GREMLIN Database
Q97Y40 - Transposase ISC1225
UniProt: Q97Y40 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 364 (304)
Sequences: 183 (123)
Seq/√Len: 7.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_T284_Y6.4421.00
110_I165_V5.0660.99
184_L283_S4.4670.98
179_V203_V3.3950.90
149_L284_Y3.1790.87
36_S179_V3.0260.84
185_D277_R3.0110.84
74_R301_F2.9680.83
113_T288_K2.8250.80
172_I182_V2.7930.79
113_T126_G2.7090.77
304_L308_L2.6910.76
260_T296_S2.6120.74
186_A205_G2.4600.69
260_T278_S2.4560.69
260_T313_Y2.4070.67
172_I202_F2.3330.65
179_V284_Y2.3140.64
282_T285_R2.2600.62
117_W314_S2.2470.62
111_D281_E2.2220.61
114_T135_N2.1980.60
312_F323_M2.1570.58
165_V168_L2.1560.58
306_F313_Y2.0940.56
112_W179_V2.0670.55
127_S133_S2.0510.54
138_T307_V2.0190.53
290_F313_Y2.0140.53
139_A151_A1.9770.51
111_D277_R1.9720.51
277_R281_E1.9720.51
189_Y206_V1.8930.48
52_A187_G1.8700.47
168_L261_N1.8610.47
185_D281_E1.7580.43
111_D185_D1.7580.43
53_C73_V1.7460.43
147_V285_R1.7410.42
132_N197_I1.7020.41
27_V203_V1.6990.41
145_N195_K1.6890.40
134_W284_Y1.6310.38
181_L289_A1.6130.38
21_Q179_V1.5950.37
273_Y280_I1.5950.37
47_R61_S1.5630.36
93_R290_F1.5540.36
188_F294_T1.5440.35
71_Q204_I1.5250.35
108_I172_I1.5180.34
101_K264_L1.5060.34
288_K313_Y1.5050.34
117_W297_T1.4990.34
149_L310_M1.4840.33
91_S193_V1.4840.33
160_S190_T1.4830.33
49_L189_Y1.4460.32
102_G134_W1.4250.31
258_R304_L1.4030.30
126_G306_F1.4020.30
111_D273_Y1.3900.30
273_Y281_E1.3900.30
137_A168_L1.3680.29
110_I261_N1.3500.29
139_A323_M1.3480.29
260_T288_K1.3480.29
168_L287_I1.3440.29
126_G296_S1.3420.28
221_Y226_K1.3400.28
169_M194_L1.3370.28
66_Y169_M1.3320.28
173_V203_V1.3290.28
138_T306_F1.3110.28
147_V180_G1.3060.27
260_T308_L1.3050.27
189_Y282_T1.3050.27
284_Y294_T1.3020.27
159_M203_V1.3000.27
45_V53_C1.2960.27
177_L222_T1.2960.27
77_V186_A1.2940.27
263_D275_K1.2830.27
134_W290_F1.2790.27
216_E219_G1.2700.26
214_Y217_F1.2690.26
274_N314_S1.2660.26
133_S278_S1.2640.26
138_T280_I1.2580.26
166_K296_S1.2550.26
32_L264_L1.2440.26
137_A202_F1.2320.25
194_L282_T1.2210.25
139_A169_M1.2210.25
274_N279_P1.2200.25
168_L202_F1.2180.25
162_D196_F1.2120.25
61_S115_K1.1880.24
282_T286_N1.1850.24
73_V189_Y1.1830.24
75_N223_T1.1820.24
288_K306_F1.1820.24
197_I255_Y1.1770.24
194_L204_I1.1760.24
261_N306_F1.1680.23
125_L263_D1.1660.23
149_L283_S1.1660.23
284_Y295_S1.1620.23
37_F46_S1.1620.23
40_R131_G1.1620.23
72_T288_K1.1570.23
291_L303_E1.1470.23
76_Y298_K1.1440.23
49_L73_V1.1430.23
297_T304_L1.1410.23
75_N298_K1.1400.23
181_L203_V1.1320.22
187_G315_L1.1300.22
261_N287_I1.1290.22
180_G278_S1.1290.22
114_T133_S1.1250.22
202_F261_N1.1250.22
184_L189_Y1.1230.22
261_N288_K1.1210.22
165_V261_N1.1170.22
278_S296_S1.1150.22
146_M180_G1.1150.22
320_K324_T1.1130.22
43_E292_P1.1110.22
242_G301_F1.1100.22
203_V241_Y1.1030.22
77_V151_A1.0900.21
293_F314_S1.0900.21
282_T318_V1.0890.21
58_S136_Y1.0780.21
124_G299_F1.0730.21
128_S293_F1.0650.21
108_I142_K1.0630.21
110_I193_V1.0630.21
179_V287_I1.0630.21
62_K66_Y1.0610.21
150_L168_L1.0600.21
273_Y277_R1.0600.21
117_W125_L1.0540.20
37_F41_K1.0480.20
296_S302_R1.0370.20
301_F305_I1.0330.20
94_R133_S1.0300.20
67_N139_A1.0270.20
165_V172_I1.0240.20
186_A294_T1.0240.20
220_E226_K1.0220.20
81_G85_I1.0210.20
70_P298_K1.0210.20
223_T275_K1.0200.20
108_I179_V1.0180.19
111_D280_I1.0170.19
296_S313_Y1.0160.19
113_T147_V1.0060.19
27_V57_D0.9980.19
63_S201_K0.9960.19
123_E203_V0.9930.19
296_S306_F0.9880.19
112_W155_Q0.9850.19
113_T287_I0.9820.19
76_Y285_R0.9820.19
41_K45_V0.9800.19
53_C312_F0.9780.19
46_S124_G0.9770.18
75_N218_D0.9730.18
188_F281_E0.9720.18
111_D188_F0.9720.18
139_A172_I0.9690.18
29_Y33_S0.9690.18
127_S308_L0.9680.18
119_G148_L0.9680.18
77_V132_N0.9670.18
193_V284_Y0.9660.18
134_W138_T0.9640.18
138_T168_L0.9640.18
27_V33_S0.9600.18
69_S206_V0.9570.18
177_L182_V0.9450.18
121_P186_A0.9450.18
35_L40_R0.9390.18
31_L80_Q0.9330.18
198_S326_E0.9300.17
281_E302_R0.9270.17
111_D302_R0.9270.17
53_C309_A0.9240.17
261_N296_S0.9200.17
151_A169_M0.9190.17
292_P305_I0.9150.17
116_T312_F0.9140.17
70_P273_Y0.9140.17
155_Q183_T0.9090.17
109_S142_K0.9060.17
91_S284_Y0.8960.17
136_Y189_Y0.8960.17
93_R285_R0.8940.17
189_Y207_P0.8850.16
126_G258_R0.8820.16
199_Q243_K0.8740.16
35_L84_V0.8710.16
78_E239_L0.8690.16
133_S317_T0.8640.16
133_S292_P0.8630.16
89_L172_I0.8600.16
128_S283_S0.8600.16
64_K189_Y0.8580.16
260_T290_F0.8580.16
92_M304_L0.8560.16
24_I32_L0.8500.16
182_V250_K0.8490.16
51_S189_Y0.8440.16
36_S241_Y0.8420.16
135_N187_G0.8410.16
204_I215_E0.8400.16
231_E255_Y0.8370.15
183_T205_G0.8340.15
39_G44_E0.8340.15
39_G109_S0.8330.15
142_K258_R0.8320.15
119_G189_Y0.8310.15
53_C104_K0.8310.15
170_E182_V0.8290.15
86_E90_E0.8270.15
317_T320_K0.8250.15
113_T202_F0.8210.15
132_N144_Q0.8180.15
163_E186_A0.8160.15
185_D273_Y0.8150.15
113_T305_I0.8110.15
128_S148_L0.8080.15
25_Q28_G0.8070.15
109_S193_V0.8060.15
194_L202_F0.8050.15
119_G136_Y0.8040.15
51_S60_E0.7970.15
197_I200_F0.7970.15
139_A314_S0.7930.15
71_Q241_Y0.7910.15
51_S161_K0.7900.15
241_Y266_K0.7890.15
176_G304_L0.7850.14
63_S169_M0.7830.14
180_G309_A0.7790.14
52_A131_G0.7780.14
126_G143_Y0.7740.14
209_G267_R0.7690.14
128_S207_P0.7680.14
184_L197_I0.7640.14
74_R283_S0.7610.14
287_I306_F0.7600.14
200_F308_L0.7600.14
48_V280_I0.7550.14
194_L273_Y0.7530.14
52_A329_R0.7510.14
62_K169_M0.7510.14
169_M235_K0.7490.14
204_I262_L0.7490.14
39_G258_R0.7490.14
203_V269_V0.7480.14
230_K250_K0.7470.14
138_T149_L0.7420.14
134_W257_A0.7390.14
104_K152_F0.7360.14
120_K219_G0.7330.13
172_I261_N0.7310.13
72_T224_N0.7300.13
83_E263_D0.7280.13
56_N169_M0.7280.13
119_G297_T0.7270.13
143_Y154_P0.7260.13
193_V282_T0.7250.13
75_N184_L0.7230.13
172_I177_L0.7220.13
269_V315_L0.7200.13
147_V206_V0.7200.13
82_T168_L0.7120.13
277_R280_I0.7110.13
35_L220_E0.7110.13
228_H239_L0.7090.13
187_G250_K0.7080.13
92_M309_A0.7060.13
154_P327_E0.7060.13
65_G199_Q0.7030.13
326_E329_R0.7030.13
35_L218_D0.7030.13
187_G207_P0.7020.13
31_L46_S0.6950.13
83_E197_I0.6940.13
90_E125_L0.6920.13
137_A164_I0.6910.13
48_V62_K0.6910.13
102_G203_V0.6900.13
110_I168_L0.6890.13
36_S228_H0.6870.13
136_Y273_Y0.6860.13
288_K296_S0.6860.13
135_N184_L0.6850.13
155_Q163_E0.6840.13
52_A194_L0.6830.13
260_T282_T0.6790.13
94_R175_M0.6780.13
121_P263_D0.6770.13
35_L285_R0.6770.13
149_L287_I0.6750.12
189_Y263_D0.6750.12
183_T292_P0.6750.12
125_L296_S0.6740.12
50_V150_L0.6730.12
48_V203_V0.6720.12
25_Q29_Y0.6720.12
141_T316_Y0.6720.12
169_M218_D0.6700.12
212_K215_E0.6700.12
221_Y228_H0.6690.12
179_V228_H0.6650.12
68_V122_V0.6640.12
213_I237_R0.6640.12
72_T271_K0.6590.12
168_L284_Y0.6560.12
152_F210_D0.6540.12
68_V73_V0.6530.12
156_V315_L0.6500.12
134_W317_T0.6490.12
57_D235_K0.6450.12
188_F277_R0.6410.12
125_L269_V0.6410.12
131_G291_L0.6370.12
184_L259_A0.6360.12
53_C289_A0.6360.12
133_S290_F0.6340.12
193_V248_K0.6300.12
131_G238_L0.6300.12
278_S313_Y0.6300.12
74_R135_N0.6290.12
277_R302_R0.6260.12
128_S154_P0.6260.12
110_I137_A0.6250.12
52_A62_K0.6240.12
188_F280_I0.6230.12
59_V169_M0.6220.12
145_N152_F0.6160.12
278_S290_F0.6140.11
129_A285_R0.6130.11
27_V157_N0.6130.11
126_G154_P0.6100.11
300_I318_V0.6090.11
223_T226_K0.6070.11
89_L289_A0.6070.11
302_R316_Y0.6070.11
104_K265_P0.6070.11
74_R325_R0.6060.11
21_Q24_I0.6060.11
310_M313_Y0.6060.11
216_E272_L0.6050.11
147_V278_S0.6040.11
231_E298_K0.6030.11
188_F314_S0.6030.11
49_L118_Y0.6000.11
161_K292_P0.6000.11
23_N168_L0.5990.11
203_V273_Y0.5980.11
72_T109_S0.5980.11
160_S163_E0.5980.11
75_N300_I0.5950.11
22_N29_Y0.5950.11
153_V167_L0.5930.11
27_V275_K0.5910.11
69_S311_I0.5910.11
45_V73_V0.5910.11
151_A212_K0.5910.11
177_L200_F0.5900.11
130_K267_R0.5900.11
114_T127_S0.5890.11
26_Q30_K0.5860.11
129_A241_Y0.5830.11
126_G288_K0.5820.11
130_K207_P0.5810.11
130_K275_K0.5800.11
110_I200_F0.5780.11
121_P211_V0.5780.11
135_N183_T0.5770.11
194_L259_A0.5760.11
131_G239_L0.5750.11
155_Q193_V0.5750.11
274_N298_K0.5730.11
139_A163_E0.5720.11
22_N26_Q0.5720.11
82_T94_R0.5720.11
291_L295_S0.5710.11
151_A250_K0.5680.11
76_Y148_L0.5670.11
194_L289_A0.5670.11
77_V85_I0.5660.11
202_F320_K0.5660.11
122_V207_P0.5630.11
114_T187_G0.5630.11
130_K160_S0.5630.11
134_W321_N0.5600.11
213_I267_R0.5580.11
261_N290_F0.5580.11
94_R125_L0.5570.11
92_M220_E0.5560.11
111_D294_T0.5550.11
281_E294_T0.5550.11
95_I301_F0.5530.11
66_Y293_F0.5520.11
280_I316_Y0.5510.11
38_K52_A0.5510.11
67_N186_A0.5500.11
124_G303_E0.5480.10
113_T296_S0.5480.10
53_C60_E0.5470.10
48_V311_I0.5460.10
207_P213_I0.5440.10
83_E224_N0.5430.10
107_D183_T0.5420.10
86_E136_Y0.5420.10
200_F264_L0.5420.10
82_T301_F0.5410.10
53_C189_Y0.5380.10
64_K311_I0.5370.10
72_T235_K0.5360.10
29_Y32_L0.5360.10
132_N274_N0.5350.10
108_I267_R0.5330.10
156_V169_M0.5290.10
75_N283_S0.5290.10
274_N317_T0.5280.10
147_V279_P0.5260.10
301_F315_L0.5250.10
25_Q49_L0.5240.10
254_V259_A0.5240.10
39_G165_V0.5230.10
188_F273_Y0.5200.10
132_N317_T0.5190.10
132_N147_V0.5180.10
117_W144_Q0.5180.10
115_K197_I0.5160.10
145_N204_I0.5150.10
141_T293_F0.5150.10
78_E249_R0.5130.10
46_S100_L0.5120.10
312_F316_Y0.5080.10
63_S104_K0.5070.10
127_S319_F0.5060.10
21_Q38_K0.5050.10
83_E156_V0.5050.10
52_A236_F0.5040.10
166_K250_K0.5030.10
117_W205_G0.5020.10
185_D280_I0.5000.10
43_E130_K0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8874 99.3 0.868 Contact Map
4xb4A 1 0.3846 11.9 0.975 Contact Map
1f6yA 2 0.6044 11.6 0.975 Contact Map
1qgpA 1 0.206 10 0.976 Contact Map
2vxzA 1 0.3901 9.6 0.976 Contact Map
1jkoC 1 0.1209 9.4 0.976 Contact Map
4x86A 1 0.1401 8.1 0.976 Contact Map
2m8eA 1 0.1566 7.9 0.977 Contact Map
1qbjA 1 0.1786 7.7 0.977 Contact Map
2jn6A 1 0.2253 7.2 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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