GREMLIN Database
Q97Y49 - First ORF in transposon ISC1904
UniProt: Q97Y49 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 111 (97)
Sequences: 480 (298)
Seq/√Len: 30.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_A31_L3.4231.00
9_V70_R3.2281.00
35_V72_V2.8621.00
44_D55_G2.8611.00
56_F79_L2.7061.00
70_R100_K2.6901.00
30_Y74_A2.5380.99
28_V41_V2.2200.99
11_L31_L2.1870.98
64_L97_S2.1080.98
63_I94_L2.0810.98
51_M85_L1.9930.97
11_L104_Q1.9610.97
40_Q62_M1.8980.96
42_I55_G1.8850.96
91_S95_R1.8060.95
49_L82_L1.6940.93
80_V84_N1.6690.92
94_L99_T1.6110.91
84_N103_G1.6060.91
28_V43_S1.5550.89
72_V102_E1.5530.89
59_L68_V1.4960.87
34_Q39_D1.4870.87
8_K62_M1.4860.87
63_I71_V1.4700.86
51_M80_V1.4290.85
34_Q38_Y1.4190.84
84_N101_P1.3490.81
72_V85_L1.3270.80
25_V29_K1.3150.79
61_R96_N1.2460.75
63_I68_V1.2080.73
62_M67_E1.2040.73
38_Y102_E1.1790.71
11_L41_V1.1790.71
9_V72_V1.1360.68
49_L83_R1.1270.68
11_L35_V1.1250.67
23_E74_A1.0840.65
53_R80_V1.0580.63
10_I59_L1.0540.62
31_L104_Q1.0420.61
10_I28_V1.0390.61
80_V90_Q1.0340.61
7_R65_N1.0260.60
60_L64_L1.0130.59
44_D74_A1.0070.59
36_K39_D0.9900.57
37_E72_V0.9890.57
29_K32_E0.9780.56
7_R99_T0.9780.56
63_I73_V0.9760.56
73_V100_K0.9690.56
12_Y15_V0.9650.55
9_V100_K0.9280.53
48_G79_L0.9120.51
56_F80_V0.9120.51
63_I99_T0.8830.49
84_N90_Q0.8710.48
9_V40_Q0.8520.46
26_N29_K0.8510.46
10_I68_V0.8380.45
20_Q23_E0.8260.44
19_T74_A0.8210.44
29_K33_E0.8180.44
30_Y105_N0.8110.43
34_Q102_E0.7980.42
60_L89_V0.7790.41
56_F89_V0.7760.41
11_L89_V0.7720.40
23_E26_N0.7710.40
61_R92_T0.7690.40
22_D58_K0.7630.40
93_Q97_S0.7580.39
30_Y44_D0.7460.38
48_G56_F0.7370.38
70_R102_E0.7340.37
18_S66_N0.7300.37
25_V28_V0.7270.37
16_P20_Q0.7210.36
17_S42_I0.7120.36
35_V39_D0.7030.35
15_V20_Q0.7010.35
17_S26_N0.7000.35
34_Q70_R0.6950.34
20_Q54_K0.6860.34
8_K40_Q0.6830.34
64_L89_V0.6750.33
54_K97_S0.6720.33
35_V74_A0.6680.33
76_P85_L0.6670.32
71_V101_P0.6660.32
72_V92_T0.6650.32
42_I59_L0.6550.32
25_V33_E0.6510.31
25_V41_V0.6450.31
32_E59_L0.6400.31
11_L105_N0.6370.30
57_L92_T0.6350.30
76_P103_G0.6310.30
18_S21_K0.6260.30
16_P82_L0.6250.30
11_L53_R0.6240.30
46_G100_K0.6240.30
19_T75_Y0.6230.29
91_S101_P0.6230.29
42_I71_V0.6210.29
45_I53_R0.6170.29
80_V89_V0.6170.29
55_G73_V0.6150.29
31_L99_T0.6130.29
18_S48_G0.6080.28
49_L89_V0.6080.28
9_V46_G0.5940.28
64_L93_Q0.5870.27
26_N56_F0.5840.27
18_S45_I0.5790.27
27_Q78_R0.5730.26
54_K69_S0.5690.26
17_S46_G0.5690.26
17_S54_K0.5570.25
9_V69_S0.5500.25
76_P100_K0.5460.25
32_E41_V0.5450.25
33_E37_E0.5410.24
17_S20_Q0.5360.24
23_E49_L0.5350.24
8_K95_R0.5340.24
53_R74_A0.5290.24
30_Y106_T0.5280.24
90_Q94_L0.5260.23
37_E76_P0.5260.23
44_D101_P0.5230.23
10_I39_D0.5220.23
19_T22_D0.5150.23
33_E65_N0.5150.23
18_S92_T0.5140.23
41_V64_L0.5140.23
43_S95_R0.5120.23
92_T104_Q0.5070.22
17_S73_V0.5060.22
50_N97_S0.5060.22
93_Q105_N0.5030.22
84_N91_S0.5020.22
52_K97_S0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lhkA 2 0.9279 99.9 0.53 Contact Map
3ilxA 2 0.9099 99.8 0.551 Contact Map
3bvpA 4 0.9459 99.8 0.58 Contact Map
2mhcA 1 0.991 99.8 0.582 Contact Map
3guvA 2 0.9279 99.8 0.587 Contact Map
3g13A 2 0.955 99.8 0.589 Contact Map
4bqqA 2 0.9099 99.7 0.604 Contact Map
2gm5A 4 0.8468 99.7 0.628 Contact Map
3pkzA 4 0.8559 99.7 0.63 Contact Map
1gdtA 2 0.9009 99.6 0.643 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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