GREMLIN Database
Q97Y73 - Uncharacterized protein
UniProt: Q97Y73 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (238)
Sequences: 2648 (2451)
Seq/√Len: 158.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_V102_Q3.3001.00
71_I74_L3.0921.00
155_V158_L2.8481.00
57_I60_L2.7501.00
50_V53_H2.7051.00
134_V137_Q2.6241.00
113_T116_L2.5991.00
78_T81_L2.5631.00
43_I46_L2.4971.00
106_I109_L2.4301.00
92_I95_L2.4251.00
36_L39_N2.1911.00
9_L12_N2.0701.00
141_I144_L2.0691.00
77_V82_Q2.0281.00
93_Q96_Q2.0001.00
29_D32_V1.9671.00
56_A61_Q1.9221.00
15_L20_A1.9081.00
64_V67_Q1.8821.00
154_E159_S1.8701.00
85_V88_H1.8571.00
126_A131_Q1.8051.00
194_K198_G1.7861.00
112_V117_Q1.7641.00
8_E13_P1.7431.00
35_K40_S1.7411.00
120_V123_H1.6841.00
162_L165_F1.6791.00
160_I164_S1.6781.00
155_V159_S1.6731.00
39_N43_I1.6551.00
140_A143_A1.6471.00
234_D237_T1.6091.00
235_K239_D1.5931.00
212_V216_D1.5631.00
59_S63_A1.5381.00
164_S168_R1.5241.00
16_L19_L1.5051.00
42_A47_Q1.4941.00
126_A129_S1.4911.00
45_A49_T1.4861.00
217_F220_T1.4851.00
31_I35_K1.4831.00
94_S98_A1.4831.00
112_V115_S1.4791.00
100_K103_G1.4731.00
91_A96_Q1.4631.00
34_K38_E1.4531.00
53_H57_I1.4471.00
170_G174_E1.4441.00
96_Q100_K1.4431.00
192_P195_V1.4351.00
17_S20_A1.4341.00
63_A68_G1.4161.00
29_D33_I1.4131.00
28_K33_I1.3991.00
227_F230_K1.3901.00
185_L188_H1.3781.00
169_A172_G1.3771.00
240_Q244_R1.3661.00
127_I130_L1.3651.00
148_V151_L1.3651.00
156_K159_S1.3341.00
30_E34_K1.3301.00
77_V80_S1.3291.00
136_K140_A1.3281.00
129_S133_A1.3141.00
43_I47_Q1.3131.00
123_H127_I1.3021.00
105_A108_A1.2891.00
237_T242_I1.2721.00
157_K161_E1.2691.00
66_E70_A1.2661.00
144_L148_V1.2641.00
133_A138_G1.2631.00
106_I110_Q1.2531.00
113_T117_Q1.2421.00
209_K214_E1.2281.00
14_Q18_V1.2271.00
64_V68_G1.2181.00
70_A75_Q1.2111.00
148_V152_G1.2021.00
39_N42_A1.2011.00
50_V54_T1.2011.00
231_N234_D1.1951.00
12_N16_L1.1931.00
90_E94_S1.1911.00
228_E232_F1.1901.00
40_S44_R1.1831.00
71_I75_Q1.1811.00
226_V234_D1.1771.00
238_Y241_I1.1761.00
140_A145_Q1.1731.00
87_K91_A1.1731.00
30_E33_I1.1711.00
42_A45_A1.1621.00
73_A77_V1.1621.00
231_N235_K1.1601.00
70_A74_L1.1551.00
184_S188_H1.1531.00
193_K197_H1.1511.00
229_I232_F1.1491.00
119_T122_K1.1441.00
167_N171_K1.1401.00
10_L13_P1.1391.00
72_Q76_Q1.1381.00
82_Q86_N1.1361.00
107_Q110_Q1.1361.00
227_F231_N1.1291.00
225_Y229_I1.1171.00
56_A59_S1.1121.00
132_E136_K1.0991.00
166_T170_G1.0930.99
79_Q82_Q1.0920.99
234_D238_Y1.0850.99
11_N15_L1.0810.99
16_L23_I1.0770.99
115_S119_T1.0720.99
47_Q50_V1.0630.99
237_T241_I1.0600.99
128_Q132_E1.0590.99
12_N15_L1.0570.99
238_Y245_K1.0550.99
51_N54_T1.0530.99
233_A237_T1.0530.99
213_F217_F1.0490.99
224_V227_F1.0490.99
147_A152_G1.0480.99
86_N90_E1.0390.99
230_K234_D1.0390.99
210_G214_E1.0370.99
119_T123_H1.0340.99
239_D243_V1.0310.99
140_A144_L1.0310.99
27_L31_I1.0300.99
88_H92_I1.0270.99
241_I245_K1.0270.99
18_V22_K1.0150.99
10_L14_Q1.0130.99
65_K68_G1.0060.99
128_Q131_Q1.0060.99
172_G175_K1.0040.99
15_L18_V1.0030.99
143_A147_A0.9990.99
114_Q117_Q0.9920.99
226_V231_N0.9820.99
159_S163_G0.9800.99
187_L191_D0.9800.99
192_P196_A0.9790.99
35_K38_E0.9670.99
75_Q79_Q0.9610.99
28_K31_I0.9580.99
93_Q97_E0.9560.99
66_E69_K0.9560.99
232_F236_G0.9540.99
8_E12_N0.9500.99
123_H126_A0.9490.99
25_G28_K0.9460.99
138_G142_E0.9460.99
102_Q106_I0.9450.99
238_Y244_R0.9390.98
86_N89_T0.9340.98
102_Q105_A0.9340.98
210_G213_F0.9290.98
182_R186_E0.9270.98
70_A73_A0.9230.98
80_S84_T0.9200.98
78_T82_Q0.9140.98
49_T54_T0.9130.98
201_V205_G0.9080.98
127_I131_Q0.9030.98
227_F233_A0.9010.98
146_K150_R0.9010.98
200_I204_E0.9010.98
89_T93_Q0.8980.98
161_E166_T0.8970.98
193_K196_A0.8950.98
58_Q61_Q0.8940.98
21_E25_G0.8920.98
79_Q83_E0.8820.98
154_E157_K0.8690.97
238_Y242_I0.8620.97
84_T87_K0.8580.97
199_K203_D0.8560.97
236_G244_R0.8520.97
208_E211_K0.8490.97
142_E146_K0.8480.97
227_F234_D0.8470.97
49_T52_K0.8460.97
236_G241_I0.8450.97
229_I234_D0.8390.97
19_L22_K0.8330.97
44_R47_Q0.8290.97
142_E145_Q0.8250.96
97_E101_E0.8210.96
57_I61_Q0.8210.96
220_T223_Y0.8160.96
72_Q75_Q0.8160.96
83_E87_K0.8110.96
119_T124_T0.8090.96
62_E66_E0.8080.96
101_E104_K0.8040.96
133_A137_Q0.8040.96
183_K186_E0.8030.96
49_T53_H0.8020.96
225_Y232_F0.7980.96
216_D221_N0.7940.96
149_L152_G0.7870.95
24_Y27_L0.7850.95
234_D244_R0.7760.95
56_A60_L0.7750.95
232_F235_K0.7750.95
188_H191_D0.7700.95
124_T128_Q0.7660.95
75_Q78_T0.7610.94
240_Q243_V0.7600.94
105_A110_Q0.7590.94
125_E129_S0.7570.94
13_P16_L0.7550.94
236_G239_D0.7530.94
234_D241_I0.7520.94
98_A103_G0.7510.94
239_D242_I0.7440.94
92_I96_Q0.7430.94
151_L155_V0.7430.94
98_A102_Q0.7420.94
11_N21_E0.7410.94
227_F237_T0.7400.94
224_V241_I0.7370.94
199_K202_D0.7340.93
179_K183_K0.7340.93
233_A236_G0.7260.93
233_A238_Y0.7240.93
232_F237_T0.7230.93
98_A101_E0.7230.93
191_D199_K0.7180.93
228_E233_A0.7150.92
91_A94_S0.7080.92
63_A66_E0.7070.92
218_Y222_E0.7060.92
236_G240_Q0.7050.92
68_G71_I0.7030.92
231_N244_R0.7020.92
17_S21_E0.6990.92
16_L20_A0.6950.91
231_N241_I0.6950.91
37_E40_S0.6920.91
11_N14_Q0.6920.91
165_F168_R0.6910.91
110_Q114_Q0.6900.91
226_V237_T0.6880.91
227_F232_F0.6850.91
183_K187_L0.6830.91
23_I26_R0.6780.90
137_Q144_L0.6770.90
237_T244_R0.6760.90
162_L166_T0.6740.90
133_A136_K0.6720.90
226_V233_A0.6680.90
48_E51_N0.6660.90
55_E59_S0.6660.90
103_G107_Q0.6630.89
78_T85_V0.6600.89
237_T240_Q0.6600.89
22_K25_G0.6600.89
45_A48_E0.6590.89
31_I34_K0.6570.89
19_L23_I0.6460.88
241_I244_R0.6390.88
63_A67_Q0.6380.87
117_Q121_N0.6370.87
202_D207_I0.6340.87
219_E223_Y0.6320.87
101_E105_A0.6300.87
230_K237_T0.6300.87
73_A76_Q0.6290.87
178_L182_R0.6280.87
8_E11_N0.6270.87
153_R157_K0.6260.86
186_E189_S0.6250.86
232_F238_Y0.6220.86
205_G208_E0.6210.86
233_A244_R0.6150.86
172_G178_L0.6150.86
232_F240_Q0.6150.86
171_K174_E0.6140.85
111_Q115_S0.6110.85
219_E222_E0.6050.85
57_I64_V0.6030.84
110_Q119_T0.6030.84
99_V103_G0.5980.84
9_L13_P0.5970.84
184_S189_S0.5970.84
74_L77_V0.5970.84
191_D196_A0.5910.83
213_F216_D0.5890.83
230_K233_A0.5880.83
37_E41_E0.5820.82
202_D205_G0.5810.82
135_K138_G0.5800.82
197_H201_V0.5770.82
150_R154_E0.5760.82
198_G202_D0.5760.82
159_S162_L0.5710.81
44_R48_E0.5710.81
230_K244_R0.5710.81
74_L78_T0.5680.81
229_I238_Y0.5670.81
11_N51_N0.5670.81
242_I245_K0.5670.81
168_R172_G0.5650.80
33_I37_E0.5620.80
137_Q140_A0.5610.80
159_S166_T0.5590.80
181_Y184_S0.5580.80
140_A179_K0.5570.79
149_L153_R0.5540.79
134_V138_G0.5520.79
67_Q70_A0.5520.79
144_L147_A0.5520.79
191_D194_K0.5440.78
95_L98_A0.5380.77
32_V35_K0.5370.77
190_V194_K0.5370.77
32_V36_L0.5350.77
124_T132_E0.5330.76
205_G209_K0.5330.76
206_V213_F0.5320.76
229_I241_I0.5320.76
224_V230_K0.5310.76
160_I163_G0.5300.76
214_E221_N0.5280.76
236_G245_K0.5250.75
42_A46_L0.5230.75
28_K32_V0.5220.75
47_Q60_L0.5220.75
195_V223_Y0.5200.75
109_L112_V0.5200.75
217_F222_E0.5190.75
12_N19_L0.5170.74
18_V21_E0.5160.74
141_I145_Q0.5140.74
233_A242_I0.5120.74
217_F221_N0.5110.73
231_N237_T0.5100.73
21_E24_Y0.5080.73
235_K245_K0.5070.73
147_A155_V0.5070.73
230_K235_K0.5060.73
161_E164_S0.5050.73
68_G72_Q0.5040.72
174_E177_M0.5020.72
126_A135_K0.5020.72
14_Q20_A0.5010.72
110_Q122_K0.5000.72
36_L40_S0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i84S 2 0.1458 99 0.523 Contact Map
1c1gA 2 0.934 98.5 0.601 Contact Map
4linA 5 0.7951 97.6 0.684 Contact Map
2dfsA 2 0.4618 97.3 0.698 Contact Map
2v71A 3 0.4931 96.9 0.716 Contact Map
3na7A 1 0.7951 96.4 0.734 Contact Map
4iloA 3 0.8125 95.8 0.747 Contact Map
3o0zA 2 0.5382 95.8 0.748 Contact Map
3ojaB 1 0.4479 95.8 0.748 Contact Map
4uxvA 1 0.9514 95.3 0.757 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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