GREMLIN Database
Q97Y48 - Second ORF in transposon ISC1904
UniProt: Q97Y48 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 400 (343)
Sequences: 4512 (2881)
Seq/√Len: 155.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
263_D267_K5.3561.00
287_D290_G4.3811.00
339_P366_N4.3001.00
319_A326_V3.6571.00
282_A375_M3.0821.00
205_L311_I3.0231.00
283_V315_L2.9731.00
19_F321_L2.9481.00
312_H328_E2.9461.00
346_R349_G2.8301.00
310_S314_V2.7101.00
270_N274_D2.6791.00
336_R345_S2.4681.00
310_S313_R2.4591.00
333_F336_R2.4371.00
172_P181_L2.4121.00
311_I315_L2.3781.00
337_S344_V2.3431.00
316_R328_E2.3361.00
273_L319_A2.3201.00
225_K301_R2.2771.00
329_V371_I2.2181.00
292_F304_S2.1831.00
266_H317_Y2.1541.00
170_G186_K2.1441.00
281_F319_A2.1351.00
334_T371_I2.1171.00
374_K377_G2.1111.00
231_K246_G2.0671.00
341_C357_C2.0421.00
266_H314_V2.0211.00
224_L260_R2.0181.00
296_N300_S2.0061.00
28_R31_S1.9591.00
283_V326_V1.9301.00
205_L264_F1.9241.00
54_K119_K1.9211.00
353_E360_K1.9211.00
36_K179_V1.8881.00
350_K363_R1.8871.00
338_C341_C1.8851.00
49_L96_I1.8721.00
266_H318_K1.8721.00
341_C354_C1.8691.00
269_V314_V1.8621.00
262_L310_S1.8391.00
246_G250_L1.8341.00
297_E300_S1.8201.00
354_C357_C1.8101.00
338_C357_C1.8051.00
316_R320_P1.7821.00
352_F361_L1.7781.00
266_H269_V1.7701.00
265_V314_V1.7481.00
37_E86_H1.7371.00
50_W99_A1.7171.00
340_R359_F1.6991.00
345_S349_G1.6771.00
51_N55_I1.6541.00
265_V310_S1.6521.00
338_C354_C1.6471.00
143_I181_L1.6421.00
35_I179_V1.6421.00
241_K244_K1.6161.00
283_V328_E1.5831.00
244_K247_R1.5731.00
198_I206_D1.5561.00
285_K328_E1.5191.00
284_E331_P1.5181.00
231_K234_K1.5111.00
178_K255_H1.5041.00
44_K83_K1.5021.00
277_P324_S1.4941.00
176_E255_H1.4681.00
207_A365_L1.4601.00
20_T182_S1.4571.00
283_V312_H1.4551.00
269_V317_Y1.4491.00
33_E37_E1.4451.00
352_F359_F1.4441.00
39_R179_V1.4431.00
269_V318_K1.3951.00
316_R326_V1.3861.00
347_K350_K1.3841.00
195_F372_Y1.3751.00
68_P71_R1.3721.00
239_A243_T1.3711.00
67_L71_R1.3701.00
109_R117_I1.3651.00
343_F355_E1.3551.00
49_L99_A1.3531.00
105_S117_I1.3501.00
369_L373_L1.3491.00
208_Y212_K1.3441.00
351_T360_K1.3441.00
32_K36_K1.3421.00
204_T207_A1.3381.00
24_K178_K1.3301.00
100_F104_K1.3231.00
110_A117_I1.3191.00
235_V247_R1.3121.00
144_T150_Y1.3121.00
103_L119_K1.3051.00
196_L208_Y1.2911.00
69_K72_E1.2811.00
133_L146_R1.2751.00
90_H130_K1.2751.00
216_I219_K1.2731.00
255_H259_N1.2691.00
303_I308_W1.2681.00
346_R350_K1.2631.00
228_M250_L1.2381.00
269_V311_I1.2161.00
104_K108_K1.2011.00
265_V311_I1.2001.00
101_S105_S1.1911.00
231_K253_Y1.1861.00
54_K58_R1.1861.00
224_L257_E1.1811.00
196_L276_Y1.1771.00
346_R363_R1.1711.00
90_H132_T1.1591.00
339_P369_L1.1561.00
228_M254_S1.1531.00
347_K363_R1.1511.00
78_R92_V1.1421.00
195_F280_F1.1401.00
271_A275_L1.1371.00
269_V315_L1.1311.00
98_D128_R1.1281.00
273_L322_Y1.1241.00
314_V317_Y1.1241.00
200_S308_W1.1221.00
56_Q60_N1.1050.99
94_K97_N1.1050.99
42_L95_A1.1030.99
145_V174_I1.1010.99
365_L369_L1.0910.99
345_S352_F1.0890.99
287_D331_P1.0870.99
29_E32_K1.0820.99
318_K321_L1.0710.99
109_R118_G1.0690.99
227_S231_K1.0600.99
46_I95_A1.0560.99
232_R236_Q1.0560.99
334_T374_K1.0540.99
198_I208_Y1.0540.99
361_L369_L1.0530.99
288_K309_G1.0520.99
329_V374_K1.0480.99
262_L314_V1.0450.99
88_A91_Y1.0410.99
265_V269_V1.0310.99
337_S374_K1.0300.99
197_A372_Y1.0270.99
137_V140_S1.0220.99
69_K74_Y1.0190.99
21_Y185_Y1.0170.99
105_S110_A1.0160.99
213_F362_D1.0130.99
202_L306_T1.0060.99
339_P361_L1.0040.99
135_K144_T1.0000.99
65_I69_K0.9980.99
106_W119_K0.9980.99
155_W158_S0.9970.99
313_R316_R0.9940.99
235_V250_L0.9930.99
232_R250_L0.9930.99
231_K250_L0.9860.99
55_I59_K0.9860.99
336_R344_V0.9850.99
105_S109_R0.9830.99
273_L324_S0.9830.99
274_D322_Y0.9810.99
127_V130_K0.9800.99
27_K31_S0.9750.99
41_L83_K0.9740.99
127_V131_T0.9720.99
50_W103_L0.9710.99
195_F376_C0.9680.99
74_Y77_L0.9670.99
40_T43_Q0.9670.99
270_N322_Y0.9650.99
207_A213_F0.9640.99
128_R171_E0.9590.99
229_E232_R0.9590.99
200_S312_H0.9580.99
339_P359_F0.9510.98
243_T247_R0.9470.98
273_L281_F0.9450.98
350_K362_D0.9430.98
361_L365_L0.9410.98
105_S108_K0.9360.98
285_K331_P0.9360.98
57_V61_G0.9350.98
296_N299_L0.9310.98
72_E75_K0.9300.98
204_T215_T0.9250.98
329_V375_M0.9200.98
212_K271_A0.9180.98
206_D268_F0.9170.98
258_R262_L0.9160.98
343_F356_R0.9140.98
98_D173_V0.9130.98
192_P277_P0.9120.98
32_K179_V0.9070.98
229_E233_A0.9060.98
339_P367_A0.9050.98
234_K238_F0.9040.98
76_P80_E0.9030.98
231_K249_L0.9000.98
18_Y186_K0.8980.98
349_G363_R0.8960.98
84_I92_V0.8930.98
46_I102_I0.8930.98
282_A371_I0.8930.98
280_F325_F0.8890.98
129_I145_V0.8860.98
70_K74_Y0.8840.98
90_H94_K0.8820.97
228_M257_E0.8790.97
106_W120_P0.8790.97
44_K48_Y0.8790.97
228_M236_Q0.8790.97
365_L368_S0.8780.97
272_L281_F0.8760.97
200_S206_D0.8750.97
54_K103_L0.8740.97
53_T100_F0.8740.97
220_Q260_R0.8700.97
270_N318_K0.8680.97
18_Y184_R0.8670.97
195_F282_A0.8640.97
90_H131_T0.8620.97
196_L209_D0.8620.97
27_K35_I0.8610.97
52_L73_V0.8610.97
94_K128_R0.8610.97
292_F296_N0.8600.97
46_I99_A0.8580.97
352_F363_R0.8570.97
345_S363_R0.8560.97
319_A324_S0.8560.97
253_Y257_E0.8520.97
351_T361_L0.8520.97
339_P373_L0.8510.97
340_R369_L0.8510.97
265_V307_V0.8500.97
58_R61_G0.8460.97
93_D97_N0.8390.97
367_A370_N0.8380.97
256_R260_R0.8340.96
75_K78_R0.8310.96
75_K79_E0.8280.96
214_V264_F0.8270.96
68_P72_E0.8260.96
70_K73_V0.8250.96
235_V246_G0.8240.96
202_L302_K0.8230.96
366_N370_N0.8230.96
94_K98_D0.8150.96
249_L252_K0.8140.96
374_K378_F0.8140.96
230_V234_K0.8070.96
153_F156_S0.8060.96
71_R75_K0.8040.96
331_P334_T0.8040.96
240_S243_T0.8030.96
290_G331_P0.8020.96
236_Q250_L0.8000.96
173_V182_S0.8000.96
288_K308_W0.7990.96
333_F374_K0.7960.95
60_N63_Y0.7910.95
220_Q224_L0.7870.95
232_R254_S0.7850.95
280_F327_K0.7830.95
292_F300_S0.7800.95
194_N210_G0.7780.95
343_F352_F0.7780.95
309_G313_R0.7730.95
203_Y207_A0.7720.95
142_R150_Y0.7710.95
247_R251_R0.7680.94
199_D364_Q0.7670.94
23_I181_L0.7670.94
285_K312_H0.7650.94
286_L331_P0.7610.94
48_Y52_L0.7600.94
57_V103_L0.7560.94
369_L372_Y0.7550.94
268_F271_A0.7510.94
70_K97_N0.7500.94
355_E363_R0.7450.94
204_T213_F0.7450.94
337_S370_N0.7440.93
201_N207_A0.7410.93
65_I68_P0.7400.93
299_L303_I0.7380.93
282_A327_K0.7370.93
96_I100_F0.7350.93
327_K375_M0.7340.93
133_L136_V0.7330.93
87_L90_H0.7310.93
290_G303_I0.7300.93
24_K180_Y0.7260.93
205_L306_T0.7190.92
34_L38_Y0.7190.92
135_K138_G0.7160.92
282_A372_Y0.7160.92
53_T103_L0.7160.92
25_N181_L0.7150.92
68_P74_Y0.7140.92
191_T194_N0.7120.92
264_F268_F0.7120.92
196_L281_F0.7110.92
134_R169_L0.7110.92
73_V96_I0.7110.92
272_L276_Y0.7070.92
90_H93_D0.7050.92
168_E186_K0.7040.91
38_Y42_L0.7040.91
41_L87_L0.7010.91
234_K246_G0.6970.91
297_E304_S0.6950.91
231_K235_V0.6950.91
94_K130_K0.6940.91
29_E33_E0.6930.91
213_F365_L0.6930.91
45_A95_A0.6880.91
345_S350_K0.6830.90
40_T44_K0.6830.90
243_T250_L0.6810.90
361_L366_N0.6800.90
235_V243_T0.6800.90
205_L269_V0.6790.90
103_L107_R0.6770.90
75_K96_I0.6770.90
234_K237_S0.6740.90
333_F337_S0.6730.90
171_E184_R0.6710.89
39_R127_V0.6700.89
216_I306_T0.6690.89
261_V305_L0.6680.89
189_W324_S0.6670.89
137_V144_T0.6670.89
51_N122_V0.6660.89
317_Y321_L0.6660.89
174_I181_L0.6660.89
23_I157_K0.6650.89
257_E305_L0.6640.89
102_I120_P0.6630.89
74_Y78_R0.6630.89
103_L106_W0.6620.89
99_A103_L0.6620.89
41_L44_K0.6610.89
89_S130_K0.6590.89
71_R96_I0.6580.88
349_G352_F0.6580.88
74_Y93_D0.6580.88
92_V95_A0.6570.88
144_T147_P0.6570.88
222_Y302_K0.6540.88
206_D311_I0.6500.88
229_E236_Q0.6490.88
235_V238_F0.6440.87
35_I39_R0.6400.87
228_M232_R0.6400.87
189_W192_P0.6400.87
55_I58_R0.6400.87
128_R173_V0.6370.87
52_L55_I0.6360.87
333_F344_V0.6360.87
95_A99_A0.6360.87
41_L84_I0.6350.87
288_K291_M0.6350.87
314_V318_K0.6330.86
90_H133_L0.6320.86
37_E41_L0.6310.86
337_S342_G0.6310.86
76_P79_E0.6290.86
49_L73_V0.6260.86
347_K362_D0.6250.86
66_T69_K0.6240.86
224_L256_R0.6190.85
319_A322_Y0.6190.85
69_K73_V0.6190.85
26_D154_S0.6180.85
315_L326_V0.6180.85
106_W109_R0.6140.85
371_I374_K0.6140.85
130_K133_L0.6120.85
262_L266_H0.6120.85
274_D280_F0.6110.85
292_F297_E0.6050.84
143_I172_P0.6050.84
153_F157_K0.6030.84
347_K351_T0.6030.84
38_Y88_A0.6010.84
30_K33_E0.5990.83
340_R361_L0.5970.83
107_R110_A0.5950.83
281_F315_L0.5950.83
282_A374_K0.5940.83
233_A236_Q0.5930.83
276_Y281_F0.5920.83
62_N65_I0.5920.83
234_K249_L0.5920.83
373_L378_F0.5910.83
207_A215_T0.5900.82
205_L265_V0.5900.82
332_R336_R0.5900.82
91_Y127_V0.5890.82
238_F246_G0.5860.82
221_L224_L0.5860.82
194_N276_Y0.5860.82
224_L228_M0.5850.82
337_S352_F0.5810.81
71_R74_Y0.5810.81
44_K81_L0.5810.81
222_Y225_K0.5790.81
254_S261_V0.5770.81
244_K248_E0.5770.81
48_Y77_L0.5760.81
70_K77_L0.5750.81
27_K151_I0.5750.81
64_K69_K0.5740.81
96_I99_A0.5740.81
145_V148_Y0.5720.80
87_L92_V0.5720.80
89_S132_T0.5700.80
243_T246_G0.5690.80
48_Y83_K0.5670.80
330_N333_F0.5610.79
208_Y214_V0.5610.79
53_T70_K0.5590.79
224_L253_Y0.5590.79
203_Y350_K0.5560.79
38_Y87_L0.5550.78
22_S182_S0.5540.78
21_Y157_K0.5530.78
56_Q62_N0.5530.78
56_Q61_G0.5530.78
52_L77_L0.5520.78
349_G355_E0.5520.78
108_K117_I0.5510.78
132_T135_K0.5510.78
254_S258_R0.5500.78
73_V93_D0.5470.77
70_K93_D0.5460.77
267_K270_N0.5450.77
27_K32_K0.5450.77
20_T184_R0.5450.77
126_Y129_I0.5440.77
34_L37_E0.5440.77
345_S348_V0.5440.77
73_V77_L0.5430.77
37_E40_T0.5430.77
222_Y301_R0.5430.77
209_D365_L0.5410.77
199_D335_S0.5400.77
38_Y129_I0.5400.77
288_K303_I0.5390.76
202_L293_V0.5370.76
242_H245_R0.5360.76
290_G293_V0.5350.76
61_G64_K0.5340.76
336_R346_R0.5340.76
238_F242_H0.5320.76
203_Y346_R0.5320.76
148_Y151_I0.5310.75
95_A98_D0.5300.75
293_V296_N0.5290.75
74_Y96_I0.5280.75
309_G312_H0.5270.75
146_R151_I0.5260.75
134_R140_S0.5260.75
126_Y130_K0.5240.74
67_L72_E0.5220.74
91_Y129_I0.5220.74
200_S283_V0.5180.74
178_K259_N0.5150.73
259_N263_D0.5150.73
218_L306_T0.5150.73
214_V268_F0.5140.73
312_H316_R0.5140.73
52_L56_Q0.5130.73
220_Q305_L0.5130.73
57_V107_R0.5130.73
22_S262_L0.5130.73
259_N262_L0.5120.73
38_Y41_L0.5110.73
270_N314_V0.5100.72
45_A92_V0.5100.72
299_L302_K0.5090.72
364_Q367_A0.5090.72
145_V151_I0.5080.72
202_L292_F0.5060.72
197_A282_A0.5060.72
66_T97_N0.5060.72
229_E301_R0.5050.72
229_E237_S0.5050.72
333_F352_F0.5040.72
265_V268_F0.5030.71
235_V239_A0.5020.71
18_Y170_G0.5020.71
39_R42_L0.5020.71
37_E87_L0.5010.71
300_S304_S0.5010.71
52_L72_E0.5000.71
341_C344_V0.5000.71
359_F365_L0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.325 95.4 0.93 Contact Map
1vhxA 2 0.345 95.3 0.93 Contact Map
1iv0A 1 0.2425 93 0.937 Contact Map
4aybP 1 0.1 84.8 0.947 Contact Map
1qypA 1 0.1075 81.2 0.949 Contact Map
2k4xA 1 0.1325 79.6 0.95 Contact Map
1ffkW 1 0.1525 79.2 0.95 Contact Map
3j20Y 1 0.12 77.9 0.95 Contact Map
4bbrM 1 0.1625 73.9 0.952 Contact Map
1vq8Z 1 0.1775 73 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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