GREMLIN Database
Q97Y46 - Uncharacterized protein
UniProt: Q97Y46 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (200)
Sequences: 3420 (3175)
Seq/√Len: 224.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_Q176_K2.6441.00
26_Q29_K2.6101.00
31_S34_D2.3911.00
156_R160_D2.3361.00
190_T194_D2.2851.00
208_N211_N2.2231.00
145_R149_D2.2221.00
93_K96_E2.1541.00
151_K154_E2.1441.00
21_V25_K2.1401.00
83_I86_L2.0731.00
164_E168_A2.0181.00
23_K26_Q1.9891.00
152_F156_R1.9381.00
110_K114_D1.8741.00
48_D52_Q1.8691.00
195_L198_D1.8681.00
182_D186_E1.8601.00
45_K48_D1.8301.00
197_S200_D1.7941.00
84_K88_D1.7861.00
157_T161_K1.7721.00
113_E117_H1.7371.00
57_K60_D1.7341.00
128_V131_D1.7341.00
193_N197_S1.7221.00
164_E167_R1.7201.00
46_R49_D1.7051.00
185_F189_D1.6921.00
75_E78_S1.6511.00
181_V184_Q1.6431.00
107_E110_K1.6291.00
162_K165_E1.6141.00
20_L23_K1.6021.00
95_D99_A1.5981.00
126_T129_Y1.5781.00
19_S22_E1.5711.00
140_K143_D1.5471.00
146_N150_T1.5431.00
167_R171_D1.5171.00
128_V132_K1.4971.00
25_K28_K1.4941.00
208_N212_L1.4851.00
196_R200_D1.4751.00
63_S67_K1.4651.00
91_E95_D1.4401.00
141_V185_F1.4351.00
84_K87_R1.4061.00
131_D135_E1.3871.00
186_E189_D1.3821.00
100_Y104_K1.3721.00
33_Q37_F1.3681.00
202_K213_I1.3671.00
57_K61_L1.3471.00
52_Q56_K1.3461.00
189_D193_N1.3341.00
109_N113_E1.3291.00
18_K22_E1.3281.00
175_V178_K1.3211.00
103_K106_E1.3161.00
33_Q36_L1.3151.00
68_R71_D1.3131.00
67_K70_D1.3041.00
48_D51_R1.2951.00
23_K31_S1.2931.00
30_L38_L1.2601.00
102_D106_E1.2461.00
95_D98_R1.2451.00
203_F206_L1.2351.00
89_Y93_K1.2341.00
178_K182_D1.2291.00
59_D62_K1.2131.00
163_F166_S1.2061.00
32_E35_Y1.1981.00
45_K49_D1.1961.00
94_F98_R1.1861.00
82_D85_G1.1841.00
179_E183_K1.1811.00
18_K24_S1.1761.00
19_S23_K1.1741.00
34_D38_L1.1721.00
99_A103_K1.1671.00
64_Y68_R1.1621.00
23_K34_D1.1551.00
70_D73_K1.1541.00
55_N59_D1.1531.00
157_T160_D1.1511.00
104_K107_E1.1491.00
209_D213_I1.1431.00
213_I216_L1.1421.00
20_L27_G1.1351.00
36_L40_M1.1331.00
22_E25_K1.1261.00
18_K21_V1.1241.00
115_L118_Y1.1191.00
24_S28_K1.1181.00
17_A21_V1.1161.00
197_S201_S1.1151.00
175_V179_E1.1121.00
51_R54_M1.1071.00
83_I87_R1.1011.00
123_F126_T1.0941.00
87_R91_E1.0811.00
29_K32_E1.0741.00
163_F185_F1.0681.00
196_R203_F1.0671.00
116_R120_D1.0611.00
211_N215_K1.0561.00
111_K115_L1.0351.00
25_K29_K1.0331.00
26_Q31_S1.0221.00
180_Y183_K1.0211.00
207_K211_N1.0201.00
198_D201_S1.0131.00
178_K189_D1.0111.00
23_K27_G1.0091.00
28_K31_S1.0041.00
36_L39_M0.9991.00
145_R156_R0.9931.00
111_K114_D0.9921.00
101_T104_K0.9911.00
153_Q156_R0.9881.00
142_E145_R0.9861.00
64_Y67_K0.9831.00
153_Q157_T0.9771.00
143_D146_N0.9761.00
160_D164_E0.9721.00
34_D37_F0.9701.00
162_K184_Q0.9651.00
66_D70_D0.9601.00
29_K33_Q0.9601.00
37_F40_M0.9601.00
187_H190_T0.9571.00
59_D63_S0.9471.00
43_N65_V0.9421.00
22_E26_Q0.9421.00
184_Q187_H0.9381.00
163_F167_R0.9341.00
195_L206_L0.9251.00
58_F62_K0.9241.00
181_V185_F0.9231.00
52_Q55_N0.9090.99
27_G31_S0.9000.99
107_E111_K0.8940.99
77_I81_E0.8900.99
92_R96_E0.8870.99
28_K32_E0.8820.99
195_L203_F0.8810.99
122_K125_E0.8730.99
30_L35_Y0.8690.99
94_F97_S0.8680.99
24_S34_D0.8670.99
30_L37_F0.8610.99
127_R131_D0.8610.99
151_K173_Q0.8570.99
167_R211_N0.8540.99
81_E85_G0.8490.99
188_V199_M0.8490.99
118_Y121_N0.8420.99
112_V115_L0.8360.99
143_D165_E0.8340.99
149_D153_Q0.8310.99
46_R51_R0.8310.99
167_R170_T0.8290.99
172_V175_V0.8290.99
81_E84_K0.8260.99
62_K66_D0.8240.99
163_F207_K0.8220.99
28_K33_Q0.8200.99
120_D124_E0.8140.99
141_V144_L0.8140.99
186_E190_T0.8130.99
198_D202_K0.8090.99
83_I105_F0.8090.99
179_E182_D0.8070.99
185_F196_R0.8000.99
110_K113_E0.8000.99
27_G30_L0.7950.99
101_T105_F0.7940.99
60_D63_S0.7920.99
63_S66_D0.7890.98
165_E169_Y0.7830.98
56_K60_D0.7780.98
202_K205_E0.7720.98
35_Y38_L0.7640.98
192_F214_I0.7630.98
132_K135_E0.7620.98
47_T69_F0.7610.98
21_V24_S0.7540.98
141_V145_R0.7520.98
20_L24_S0.7520.98
203_F207_K0.7510.98
77_I80_K0.7500.98
174_F196_R0.7490.98
180_Y184_Q0.7390.98
205_E208_N0.7390.98
30_L34_D0.7380.98
144_L155_L0.7230.97
27_G35_Y0.7200.97
32_E36_L0.7150.97
194_D198_D0.7140.97
83_I90_T0.7140.97
170_T214_I0.7140.97
17_A22_E0.7120.97
134_F145_R0.7070.97
23_K37_F0.7070.97
46_R53_D0.7060.97
171_D175_V0.7040.97
191_R213_I0.7040.97
169_Y172_V0.7020.97
80_K84_K0.7020.97
92_R100_Y0.6960.97
142_E146_N0.6950.97
184_Q206_L0.6930.97
122_K126_T0.6900.96
202_K206_L0.6900.96
51_R55_N0.6880.96
117_H121_N0.6870.96
16_Y20_L0.6850.96
146_N149_D0.6840.96
48_D53_D0.6820.96
148_V154_E0.6810.96
82_D86_L0.6760.96
195_L199_M0.6730.96
204_N208_N0.6630.96
30_L33_Q0.6600.95
106_E110_K0.6600.95
66_D73_K0.6590.95
169_Y173_Q0.6590.95
169_Y191_R0.6560.95
177_F181_V0.6490.95
22_E33_Q0.6490.95
20_L30_L0.6400.95
23_K38_L0.6380.95
17_A25_K0.6370.94
159_T203_F0.6360.94
205_E216_L0.6350.94
150_T154_E0.6290.94
96_E100_Y0.6270.94
154_E158_Y0.6190.94
176_K181_V0.6180.94
16_Y27_G0.6160.93
114_D118_Y0.6120.93
108_T177_F0.6110.93
155_L166_S0.6100.93
58_F61_L0.6080.93
108_T112_V0.6070.93
199_M207_K0.6050.93
58_F69_F0.6050.93
22_E36_L0.6030.93
20_L31_S0.6000.93
174_F181_V0.5970.92
200_D211_N0.5960.92
98_R102_D0.5920.92
202_K209_D0.5890.92
185_F207_K0.5840.92
71_D74_A0.5840.92
91_E98_R0.5840.92
140_K151_K0.5810.91
57_K62_K0.5800.91
190_T193_N0.5760.91
91_E97_S0.5720.91
64_Y70_D0.5710.91
49_D52_Q0.5690.90
108_T111_K0.5650.90
184_Q196_R0.5630.90
69_F72_T0.5610.90
19_S27_G0.5610.90
44_S47_T0.5600.90
152_F174_F0.5590.90
74_A78_S0.5580.90
209_D212_L0.5570.90
212_L215_K0.5530.89
172_V177_F0.5530.89
194_D197_S0.5510.89
152_F196_R0.5480.89
143_D147_Y0.5450.89
25_K37_F0.5450.89
20_L34_D0.5440.88
191_R195_L0.5430.88
30_L40_M0.5420.88
19_S47_T0.5390.88
150_T153_Q0.5390.88
61_L68_R0.5370.88
19_S30_L0.5360.88
131_D134_F0.5340.88
68_R72_T0.5300.87
152_F155_L0.5240.87
158_Y161_K0.5230.86
206_L212_L0.5200.86
17_A26_Q0.5170.86
60_D64_Y0.5110.85
200_D204_N0.5110.85
23_K30_L0.5100.85
34_D40_M0.5090.85
20_L37_F0.5090.85
91_E96_E0.5050.85
191_R198_D0.5040.84
24_S31_S0.5030.84
161_K165_E0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a01A 1 0.9736 98.6 0.553 Contact Map
3s84A 2 0.8414 98.6 0.553 Contact Map
2l7bA 1 0.9648 98 0.625 Contact Map
2lemA 1 0.9119 97.9 0.631 Contact Map
3r2pA 2 0.7753 97.2 0.681 Contact Map
1nfnA 1 0.5727 95.9 0.726 Contact Map
1eq1A 1 0.7225 90.3 0.779 Contact Map
4k1pA 1 0.9383 90.1 0.78 Contact Map
1gs9A 1 0.6211 87.6 0.79 Contact Map
2nrjA 1 0.9075 85.1 0.797 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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