0.7180.97
119_R123_V0.7170.97
353_Q356_Y0.7150.97
342_D355_T0.7150.97
92_Y95_Y0.7100.97
145_T218_S0.7090.97
367_R371_E0.7070.97
359_D362_E0.7060.97
342_D357_T0.7060.97
186_K200_G0.6990.96
38_E201_K0.6990.96
80_N84_L0.6980.96
231_F263_A0.6970.96
39_V149_S0.6970.96
75_R92_Y0.6970.96
50_R144_L0.6950.96
67_A91_I0.6940.96
225_I229_R0.6930.96
216_I219_R0.6910.96
104_L117_V0.6900.96
139_E142_T0.6890.96
242_E335_M0.6890.96
367_R370_I0.6880.96
341_V375_L0.6870.96
79_L86_K0.6850.96
350_R380_K0.6830.96
389_E392_I0.6800.96
314_I356_Y0.6800.96
95_Y100_D0.6780.96
382_L386_W0.6740.96
118_S121_R0.6730.96
115_L142_T0.6720.96
148_H210_D0.6700.95
69_V73_D0.6700.95
234_T252_L0.6700.95
354_V382_L0.6660.95
391_K401_V0.6650.95
78_N82_G0.6630.95
216_I220_Y0.6610.95
144_L147_R0.6580.95
311_G355_T0.6560.95
361_I368_G0.6540.95
54_S134_K0.6540.95
352_I380_K0.6530.95
341_V381_L0.6520.95
72_D119_R0.6500.95
398_N401_V0.6460.95
37_L127_I0.6400.94
364_R368_G0.6370.94
75_R78_N0.6360.94
366_I369_L0.6360.94
156_F194_P0.6340.94
192_G296_D0.6340.94
231_F254_L0.6340.94
145_T148_H0.6300.94
44_A150_D0.6290.94
32_N151_Y0.6290.94
239_Y294_V0.6270.94
69_V72_D0.6260.94
248_I259_V0.6260.94
106_E340_E0.6240.93
341_V368_G0.6240.93
222_I265_G0.6210.93
322_L354_V0.6190.93
30_V60_L0.6180.93
154_F323_L0.6170.93
233_R237_S0.6100.93
315_E357_T0.6050.92
266_L272_T0.6050.92
155_P193_F0.6040.92
157_S161_Y0.6030.92
314_I386_W0.6000.92
193_F196_A0.5990.92
36_Y43_L0.5990.92
355_T358_S0.5980.92
35_K203_Q0.5980.92
283_K286_L0.5960.92
77_Y115_L0.5950.92
339_Y368_G0.5950.92
397_V401_V0.5950.92
43_L125_K0.5930.92
247_S283_K0.5930.92
45_I151_Y0.5880.91
118_S134_K0.5880.91
216_I265_G0.5850.91
164_Y197_L0.5850.91
240_S243_I0.5850.91
154_F295_V0.5840.91
80_N83_D0.5830.91
41_N121_R0.5830.91
239_Y271_L0.5820.91
35_K39_V0.5820.91
293_Y319_A0.5810.91
319_A356_Y0.5800.91
47_G52_G0.5790.91
49_R215_D0.5780.91
139_E219_R0.5750.90
43_L151_Y0.5750.90
36_Y40_P0.5720.90
43_L149_S0.5720.90
91_I95_Y0.5720.90
48_V54_S0.5710.90
213_F233_R0.5710.90
358_S365_E0.5680.90
371_E375_L0.5680.90
49_R130_G0.5650.90
55_T58_L0.5650.90
109_N143_Y0.5650.90
114_E148_H0.5640.90
142_T219_R0.5630.89
222_I228_F0.5630.89
71_F76_F0.5610.89
236_I299_I0.5600.89
156_F160_E0.5590.89
184_L310_K0.5590.89
382_L387_D0.5590.89
360_K363_N0.5580.89
380_K398_N0.5580.89
291_K333_Y0.5570.89
382_L388_L0.5570.89
230_E260_E0.5560.89
281_K284_Q0.5550.89
224_E261_K0.5540.89
377_K381_L0.5530.89
334_Y376_T0.5530.89
271_L294_V0.5520.88
245_L259_V0.5520.88
186_K190_V0.5510.88
277_R289_N0.5470.88
205_N328_G0.5440.88
87_V110_V0.5440.88
158_F317_L0.5420.88
276_P290_K0.5420.88
54_S105_D0.5390.87
165_K200_G0.5380.87
166_E169_V0.5370.87
132_N136_L0.5350.87
217_V229_R0.5330.87
74_E84_L0.5320.87
363_N370_I0.5310.87
263_A272_T0.5310.87
40_P43_L0.5310.87
346_E351_L0.5300.86
361_I366_I0.5300.86
72_D109_N0.5280.86
300_V304_A0.5280.86
277_R335_M0.5260.86
212_L232_A0.5250.86
74_E85_N0.5220.86
142_T145_T0.5220.86
65_K71_F0.5200.85
193_F295_V0.5190.85
132_N137_S0.5190.85
30_V151_Y0.5180.85
307_G311_G0.5170.85
100_D125_K0.5170.85
278_Y332_L0.5160.85
240_S312_R0.5150.85
241_N291_K0.5140.85
193_F297_V0.5140.85
101_Y125_K0.5130.85
248_I252_L0.5130.85
370_I398_N0.5120.85
117_V120_L0.5120.85
61_L68_Y0.5110.84
120_L125_K0.5110.84
149_S207_I0.5100.84
50_R147_R0.5100.84
60_L151_Y0.5090.84
40_P149_S0.5090.84
369_L399_I0.5090.84
355_T383_I0.5080.84
99_V125_K0.5070.84
106_E357_T0.5070.84
205_N211_I0.5060.84
104_L107_I0.5060.84
236_I300_V0.5060.84
120_L126_L0.5050.84
390_E400_E0.5040.84
267_R292_V0.5030.83
131_S147_R0.5030.83
364_R367_R0.5020.83
223_R261_K0.5020.83
204_V208_Y0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qenA 1 0.6707 100 0.678 Contact Map
2fnaA 1 0.6585 100 0.68 Contact Map
3pfiA 3 0.6415 99.8 0.781 Contact Map
1hqcA 1 0.6634 99.7 0.802 Contact Map
1w5sA 1 0.7171 99.6 0.815 Contact Map
1fnnA 1 0.7146 99.5 0.828 Contact Map
1in4A 1 0.661 99.4 0.834 Contact Map
2qbyA 1 0.7024 99.4 0.835 Contact Map
2v1uA 1 0.7317 99.4 0.837 Contact Map
4xgcA 1 0.6146 99.4 0.842 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0109 seconds.