Q97Y74 - SULSO - GREMLIN Contacts

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Q97Y74 - Uncharacterized protein

UniProt:	Q97Y74	Sequences: MYIEEIKRVLSDQRDVLEEKMSRKLVERDVPNLLKYLEVPNALAILGVRRSGKSTLSLLLLKRKKFAYVNFDDERFYNLNIGDLNKVLQAIYELYGVDVDYIVLDEIHNVKGWELFVSRLRDVKKLIITGSNSKMLSGELATYLTGRHSDYILFPFSFQEYLKYKEVKVEYFSTRVISTLKNELEKYTEVGGFPEALMLGKEQVNVIYNDILFKDIVSRYKIREIEKFREFARTVISYYSNEISLSSIAKILGLNKRTVEKWASGLREAYLTFFIPRYGEKLKQRLTYNKKVYVVDVGIVSNLAIKGKDKGRIIENLVAIKLLRELQGEEKLYYMRNNYEVDFYDEKNSRLIQVTYTSDKIENREIRGLIEGYRLTKAKKLLIITWDLEEKIQVEGVNIEVLPLYRFLLE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	410 (356)
Sequences:	4969 (4126)
Seq/√Len:	218.7

SULSO - Q97Y74 Q97YN5 Q97YZ4 Q97YB3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
42_A	121_R	3.701	1.00
267_R	274_F	3.606	1.00
59_L	62_K	3.555	1.00
246_S	250_K	3.422	1.00
239_Y	316_N	3.330	1.00
57_S	129_T	3.175	1.00
48_V	51_S	3.163	1.00
71_F	104_L	3.139	1.00
56_L	153_L	3.001	1.00
117_V	128_I	2.999	1.00
322_L	343_F	2.766	1.00
45_I	57_S	2.570	1.00
57_S	127_I	2.518	1.00
34_L	63_R	2.466	1.00
319_A	343_F	2.462	1.00
58_L	68_Y	2.449	1.00
380_K	400_E	2.448	1.00
61_L	103_V	2.376	1.00
118_S	122_D	2.368	1.00
31_P	35_K	2.284	1.00
157_S	324_R	2.276	1.00
30_V	56_L	2.269	1.00
64_K	99_V	2.212	1.00
318_V	356_Y	2.194	1.00
41_N	195_E	2.174	1.00
245_L	260_E	2.108	1.00
42_A	117_V	2.063	1.00
264_S	267_R	2.044	1.00
330_E	346_E	1.950	1.00
254_L	259_V	1.945	1.00
73_D	123_V	1.940	1.00
27_E	31_P	1.908	1.00
57_S	103_V	1.905	1.00
236_I	294_V	1.882	1.00
264_S	268_E	1.834	1.00
363_N	367_R	1.832	1.00
235_V	272_T	1.828	1.00
267_R	272_T	1.797	1.00
204_V	298_G	1.788	1.00
293_Y	316_N	1.775	1.00
273_F	323_L	1.763	1.00
207_I	211_I	1.753	1.00
31_P	34_L	1.738	1.00
274_F	290_K	1.735	1.00
353_Q	381_L	1.713	1.00
188_T	317_L	1.709	1.00
278_Y	344_Y	1.706	1.00
165_K	186_K	1.702	1.00
195_E	199_L	1.675	1.00
343_F	356_Y	1.667	1.00
55_T	59_L	1.657	1.00
32_N	35_K	1.625	1.00
48_V	295_V	1.624	1.00
273_F	295_V	1.615	1.00
162_L	183_E	1.594	1.00
332_L	346_E	1.588	1.00
209_N	213_F	1.580	1.00
321_K	325_E	1.578	1.00
48_V	193_F	1.577	1.00
252_L	259_V	1.568	1.00
366_I	370_I	1.566	1.00
263_A	292_V	1.563	1.00
51_S	153_L	1.556	1.00
161_Y	197_L	1.537	1.00
226_E	230_E	1.532	1.00
61_L	101_Y	1.520	1.00
205_N	209_N	1.514	1.00
275_I	319_A	1.513	1.00
158_F	187_Y	1.506	1.00
383_I	401_V	1.506	1.00
275_I	293_Y	1.490	1.00
29_D	159_Q	1.475	1.00
27_E	163_K	1.472	1.00
44_A	148_H	1.470	1.00
33_L	151_Y	1.462	1.00
156_F	164_Y	1.462	1.00
205_N	302_N	1.458	1.00
83_D	86_K	1.443	1.00
274_F	292_V	1.433	1.00
46_L	270_Y	1.428	1.00
36_Y	149_S	1.427	1.00
68_Y	71_F	1.388	1.00
316_N	320_I	1.383	1.00
158_F	180_L	1.381	1.00
321_K	324_R	1.375	1.00
231_F	262_W	1.369	1.00
206_V	210_D	1.367	1.00
29_D	157_S	1.360	1.00
319_A	331_K	1.347	1.00
232_A	266_L	1.343	1.00
247_S	250_K	1.338	1.00
370_I	397_V	1.325	1.00
242_E	289_N	1.324	1.00
152_I	270_Y	1.323	1.00
110_V	113_W	1.320	1.00
146_G	340_E	1.320	1.00
184_L	317_L	1.309	1.00
59_L	63_R	1.306	1.00
358_S	361_I	1.306	1.00
320_I	324_R	1.304	1.00
35_K	201_K	1.297	1.00
188_T	313_I	1.294	1.00
224_E	227_K	1.293	1.00
339_Y	371_E	1.292	1.00
208_Y	211_I	1.292	1.00
347_K	350_R	1.292	1.00
256_K	260_E	1.280	1.00
58_L	123_V	1.279	1.00
334_Y	339_Y	1.279	1.00
61_L	66_F	1.274	1.00
284_Q	287_T	1.253	1.00
106_E	131_S	1.250	1.00
273_F	320_I	1.244	1.00
300_V	313_I	1.243	1.00
217_V	220_Y	1.241	1.00
207_I	212_L	1.236	1.00
65_K	98_D	1.236	1.00
90_A	94_L	1.235	1.00
344_Y	353_Q	1.228	1.00
109_N	115_L	1.223	1.00
230_E	233_R	1.223	1.00
206_V	209_N	1.214	1.00
227_K	254_L	1.214	1.00
385_T	388_L	1.202	1.00
318_V	354_V	1.194	1.00
122_D	147_R	1.192	1.00
158_F	161_Y	1.191	1.00
181_K	185_E	1.190	1.00
117_V	126_L	1.188	1.00
34_L	38_E	1.184	1.00
239_Y	300_V	1.175	1.00
391_K	400_E	1.162	1.00
73_D	119_R	1.152	1.00
107_I	114_E	1.148	1.00
155_P	192_G	1.147	1.00
246_S	256_K	1.144	1.00
234_T	238_Y	1.144	1.00
190_V	196_A	1.142	1.00
149_S	206_V	1.137	1.00
108_H	130_G	1.134	1.00
115_L	118_S	1.134	1.00
156_F	161_Y	1.132	1.00
378_A	381_L	1.131	1.00
161_Y	186_K	1.131	1.00
45_I	153_L	1.130	1.00
187_Y	192_G	1.128	1.00
182_N	186_K	1.126	1.00
231_F	248_I	1.122	1.00
311_G	357_T	1.122	1.00
204_V	207_I	1.121	1.00
241_N	312_R	1.120	1.00
235_V	263_A	1.113	1.00
76_F	79_L	1.113	1.00
51_S	193_F	1.108	1.00
196_A	204_V	1.105	1.00
258_T	262_W	1.102	1.00
208_Y	212_L	1.100	1.00
157_S	160_E	1.095	1.00
158_F	183_E	1.092	1.00
249_A	256_K	1.088	1.00
245_L	263_A	1.088	1.00
68_Y	103_V	1.086	1.00
42_A	128_I	1.084	1.00
130_G	147_R	1.079	1.00
207_I	213_F	1.078	1.00
370_I	381_L	1.075	1.00
106_E	147_R	1.075	1.00
300_V	309_D	1.072	1.00
37_L	60_L	1.071	1.00
352_I	382_L	1.069	1.00
154_F	273_F	1.066	1.00
66_F	101_Y	1.059	1.00
161_Y	183_E	1.059	1.00
185_E	189_E	1.056	1.00
130_G	311_G	1.054	1.00
362_E	366_I	1.052	1.00
208_Y	303_L	1.052	1.00
228_F	231_F	1.047	1.00
33_L	60_L	1.043	1.00
392_I	401_V	1.039	1.00
102_I	126_L	1.038	1.00
88_L	92_Y	1.032	1.00
187_Y	317_L	1.027	1.00
319_A	323_L	1.018	1.00
158_F	162_L	1.017	1.00
46_L	150_D	1.012	1.00
350_R	379_K	1.012	1.00
255_N	258_T	1.011	1.00
44_A	128_I	1.009	1.00
43_L	127_I	1.006	1.00
183_E	186_K	1.005	1.00
229_R	233_R	1.004	1.00
339_Y	367_R	1.000	1.00
215_D	219_R	0.991	1.00
359_D	363_N	0.990	1.00
65_K	100_D	0.987	1.00
209_N	229_R	0.987	1.00
30_V	153_L	0.987	1.00
235_V	292_V	0.986	1.00
188_T	310_K	0.981	1.00
103_V	127_I	0.980	1.00
85_N	89_Q	0.979	1.00
74_E	77_Y	0.978	1.00
33_L	37_L	0.976	1.00
385_T	389_E	0.972	1.00
382_L	400_E	0.971	1.00
242_E	333_Y	0.970	1.00
275_I	331_K	0.967	1.00
154_F	324_R	0.967	1.00
50_R	146_G	0.966	1.00
257_R	260_E	0.966	1.00
231_F	259_V	0.958	1.00
340_E	357_T	0.955	1.00
138_G	268_E	0.952	1.00
167_V	183_E	0.946	1.00
365_E	368_G	0.945	1.00
236_I	303_L	0.945	1.00
354_V	384_I	0.933	1.00
346_E	349_S	0.932	1.00
301_S	313_I	0.932	1.00
345_D	352_I	0.931	0.99
234_T	251_I	0.930	0.99
208_Y	232_A	0.925	0.99
247_S	251_I	0.923	0.99
329_E	347_K	0.921	0.99
37_L	125_K	0.918	0.99
294_V	316_N	0.918	0.99
69_V	76_F	0.916	0.99
317_L	321_K	0.915	0.99
220_Y	265_G	0.914	0.99
106_E	130_G	0.910	0.99
341_V	353_Q	0.909	0.99
90_A	93_E	0.907	0.99
263_A	274_F	0.905	0.99
66_F	103_V	0.903	0.99
34_L	60_L	0.902	0.99
130_G	146_G	0.898	0.99
340_E	355_T	0.898	0.99
120_L	124_K	0.896	0.99
291_K	315_E	0.893	0.99
228_F	266_L	0.891	0.99
190_V	200_G	0.890	0.99
103_V	129_T	0.889	0.99
34_L	37_L	0.884	0.99
235_V	294_V	0.881	0.99
106_E	311_G	0.881	0.99
45_I	56_L	0.878	0.99
159_Q	163_K	0.878	0.99
297_V	320_I	0.876	0.99
275_I	333_Y	0.875	0.99
328_G	331_K	0.871	0.99
147_R	342_D	0.871	0.99
48_V	154_F	0.865	0.99
84_L	91_I	0.855	0.99
365_E	369_L	0.855	0.99
245_L	256_K	0.855	0.99
155_P	295_V	0.853	0.99
46_L	152_I	0.850	0.99
57_S	61_L	0.850	0.99
145_T	210_D	0.849	0.99
293_Y	343_F	0.847	0.99
180_L	183_E	0.847	0.99
74_E	78_N	0.845	0.99
81_I	112_G	0.837	0.99
195_E	198_M	0.837	0.99
184_L	188_T	0.837	0.99
228_F	262_W	0.836	0.99
122_D	143_Y	0.836	0.99
322_L	331_K	0.835	0.99
185_E	310_K	0.832	0.99
33_L	43_L	0.828	0.99
318_V	384_I	0.826	0.99
261_K	265_G	0.823	0.99
88_L	91_I	0.823	0.99
392_I	400_E	0.822	0.99
311_G	315_E	0.821	0.99
152_I	323_L	0.819	0.99
376_T	379_K	0.818	0.99
71_F	110_V	0.817	0.99
361_I	365_E	0.817	0.99
232_A	294_V	0.817	0.99
72_D	118_S	0.817	0.99
341_V	369_L	0.814	0.99
368_G	371_E	0.813	0.99
73_D	122_D	0.810	0.99
278_Y	346_E	0.810	0.99
138_G	141_A	0.809	0.99
297_V	316_N	0.808	0.99
50_R	340_E	0.806	0.99
49_R	106_E	0.806	0.99
227_K	252_L	0.804	0.99
313_I	317_L	0.802	0.98
93_E	96_G	0.800	0.98
362_E	365_E	0.799	0.98
297_V	301_S	0.799	0.98
101_Y	127_I	0.798	0.98
246_S	249_A	0.798	0.98
277_R	288_Y	0.796	0.98
131_S	146_G	0.794	0.98
40_P	206_V	0.794	0.98
381_L	398_N	0.793	0.98
201_K	330_E	0.793	0.98
388_L	391_K	0.790	0.98
74_E	119_R	0.788	0.98
205_N	208_Y	0.786	0.98
249_A	259_V	0.785	0.98
104_L	126_L	0.782	0.98
240_S	293_Y	0.776	0.98
233_R	303_L	0.775	0.98
67_A	70_N	0.775	0.98
238_Y	241_N	0.773	0.98
234_T	248_I	0.771	0.98
71_F	113_W	0.768	0.98
155_P	296_D	0.765	0.98
315_E	355_T	0.765	0.98
390_E	401_V	0.759	0.98
315_E	340_E	0.759	0.98
51_S	155_P	0.757	0.98
297_V	313_I	0.757	0.98
161_Y	164_Y	0.756	0.98
42_A	126_L	0.756	0.98
299_I	303_L	0.755	0.98
205_N	212_L	0.755	0.98
112_G	115_L	0.754	0.98
385_T	401_V	0.752	0.98
190_V	197_L	0.752	0.98
273_F	319_A	0.750	0.98
106_E	355_T	0.745	0.98
238_Y	251_I	0.744	0.98
165_K	183_E	0.743	0.98
295_V	320_I	0.743	0.98
365_E	370_I	0.742	0.98
297_V	317_L	0.740	0.97
33_L	56_L	0.739	0.97
217_V	225_I	0.739	0.97
130_G	342_D	0.738	0.97
215_D	218_S	0.737	0.97
87_V	91_I	0.736	0.97
332_L	335_M	0.735	0.97
86_K	89_Q	0.735	0.97
36_Y	41_N	0.731	0.97
311_G	342_D	0.731	0.97
243_I	248_I	0.730	0.97
238_Y	247_S	0.730	0.97
162_L	180_L	0.728	0.97
361_I	364_R	0.728	0.97
29_D	163_K	0.726	0.97
84_L	88_L	0.726	0.97
228_F	265_G	0.725	0.97
361_I	385_T	0.720	0.97
50_R	130_G	0.718	0.97
119_R	123_V	0.717	0.97
353_Q	356_Y	0.715	0.97
342_D	355_T	0.715	0.97
92_Y	95_Y	0.710	0.97
145_T	218_S	0.709	0.97
367_R	371_E	0.707	0.97
359_D	362_E	0.706	0.97
342_D	357_T	0.706	0.97
186_K	200_G	0.699	0.96
38_E	201_K	0.699	0.96
80_N	84_L	0.698	0.96
231_F	263_A	0.697	0.96
39_V	149_S	0.697	0.96
75_R	92_Y	0.697	0.96
50_R	144_L	0.695	0.96
67_A	91_I	0.694	0.96
225_I	229_R	0.693	0.96
216_I	219_R	0.691	0.96
104_L	117_V	0.690	0.96
139_E	142_T	0.689	0.96
242_E	335_M	0.689	0.96
367_R	370_I	0.688	0.96
341_V	375_L	0.687	0.96
79_L	86_K	0.685	0.96
350_R	380_K	0.683	0.96
389_E	392_I	0.680	0.96
314_I	356_Y	0.680	0.96
95_Y	100_D	0.678	0.96
382_L	386_W	0.674	0.96
118_S	121_R	0.673	0.96
115_L	142_T	0.672	0.96
148_H	210_D	0.670	0.95
69_V	73_D	0.670	0.95
234_T	252_L	0.670	0.95
354_V	382_L	0.666	0.95
391_K	401_V	0.665	0.95
78_N	82_G	0.663	0.95
216_I	220_Y	0.661	0.95
144_L	147_R	0.658	0.95
311_G	355_T	0.656	0.95
361_I	368_G	0.654	0.95
54_S	134_K	0.654	0.95
352_I	380_K	0.653	0.95
341_V	381_L	0.652	0.95
72_D	119_R	0.650	0.95
398_N	401_V	0.646	0.95
37_L	127_I	0.640	0.94
364_R	368_G	0.637	0.94
75_R	78_N	0.636	0.94
366_I	369_L	0.636	0.94
156_F	194_P	0.634	0.94
192_G	296_D	0.634	0.94
231_F	254_L	0.634	0.94
145_T	148_H	0.630	0.94
44_A	150_D	0.629	0.94
32_N	151_Y	0.629	0.94
239_Y	294_V	0.627	0.94
69_V	72_D	0.626	0.94
248_I	259_V	0.626	0.94
106_E	340_E	0.624	0.93
341_V	368_G	0.624	0.93
222_I	265_G	0.621	0.93
322_L	354_V	0.619	0.93
30_V	60_L	0.618	0.93
154_F	323_L	0.617	0.93
233_R	237_S	0.610	0.93
315_E	357_T	0.605	0.92
266_L	272_T	0.605	0.92
155_P	193_F	0.604	0.92
157_S	161_Y	0.603	0.92
314_I	386_W	0.600	0.92
193_F	196_A	0.599	0.92
36_Y	43_L	0.599	0.92
355_T	358_S	0.598	0.92
35_K	203_Q	0.598	0.92
283_K	286_L	0.596	0.92
77_Y	115_L	0.595	0.92
339_Y	368_G	0.595	0.92
397_V	401_V	0.595	0.92
43_L	125_K	0.593	0.92
247_S	283_K	0.593	0.92
45_I	151_Y	0.588	0.91
118_S	134_K	0.588	0.91
216_I	265_G	0.585	0.91
164_Y	197_L	0.585	0.91
240_S	243_I	0.585	0.91
154_F	295_V	0.584	0.91
80_N	83_D	0.583	0.91
41_N	121_R	0.583	0.91
239_Y	271_L	0.582	0.91
35_K	39_V	0.582	0.91
293_Y	319_A	0.581	0.91
319_A	356_Y	0.580	0.91
47_G	52_G	0.579	0.91
49_R	215_D	0.578	0.91
139_E	219_R	0.575	0.90
43_L	151_Y	0.575	0.90
36_Y	40_P	0.572	0.90
43_L	149_S	0.572	0.90
91_I	95_Y	0.572	0.90
48_V	54_S	0.571	0.90
213_F	233_R	0.571	0.90
358_S	365_E	0.568	0.90
371_E	375_L	0.568	0.90
49_R	130_G	0.565	0.90
55_T	58_L	0.565	0.90
109_N	143_Y	0.565	0.90
114_E	148_H	0.564	0.90
142_T	219_R	0.563	0.89
222_I	228_F	0.563	0.89
71_F	76_F	0.561	0.89
236_I	299_I	0.560	0.89
156_F	160_E	0.559	0.89
184_L	310_K	0.559	0.89
382_L	387_D	0.559	0.89
360_K	363_N	0.558	0.89
380_K	398_N	0.558	0.89
291_K	333_Y	0.557	0.89
382_L	388_L	0.557	0.89
230_E	260_E	0.556	0.89
281_K	284_Q	0.555	0.89
224_E	261_K	0.554	0.89
377_K	381_L	0.553	0.89
334_Y	376_T	0.553	0.89
271_L	294_V	0.552	0.88
245_L	259_V	0.552	0.88
186_K	190_V	0.551	0.88
277_R	289_N	0.547	0.88
205_N	328_G	0.544	0.88
87_V	110_V	0.544	0.88
158_F	317_L	0.542	0.88
276_P	290_K	0.542	0.88
54_S	105_D	0.539	0.87
165_K	200_G	0.538	0.87
166_E	169_V	0.537	0.87
132_N	136_L	0.535	0.87
217_V	229_R	0.533	0.87
74_E	84_L	0.532	0.87
363_N	370_I	0.531	0.87
263_A	272_T	0.531	0.87
40_P	43_L	0.531	0.87
346_E	351_L	0.530	0.86
361_I	366_I	0.530	0.86
72_D	109_N	0.528	0.86
300_V	304_A	0.528	0.86
277_R	335_M	0.526	0.86
212_L	232_A	0.525	0.86
74_E	85_N	0.522	0.86
142_T	145_T	0.522	0.86
65_K	71_F	0.520	0.85
193_F	295_V	0.519	0.85
132_N	137_S	0.519	0.85
30_V	151_Y	0.518	0.85
307_G	311_G	0.517	0.85
100_D	125_K	0.517	0.85
278_Y	332_L	0.516	0.85
240_S	312_R	0.515	0.85
241_N	291_K	0.514	0.85
193_F	297_V	0.514	0.85
101_Y	125_K	0.513	0.85
248_I	252_L	0.513	0.85
370_I	398_N	0.512	0.85
117_V	120_L	0.512	0.85
61_L	68_Y	0.511	0.84
120_L	125_K	0.511	0.84
149_S	207_I	0.510	0.84
50_R	147_R	0.510	0.84
60_L	151_Y	0.509	0.84
40_P	149_S	0.509	0.84
369_L	399_I	0.509	0.84
355_T	383_I	0.508	0.84
99_V	125_K	0.507	0.84
106_E	357_T	0.507	0.84
205_N	211_I	0.506	0.84
104_L	107_I	0.506	0.84
236_I	300_V	0.506	0.84
120_L	126_L	0.505	0.84
390_E	400_E	0.504	0.84
267_R	292_V	0.503	0.83
131_S	147_R	0.503	0.83
364_R	367_R	0.502	0.83
223_R	261_K	0.502	0.83
204_V	208_Y	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qenA	1	0.6707	100	0.678	Contact Map
2fnaA	1	0.6585	100	0.68	Contact Map
3pfiA	3	0.6415	99.8	0.781	Contact Map
1hqcA	1	0.6634	99.7	0.802	Contact Map
1w5sA	1	0.7171	99.6	0.815	Contact Map
1fnnA	1	0.7146	99.5	0.828	Contact Map
1in4A	1	0.661	99.4	0.834	Contact Map
2qbyA	1	0.7024	99.4	0.835	Contact Map
2v1uA	1	0.7317	99.4	0.837	Contact Map
4xgcA	1	0.6146	99.4	0.842	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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