Q97Y73 - SULSO - GREMLIN Contacts

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Q97Y73 - Uncharacterized protein

UniProt:	Q97Y73	Sequences: MSEKIIDELLNNPQLLSVLAEKIYGRLKDEIVIKKLEENSEAIRALQETVNKHTEAIQSLQEAVKEQGKAIQALQQVTQSLQETVNKHTEAIQSLQEAVKEQGKAIQALQQVTQSLQETVNKHTEAIQSLQEAVKKQGEAIEALQKAVLRLGREVKKLSIELGSFTNRAGKGMEKAMLKLYRKSLELHSVDPKKVAHGKIVDDEGVIEKGKVFEVDFYETNEYVYVFEIKNFADKGTYDQIIVRKKLFSAKYKNKKIKIFVVANFVDEKVKKKLEEEGVEVIASHVIK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	288 (238)
Sequences:	2648 (2451)
Seq/√Len:	158.8

SULSO - Q97Y73 Q97XV2 Q7LXD0 Q97XC5 Q97XI5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
99_V	102_Q	3.300	1.00
71_I	74_L	3.092	1.00
155_V	158_L	2.848	1.00
57_I	60_L	2.750	1.00
50_V	53_H	2.705	1.00
134_V	137_Q	2.624	1.00
113_T	116_L	2.599	1.00
78_T	81_L	2.563	1.00
43_I	46_L	2.497	1.00
106_I	109_L	2.430	1.00
92_I	95_L	2.425	1.00
36_L	39_N	2.191	1.00
9_L	12_N	2.070	1.00
141_I	144_L	2.069	1.00
77_V	82_Q	2.028	1.00
93_Q	96_Q	2.000	1.00
29_D	32_V	1.967	1.00
56_A	61_Q	1.922	1.00
15_L	20_A	1.908	1.00
64_V	67_Q	1.882	1.00
154_E	159_S	1.870	1.00
85_V	88_H	1.857	1.00
126_A	131_Q	1.805	1.00
194_K	198_G	1.786	1.00
112_V	117_Q	1.764	1.00
8_E	13_P	1.743	1.00
35_K	40_S	1.741	1.00
120_V	123_H	1.684	1.00
162_L	165_F	1.679	1.00
160_I	164_S	1.678	1.00
155_V	159_S	1.673	1.00
39_N	43_I	1.655	1.00
140_A	143_A	1.647	1.00
234_D	237_T	1.609	1.00
235_K	239_D	1.593	1.00
212_V	216_D	1.563	1.00
59_S	63_A	1.538	1.00
164_S	168_R	1.524	1.00
16_L	19_L	1.505	1.00
42_A	47_Q	1.494	1.00
126_A	129_S	1.491	1.00
45_A	49_T	1.486	1.00
217_F	220_T	1.485	1.00
31_I	35_K	1.483	1.00
94_S	98_A	1.483	1.00
112_V	115_S	1.479	1.00
100_K	103_G	1.473	1.00
91_A	96_Q	1.463	1.00
34_K	38_E	1.453	1.00
53_H	57_I	1.447	1.00
170_G	174_E	1.444	1.00
96_Q	100_K	1.443	1.00
192_P	195_V	1.435	1.00
17_S	20_A	1.434	1.00
63_A	68_G	1.416	1.00
29_D	33_I	1.413	1.00
28_K	33_I	1.399	1.00
227_F	230_K	1.390	1.00
185_L	188_H	1.378	1.00
169_A	172_G	1.377	1.00
240_Q	244_R	1.366	1.00
127_I	130_L	1.365	1.00
148_V	151_L	1.365	1.00
156_K	159_S	1.334	1.00
30_E	34_K	1.330	1.00
77_V	80_S	1.329	1.00
136_K	140_A	1.328	1.00
129_S	133_A	1.314	1.00
43_I	47_Q	1.313	1.00
123_H	127_I	1.302	1.00
105_A	108_A	1.289	1.00
237_T	242_I	1.272	1.00
157_K	161_E	1.269	1.00
66_E	70_A	1.266	1.00
144_L	148_V	1.264	1.00
133_A	138_G	1.263	1.00
106_I	110_Q	1.253	1.00
113_T	117_Q	1.242	1.00
209_K	214_E	1.228	1.00
14_Q	18_V	1.227	1.00
64_V	68_G	1.218	1.00
70_A	75_Q	1.211	1.00
148_V	152_G	1.202	1.00
39_N	42_A	1.201	1.00
50_V	54_T	1.201	1.00
231_N	234_D	1.195	1.00
12_N	16_L	1.193	1.00
90_E	94_S	1.191	1.00
228_E	232_F	1.190	1.00
40_S	44_R	1.183	1.00
71_I	75_Q	1.181	1.00
226_V	234_D	1.177	1.00
238_Y	241_I	1.176	1.00
140_A	145_Q	1.173	1.00
87_K	91_A	1.173	1.00
30_E	33_I	1.171	1.00
42_A	45_A	1.162	1.00
73_A	77_V	1.162	1.00
231_N	235_K	1.160	1.00
70_A	74_L	1.155	1.00
184_S	188_H	1.153	1.00
193_K	197_H	1.151	1.00
229_I	232_F	1.149	1.00
119_T	122_K	1.144	1.00
167_N	171_K	1.140	1.00
10_L	13_P	1.139	1.00
72_Q	76_Q	1.138	1.00
82_Q	86_N	1.136	1.00
107_Q	110_Q	1.136	1.00
227_F	231_N	1.129	1.00
225_Y	229_I	1.117	1.00
56_A	59_S	1.112	1.00
132_E	136_K	1.099	1.00
166_T	170_G	1.093	0.99
79_Q	82_Q	1.092	0.99
234_D	238_Y	1.085	0.99
11_N	15_L	1.081	0.99
16_L	23_I	1.077	0.99
115_S	119_T	1.072	0.99
47_Q	50_V	1.063	0.99
237_T	241_I	1.060	0.99
128_Q	132_E	1.059	0.99
12_N	15_L	1.057	0.99
238_Y	245_K	1.055	0.99
51_N	54_T	1.053	0.99
233_A	237_T	1.053	0.99
213_F	217_F	1.049	0.99
224_V	227_F	1.049	0.99
147_A	152_G	1.048	0.99
86_N	90_E	1.039	0.99
230_K	234_D	1.039	0.99
210_G	214_E	1.037	0.99
119_T	123_H	1.034	0.99
239_D	243_V	1.031	0.99
140_A	144_L	1.031	0.99
27_L	31_I	1.030	0.99
88_H	92_I	1.027	0.99
241_I	245_K	1.027	0.99
18_V	22_K	1.015	0.99
10_L	14_Q	1.013	0.99
65_K	68_G	1.006	0.99
128_Q	131_Q	1.006	0.99
172_G	175_K	1.004	0.99
15_L	18_V	1.003	0.99
143_A	147_A	0.999	0.99
114_Q	117_Q	0.992	0.99
226_V	231_N	0.982	0.99
159_S	163_G	0.980	0.99
187_L	191_D	0.980	0.99
192_P	196_A	0.979	0.99
35_K	38_E	0.967	0.99
75_Q	79_Q	0.961	0.99
28_K	31_I	0.958	0.99
93_Q	97_E	0.956	0.99
66_E	69_K	0.956	0.99
232_F	236_G	0.954	0.99
8_E	12_N	0.950	0.99
123_H	126_A	0.949	0.99
25_G	28_K	0.946	0.99
138_G	142_E	0.946	0.99
102_Q	106_I	0.945	0.99
238_Y	244_R	0.939	0.98
86_N	89_T	0.934	0.98
102_Q	105_A	0.934	0.98
210_G	213_F	0.929	0.98
182_R	186_E	0.927	0.98
70_A	73_A	0.923	0.98
80_S	84_T	0.920	0.98
78_T	82_Q	0.914	0.98
49_T	54_T	0.913	0.98
201_V	205_G	0.908	0.98
127_I	131_Q	0.903	0.98
227_F	233_A	0.901	0.98
146_K	150_R	0.901	0.98
200_I	204_E	0.901	0.98
89_T	93_Q	0.898	0.98
161_E	166_T	0.897	0.98
193_K	196_A	0.895	0.98
58_Q	61_Q	0.894	0.98
21_E	25_G	0.892	0.98
79_Q	83_E	0.882	0.98
154_E	157_K	0.869	0.97
238_Y	242_I	0.862	0.97
84_T	87_K	0.858	0.97
199_K	203_D	0.856	0.97
236_G	244_R	0.852	0.97
208_E	211_K	0.849	0.97
142_E	146_K	0.848	0.97
227_F	234_D	0.847	0.97
49_T	52_K	0.846	0.97
236_G	241_I	0.845	0.97
229_I	234_D	0.839	0.97
19_L	22_K	0.833	0.97
44_R	47_Q	0.829	0.97
142_E	145_Q	0.825	0.96
97_E	101_E	0.821	0.96
57_I	61_Q	0.821	0.96
220_T	223_Y	0.816	0.96
72_Q	75_Q	0.816	0.96
83_E	87_K	0.811	0.96
119_T	124_T	0.809	0.96
62_E	66_E	0.808	0.96
101_E	104_K	0.804	0.96
133_A	137_Q	0.804	0.96
183_K	186_E	0.803	0.96
49_T	53_H	0.802	0.96
225_Y	232_F	0.798	0.96
216_D	221_N	0.794	0.96
149_L	152_G	0.787	0.95
24_Y	27_L	0.785	0.95
234_D	244_R	0.776	0.95
56_A	60_L	0.775	0.95
232_F	235_K	0.775	0.95
188_H	191_D	0.770	0.95
124_T	128_Q	0.766	0.95
75_Q	78_T	0.761	0.94
240_Q	243_V	0.760	0.94
105_A	110_Q	0.759	0.94
125_E	129_S	0.757	0.94
13_P	16_L	0.755	0.94
236_G	239_D	0.753	0.94
234_D	241_I	0.752	0.94
98_A	103_G	0.751	0.94
239_D	242_I	0.744	0.94
92_I	96_Q	0.743	0.94
151_L	155_V	0.743	0.94
98_A	102_Q	0.742	0.94
11_N	21_E	0.741	0.94
227_F	237_T	0.740	0.94
224_V	241_I	0.737	0.94
199_K	202_D	0.734	0.93
179_K	183_K	0.734	0.93
233_A	236_G	0.726	0.93
233_A	238_Y	0.724	0.93
232_F	237_T	0.723	0.93
98_A	101_E	0.723	0.93
191_D	199_K	0.718	0.93
228_E	233_A	0.715	0.92
91_A	94_S	0.708	0.92
63_A	66_E	0.707	0.92
218_Y	222_E	0.706	0.92
236_G	240_Q	0.705	0.92
68_G	71_I	0.703	0.92
231_N	244_R	0.702	0.92
17_S	21_E	0.699	0.92
16_L	20_A	0.695	0.91
231_N	241_I	0.695	0.91
37_E	40_S	0.692	0.91
11_N	14_Q	0.692	0.91
165_F	168_R	0.691	0.91
110_Q	114_Q	0.690	0.91
226_V	237_T	0.688	0.91
227_F	232_F	0.685	0.91
183_K	187_L	0.683	0.91
23_I	26_R	0.678	0.90
137_Q	144_L	0.677	0.90
237_T	244_R	0.676	0.90
162_L	166_T	0.674	0.90
133_A	136_K	0.672	0.90
226_V	233_A	0.668	0.90
48_E	51_N	0.666	0.90
55_E	59_S	0.666	0.90
103_G	107_Q	0.663	0.89
78_T	85_V	0.660	0.89
237_T	240_Q	0.660	0.89
22_K	25_G	0.660	0.89
45_A	48_E	0.659	0.89
31_I	34_K	0.657	0.89
19_L	23_I	0.646	0.88
241_I	244_R	0.639	0.88
63_A	67_Q	0.638	0.87
117_Q	121_N	0.637	0.87
202_D	207_I	0.634	0.87
219_E	223_Y	0.632	0.87
101_E	105_A	0.630	0.87
230_K	237_T	0.630	0.87
73_A	76_Q	0.629	0.87
178_L	182_R	0.628	0.87
8_E	11_N	0.627	0.87
153_R	157_K	0.626	0.86
186_E	189_S	0.625	0.86
232_F	238_Y	0.622	0.86
205_G	208_E	0.621	0.86
233_A	244_R	0.615	0.86
172_G	178_L	0.615	0.86
232_F	240_Q	0.615	0.86
171_K	174_E	0.614	0.85
111_Q	115_S	0.611	0.85
219_E	222_E	0.605	0.85
57_I	64_V	0.603	0.84
110_Q	119_T	0.603	0.84
99_V	103_G	0.598	0.84
9_L	13_P	0.597	0.84
184_S	189_S	0.597	0.84
74_L	77_V	0.597	0.84
191_D	196_A	0.591	0.83
213_F	216_D	0.589	0.83
230_K	233_A	0.588	0.83
37_E	41_E	0.582	0.82
202_D	205_G	0.581	0.82
135_K	138_G	0.580	0.82
197_H	201_V	0.577	0.82
150_R	154_E	0.576	0.82
198_G	202_D	0.576	0.82
159_S	162_L	0.571	0.81
44_R	48_E	0.571	0.81
230_K	244_R	0.571	0.81
74_L	78_T	0.568	0.81
229_I	238_Y	0.567	0.81
11_N	51_N	0.567	0.81
242_I	245_K	0.567	0.81
168_R	172_G	0.565	0.80
33_I	37_E	0.562	0.80
137_Q	140_A	0.561	0.80
159_S	166_T	0.559	0.80
181_Y	184_S	0.558	0.80
140_A	179_K	0.557	0.79
149_L	153_R	0.554	0.79
134_V	138_G	0.552	0.79
67_Q	70_A	0.552	0.79
144_L	147_A	0.552	0.79
191_D	194_K	0.544	0.78
95_L	98_A	0.538	0.77
32_V	35_K	0.537	0.77
190_V	194_K	0.537	0.77
32_V	36_L	0.535	0.77
124_T	132_E	0.533	0.76
205_G	209_K	0.533	0.76
206_V	213_F	0.532	0.76
229_I	241_I	0.532	0.76
224_V	230_K	0.531	0.76
160_I	163_G	0.530	0.76
214_E	221_N	0.528	0.76
236_G	245_K	0.525	0.75
42_A	46_L	0.523	0.75
28_K	32_V	0.522	0.75
47_Q	60_L	0.522	0.75
195_V	223_Y	0.520	0.75
109_L	112_V	0.520	0.75
217_F	222_E	0.519	0.75
12_N	19_L	0.517	0.74
18_V	21_E	0.516	0.74
141_I	145_Q	0.514	0.74
233_A	242_I	0.512	0.74
217_F	221_N	0.511	0.73
231_N	237_T	0.510	0.73
21_E	24_Y	0.508	0.73
235_K	245_K	0.507	0.73
147_A	155_V	0.507	0.73
230_K	235_K	0.506	0.73
161_E	164_S	0.505	0.73
68_G	72_Q	0.504	0.72
174_E	177_M	0.502	0.72
126_A	135_K	0.502	0.72
14_Q	20_A	0.501	0.72
110_Q	122_K	0.500	0.72
36_L	40_S	0.500	0.72

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1i84S	2	0.1458	99	0.523	Contact Map
1c1gA	2	0.934	98.5	0.601	Contact Map
4linA	5	0.7951	97.6	0.684	Contact Map
2dfsA	2	0.4618	97.3	0.698	Contact Map
2v71A	3	0.4931	96.9	0.716	Contact Map
3na7A	1	0.7951	96.4	0.734	Contact Map
4iloA	3	0.8125	95.8	0.747	Contact Map
3o0zA	2	0.5382	95.8	0.748	Contact Map
3ojaB	1	0.4479	95.8	0.748	Contact Map
4uxvA	1	0.9514	95.3	0.757	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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