GREMLIN Database
Q97Y59 - Transposon ISC1190
UniProt: Q97Y59 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (308)
Sequences: 4572 (3476)
Seq/√Len: 198.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_A99_V4.2731.00
125_I176_E3.0861.00
195_L311_P2.6631.00
18_Y92_A2.6591.00
163_S185_E2.6131.00
226_F299_A2.5751.00
167_F178_R2.4931.00
170_D178_R2.4471.00
281_H284_N2.4281.00
76_L95_L2.3601.00
124_S127_R2.2501.00
47_A95_L2.1791.00
230_C256_L2.1651.00
214_V226_F2.1171.00
118_W122_T2.1061.00
46_V66_Y2.0981.00
210_I302_T2.0581.00
78_K81_D2.0291.00
275_K279_E2.0251.00
221_G225_R1.9901.00
87_S236_V1.9851.00
296_R300_V1.9851.00
198_T311_P1.9741.00
125_I179_K1.9661.00
248_I292_T1.9381.00
118_W183_E1.9201.00
174_R178_R1.9081.00
124_S131_R1.8831.00
146_S149_N1.8721.00
14_K25_E1.8581.00
195_L305_V1.8561.00
238_S243_V1.8411.00
222_D225_R1.8221.00
8_I36_V1.8121.00
149_N152_E1.7921.00
171_E178_R1.7871.00
126_V130_N1.7871.00
202_I207_G1.7841.00
286_K289_K1.7721.00
171_E174_R1.7621.00
8_I15_L1.7411.00
6_A19_F1.7351.00
220_F229_Y1.7291.00
119_D258_R1.7111.00
199_I302_T1.7001.00
185_E188_D1.6971.00
310_K313_D1.6941.00
124_S171_E1.6921.00
45_K69_R1.6761.00
125_I172_L1.6721.00
121_I179_K1.6701.00
116_S213_R1.6621.00
230_C299_A1.6591.00
132_L172_L1.6281.00
196_I302_T1.6051.00
48_I68_V1.5901.00
232_L295_A1.5841.00
305_V311_P1.5671.00
97_E101_S1.5591.00
77_K80_K1.5471.00
17_V36_V1.5331.00
304_A308_Y1.5301.00
280_E284_N1.5281.00
150_L153_V1.5201.00
143_D153_V1.5141.00
206_L259_A1.5121.00
209_I259_A1.4901.00
274_I301_I1.4651.00
122_T125_I1.4551.00
197_F204_R1.4511.00
11_S16_V1.4471.00
8_I58_L1.4451.00
60_K109_S1.4361.00
146_S157_E1.4351.00
29_N32_G1.4241.00
195_L198_T1.4211.00
274_I294_C1.4181.00
190_V197_F1.4121.00
13_D241_K1.4001.00
180_R183_E1.3981.00
285_L289_K1.3971.00
153_V156_G1.3951.00
132_L165_V1.3941.00
262_L265_L1.3841.00
183_E186_L1.3791.00
143_D146_S1.3761.00
146_S153_V1.3761.00
199_I305_V1.3741.00
149_N153_V1.3701.00
153_V157_E1.3631.00
277_F297_K1.3611.00
151_N155_R1.3581.00
145_L153_V1.3571.00
61_Y64_K1.3551.00
16_V25_E1.3521.00
268_I278_Y1.3511.00
278_Y294_C1.3451.00
85_K236_V1.3391.00
145_L149_N1.3391.00
18_Y93_K1.3301.00
48_I59_A1.3301.00
146_S151_N1.3291.00
122_T179_K1.3281.00
170_D174_R1.3211.00
146_S156_G1.3181.00
279_E283_G1.3091.00
264_A295_A1.3051.00
150_L157_E1.3021.00
119_D255_V1.2951.00
264_A298_L1.2941.00
154_L157_E1.2941.00
24_Y39_V1.2921.00
172_L176_E1.2791.00
167_F181_E1.2711.00
170_D177_V1.2641.00
147_K151_N1.2611.00
118_W205_T1.2441.00
278_Y290_L1.2291.00
124_S128_V1.2281.00
125_I129_K1.2261.00
227_V233_D1.2221.00
188_D192_K1.2211.00
146_S155_R1.2161.00
264_A294_C1.2161.00
303_W307_Y1.2061.00
146_S150_L1.1841.00
149_N156_G1.1841.00
47_A71_I1.1821.00
40_L46_V1.1811.00
227_V296_R1.1761.00
8_I17_V1.1751.00
128_V131_R1.1691.00
261_Y295_A1.1611.00
11_S14_K1.1551.00
258_R262_L1.1541.00
149_N154_L1.1491.00
202_I206_L1.1341.00
272_P276_R1.1321.00
213_R253_D1.1311.00
206_L263_A1.1271.00
169_L173_E1.1231.00
7_G96_A1.1221.00
199_I298_L1.1111.00
117_Q121_I1.1071.00
282_K287_G1.1061.00
27_Q32_G1.1021.00
149_N157_E1.1001.00
118_W179_K1.0991.00
120_F131_R1.0971.00
145_L154_L1.0971.00
146_S152_E1.0961.00
187_E204_R1.0951.00
143_D149_N1.0921.00
145_L150_L1.0911.00
196_I207_G1.0891.00
282_K290_L1.0861.00
150_L156_G1.0851.00
202_I302_T1.0721.00
33_F57_N1.0651.00
123_R127_R1.0621.00
248_I257_R1.0581.00
16_V23_Y1.0551.00
10_V15_L1.0541.00
33_F61_Y1.0521.00
23_Y93_K1.0501.00
146_S154_L1.0481.00
45_K67_D1.0471.00
145_L152_E1.0421.00
183_E187_E1.0401.00
304_A307_Y1.0371.00
263_A298_L1.0361.00
261_Y292_T1.0251.00
74_L78_K1.0181.00
174_R177_V1.0171.00
115_T255_V1.0161.00
127_R130_N1.0131.00
37_K61_Y1.0071.00
305_V310_K0.9931.00
281_H290_L0.9921.00
71_I76_L0.9911.00
80_K94_K0.9911.00
12_K137_I0.9901.00
6_A46_V0.9861.00
26_F32_G0.9821.00
277_F281_H0.9750.99
277_F293_A0.9710.99
6_A17_V0.9670.99
301_I305_V0.9650.99
148_K152_E0.9630.99
46_V62_L0.9630.99
5_V99_V0.9590.99
178_R181_E0.9580.99
6_A40_L0.9570.99
151_N154_L0.9530.99
26_F39_V0.9530.99
147_K150_L0.9510.99
277_F294_C0.9510.99
143_D147_K0.9410.99
114_L182_I0.9410.99
261_Y265_L0.9390.99
17_V39_V0.9330.99
93_K97_E0.9320.99
148_K151_N0.9290.99
176_E180_R0.9240.99
86_K91_D0.9230.99
264_A291_I0.9190.99
105_E108_T0.9160.99
145_L148_K0.9130.99
196_I306_L0.9120.99
145_L156_G0.9010.99
128_V132_L0.8960.99
152_E156_G0.8880.99
38_Q41_P0.8800.99
250_R257_R0.8790.99
147_K154_L0.8780.99
143_D156_G0.8710.99
150_L154_L0.8630.99
158_D161_V0.8600.99
281_H285_L0.8580.99
260_F299_A0.8550.99
148_K155_R0.8510.99
167_F185_E0.8500.99
32_G35_G0.8490.99
55_H70_I0.8480.99
145_L155_R0.8460.99
59_A68_V0.8420.98
214_V217_V0.8400.98
265_L268_I0.8380.98
59_A70_I0.8350.98
115_T186_L0.8340.98
176_E179_K0.8330.98
5_V100_I0.8330.98
84_G228_A0.8330.98
69_R99_V0.8310.98
122_T126_V0.8250.98
217_V306_L0.8180.98
112_K213_R0.8180.98
128_V172_L0.8120.98
185_E189_L0.8080.98
150_L155_R0.8040.98
73_P213_R0.8020.98
129_K172_L0.8010.98
239_S243_V0.7960.98
144_S149_N0.7950.98
160_I163_S0.7950.98
167_F171_E0.7900.98
277_F280_E0.7850.98
202_I298_L0.7800.98
115_T208_C0.7780.97
16_V89_K0.7770.97
121_I182_I0.7760.97
292_T295_A0.7750.97
95_L98_L0.7740.97
143_D157_E0.7740.97
117_Q167_F0.7740.97
143_D151_N0.7730.97
144_S157_E0.7680.97
11_S15_L0.7670.97
10_V48_I0.7650.97
50_S73_P0.7650.97
159_N185_E0.7640.97
281_H286_K0.7620.97
147_K153_V0.7620.97
274_I298_L0.7610.97
143_D152_E0.7570.97
238_S244_V0.7570.97
177_V181_E0.7550.97
15_L28_N0.7530.97
288_K291_I0.7510.97
144_S155_R0.7510.97
229_Y253_D0.7490.97
265_L288_K0.7470.97
45_K99_V0.7440.97
147_K155_R0.7430.97
40_L62_L0.7430.97
51_T54_Y0.7420.97
261_Y288_K0.7410.97
213_R255_V0.7400.97
115_T209_I0.7380.97
272_P275_K0.7370.96
117_Q164_E0.7350.96
187_E191_P0.7340.96
31_Q35_G0.7290.96
225_R228_A0.7290.96
132_L169_L0.7220.96
71_I98_L0.7210.96
302_T305_V0.7210.96
193_D211_L0.7170.96
84_G251_R0.7170.96
265_L295_A0.7170.96
107_T192_K0.7160.96
105_E109_S0.7140.96
36_V40_L0.7140.96
233_D250_R0.7100.96
15_L26_F0.7090.96
233_D249_S0.7070.96
286_K290_L0.7060.96
197_F207_G0.7060.96
144_S150_L0.7050.95
195_L309_N0.7050.95
145_L157_E0.6990.95
175_L179_K0.6980.95
144_S147_K0.6970.95
110_E158_D0.6970.95
72_N75_I0.6940.95
262_L288_K0.6940.95
280_E283_G0.6930.95
37_K41_P0.6870.95
175_L178_R0.6860.95
128_V171_E0.6840.95
151_N156_G0.6830.95
268_I282_K0.6810.95
17_V26_F0.6810.95
152_E157_E0.6790.94
276_R280_E0.6780.94
15_L58_L0.6760.94
267_A274_I0.6750.94
222_D303_W0.6740.94
117_Q182_I0.6720.94
98_L102_M0.6720.94
190_V208_C0.6680.94
168_L171_E0.6660.94
7_G92_A0.6660.94
273_I312_F0.6650.94
235_L249_S0.6630.94
210_I256_L0.6620.94
43_G67_D0.6610.94
143_D154_L0.6600.94
88_D239_S0.6590.94
166_R170_D0.6580.94
162_L166_R0.6560.93
128_V175_L0.6540.93
131_R168_L0.6510.93
6_A44_C0.6510.93
119_D123_R0.6500.93
233_D236_V0.6490.93
199_I202_I0.6480.93
30_K34_E0.6470.93
160_I185_E0.6470.93
177_V180_R0.6450.93
85_K90_N0.6440.93
122_T183_E0.6410.93
252_G257_R0.6410.93
43_G66_Y0.6400.93
216_D219_R0.6390.93
50_S70_I0.6380.92
144_S148_K0.6360.92
109_S113_E0.6360.92
236_V243_V0.6350.92
115_T212_A0.6330.92
32_G39_V0.6330.92
37_K66_Y0.6290.92
289_K293_A0.6280.92
281_H293_A0.6280.92
53_I137_I0.6270.92
111_A186_L0.6260.92
79_F98_L0.6240.92
128_V168_L0.6210.91
131_R134_R0.6150.91
120_F124_S0.6150.91
76_L98_L0.6120.91
32_G36_V0.6100.91
10_V54_Y0.6090.91
144_S156_G0.6090.91
278_Y282_K0.6090.91
270_V275_K0.6090.91
130_N134_R0.6070.90
214_V230_C0.6060.90
147_K157_E0.6050.90
18_Y23_Y0.6040.90
265_L291_I0.6040.90
107_T110_E0.6020.90
147_K152_E0.6020.90
74_L251_R0.6000.90
262_L266_T0.5980.90
34_E38_Q0.5960.90
202_I210_I0.5930.89
268_I291_I0.5920.89
6_A62_L0.5910.89
113_E161_V0.5870.89
120_F164_E0.5850.89
172_L175_L0.5850.89
28_N33_F0.5820.89
260_F295_A0.5800.88
62_L298_L0.5780.88
77_K81_D0.5770.88
209_I213_R0.5760.88
300_V303_W0.5760.88
116_S255_V0.5750.88
181_E185_E0.5750.88
18_Y96_A0.5750.88
144_S154_L0.5710.88
233_D257_R0.5680.87
116_S253_D0.5670.87
258_R261_Y0.5670.87
35_G38_Q0.5660.87
114_L185_E0.5660.87
11_S240_G0.5660.87
33_F39_V0.5660.87
7_G62_L0.5650.87
265_L269_K0.5640.87
173_E176_E0.5610.87
163_S174_R0.5610.87
48_I95_L0.5580.86
51_T55_H0.5560.86
145_L151_N0.5550.86
190_V193_D0.5540.86
248_I252_G0.5540.86
268_I294_C0.5530.86
31_Q39_V0.5520.86
79_F101_S0.5510.86
25_E28_N0.5500.86
90_N94_K0.5500.86
184_E188_D0.5480.85
48_I70_I0.5480.85
163_S166_R0.5480.85
217_V303_W0.5480.85
223_K303_W0.5460.85
58_L62_L0.5460.85
76_L94_K0.5460.85
271_N275_K0.5450.85
259_A263_A0.5440.85
237_E246_R0.5430.85
167_F170_D0.5430.85
276_R279_E0.5420.85
121_I175_L0.5420.85
17_V40_L0.5410.85
111_A189_L0.5380.84
227_V300_V0.5370.84
173_E177_V0.5350.84
119_D209_I0.5350.84
224_K296_R0.5350.84
143_D150_L0.5320.84
215_G219_R0.5320.84
232_L296_R0.5310.84
16_V239_S0.5300.84
189_L192_K0.5290.83
223_K300_V0.5290.83
117_Q128_V0.5280.83
202_I263_A0.5280.83
228_A233_D0.5240.83
125_I175_L0.5230.83
267_A298_L0.5230.83
266_T270_V0.5210.82
97_E100_I0.5200.82
111_A193_D0.5200.82
120_F127_R0.5190.82
87_S238_S0.5180.82
114_L118_W0.5160.82
143_D155_R0.5120.81
41_P66_Y0.5090.81
235_L246_R0.5090.81
279_E282_K0.5090.81
183_E205_T0.5080.81
144_S153_V0.5070.81
74_L84_G0.5040.80
190_V207_G0.5030.80
218_K307_Y0.5010.80
209_I255_V0.5000.80
271_N301_I0.5000.80
186_L190_V0.5000.80
186_L208_C0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ep4A 2 0.3418 89 0.939 Contact Map
1hjrA 2 0.3323 88.6 0.939 Contact Map
3c1yA 5 0.7627 86.9 0.941 Contact Map
3fhfA 1 0.6203 85 0.942 Contact Map
1pu6A 1 0.6076 84.8 0.942 Contact Map
1keaA 2 0.6266 83.4 0.943 Contact Map
1nu0A 1 0.3133 83 0.944 Contact Map
2a1jB 2 0.2437 79.4 0.946 Contact Map
4b21A 2 0.5918 78.2 0.946 Contact Map
2duyA 1 0.2057 78.1 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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