GREMLIN Database
Q97Y44 - Transposase ISC1316
UniProt: Q97Y44 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (352)
Sequences: 4628 (2974)
Seq/√Len: 158.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
257_D261_K5.3501.00
331_A361_N4.2521.00
279_H282_Q4.2191.00
311_L318_L3.6631.00
275_M307_I2.9721.00
274_V370_S2.9721.00
198_L303_L2.9101.00
304_R320_L2.9071.00
264_K268_E2.7371.00
302_E306_L2.7121.00
341_S344_D2.5491.00
159_V171_I2.5091.00
284_I296_S2.4961.00
325_Y328_K2.4091.00
302_E305_D2.4061.00
308_K320_L2.4021.00
329_T336_V2.3151.00
267_A311_L2.3071.00
217_L293_R2.3001.00
321_V366_I2.2661.00
369_G372_S2.2071.00
303_L307_I2.1651.00
273_V311_L2.1471.00
36_W40_Y2.1141.00
348_V355_I2.1121.00
223_L240_A2.0891.00
330_C333_C2.0811.00
260_M309_Y2.0681.00
326_T366_I2.0521.00
275_M318_L2.0511.00
13_D16_T2.0471.00
260_M306_L2.0281.00
289_R292_R2.0091.00
157_K176_D2.0031.00
333_C352_C2.0011.00
216_A254_L1.9701.00
328_K340_L1.9371.00
256_T302_E1.9331.00
263_G306_L1.9311.00
39_I97_F1.9181.00
240_A244_L1.8741.00
345_R358_R1.8701.00
333_C349_C1.8701.00
51_R55_R1.8541.00
259_Y306_L1.8521.00
34_L80_A1.8441.00
349_C352_C1.8071.00
308_K312_E1.8011.00
21_K169_I1.8001.00
22_A70_Q1.7981.00
52_T55_R1.7981.00
330_C352_C1.7951.00
260_M310_Q1.7731.00
198_L258_L1.7691.00
260_M263_G1.7671.00
332_K354_W1.7541.00
235_H238_F1.7441.00
271_D316_K1.7211.00
51_R81_D1.7201.00
330_C349_C1.7051.00
347_F356_A1.6771.00
35_R83_Y1.6551.00
9_R168_R1.6271.00
259_Y302_E1.5941.00
135_L171_I1.5911.00
29_K67_E1.5791.00
275_M320_L1.5701.00
191_I199_I1.5461.00
275_M304_R1.5461.00
238_F241_K1.5301.00
226_E230_K1.5071.00
263_G309_Y1.5041.00
20_L169_I1.4901.00
230_K240_A1.4901.00
337_K340_L1.4881.00
227_L241_K1.4831.00
82_R110_V1.4821.00
346_V355_I1.4721.00
347_F354_W1.4651.00
18_R22_A1.4571.00
17_L21_K1.4511.00
74_Q113_Q1.4411.00
74_Q112_P1.4331.00
84_Y88_K1.4331.00
5_G172_T1.4141.00
188_V367_L1.4021.00
200_V360_Y1.3991.00
206_Y357_D1.3941.00
189_V201_T1.3901.00
277_G320_L1.3841.00
335_Y350_P1.3821.00
364_L368_R1.3761.00
52_T56_Q1.3741.00
340_L344_D1.3731.00
233_L237_W1.3651.00
89_R95_A1.3591.00
223_L226_E1.3551.00
263_G303_L1.3531.00
201_T205_E1.3471.00
308_K318_L1.3411.00
34_L83_Y1.3271.00
342_L345_R1.3181.00
197_K200_V1.2991.00
39_I43_Q1.2971.00
263_G310_Q1.2941.00
276_E323_P1.2871.00
166_S249_E1.2801.00
216_A251_L1.2671.00
249_E253_N1.2661.00
295_L300_F1.2651.00
24_L169_I1.2641.00
168_R249_E1.2551.00
37_A57_L1.2351.00
55_R81_D1.2281.00
267_A314_Y1.2251.00
136_K142_T1.2221.00
87_K97_F1.2191.00
337_K347_F1.2141.00
188_V272_V1.2041.00
220_V244_L1.2001.00
189_V270_Y1.2001.00
50_T53_E1.1991.00
14_E17_L1.1931.00
331_A364_L1.1841.00
85_E89_R1.1821.00
164_T168_R1.1711.00
356_A364_L1.1701.00
227_L240_A1.1651.00
88_K92_E1.1621.00
360_Y364_L1.1601.00
220_V248_Y1.1551.00
265_W269_H1.1551.00
224_H228_S1.1461.00
134_T142_T1.1421.00
219_K223_L1.1401.00
78_Q81_D1.1341.00
55_R80_A1.1331.00
193_V300_F1.1311.00
38_D54_L1.1291.00
51_R80_A1.1221.00
342_L358_R1.1171.00
195_V298_V1.1161.00
27_A79_V1.1121.00
223_L247_A1.1091.00
259_Y303_L1.1091.00
284_I292_R1.1031.00
259_Y263_G1.1031.00
78_Q112_P1.0981.00
200_V206_Y1.0970.99
331_A356_A1.0930.99
12_T16_T1.0920.99
191_I201_T1.0900.99
328_K336_V1.0880.99
279_H323_P1.0870.99
310_Q313_K1.0860.99
164_T167_E1.0790.99
190_A367_L1.0740.99
197_K208_P1.0730.99
337_K341_S1.0730.99
341_S345_R1.0680.99
321_V369_G1.0660.99
162_K172_T1.0640.99
267_A273_V1.0540.99
267_A316_K1.0480.99
62_R76_V1.0410.99
306_L309_Y1.0390.99
58_A80_A1.0350.99
256_T306_L1.0350.99
264_K314_Y1.0320.99
227_L244_L1.0300.99
326_T369_G1.0260.99
337_K350_P1.0210.99
328_K339_D1.0110.99
31_Y79_V1.0100.99
12_T20_L1.0080.99
185_T271_D1.0080.99
328_K338_E1.0060.99
329_T369_G1.0030.99
6_F175_V1.0010.99
268_E314_Y1.0010.99
40_Y44_R0.9960.99
31_Y86_A0.9940.99
341_S358_R0.9900.99
356_A360_Y0.9880.99
202_S363_S0.9870.99
137_L161_V0.9850.99
117_K136_K0.9790.99
193_V304_R0.9720.99
72_Y75_V0.9710.99
197_K206_Y0.9660.99
89_R94_L0.9640.99
56_Q59_L0.9620.99
263_G307_I0.9600.99
252_K256_T0.9520.99
224_H244_L0.9510.99
321_V370_S0.9450.98
274_V366_I0.9410.98
35_R87_K0.9410.98
29_K33_T0.9370.98
74_Q78_Q0.9360.98
111_Y114_Y0.9310.98
188_V371_G0.9240.98
344_D347_F0.9230.98
331_A354_W0.9150.98
82_R160_V0.9150.98
277_G323_P0.9140.98
90_F97_F0.9120.98
116_W120_Q0.9080.98
220_V228_S0.9050.98
331_A362_A0.9050.98
280_V301_S0.9040.98
110_V158_R0.9000.98
26_S67_E0.8990.98
247_A251_L0.8980.98
259_Y299_A0.8980.98
164_T249_E0.8950.98
78_Q110_V0.8900.98
243_K246_R0.8890.98
344_D358_R0.8890.98
311_L316_K0.8870.98
220_V251_L0.8840.98
237_W241_K0.8830.98
340_L347_F0.8820.98
58_A77_Q0.8780.98
117_K120_Q0.8750.98
33_T37_A0.8730.97
223_L244_L0.8710.97
346_V356_A0.8710.97
230_K236_N0.8700.97
39_I87_K0.8670.97
120_Q133_I0.8670.97
42_Y87_K0.8660.97
305_D308_K0.8630.97
41_F45_D0.8620.97
31_Y83_Y0.8620.97
59_L63_K0.8620.97
188_V274_V0.8590.97
8_F171_I0.8590.97
272_V317_K0.8530.97
77_Q81_D0.8480.97
347_F358_R0.8450.97
323_P326_T0.8410.97
68_Y76_V0.8380.97
272_V319_I0.8360.97
224_H248_Y0.8330.97
226_E229_R0.8330.97
331_A368_R0.8320.97
195_V284_I0.8310.97
74_Q114_Y0.8300.97
189_V202_S0.8300.97
110_V160_V0.8290.97
250_Y254_L0.8270.97
228_S244_L0.8260.96
89_R92_E0.8260.96
360_Y363_S0.8240.96
325_Y369_G0.8230.96
291_L295_L0.8210.96
361_N365_N0.8200.96
160_V172_T0.8150.96
212_P254_L0.8140.96
60_D64_Q0.8130.96
200_V207_F0.8130.96
193_V199_I0.8120.96
364_L367_L0.8110.96
30_I79_V0.8070.96
301_S305_D0.8060.96
345_R357_D0.8050.96
17_L169_I0.8040.96
338_E341_S0.8040.96
258_L262_L0.8040.96
25_K28_C0.8030.96
213_Y216_A0.8020.96
41_F49_L0.7990.96
264_K310_Q0.7980.96
158_R174_V0.7970.96
221_K224_H0.7970.96
266_F273_V0.7930.96
274_V319_I0.7900.95
34_L54_L0.7900.95
335_Y351_N0.7890.95
289_R296_S0.7880.95
186_G271_D0.7870.95
187_K271_D0.7850.95
90_F98_P0.7840.95
277_G304_R0.7840.95
328_K337_K0.7840.95
362_A365_N0.7830.95
332_K364_L0.7830.95
161_V171_I0.7820.95
25_K29_K0.7810.95
104_H107_Y0.7780.95
195_V294_R0.7770.95
262_L265_W0.7760.95
119_L136_K0.7760.95
209_N212_P0.7730.95
74_Q77_Q0.7730.95
227_L237_W0.7730.95
59_L62_R0.7720.95
213_Y217_L0.7690.95
207_F262_L0.7690.95
53_E56_Q0.7660.95
78_Q82_R0.7650.95
221_K225_R0.7640.95
111_Y137_L0.7620.95
23_Q27_A0.7580.94
71_L74_Q0.7550.94
34_L58_A0.7550.94
205_E265_W0.7520.94
199_I262_L0.7500.94
135_L159_V0.7470.94
196_E200_V0.7450.94
340_L358_R0.7450.94
338_E347_F0.7410.94
115_G138_S0.7390.94
14_E18_R0.7380.94
222_H226_E0.7380.94
189_V273_V0.7370.93
87_K91_F0.7330.93
38_D87_K0.7330.93
109_L113_Q0.7320.93
36_W100_E0.7290.93
329_T365_N0.7290.93
26_S68_Y0.7260.93
155_K176_D0.7250.93
51_R54_L0.7250.93
241_K245_A0.7230.93
223_L243_K0.7230.93
55_R59_L0.7220.93
134_T144_K0.7210.93
329_T338_E0.7210.93
38_D84_Y0.7180.93
319_I370_S0.7170.93
12_T143_F0.7140.92
278_I323_P0.7120.92
132_L137_L0.7110.92
274_V367_L0.7090.92
220_V224_H0.7090.92
226_E243_K0.7080.92
26_S71_L0.7080.92
203_D270_Y0.7070.92
182_L185_T0.7060.92
216_A220_V0.7030.92
184_N187_K0.7030.92
37_A61_L0.7020.92
236_N239_K0.7020.92
206_Y360_Y0.7010.92
62_R65_D0.6960.91
93_G96_H0.6950.91
282_Q323_P0.6950.91
37_A54_L0.6920.91
74_Q115_G0.6920.91
233_L238_F0.6900.91
273_V307_I0.6840.91
19_A23_Q0.6830.91
10_A171_I0.6830.91
26_S29_K0.6810.90
199_I303_L0.6800.90
7_R162_K0.6790.90
20_L24_L0.6790.90
216_A247_A0.6780.90
227_L230_K0.6780.90
325_Y336_V0.6760.90
325_Y329_T0.6750.90
251_L297_D0.6730.90
234_S237_W0.6650.89
192_D359_D0.6650.89
199_I207_F0.6640.89
309_Y313_K0.6640.89
209_N298_V0.6620.89
339_D344_D0.6600.89
11_Y146_I0.6600.89
255_R297_D0.6590.89
210_L258_L0.6580.89
80_A84_Y0.6570.89
266_F270_Y0.6560.89
86_A98_P0.6550.89
202_S360_Y0.6490.88
337_K358_R0.6470.88
366_I369_G0.6470.88
268_E272_V0.6450.88
212_P216_A0.6450.88
147_V150_D0.6430.88
33_T61_L0.6420.88
42_Y46_G0.6400.88
194_G200_V0.6390.87
79_V83_Y0.6390.87
9_R170_Y0.6390.87
311_L314_Y0.6380.87
192_D327_S0.6380.87
5_G174_V0.6380.87
198_L263_G0.6380.87
87_K90_F0.6350.87
115_G118_I0.6350.87
19_A22_A0.6350.87
8_F149_R0.6330.87
83_Y87_K0.6310.87
73_S115_G0.6300.87
145_V148_H0.6290.87
12_T17_L0.6280.87
342_L357_D0.6260.86
306_L310_Q0.6260.86
225_R229_R0.6250.86
190_A274_V0.6230.86
280_V300_F0.6230.86
253_N256_T0.6230.86
22_A26_S0.6220.86
340_L345_R0.6210.86
114_Y117_K0.6210.86
216_A250_Y0.6190.86
222_H225_R0.6170.86
8_F147_V0.6160.86
7_R256_T0.6160.86
356_A361_N0.6150.85
59_L73_S0.6120.85
368_R371_G0.6120.85
225_R228_S0.6120.85
187_K270_Y0.6110.85
332_K356_A0.6090.85
198_L298_V0.6090.85
15_Q18_R0.6070.85
283_L295_L0.6070.85
226_E240_A0.6050.85
149_R152_P0.6020.84
221_K228_S0.6000.84
81_D112_P0.5970.84
51_R59_L0.5940.83
119_L142_T0.5900.83
207_F258_L0.5900.83
256_T260_M0.5880.83
37_A41_F0.5870.83
270_Y273_V0.5850.83
198_L259_Y0.5830.82
21_K164_T0.5830.82
111_Y116_W0.5830.82
214_E217_L0.5800.82
284_I289_R0.5790.82
20_L109_L0.5790.82
45_D48_G0.5760.82
322_N325_Y0.5740.81
23_Q71_L0.5730.81
37_A40_Y0.5720.81
179_F312_E0.5720.81
348_V354_W0.5690.81
137_L159_V0.5670.81
282_Q291_L0.5670.81
214_E293_R0.5670.81
23_Q109_L0.5660.80
282_Q295_L0.5660.80
73_S112_P0.5660.80
76_V79_V0.5650.80
116_W156_V0.5650.80
329_T334_G0.5630.80
42_Y45_D0.5590.80
264_K267_A0.5580.79
194_G197_K0.5580.79
72_Y111_Y0.5580.79
38_D41_F0.5580.79
337_K344_D0.5560.79
10_A145_V0.5540.79
329_T347_F0.5530.79
23_Q111_Y0.5510.79
214_E294_R0.5510.79
274_V369_G0.5510.79
190_A363_S0.5510.79
71_L76_V0.5500.79
31_Y35_R0.5490.78
190_A202_S0.5490.78
230_K234_S0.5490.78
54_L57_L0.5470.78
136_K140_L0.5460.78
248_Y255_R0.5450.78
33_T67_E0.5450.78
112_P116_W0.5430.78
292_R296_S0.5420.78
5_G162_K0.5420.78
72_Y113_Q0.5420.78
196_E345_R0.5420.78
36_W39_I0.5420.78
324_A328_K0.5410.77
207_F265_W0.5410.77
168_R253_N0.5410.77
299_A302_E0.5400.77
223_L227_L0.5400.77
145_V150_D0.5370.77
133_I147_V0.5360.77
137_L143_F0.5360.77
30_I76_V0.5350.77
182_L316_K0.5350.77
59_L80_A0.5340.76
231_K237_W0.5330.76
350_P358_R0.5330.76
7_R172_T0.5330.76
219_K222_H0.5320.76
307_I318_L0.5310.76
15_Q19_A0.5310.76
54_L59_L0.5300.76
291_L294_R0.5290.76
47_K53_E0.5290.76
342_L346_V0.5290.76
75_V109_L0.5280.76
248_Y252_K0.5280.76
8_F150_D0.5250.75
23_Q72_Y0.5220.75
304_R308_K0.5210.75
58_A62_R0.5210.75
262_L303_L0.5210.75
221_K289_R0.5200.75
10_A143_F0.5190.74
203_D265_W0.5170.74
38_D45_D0.5160.74
135_L138_S0.5150.74
231_K234_S0.5130.74
48_G54_L0.5120.73
102_K105_K0.5110.73
22_A25_K0.5100.73
141_G144_K0.5080.73
192_D276_E0.5080.73
237_W240_A0.5070.73
162_K165_R0.5060.73
47_K50_T0.5060.73
267_A307_I0.5060.73
259_Y262_L0.5050.72
264_K306_L0.5040.72
232_F237_W0.5040.72
73_S113_Q0.5020.72
238_F242_V0.5010.72
260_M264_K0.5000.72
274_V371_G0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhxA 2 0.3504 91.5 0.937 Contact Map
1nu0A 1 0.3325 91 0.938 Contact Map
4aybP 1 0.11 89.2 0.94 Contact Map
1qypA 1 0.1176 88.2 0.941 Contact Map
1iv0A 1 0.2481 87.9 0.942 Contact Map
1ffkW 1 0.1841 85.2 0.944 Contact Map
1vq8Z 1 0.1867 84.9 0.944 Contact Map
1vd4A 1 0.1432 84.7 0.944 Contact Map
3j20Y 1 0.1279 83.4 0.945 Contact Map
2k4xA 1 0.1407 81.2 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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