GREMLIN Database
Q97Y67 - Transposase ISC1476
UniProt: Q97Y67 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 416 (348)
Sequences: 4485 (2888)
Seq/√Len: 154.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
252_H256_S5.5401.00
327_S357_N4.4481.00
307_G314_V3.8551.00
274_V280_E3.6581.00
300_I316_T3.0591.00
192_L299_I3.0531.00
259_R263_E2.8521.00
269_N366_P2.8161.00
298_Y302_R2.7941.00
3_R309_E2.6831.00
298_Y301_K2.5761.00
321_Y324_K2.5331.00
299_I303_L2.5031.00
153_L166_A2.4991.00
214_Y289_L2.4901.00
304_E316_T2.4881.00
325_T332_A2.4581.00
262_M307_G2.4471.00
317_V362_I2.3981.00
324_K336_G2.3431.00
337_R340_R2.2911.00
151_G171_E2.2881.00
365_I368_S2.2421.00
282_A292_N2.1981.00
220_R235_R2.1371.00
213_H249_F2.1241.00
255_N305_D2.1181.00
322_T362_I2.1111.00
255_N302_R2.1021.00
35_W39_K2.1011.00
344_V351_A2.0821.00
329_C348_T2.0521.00
38_M102_P2.0431.00
235_R239_L1.9861.00
20_K157_Y1.9841.00
326_C329_C1.9781.00
258_V302_R1.9431.00
33_V72_A1.9391.00
21_R62_S1.9371.00
20_K164_W1.9251.00
53_E56_V1.8871.00
266_R312_I1.8851.00
12_S15_Q1.8811.00
251_K298_Y1.8801.00
329_C345_C1.8551.00
230_R233_Q1.8481.00
192_L253_A1.8241.00
284_H288_K1.8131.00
345_C348_T1.8111.00
304_E308_E1.8011.00
341_G354_A1.7931.00
270_V303_L1.7891.00
34_N75_N1.7621.00
285_H288_K1.7591.00
255_N306_I1.7481.00
8_R163_I1.7481.00
324_K334_E1.7431.00
343_F352_I1.7411.00
254_L302_R1.7401.00
326_C348_T1.7261.00
328_L350_K1.6941.00
185_I193_A1.6871.00
326_C345_C1.6391.00
255_N258_V1.6321.00
337_R354_A1.6231.00
233_Q236_S1.6101.00
19_L164_W1.6091.00
128_V166_A1.5841.00
333_H336_G1.5531.00
254_L298_Y1.5421.00
195_V199_D1.5341.00
17_E21_R1.5021.00
76_A80_R1.4941.00
191_N194_T1.4941.00
194_T356_L1.4931.00
4_S167_H1.4811.00
227_T235_R1.4691.00
220_R223_I1.4671.00
343_F350_K1.4641.00
272_E316_T1.4581.00
16_H20_K1.4561.00
342_L351_A1.4421.00
182_K363_L1.4371.00
183_A195_V1.4361.00
74_K114_I1.4121.00
163_I244_E1.4001.00
33_V75_N1.3851.00
333_H343_F1.3681.00
66_V116_R1.3641.00
258_V306_I1.3611.00
360_I364_H1.3581.00
158_D244_E1.3581.00
258_V305_D1.3341.00
223_I227_T1.3301.00
331_E346_P1.3271.00
52_T56_V1.3241.00
304_E314_V1.3231.00
220_R242_L1.3221.00
23_G164_W1.3111.00
270_V314_V1.3011.00
258_V299_I1.2961.00
66_V118_D1.2931.00
77_E81_S1.2901.00
224_V236_S1.2841.00
79_W102_P1.2831.00
244_E248_R1.2681.00
213_H246_R1.2611.00
11_V15_Q1.2591.00
291_V296_Y1.2591.00
336_G340_R1.2481.00
217_Y239_L1.2461.00
51_I56_V1.2411.00
327_S360_I1.2221.00
270_V300_I1.2201.00
281_I284_H1.2191.00
26_T71_V1.2191.00
13_K16_H1.2171.00
262_M310_L1.2121.00
161_R244_E1.2061.00
80_R84_S1.2001.00
224_V239_L1.1991.00
327_S352_I1.1951.00
274_V319_E1.1931.00
356_L360_I1.1921.00
338_V341_G1.1861.00
333_H346_P1.1851.00
275_V297_S1.1611.00
260_R264_I1.1561.00
141_K144_L1.1561.00
187_L296_Y1.1541.00
70_Q73_R1.1521.00
196_Y359_A1.1501.00
38_M42_K1.1451.00
221_I225_Q1.1361.00
280_E284_H1.1361.00
183_A265_L1.1341.00
115_I130_Y1.1341.00
184_S363_L1.1171.00
322_T365_I1.1151.00
156_I167_H1.1030.99
352_I360_I1.1000.99
36_L55_A1.0920.99
268_K307_G1.0920.99
254_L299_I1.0840.99
52_T55_A1.0800.99
143_R146_W1.0790.99
189_I294_W1.0740.99
129_V135_N1.0710.99
185_I195_V1.0700.99
302_R305_D1.0690.99
317_V365_I1.0680.99
121_T129_V1.0670.99
259_R310_L1.0650.99
306_I309_E1.0630.99
251_K302_R1.0590.99
60_Y68_A1.0530.99
194_T200_G1.0520.99
30_W71_V1.0510.99
317_V366_P1.0360.99
187_L300_I1.0360.99
81_S87_R1.0350.99
39_K43_E1.0340.99
82_F102_P1.0330.99
158_D161_R1.0300.99
217_Y243_H1.0300.99
216_N220_R1.0300.99
262_M312_I1.0230.99
200_G353_N1.0220.99
325_T365_I1.0180.99
179_E266_R1.0180.99
182_K367_E1.0170.99
258_V303_L1.0150.99
81_S86_T1.0140.99
324_K332_A1.0120.99
70_Q116_R1.0080.99
113_V117_N1.0050.99
6_T158_D1.0050.99
272_E319_E0.9970.99
263_E310_L0.9940.99
64_L67_N0.9920.99
218_S222_T0.9840.99
220_R239_L0.9830.99
352_I356_L0.9770.99
273_V307_G0.9750.99
336_G343_F0.9730.99
66_V70_Q0.9720.99
85_L101_R0.9690.99
142_G145_K0.9660.99
183_A196_Y0.9660.99
5_N170_V0.9650.99
254_L258_V0.9620.99
130_Y155_I0.9590.99
38_M79_W0.9540.98
28_K32_E0.9520.98
333_H337_R0.9520.98
221_I239_L0.9510.98
327_S350_K0.9460.98
66_V117_N0.9420.98
261_I268_K0.9380.98
131_L134_F0.9380.98
50_G53_E0.9350.98
24_I27_A0.9350.98
48_D51_I0.9340.98
281_I288_K0.9290.98
337_R341_G0.9230.98
49_F53_E0.9220.98
81_S85_L0.9210.98
34_N79_W0.9210.98
247_S251_K0.9190.98
340_R343_F0.9130.98
358_G361_N0.9060.98
7_V166_A0.9030.98
259_R306_I0.9000.98
36_L40_Q0.8960.98
341_G353_N0.8950.98
254_L295_N0.8930.98
74_K154_E0.8920.98
199_D260_R0.8890.98
301_K304_E0.8870.98
140_F143_R0.8820.97
224_V235_R0.8790.97
269_N362_I0.8780.97
187_L193_A0.8770.97
238_R241_L0.8730.97
319_E322_T0.8710.97
220_R238_R0.8690.97
41_Y79_W0.8670.97
196_Y200_G0.8660.97
232_R236_S0.8650.97
158_D163_I0.8630.97
145_K148_G0.8620.97
197_V265_L0.8600.97
245_K249_F0.8600.97
11_V19_L0.8590.97
65_R118_D0.8580.97
41_Y44_G0.8570.97
154_E167_H0.8570.97
30_W75_N0.8500.97
45_K48_D0.8470.97
193_A257_M0.8460.97
262_M268_K0.8450.97
223_I226_K0.8440.97
53_E73_R0.8430.97
189_I290_T0.8430.97
331_E343_F0.8420.97
37_R76_A0.8400.97
336_G354_A0.8390.97
342_L352_I0.8390.97
140_F144_L0.8380.97
72_A76_A0.8330.96
242_L246_R0.8310.96
191_N200_G0.8280.96
37_R79_W0.8260.96
323_S336_G0.8240.96
155_I166_A0.8230.96
82_F103_P0.8220.96
152_R169_P0.8220.96
209_S249_F0.8220.96
366_P370_G0.8180.96
35_W105_Y0.8170.96
275_V296_Y0.8160.96
206_K294_W0.8150.96
217_Y225_Q0.8090.96
221_I243_H0.8080.96
32_E36_L0.8070.96
340_R354_A0.8060.96
356_L359_A0.8050.96
142_G146_W0.8050.96
113_V116_R0.8020.96
325_T361_N0.8000.95
218_S221_I0.8000.95
222_T225_Q0.7980.95
69_Q73_R0.7970.95
365_I369_R0.7960.95
357_N361_N0.7960.95
331_E347_R0.7940.95
114_I154_E0.7920.95
127_R137_S0.7910.95
297_S301_K0.7910.95
321_Y365_I0.7910.95
327_S358_G0.7910.95
307_G312_I0.7900.95
191_N205_F0.7880.95
270_V316_T0.7870.95
127_R135_N0.7870.95
217_Y246_R0.7850.95
44_G48_D0.7850.95
70_Q74_K0.7810.95
368_S371_S0.7800.95
9_L166_A0.7800.95
30_W78_D0.7790.95
194_T204_L0.7780.95
157_Y164_W0.7780.95
70_Q114_I0.7740.95
81_S84_S0.7740.95
16_H164_W0.7710.94
190_V194_T0.7690.94
338_V354_A0.7640.94
24_I28_K0.7640.94
114_I152_R0.7640.94
335_D340_R0.7630.94
119_R131_L0.7620.94
315_I366_P0.7570.94
33_V56_V0.7550.94
123_D129_V0.7550.94
182_K267_E0.7510.94
236_S240_K0.7510.94
115_I118_D0.7470.94
40_Q47_V0.7470.94
63_V66_V0.7440.93
328_L360_I0.7430.93
268_K271_G0.7410.93
29_C71_V0.7400.93
183_A273_V0.7380.93
327_S364_H0.7350.93
253_A257_M0.7320.93
47_V50_G0.7310.93
367_E371_S0.7250.92
22_L26_T0.7230.92
199_D204_L0.7220.92
25_A28_K0.7190.92
111_L114_I0.7190.92
8_R165_Y0.7170.92
66_V69_Q0.7150.92
6_T156_I0.7140.92
75_N79_W0.7120.92
257_M260_R0.7120.92
79_W82_F0.7110.92
49_F72_A0.7090.92
19_L113_V0.7040.91
269_N273_V0.7010.91
87_R101_R0.7010.91
209_S213_H0.6990.91
204_L257_M0.6950.91
246_R293_F0.6940.91
360_I363_L0.6930.91
51_I54_K0.6910.91
128_V153_L0.6900.91
119_R122_V0.6890.90
217_Y221_I0.6880.90
36_L39_K0.6860.90
25_A63_V0.6850.90
225_Q239_L0.6850.90
287_N291_V0.6850.90
279_K292_N0.6840.90
14_E17_E0.6810.90
324_K333_H0.6790.90
178_K181_I0.6740.89
263_E267_E0.6730.89
233_Q237_R0.6720.89
331_E334_E0.6700.89
21_R25_A0.6690.89
219_K223_I0.6670.89
18_V22_L0.6630.89
343_F354_A0.6610.89
275_V303_L0.6590.88
79_W83_F0.6580.88
284_H287_N0.6530.88
200_G356_L0.6490.88
206_K209_S0.6480.88
211_L289_L0.6460.87
49_F73_R0.6400.87
352_I357_N0.6400.87
192_L258_V0.6390.87
181_I197_V0.6390.87
186_D355_D0.6350.87
149_K171_E0.6340.86
71_V75_N0.6320.86
218_S225_Q0.6310.86
141_K146_W0.6250.86
118_D121_T0.6250.86
321_Y332_A0.6250.86
323_S337_R0.6240.86
333_H340_R0.6180.85
123_D127_R0.6170.85
56_V72_A0.6170.85
19_L23_G0.6160.85
362_I365_I0.6160.85
228_L232_R0.6160.85
321_Y325_T0.6150.85
213_H242_L0.6150.85
223_I235_R0.6140.85
22_L115_I0.6140.85
224_V227_T0.6130.85
302_R306_I0.6120.84
124_E127_R0.6110.84
193_A204_L0.6110.84
196_Y356_L0.6100.84
67_N113_V0.6100.84
192_L294_W0.6070.84
28_K59_K0.6070.84
13_K17_E0.6070.84
50_G54_K0.6060.84
364_H367_E0.6050.84
303_L314_V0.6050.84
84_S87_R0.6040.84
112_I116_R0.6040.84
243_H250_L0.6020.84
180_G266_R0.6010.83
261_I265_L0.6000.83
121_T124_E0.5980.83
127_R130_Y0.5980.83
66_V119_R0.5970.83
282_A288_K0.5970.83
112_I115_I0.5960.83
22_L113_V0.5950.83
338_V353_N0.5930.83
63_V68_A0.5920.82
111_L115_I0.5910.82
18_V21_R0.5910.82
115_I119_R0.5890.82
193_A299_I0.5890.82
232_R235_R0.5880.82
4_S156_I0.5870.82
163_I248_R0.5860.82
46_R49_F0.5860.82
46_R50_G0.5860.82
157_Y165_Y0.5840.82
265_L273_V0.5840.82
25_A60_Y0.5830.82
210_A213_H0.5830.82
37_R52_T0.5800.81
188_G194_T0.5780.81
305_D309_E0.5770.81
120_Y131_L0.5760.81
367_E370_G0.5760.81
182_K269_N0.5760.81
45_K49_F0.5750.81
282_A285_H0.5740.81
329_C333_H0.5730.80
35_W38_M0.5730.80
184_S196_Y0.5700.80
248_R252_H0.5670.80
364_H369_R0.5670.80
82_F85_L0.5670.80
251_K255_N0.5660.80
250_L293_F0.5650.79
307_G310_L0.5640.79
51_I55_A0.5640.79
138_L141_K0.5630.79
6_T167_H0.5630.79
73_R116_R0.5630.79
56_V69_Q0.5630.79
229_H232_R0.5620.79
337_R343_F0.5580.79
192_L254_L0.5570.79
220_R224_V0.5570.79
331_E335_D0.5570.79
325_T343_F0.5560.78
72_A75_N0.5540.78
131_L136_L0.5540.78
53_E72_A0.5530.78
190_V341_G0.5530.78
267_E313_K0.5510.78
248_R251_K0.5510.78
318_D321_Y0.5500.78
181_I266_R0.5490.78
44_G47_V0.5490.78
141_K145_K0.5480.77
195_V200_G0.5480.77
40_Q43_E0.5470.77
332_A335_D0.5470.77
22_L63_V0.5470.77
210_A214_Y0.5470.77
211_L214_Y0.5450.77
228_L236_S0.5430.77
284_H291_V0.5420.77
21_R24_I0.5400.76
280_E288_K0.5400.76
281_I292_N0.5390.76
254_L257_M0.5370.76
281_I286_G0.5360.76
64_L115_I0.5360.76
271_G274_V0.5350.76
4_S169_P0.5350.76
53_E57_Y0.5330.75
130_Y136_L0.5330.75
6_T251_K0.5330.75
332_A336_G0.5330.75
333_H354_A0.5320.75
213_H217_Y0.5310.75
68_A71_V0.5310.75
36_L52_T0.5310.75
108_D111_L0.5310.75
328_L352_I0.5260.75
344_V350_K0.5260.75
174_T308_E0.5260.75
362_I366_P0.5260.75
22_L64_L0.5250.74
295_N298_Y0.5250.74
221_I224_V0.5250.74
33_V52_T0.5240.74
300_I304_E0.5240.74
71_V74_K0.5240.74
130_Y133_D0.5230.74
268_K273_V0.5220.74
262_M314_V0.5220.74
32_E35_W0.5220.74
285_H292_N0.5210.74
69_Q72_A0.5200.74
211_L290_T0.5160.73
243_H247_S0.5160.73
232_R239_L0.5150.73
275_V291_V0.5150.73
223_I238_R0.5150.73
135_N139_K0.5150.73
26_T113_V0.5130.73
29_C68_A0.5110.72
322_T361_N0.5110.72
46_R52_T0.5100.72
41_Y83_F0.5090.72
47_V52_T0.5090.72
219_K222_T0.5080.72
144_L148_G0.5070.72
21_R63_V0.5060.72
325_T331_E0.5060.72
207_G253_A0.5050.72
181_I265_L0.5030.71
137_S140_F0.5020.71
246_R250_L0.5020.71
41_Y82_F0.5000.71
218_S226_K0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3149 94.6 0.933 Contact Map
1vhxA 2 0.3317 93.8 0.936 Contact Map
1iv0A 1 0.2356 92.9 0.938 Contact Map
1ffkW 1 0.1635 88.1 0.944 Contact Map
4aybP 1 0.1034 86.9 0.945 Contact Map
1vq8Z 1 0.1683 80.2 0.95 Contact Map
1vd4A 1 0.1346 78.9 0.95 Contact Map
1qypA 1 0.1106 78.8 0.95 Contact Map
3j20Y 1 0.1202 77.4 0.951 Contact Map
2k4xA 1 0.1322 73.5 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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