GREMLIN Database
Q97Y64 - Second ORF in transposon ISC1225
UniProt: Q97Y64 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (261)
Sequences: 188 (127)
Seq/√Len: 7.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_T217_Y5.4831.00
117_L216_S4.4300.99
112_V136_V4.1520.98
193_T229_S3.1380.89
43_I98_V3.1250.89
46_T221_K3.1060.89
7_R234_F2.8630.84
46_T59_G2.8100.83
196_D208_K2.7890.83
22_L26_R2.7380.81
119_A138_G2.5980.78
237_L241_L2.5540.76
105_I115_V2.4790.74
82_L217_Y2.3790.71
72_A84_A2.2340.66
217_Y227_T2.2020.65
193_T211_S2.1450.62
118_D210_R2.1390.62
223_F246_Y2.1210.62
221_K246_Y2.0600.59
50_W247_S2.0360.58
88_Q116_T2.0190.58
98_V101_L2.0030.57
59_G229_S1.9990.57
21_L25_M1.9880.56
78_N128_K1.9760.56
47_T68_N1.9530.55
120_G248_L1.9270.54
245_F256_M1.9210.54
264_L268_C1.9170.53
45_W112_V1.8830.52
215_T218_R1.8610.51
191_R194_N1.8290.50
70_A101_L1.8140.49
122_Y139_V1.8130.49
41_I105_I1.8050.49
193_T246_Y1.7610.47
67_W217_Y1.7340.46
44_D214_E1.7160.45
14_G18_I1.6700.43
88_Q98_V1.6630.43
206_Y213_I1.6630.43
193_T215_T1.6400.42
80_V218_R1.6320.42
112_V217_Y1.6260.42
82_L243_M1.6020.41
72_A105_I1.5930.40
71_T213_I1.5390.38
105_I135_F1.5320.38
114_L222_A1.5270.38
210_R214_E1.4620.35
18_I21_L1.4580.35
72_A256_M1.4490.35
46_T229_S1.4390.35
19_E23_E1.4280.34
10_V18_I1.4160.34
225_P238_I1.4120.34
239_F246_Y1.4120.34
47_T120_G1.4000.33
46_T203_L1.3650.32
70_A97_I1.3630.32
118_D214_E1.3580.32
50_W230_T1.3530.31
229_S239_F1.3460.31
112_V220_I1.3440.31
110_L115_V1.3340.31
61_S117_L1.3150.30
206_Y214_E1.3070.30
46_T80_V1.2990.30
168_K202_V1.2930.29
61_S234_F1.2910.29
164_E231_K1.2890.29
262_R265_L1.2840.29
61_S74_T1.2760.29
221_K229_S1.2760.29
114_L197_L1.2470.28
93_S123_T1.2400.28
234_F238_I1.2350.27
265_L269_F1.2290.27
152_G168_K1.2290.27
26_R130_I1.2250.27
264_L267_L1.2230.27
253_K257_T1.2130.27
261_F264_L1.1910.26
221_K239_F1.1850.26
117_L122_Y1.1760.26
70_A135_F1.1760.26
44_D210_R1.1740.26
109_G237_L1.1730.26
6_V225_P1.1720.25
226_F247_S1.1690.25
26_R92_M1.1630.25
117_L192_A1.1580.25
4_Q7_R1.1500.25
121_F227_T1.1400.25
80_V113_G1.1400.25
10_V65_N1.1390.24
215_T248_L1.1260.24
52_G122_Y1.1250.24
79_M113_G1.1230.24
9_Y218_R1.1190.24
67_W223_F1.1130.24
217_Y228_S1.1030.23
60_S66_S1.0960.23
74_T249_Y1.0930.23
211_S229_S1.0920.23
66_S211_S1.0910.23
43_I70_A1.0870.23
191_R229_S1.0860.23
122_Y215_T1.0850.23
81_L143_D1.0820.23
127_L135_F1.0710.23
44_D118_D1.0700.22
173_V233_I1.0540.22
222_A245_F1.0450.22
84_A102_M1.0410.22
215_T251_V1.0380.22
194_N239_F1.0370.22
64_G262_R1.0350.21
147_Y150_F1.0350.21
82_L122_Y1.0350.21
92_M136_V1.0340.21
86_V93_S1.0330.21
89_V248_L1.0300.21
4_Q11_E1.0290.21
82_L216_S1.0280.21
41_I75_K1.0280.21
259_E262_R1.0250.21
110_L133_F1.0200.21
149_E153_E1.0180.21
33_L152_G1.0170.21
72_A247_S1.0160.21
44_D206_Y1.0130.21
69_Y122_Y1.0110.21
152_G164_E1.0060.21
14_G115_V0.9990.21
250_T253_K0.9990.21
138_G253_K0.9940.20
120_G140_P0.9790.20
260_E263_L0.9740.20
49_T245_F0.9740.20
8_N12_E0.9720.20
125_E162_K0.9700.20
121_F214_E0.9690.20
122_Y248_L0.9650.20
24_S126_V0.9640.20
47_T66_S0.9600.20
22_L25_M0.9580.19
84_A117_L0.9540.19
230_T237_L0.9540.19
101_L220_I0.9490.19
52_G230_T0.9480.19
138_G227_T0.9460.19
235_R249_Y0.9440.19
62_A69_Y0.9400.19
65_N130_I0.9400.19
6_V19_E0.9380.19
135_F188_Y0.9380.19
207_N247_S0.9200.19
108_M153_E0.9180.18
71_T239_F0.9160.18
17_V231_K0.9140.18
21_L26_R0.9080.18
136_V166_Q0.9050.18
69_Y143_D0.9030.18
113_G211_S0.9010.18
95_D129_F0.8980.18
78_N85_F0.8940.18
40_D116_T0.8920.18
52_G69_Y0.8910.18
16_E158_S0.8900.18
101_L194_N0.8870.18
110_L155_T0.8870.18
220_I239_F0.8830.18
42_S126_V0.8820.18
246_Y253_K0.8730.17
5_T42_S0.8710.17
229_S246_Y0.8700.17
120_G183_K0.8680.17
69_Y206_Y0.8640.17
61_S66_S0.8630.17
135_F231_K0.8610.17
131_S259_E0.8580.17
76_Y240_V0.8580.17
101_L246_Y0.8570.17
262_R267_L0.8570.17
9_Y97_I0.8550.17
4_Q25_M0.8520.17
45_W88_Q0.8520.17
194_N217_Y0.8510.17
63_K164_E0.8500.17
23_E26_R0.8450.17
135_F253_K0.8420.17
28_I148_E0.8400.17
26_R102_M0.8290.16
42_S171_L0.8280.16
25_M104_Q0.8270.16
66_S250_T0.8180.16
25_M173_V0.8170.16
83_L90_N0.8150.16
207_N212_P0.8130.16
98_V105_I0.8070.16
76_Y253_K0.8060.16
257_T263_L0.8060.16
117_L120_G0.8050.16
127_L137_I0.8040.16
207_N226_F0.8010.16
99_K166_Q0.7970.16
89_V102_M0.7960.16
101_L105_I0.7960.16
215_T219_N0.7940.16
69_Y237_L0.7930.16
212_P242_A0.7920.16
38_E165_E0.7910.16
42_S75_K0.7900.16
144_V244_I0.7890.16
88_Q224_L0.7880.15
10_V261_F0.7850.15
59_G218_R0.7820.15
70_A126_V0.7790.15
174_Y207_N0.7750.15
15_T27_R0.7720.15
21_L148_E0.7720.15
214_E235_R0.7700.15
253_K263_L0.7640.15
99_K229_S0.7570.15
119_A236_E0.7540.15
84_A187_V0.7540.15
130_I133_F0.7510.15
112_V233_I0.7500.15
54_P234_F0.7450.15
7_R258_R0.7450.15
105_I235_R0.7340.14
207_N231_K0.7320.14
121_F206_Y0.7320.14
9_Y231_K0.7310.14
99_K158_S0.7310.14
43_I227_T0.7280.14
80_V88_Q0.7280.14
80_V211_S0.7270.14
67_W106_V0.7230.14
71_T240_V0.7190.14
194_N223_F0.7190.14
55_V58_L0.7180.14
81_L166_Q0.7160.14
4_Q137_I0.7120.14
21_L237_L0.7110.14
19_E81_L0.7100.14
157_N269_F0.7080.14
127_L206_Y0.7050.14
49_T187_V0.7050.14
43_I194_N0.7050.14
133_F240_V0.7040.14
81_L167_V0.7040.14
23_E225_P0.6980.14
36_V202_V0.6960.14
152_G261_F0.6950.14
260_E265_L0.6930.14
102_M168_K0.6930.14
22_L28_I0.6900.14
122_Y140_P0.6870.13
130_I238_I0.6850.13
119_A157_N0.6840.13
18_I22_L0.6780.13
37_K111_K0.6770.13
186_V189_F0.6750.13
57_G234_F0.6730.13
121_F213_I0.6730.13
163_K168_K0.6680.13
44_D121_F0.6670.13
78_N132_Q0.6670.13
127_L192_A0.6630.13
6_V122_Y0.6630.13
42_S202_V0.6610.13
83_L190_A0.6560.13
105_I112_V0.6560.13
126_V213_I0.6510.13
206_Y210_R0.6510.13
234_F248_L0.6500.13
192_A237_L0.6500.13
52_G81_L0.6480.13
80_V139_V0.6480.13
231_K269_F0.6470.13
16_E149_E0.6470.13
98_V194_N0.6460.13
7_R19_E0.6460.13
7_R13_Q0.6440.13
98_V135_F0.6410.13
101_L135_F0.6360.13
113_G242_A0.6330.12
7_R216_S0.6320.12
112_V155_T0.6320.12
23_E120_G0.6310.12
86_V100_L0.6300.12
205_L218_R0.6290.12
83_L147_Y0.6230.12
74_T88_Q0.6220.12
18_I69_Y0.6210.12
126_V217_Y0.6210.12
44_D213_I0.6170.12
88_Q236_E0.6110.12
86_V215_T0.6100.12
111_K134_K0.6080.12
126_V215_T0.6070.12
36_V109_G0.6070.12
128_K136_V0.6050.12
47_T248_L0.6040.12
138_G206_Y0.6020.12
26_R35_G0.6010.12
139_V202_V0.6000.12
74_T84_A0.6000.12
40_D244_I0.5950.12
116_T216_S0.5940.12
55_V144_V0.5930.12
174_Y203_L0.5920.12
201_E254_N0.5900.12
68_N220_I0.5890.12
52_G117_L0.5880.12
207_N259_E0.5860.12
117_L211_S0.5860.12
88_Q126_V0.5850.12
127_L136_V0.5850.12
46_T220_I0.5840.12
84_A230_T0.5830.12
7_R17_V0.5810.12
101_L235_R0.5800.12
69_Y246_Y0.5760.11
254_N258_R0.5710.11
65_N82_L0.5710.11
82_L117_L0.5700.11
47_T71_T0.5700.11
30_M196_D0.5680.11
62_A217_Y0.5680.11
50_W77_Q0.5670.11
87_P135_F0.5670.11
73_I143_D0.5660.11
66_S223_F0.5650.11
20_K24_S0.5640.11
83_L248_L0.5630.11
138_G199_K0.5580.11
69_Y175_G0.5550.11
167_V173_V0.5550.11
139_V226_F0.5510.11
181_K246_Y0.5490.11
18_I25_M0.5470.11
77_Q131_S0.5450.11
62_A225_P0.5450.11
127_L130_I0.5450.11
237_L245_F0.5440.11
25_M240_V0.5440.11
33_L104_Q0.5440.11
232_F247_S0.5440.11
54_P77_Q0.5420.11
189_F231_K0.5410.11
153_E196_D0.5400.11
40_D95_D0.5380.11
70_A217_Y0.5380.11
43_I180_K0.5380.11
110_L196_D0.5370.11
13_Q28_I0.5360.11
7_R68_N0.5350.11
29_S251_V0.5350.11
211_S223_F0.5330.11
212_P249_Y0.5330.11
118_D206_Y0.5310.11
42_S191_R0.5310.11
148_E251_V0.5290.11
7_R61_S0.5280.11
215_T233_I0.5230.11
148_E183_K0.5220.11
96_E219_N0.5220.11
58_L244_I0.5210.11
78_N245_F0.5200.11
123_T230_T0.5200.11
65_N177_E0.5180.11
27_R56_E0.5180.11
252_F255_V0.5170.11
228_S240_V0.5170.11
260_E264_L0.5160.11
242_A259_E0.5150.11
63_K95_D0.5150.11
11_E172_L0.5140.11
26_R217_Y0.5120.10
13_Q158_S0.5090.10
20_K38_E0.5090.10
136_V206_Y0.5060.10
51_Y69_Y0.5050.10
201_E204_K0.5030.10
164_E172_L0.5010.10
10_V77_Q0.5000.10
55_V112_V0.5000.10
110_L119_A0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9158 99.2 0.845 Contact Map
4xb4A 1 0.3333 8.4 0.971 Contact Map
3flkA 3 0.1987 7.5 0.972 Contact Map
2vxzA 1 0.3737 7.2 0.972 Contact Map
2ia0A 2 0.404 6.8 0.972 Contact Map
1cxqA 2 0.4613 6.4 0.972 Contact Map
4mq3A 1 0.4141 5.6 0.973 Contact Map
3c57A 2 0.0774 5.1 0.974 Contact Map
1je8A 2 0.1145 5 0.974 Contact Map
2rnjA 1 0.1178 5 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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