GREMLIN Database
Q97Y57 - Transposase ISC1058
UniProt: Q97Y57 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (256)
Sequences: 312 (185)
Seq/√Len: 11.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_M27_F4.5661.00
41_N46_T3.5360.98
170_T195_V3.4580.98
240_G243_W3.3170.97
17_V20_R2.8680.94
248_L251_A2.7040.92
14_D89_Y2.6930.91
10_W13_Y2.6070.90
252_V260_V2.5390.89
239_Y246_E2.4930.88
156_N200_V2.3410.84
213_K216_L2.2840.83
17_V21_Y2.2480.82
88_D91_T2.2260.81
140_F144_E2.1630.79
202_V221_A2.1630.79
191_D207_K2.1450.78
239_Y242_R2.1190.77
121_T139_K2.0180.74
43_N46_T2.0040.73
51_P54_F1.9670.72
114_A174_L1.9600.72
63_I83_I1.9540.71
242_R246_E1.9470.71
243_W249_F1.9420.71
95_R233_W1.9130.70
65_L193_N1.9020.69
191_D218_R1.8930.69
145_I249_F1.8930.69
58_L74_L1.8640.68
130_A135_T1.8190.66
90_S232_R1.8010.65
218_R233_W1.7880.64
159_V260_V1.7840.64
69_A160_T1.7700.63
119_I159_V1.7520.63
123_T126_Q1.7420.62
206_P210_A1.7400.62
81_K143_I1.6870.59
147_M245_V1.6740.59
169_K172_K1.6660.58
95_R218_R1.6580.58
197_K252_V1.6570.58
92_I185_Y1.6310.57
229_G233_W1.6270.57
146_V150_N1.5790.54
119_I260_V1.5760.54
195_V213_K1.5600.53
161_S245_V1.5580.53
127_Y140_F1.5470.53
15_E19_T1.5470.53
24_M29_V1.5440.53
188_K207_K1.5260.52
122_N139_K1.5220.51
124_G240_G1.5180.51
41_N47_K1.5170.51
113_I149_N1.5150.51
6_Y114_A1.5130.51
246_E253_K1.5010.50
231_D234_K1.4800.49
88_D202_V1.4730.49
55_N95_R1.4650.49
29_V57_F1.4590.48
163_E225_F1.4450.48
125_G181_V1.4210.46
25_F61_L1.4190.46
159_V252_V1.4170.46
114_A139_K1.3920.45
18_I75_R1.3750.44
65_L149_N1.3750.44
5_K155_I1.3460.43
134_K259_S1.3350.42
247_S250_S1.3200.42
242_R253_K1.3200.42
127_Y144_E1.3070.41
144_E160_T1.3000.41
186_G190_Y1.2710.39
244_R248_L1.2540.38
244_R247_S1.2510.38
252_V256_F1.2510.38
66_P69_A1.2480.38
26_P29_V1.2430.38
101_I106_T1.2280.37
234_K252_V1.2070.36
52_K55_N1.1990.36
111_E249_F1.1940.36
111_E149_N1.1930.36
124_G128_I1.1920.36
192_A195_V1.1870.35
73_V210_A1.1870.35
248_L256_F1.1850.35
93_W145_I1.1830.35
185_Y203_V1.1810.35
120_S132_W1.1710.35
208_K211_S1.1710.35
46_T250_S1.1650.34
12_K31_E1.1630.34
77_L102_T1.1620.34
144_E166_S1.1600.34
122_N136_R1.1580.34
112_V155_I1.1580.34
152_F251_A1.1560.34
119_I251_A1.1550.34
77_L155_I1.1460.34
42_R46_T1.1370.33
67_Y80_L1.1360.33
11_S15_E1.1240.33
28_Y200_V1.1220.33
132_W140_F1.1190.32
17_V191_D1.1170.32
71_E89_Y1.1020.32
56_E104_P1.1010.32
142_K166_S1.1000.32
57_F260_V1.0970.31
130_A136_R1.0900.31
184_F200_V1.0900.31
125_G207_K1.0860.31
22_K51_P1.0820.31
13_Y115_D1.0770.31
19_T90_S1.0760.31
234_K240_G1.0620.30
50_A121_T1.0540.30
5_K14_D1.0530.30
199_G224_E1.0510.30
231_D237_K1.0510.30
23_L108_D1.0500.29
51_P59_A1.0430.29
70_I73_V1.0380.29
99_M241_V1.0350.29
11_S29_V1.0250.28
52_K95_R1.0160.28
152_F248_L1.0110.28
148_D189_A1.0090.28
140_F205_P1.0080.28
139_K162_N1.0070.28
86_S133_G1.0060.28
94_E160_T1.0010.28
90_S164_V0.9980.27
47_K196_Y0.9870.27
184_F195_V0.9860.27
137_D141_L0.9840.27
33_W54_F0.9840.27
26_P30_F0.9800.27
83_I117_T0.9770.27
111_E124_G0.9730.26
114_A170_T0.9700.26
8_R18_I0.9700.26
213_K249_F0.9680.26
161_S164_V0.9570.26
239_Y253_K0.9560.26
24_M206_P0.9550.26
83_I154_V0.9540.26
12_K216_L0.9420.25
120_S126_Q0.9270.25
187_D190_Y0.9220.25
56_E96_V0.9210.24
93_W214_R0.9140.24
45_R144_E0.9130.24
184_F202_V0.9110.24
61_L136_R0.9090.24
90_S207_K0.9050.24
13_Y17_V0.8980.24
45_R55_N0.8950.24
32_H36_L0.8930.23
170_T249_F0.8900.23
72_G95_R0.8890.23
20_R33_W0.8860.23
73_V97_R0.8810.23
92_I212_T0.8790.23
62_H202_V0.8770.23
128_I234_K0.8770.23
102_T235_E0.8730.23
74_L261_R0.8660.23
92_I175_Q0.8660.23
116_A166_S0.8650.22
16_N62_H0.8630.22
71_E75_R0.8600.22
167_A259_S0.8590.22
81_K197_K0.8550.22
174_L262_Q0.8510.22
89_Y180_K0.8490.22
128_I135_T0.8480.22
13_Y20_R0.8460.22
175_Q194_E0.8450.22
76_A127_Y0.8410.22
49_K154_V0.8390.22
44_A165_E0.8370.22
109_E160_T0.8320.21
15_E91_T0.8290.21
18_I71_E0.8260.21
72_G206_P0.8260.21
145_I183_K0.8250.21
224_E236_E0.8200.21
109_E180_K0.8190.21
100_N202_V0.8150.21
165_E168_V0.8090.21
236_E240_G0.8090.21
80_L124_G0.8050.20
95_R191_D0.8010.20
99_M107_S0.7990.20
115_D131_K0.7980.20
206_P221_A0.7970.20
145_I189_A0.7940.20
141_L251_A0.7920.20
72_G126_Q0.7910.20
123_T251_A0.7890.20
153_N165_E0.7890.20
181_V256_F0.7870.20
35_D259_S0.7870.20
128_I244_R0.7850.20
131_K144_E0.7790.20
92_I227_K0.7780.20
94_E177_K0.7730.19
152_F256_F0.7730.19
19_T197_K0.7720.19
251_A260_V0.7710.19
59_A67_Y0.7650.19
206_P218_R0.7640.19
151_E240_G0.7560.19
212_T222_V0.7560.19
25_F220_K0.7550.19
63_I157_A0.7540.19
8_R58_L0.7530.19
136_R202_V0.7530.19
146_V162_N0.7490.19
129_V135_T0.7470.19
168_V221_A0.7460.19
241_V247_S0.7450.19
72_G125_G0.7420.19
213_K240_G0.7410.19
100_N163_E0.7410.19
81_K255_T0.7340.18
33_W218_R0.7330.18
16_N32_H0.7320.18
86_S230_Y0.7300.18
93_W111_E0.7290.18
116_A144_E0.7280.18
26_P56_E0.7250.18
72_G144_E0.7250.18
206_P251_A0.7230.18
73_V206_P0.7210.18
29_V32_H0.7200.18
200_V244_R0.7190.18
11_S19_T0.7160.18
156_N173_D0.7140.18
166_S187_D0.7130.18
52_K145_I0.7120.18
136_R240_G0.7110.18
135_T208_K0.7070.18
28_Y58_L0.7070.18
66_P262_Q0.7060.17
115_D190_Y0.7040.17
148_D243_W0.7030.17
148_D207_K0.7010.17
247_S251_A0.6920.17
223_R226_R0.6900.17
115_D118_G0.6890.17
162_N208_K0.6870.17
227_K264_L0.6840.17
19_T30_F0.6830.17
45_R218_R0.6770.17
82_I92_I0.6750.17
29_V258_E0.6750.17
30_F92_I0.6680.16
15_E25_F0.6620.16
116_A160_T0.6610.16
107_S262_Q0.6610.16
15_E200_V0.6600.16
172_K208_K0.6590.16
72_G88_D0.6590.16
242_R257_G0.6590.16
153_N158_E0.6570.16
61_L167_A0.6550.16
143_I206_P0.6530.16
251_A256_F0.6500.16
175_Q180_K0.6500.16
123_T249_F0.6470.16
99_M134_K0.6460.16
128_I185_Y0.6450.16
90_S150_N0.6440.16
123_T154_V0.6410.16
85_T89_Y0.6410.16
48_Y90_S0.6390.16
9_D21_Y0.6370.16
58_L248_L0.6360.16
55_N126_Q0.6350.16
253_K262_Q0.6340.16
17_V187_D0.6330.16
7_K11_S0.6330.16
134_K138_S0.6300.15
130_A213_K0.6270.15
41_N202_V0.6250.15
128_I216_L0.6240.15
148_D203_V0.6170.15
114_A161_S0.6170.15
167_A262_Q0.6150.15
46_T127_Y0.6120.15
65_L174_L0.6110.15
28_Y100_N0.6090.15
140_F190_Y0.6070.15
9_D13_Y0.6070.15
106_T230_Y0.6060.15
62_H145_I0.6060.15
23_L168_V0.6060.15
185_Y216_L0.6050.15
132_W195_V0.6040.15
176_D263_V0.6000.15
31_E34_W0.6000.15
123_T132_W0.5930.15
67_Y250_S0.5930.15
12_K100_N0.5920.14
245_V259_S0.5920.14
138_S233_W0.5910.14
149_N189_A0.5890.14
49_K152_F0.5870.14
187_D204_V0.5870.14
193_N219_R0.5870.14
120_S247_S0.5840.14
66_P238_G0.5820.14
154_V235_E0.5790.14
133_G141_L0.5780.14
99_M145_I0.5780.14
257_G262_Q0.5780.14
232_R240_G0.5770.14
35_D47_K0.5770.14
33_W229_G0.5730.14
119_I261_R0.5710.14
30_F34_W0.5670.14
248_L255_T0.5670.14
253_K257_G0.5660.14
76_A95_R0.5650.14
95_R126_Q0.5650.14
65_L73_V0.5640.14
66_P99_M0.5630.14
92_I194_E0.5630.14
33_W95_R0.5630.14
143_I159_V0.5620.14
117_T245_V0.5610.14
72_G112_V0.5610.14
61_L65_L0.5600.14
19_T22_K0.5600.14
113_I185_Y0.5580.14
47_K169_K0.5550.14
56_E90_S0.5540.14
25_F264_L0.5530.14
45_R95_R0.5530.14
24_M33_W0.5530.14
59_A96_V0.5520.14
10_W133_G0.5510.14
206_P260_V0.5460.13
20_R218_R0.5440.13
8_R37_L0.5430.13
121_T127_Y0.5400.13
67_Y93_W0.5390.13
35_D92_I0.5380.13
198_T207_K0.5380.13
62_H249_F0.5380.13
14_D32_H0.5360.13
110_L186_G0.5330.13
25_F34_W0.5330.13
47_K183_K0.5320.13
21_Y45_R0.5300.13
16_N117_T0.5300.13
205_P260_V0.5270.13
62_H219_R0.5260.13
86_S141_L0.5230.13
158_E165_E0.5220.13
11_S25_F0.5210.13
100_N117_T0.5210.13
8_R215_H0.5200.13
108_D199_G0.5200.13
92_I161_S0.5180.13
16_N162_N0.5160.13
55_N140_F0.5150.13
123_T141_L0.5140.13
104_P222_V0.5100.13
228_L232_R0.5090.13
231_D236_E0.5090.13
19_T37_L0.5080.13
14_D90_S0.5070.13
58_L92_I0.5050.12
112_V126_Q0.5040.12
72_G140_F0.5010.12
159_V224_E0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8689 92 0.943 Contact Map
4fcyA 4 0.8801 71.7 0.956 Contact Map
4fw1A 2 0.4419 46.2 0.962 Contact Map
4u7bA 2 0.824 32.6 0.965 Contact Map
1bcoA 1 0.5206 30.8 0.966 Contact Map
1cxqA 2 0.4307 30.1 0.966 Contact Map
2gloA 1 0.221 25.2 0.967 Contact Map
3l3uA 2 0.412 16.2 0.97 Contact Map
2cobA 1 0.2584 12.2 0.971 Contact Map
4fw2A 2 0.4195 11.9 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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