Q97Y46 - SULSO - GREMLIN Contacts

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Q97Y46 - Uncharacterized protein

UniProt:	Q97Y46	Sequences: MADVFIQMLSDAVTEYAKSLVEKSKQGKKLSEQDYLFLMMYLNSKRTDDLRQDMNKKFDDLKSYVDKRFDDTKAEIISVKEDIKGLRDYTERKFDESRAYTDKKFEETNKKVEDLRHYVDNKFEETRVYTDKKFEETNKKVEDLRNYVDTKFQELRTYTDKKFEESRAYTDVQFVKFKEYVDKQFEHVDTRFNDLRSDMDSKFNELKNDLNLIIKLLVGKEKEEEKS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	227 (200)
Sequences:	3420 (3175)
Seq/√Len:	224.5

SULSO - Q97Y46

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
173_Q	176_K	2.644	1.00
26_Q	29_K	2.610	1.00
31_S	34_D	2.391	1.00
156_R	160_D	2.336	1.00
190_T	194_D	2.285	1.00
208_N	211_N	2.223	1.00
145_R	149_D	2.222	1.00
93_K	96_E	2.154	1.00
151_K	154_E	2.144	1.00
21_V	25_K	2.140	1.00
83_I	86_L	2.073	1.00
164_E	168_A	2.018	1.00
23_K	26_Q	1.989	1.00
152_F	156_R	1.938	1.00
110_K	114_D	1.874	1.00
48_D	52_Q	1.869	1.00
195_L	198_D	1.868	1.00
182_D	186_E	1.860	1.00
45_K	48_D	1.830	1.00
197_S	200_D	1.794	1.00
84_K	88_D	1.786	1.00
157_T	161_K	1.772	1.00
113_E	117_H	1.737	1.00
57_K	60_D	1.734	1.00
128_V	131_D	1.734	1.00
193_N	197_S	1.722	1.00
164_E	167_R	1.720	1.00
46_R	49_D	1.705	1.00
185_F	189_D	1.692	1.00
75_E	78_S	1.651	1.00
181_V	184_Q	1.643	1.00
107_E	110_K	1.629	1.00
162_K	165_E	1.614	1.00
20_L	23_K	1.602	1.00
95_D	99_A	1.598	1.00
126_T	129_Y	1.578	1.00
19_S	22_E	1.571	1.00
140_K	143_D	1.547	1.00
146_N	150_T	1.543	1.00
167_R	171_D	1.517	1.00
128_V	132_K	1.497	1.00
25_K	28_K	1.494	1.00
208_N	212_L	1.485	1.00
196_R	200_D	1.475	1.00
63_S	67_K	1.465	1.00
91_E	95_D	1.440	1.00
141_V	185_F	1.435	1.00
84_K	87_R	1.406	1.00
131_D	135_E	1.387	1.00
186_E	189_D	1.382	1.00
100_Y	104_K	1.372	1.00
33_Q	37_F	1.368	1.00
202_K	213_I	1.367	1.00
57_K	61_L	1.347	1.00
52_Q	56_K	1.346	1.00
189_D	193_N	1.334	1.00
109_N	113_E	1.329	1.00
18_K	22_E	1.328	1.00
175_V	178_K	1.321	1.00
103_K	106_E	1.316	1.00
33_Q	36_L	1.315	1.00
68_R	71_D	1.313	1.00
67_K	70_D	1.304	1.00
48_D	51_R	1.295	1.00
23_K	31_S	1.293	1.00
30_L	38_L	1.260	1.00
102_D	106_E	1.246	1.00
95_D	98_R	1.245	1.00
203_F	206_L	1.235	1.00
89_Y	93_K	1.234	1.00
178_K	182_D	1.229	1.00
59_D	62_K	1.213	1.00
163_F	166_S	1.206	1.00
32_E	35_Y	1.198	1.00
45_K	49_D	1.196	1.00
94_F	98_R	1.186	1.00
82_D	85_G	1.184	1.00
179_E	183_K	1.181	1.00
18_K	24_S	1.176	1.00
19_S	23_K	1.174	1.00
34_D	38_L	1.172	1.00
99_A	103_K	1.167	1.00
64_Y	68_R	1.162	1.00
23_K	34_D	1.155	1.00
70_D	73_K	1.154	1.00
55_N	59_D	1.153	1.00
157_T	160_D	1.151	1.00
104_K	107_E	1.149	1.00
209_D	213_I	1.143	1.00
213_I	216_L	1.142	1.00
20_L	27_G	1.135	1.00
36_L	40_M	1.133	1.00
22_E	25_K	1.126	1.00
18_K	21_V	1.124	1.00
115_L	118_Y	1.119	1.00
24_S	28_K	1.118	1.00
17_A	21_V	1.116	1.00
197_S	201_S	1.115	1.00
175_V	179_E	1.112	1.00
51_R	54_M	1.107	1.00
83_I	87_R	1.101	1.00
123_F	126_T	1.094	1.00
87_R	91_E	1.081	1.00
29_K	32_E	1.074	1.00
163_F	185_F	1.068	1.00
196_R	203_F	1.067	1.00
116_R	120_D	1.061	1.00
211_N	215_K	1.056	1.00
111_K	115_L	1.035	1.00
25_K	29_K	1.033	1.00
26_Q	31_S	1.022	1.00
180_Y	183_K	1.021	1.00
207_K	211_N	1.020	1.00
198_D	201_S	1.013	1.00
178_K	189_D	1.011	1.00
23_K	27_G	1.009	1.00
28_K	31_S	1.004	1.00
36_L	39_M	0.999	1.00
145_R	156_R	0.993	1.00
111_K	114_D	0.992	1.00
101_T	104_K	0.991	1.00
153_Q	156_R	0.988	1.00
142_E	145_R	0.986	1.00
64_Y	67_K	0.983	1.00
153_Q	157_T	0.977	1.00
143_D	146_N	0.976	1.00
160_D	164_E	0.972	1.00
34_D	37_F	0.970	1.00
162_K	184_Q	0.965	1.00
66_D	70_D	0.960	1.00
29_K	33_Q	0.960	1.00
37_F	40_M	0.960	1.00
187_H	190_T	0.957	1.00
59_D	63_S	0.947	1.00
43_N	65_V	0.942	1.00
22_E	26_Q	0.942	1.00
184_Q	187_H	0.938	1.00
163_F	167_R	0.934	1.00
195_L	206_L	0.925	1.00
58_F	62_K	0.924	1.00
181_V	185_F	0.923	1.00
52_Q	55_N	0.909	0.99
27_G	31_S	0.900	0.99
107_E	111_K	0.894	0.99
77_I	81_E	0.890	0.99
92_R	96_E	0.887	0.99
28_K	32_E	0.882	0.99
195_L	203_F	0.881	0.99
122_K	125_E	0.873	0.99
30_L	35_Y	0.869	0.99
94_F	97_S	0.868	0.99
24_S	34_D	0.867	0.99
30_L	37_F	0.861	0.99
127_R	131_D	0.861	0.99
151_K	173_Q	0.857	0.99
167_R	211_N	0.854	0.99
81_E	85_G	0.849	0.99
188_V	199_M	0.849	0.99
118_Y	121_N	0.842	0.99
112_V	115_L	0.836	0.99
143_D	165_E	0.834	0.99
149_D	153_Q	0.831	0.99
46_R	51_R	0.831	0.99
167_R	170_T	0.829	0.99
172_V	175_V	0.829	0.99
81_E	84_K	0.826	0.99
62_K	66_D	0.824	0.99
163_F	207_K	0.822	0.99
28_K	33_Q	0.820	0.99
120_D	124_E	0.814	0.99
141_V	144_L	0.814	0.99
186_E	190_T	0.813	0.99
198_D	202_K	0.809	0.99
83_I	105_F	0.809	0.99
179_E	182_D	0.807	0.99
185_F	196_R	0.800	0.99
110_K	113_E	0.800	0.99
27_G	30_L	0.795	0.99
101_T	105_F	0.794	0.99
60_D	63_S	0.792	0.99
63_S	66_D	0.789	0.98
165_E	169_Y	0.783	0.98
56_K	60_D	0.778	0.98
202_K	205_E	0.772	0.98
35_Y	38_L	0.764	0.98
192_F	214_I	0.763	0.98
132_K	135_E	0.762	0.98
47_T	69_F	0.761	0.98
21_V	24_S	0.754	0.98
141_V	145_R	0.752	0.98
20_L	24_S	0.752	0.98
203_F	207_K	0.751	0.98
77_I	80_K	0.750	0.98
174_F	196_R	0.749	0.98
180_Y	184_Q	0.739	0.98
205_E	208_N	0.739	0.98
30_L	34_D	0.738	0.98
144_L	155_L	0.723	0.97
27_G	35_Y	0.720	0.97
32_E	36_L	0.715	0.97
194_D	198_D	0.714	0.97
83_I	90_T	0.714	0.97
170_T	214_I	0.714	0.97
17_A	22_E	0.712	0.97
134_F	145_R	0.707	0.97
23_K	37_F	0.707	0.97
46_R	53_D	0.706	0.97
171_D	175_V	0.704	0.97
191_R	213_I	0.704	0.97
169_Y	172_V	0.702	0.97
80_K	84_K	0.702	0.97
92_R	100_Y	0.696	0.97
142_E	146_N	0.695	0.97
184_Q	206_L	0.693	0.97
122_K	126_T	0.690	0.96
202_K	206_L	0.690	0.96
51_R	55_N	0.688	0.96
117_H	121_N	0.687	0.96
16_Y	20_L	0.685	0.96
146_N	149_D	0.684	0.96
48_D	53_D	0.682	0.96
148_V	154_E	0.681	0.96
82_D	86_L	0.676	0.96
195_L	199_M	0.673	0.96
204_N	208_N	0.663	0.96
30_L	33_Q	0.660	0.95
106_E	110_K	0.660	0.95
66_D	73_K	0.659	0.95
169_Y	173_Q	0.659	0.95
169_Y	191_R	0.656	0.95
177_F	181_V	0.649	0.95
22_E	33_Q	0.649	0.95
20_L	30_L	0.640	0.95
23_K	38_L	0.638	0.95
17_A	25_K	0.637	0.94
159_T	203_F	0.636	0.94
205_E	216_L	0.635	0.94
150_T	154_E	0.629	0.94
96_E	100_Y	0.627	0.94
154_E	158_Y	0.619	0.94
176_K	181_V	0.618	0.94
16_Y	27_G	0.616	0.93
114_D	118_Y	0.612	0.93
108_T	177_F	0.611	0.93
155_L	166_S	0.610	0.93
58_F	61_L	0.608	0.93
108_T	112_V	0.607	0.93
199_M	207_K	0.605	0.93
58_F	69_F	0.605	0.93
22_E	36_L	0.603	0.93
20_L	31_S	0.600	0.93
174_F	181_V	0.597	0.92
200_D	211_N	0.596	0.92
98_R	102_D	0.592	0.92
202_K	209_D	0.589	0.92
185_F	207_K	0.584	0.92
71_D	74_A	0.584	0.92
91_E	98_R	0.584	0.92
140_K	151_K	0.581	0.91
57_K	62_K	0.580	0.91
190_T	193_N	0.576	0.91
91_E	97_S	0.572	0.91
64_Y	70_D	0.571	0.91
49_D	52_Q	0.569	0.90
108_T	111_K	0.565	0.90
184_Q	196_R	0.563	0.90
69_F	72_T	0.561	0.90
19_S	27_G	0.561	0.90
44_S	47_T	0.560	0.90
152_F	174_F	0.559	0.90
74_A	78_S	0.558	0.90
209_D	212_L	0.557	0.90
212_L	215_K	0.553	0.89
172_V	177_F	0.553	0.89
194_D	197_S	0.551	0.89
152_F	196_R	0.548	0.89
143_D	147_Y	0.545	0.89
25_K	37_F	0.545	0.89
20_L	34_D	0.544	0.88
191_R	195_L	0.543	0.88
30_L	40_M	0.542	0.88
19_S	47_T	0.539	0.88
150_T	153_Q	0.539	0.88
61_L	68_R	0.537	0.88
19_S	30_L	0.536	0.88
131_D	134_F	0.534	0.88
68_R	72_T	0.530	0.87
152_F	155_L	0.524	0.87
158_Y	161_K	0.523	0.86
206_L	212_L	0.520	0.86
17_A	26_Q	0.517	0.86
60_D	64_Y	0.511	0.85
200_D	204_N	0.511	0.85
23_K	30_L	0.510	0.85
34_D	40_M	0.509	0.85
20_L	37_F	0.509	0.85
91_E	96_E	0.505	0.85
191_R	198_D	0.504	0.84
24_S	31_S	0.503	0.84
161_K	165_E	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2a01A	1	0.9736	98.6	0.553	Contact Map
3s84A	2	0.8414	98.6	0.553	Contact Map
2l7bA	1	0.9648	98	0.625	Contact Map
2lemA	1	0.9119	97.9	0.631	Contact Map
3r2pA	2	0.7753	97.2	0.681	Contact Map
1nfnA	1	0.5727	95.9	0.726	Contact Map
1eq1A	1	0.7225	90.3	0.779	Contact Map
4k1pA	1	0.9383	90.1	0.78	Contact Map
1gs9A	1	0.6211	87.6	0.79	Contact Map
2nrjA	1	0.9075	85.1	0.797	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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