GREMLIN Database
MSRA - Peptide methionine sulfoxide reductase MsrA
UniProt: Q97Y45 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 177 (158)
Sequences: 5894 (3651)
Seq/√Len: 290.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_R109_E3.4371.00
4_A66_Y3.2811.00
5_T100_H3.2691.00
3_V56_Q3.1551.00
74_F111_M2.8141.00
32_S54_V2.3631.00
99_Y105_R2.3451.00
112_I127_L2.1391.00
28_K133_F2.0541.00
36_V43_D1.9661.00
28_K135_E1.9391.00
99_Y129_P1.9321.00
74_F112_I1.9161.00
6_L69_I1.8681.00
8_G14_T1.8571.00
32_S130_F1.8381.00
82_L124_V1.8381.00
7_G54_V1.8311.00
67_R107_I1.8311.00
21_V72_I1.8211.00
22_K63_I1.8041.00
5_T56_Q1.8001.00
47_D92_Q1.7601.00
52_A94_R1.7571.00
40_T43_D1.7431.00
65_S68_E1.7111.00
19_K142_D1.6731.00
113_R117_K1.6661.00
29_P141_H1.6541.00
28_K56_Q1.6411.00
21_V64_I1.6341.00
97_I108_A1.6181.00
14_T76_I1.5731.00
52_A128_K1.5641.00
102_E105_R1.5581.00
19_K145_D1.5491.00
2_E104_Q1.5371.00
2_E101_N1.5271.00
84_R89_V1.5001.00
33_G96_I1.4901.00
3_V58_T1.4591.00
52_A96_I1.4551.00
5_T54_V1.4401.00
67_R110_E1.4271.00
106_K110_E1.4241.00
26_S58_T1.4171.00
81_T84_R1.3941.00
77_H95_S1.3891.00
5_T32_S1.3551.00
71_E111_M1.3481.00
34_G51_H1.3481.00
28_K58_T1.3431.00
11_F31_Y1.2711.00
70_L107_I1.2311.00
7_G96_I1.2171.00
50_G91_T1.2011.00
60_D63_I1.1981.00
19_K27_V1.1781.00
2_E61_S1.1751.00
138_D146_K1.1651.00
110_E114_E1.1601.00
100_H104_Q1.1461.00
8_G76_I1.1451.00
96_I128_K1.1441.00
32_S131_E1.1381.00
68_E71_E1.1211.00
15_E19_K1.1141.00
45_C92_Q1.0961.00
103_E106_K1.0941.00
96_I126_E1.0911.00
67_R114_E1.0781.00
142_D145_D1.0621.00
59_F104_Q1.0541.00
100_H130_F1.0521.00
99_Y127_L1.0421.00
17_V76_I1.0401.00
98_L126_E1.0311.00
95_S125_T1.0311.00
39_P134_Y1.0251.00
115_V118_R1.0141.00
77_H125_T0.9901.00
154_R158_S0.9871.00
42_E139_Y0.9831.00
94_R126_E0.9731.00
91_T94_R0.9721.00
116_E123_V0.9611.00
2_E59_F0.9551.00
6_L70_L0.9461.00
109_E113_R0.9411.00
37_P132_V0.9411.00
115_V123_V0.9401.00
24_V64_I0.9401.00
3_V100_H0.9381.00
16_A156_V0.9331.00
44_V49_T0.9321.00
5_T130_F0.9171.00
16_A19_K0.9131.00
109_E112_I0.9081.00
105_R129_P0.9061.00
6_L66_Y0.8971.00
31_Y137_E0.8861.00
36_V39_P0.8861.00
106_K109_E0.8791.00
52_A98_L0.8751.00
112_I123_V0.8741.00
18_Y57_I0.8691.00
150_N154_R0.8661.00
70_L97_I0.8661.00
16_A144_Y0.8651.00
21_V24_V0.8641.00
154_R157_I0.8621.00
111_M115_V0.8561.00
15_E27_V0.8461.00
119_I122_K0.8421.00
6_L18_Y0.8361.00
102_E106_K0.8311.00
108_A127_L0.8251.00
66_Y108_A0.8101.00
143_F150_N0.8091.00
128_K131_E0.8081.00
37_P134_Y0.8020.99
70_L111_M0.8020.99
103_E107_I0.8010.99
36_V49_T0.8010.99
112_I116_E0.8010.99
110_E113_R0.8000.99
25_I28_K0.7940.99
71_E114_E0.7870.99
38_N134_Y0.7830.99
35_H50_G0.7650.99
32_S132_V0.7620.99
116_E120_G0.7600.99
64_I68_E0.7590.99
153_C157_I0.7580.99
83_N91_T0.7550.99
115_V119_I0.7550.99
16_A20_R0.7520.99
13_C144_Y0.7450.99
87_N156_V0.7410.99
83_N89_V0.7400.99
67_R111_M0.7400.99
151_P154_R0.7390.99
2_E103_E0.7370.99
87_N159_P0.7360.99
67_R71_E0.7340.99
43_D48_T0.7340.99
116_E122_K0.7320.99
81_T124_V0.7290.99
81_T89_V0.7210.99
14_T17_V0.7190.99
148_K151_P0.7160.99
20_R145_D0.7150.99
109_E127_L0.7120.99
17_V72_I0.7070.99
142_D146_K0.7050.99
72_I75_E0.7040.99
87_N155_L0.7010.99
25_I58_T0.6930.98
36_V51_H0.6920.98
72_I76_I0.6860.98
43_D49_T0.6850.98
29_P142_D0.6830.98
24_V57_I0.6790.98
30_G133_F0.6730.98
114_E117_K0.6720.98
56_Q100_H0.6690.98
144_Y158_S0.6670.98
111_M114_E0.6650.98
11_F137_E0.6630.98
44_V92_Q0.6560.98
80_T119_I0.6560.98
135_E138_D0.6500.98
6_L57_I0.6480.98
7_G52_A0.6450.98
139_Y147_H0.6440.98
151_P155_L0.6400.97
66_Y104_Q0.6370.97
16_A145_D0.6360.97
32_S96_I0.6340.97
29_P55_V0.6330.97
47_D91_T0.6290.97
33_G51_H0.6270.97
99_Y130_F0.6220.97
25_I63_I0.6220.97
99_Y108_A0.6120.97
107_I111_M0.6110.97
27_V55_V0.6110.97
70_L74_F0.6100.97
73_F95_S0.6100.97
102_E129_P0.6030.96
33_G98_L0.6000.96
156_V159_P0.5920.96
113_R116_E0.5880.96
147_H150_N0.5880.96
114_E118_R0.5870.96
101_N104_Q0.5860.96
107_I110_E0.5840.96
52_A91_T0.5810.96
32_S98_L0.5750.95
42_E45_C0.5660.95
157_I160_K0.5650.95
73_F77_H0.5650.95
155_L158_S0.5640.95
36_V40_T0.5620.95
16_A21_V0.5620.95
49_T91_T0.5590.95
28_K141_H0.5530.94
39_P43_D0.5500.94
85_Q90_G0.5500.94
80_T124_V0.5480.94
13_C17_V0.5480.94
36_V48_T0.5460.94
14_T55_V0.5460.94
46_T91_T0.5450.94
144_Y148_K0.5450.94
31_Y45_C0.5370.93
16_A153_C0.5360.93
46_T49_T0.5350.93
45_C87_N0.5310.93
14_T73_F0.5300.93
78_D84_R0.5290.93
82_L91_T0.5260.93
156_V160_K0.5260.93
44_V47_D0.5240.92
52_A95_S0.5230.92
40_T45_C0.5190.92
24_V27_V0.5190.92
6_L97_I0.5180.92
87_N154_R0.5180.92
17_V156_V0.5180.92
150_N155_L0.5170.92
31_Y136_A0.5150.92
41_Y137_E0.5140.92
14_T29_P0.5110.92
13_C29_P0.5020.91
143_F147_H0.5000.91
26_S56_Q0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bqhA 1 0.9096 100 0.032 Contact Map
1ff3A 5 0.9266 100 0.043 Contact Map
1fvgA 1 0.8588 100 0.05 Contact Map
4d7lA 3 0.9322 100 0.051 Contact Map
3e0mA 4 0.9831 100 0.051 Contact Map
2j89A 1 0.9492 100 0.053 Contact Map
3pimA 2 0.8644 100 0.073 Contact Map
1nwaA 1 0.8814 100 0.084 Contact Map
4gwbA 2 0.9153 100 0.091 Contact Map
4lwlA 1 0.9492 100 0.155 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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