GREMLIN Database
Q97Y39 - Uncharacterized protein
UniProt: Q97Y39 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 246 (206)
Sequences: 294 (264)
Seq/√Len: 18.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_T187_I3.4961.00
144_F194_A3.4441.00
158_D231_Y3.4071.00
97_D100_L2.9790.99
131_L141_V2.9580.99
162_P178_I2.8160.98
82_G145_N2.6730.98
72_T188_T2.4600.96
84_S169_D2.4180.96
168_K171_Y2.3700.95
193_L208_L2.2570.94
109_E183_I2.1810.93
105_I223_W2.1020.91
166_G173_V2.0910.91
74_I188_T2.0840.91
84_S87_Y2.0800.91
96_W100_L2.0530.90
114_V214_T2.0510.90
164_Y173_V2.0470.90
74_I235_D2.0310.90
110_I114_V2.0290.90
141_V193_L1.9200.87
170_E173_V1.9030.86
87_Y100_L1.8760.85
35_N38_E1.8570.85
81_T106_A1.8320.84
59_R62_D1.8160.83
100_L167_A1.8140.83
144_F148_P1.8050.83
84_S101_D1.7670.82
115_K119_K1.7600.81
159_I191_T1.7410.81
167_A171_Y1.7330.80
82_G181_L1.7210.80
114_V143_F1.6990.79
114_V218_S1.6940.79
218_S228_T1.6770.78
114_V211_L1.6510.77
101_D167_A1.6500.77
114_V118_F1.6460.77
81_T105_I1.6030.75
224_G227_V1.5970.74
182_A228_T1.5890.74
109_E227_V1.5810.74
97_D104_Y1.5600.73
115_K128_E1.5490.72
111_K226_K1.5380.72
84_S167_A1.5370.72
158_D180_F1.5060.70
110_I191_T1.5010.70
89_I92_V1.4970.69
97_D102_T1.4900.69
157_Y183_I1.4730.68
139_G143_F1.4560.67
104_Y115_K1.4510.67
113_I223_W1.4070.64
97_D171_Y1.3920.64
77_S214_T1.3890.63
191_T225_R1.3880.63
171_Y226_K1.3850.63
164_Y189_F1.3750.63
165_N173_V1.3550.61
53_Y62_D1.3510.61
95_A161_T1.3460.61
163_H226_K1.3420.61
100_L171_Y1.3400.61
119_K125_D1.3350.60
175_P189_F1.3330.60
70_K134_D1.3100.59
96_W101_D1.2720.56
106_A145_N1.2700.56
101_D171_Y1.2690.56
111_K163_H1.2570.56
80_L83_W1.2370.54
83_W93_P1.2260.54
81_T223_W1.2240.54
156_T182_A1.2130.53
84_S160_I1.2120.53
89_I96_W1.2120.53
38_E42_N1.2120.53
156_T184_N1.2120.53
197_N216_I1.2110.53
73_F191_T1.2100.53
79_L183_I1.1890.51
81_T96_W1.1780.51
101_D232_G1.1780.51
106_A158_D1.1720.50
155_L233_S1.1690.50
224_G231_Y1.1520.49
225_R229_R1.1500.49
80_L158_D1.1420.48
144_F232_G1.1310.48
51_K216_I1.1280.48
160_I178_I1.1240.47
163_H227_V1.0970.46
110_I117_Y1.0850.45
89_I100_L1.0780.44
161_T179_K1.0740.44
104_Y145_N1.0550.43
26_E33_K1.0500.43
223_W234_L1.0400.42
120_E228_T1.0280.41
209_Y213_K1.0190.41
91_E164_Y1.0130.41
80_L160_I1.0010.40
145_N222_G0.9970.40
56_D59_R0.9940.39
83_W170_E0.9910.39
79_L110_I0.9720.38
92_V95_A0.9520.37
155_L212_L0.9510.37
183_I227_V0.9510.37
84_S111_K0.9480.37
84_S181_L0.9470.37
160_I194_A0.9330.36
182_A211_L0.9310.36
132_Y139_G0.9260.35
147_Y233_S0.9260.35
50_I56_D0.9200.35
48_N209_Y0.9190.35
148_P189_F0.9160.35
73_F234_L0.9110.35
92_V218_S0.9110.35
50_I54_L0.8980.34
105_I224_G0.8930.34
98_M159_I0.8860.33
106_A231_Y0.8820.33
118_F179_K0.8800.33
83_W225_R0.8790.33
130_C140_K0.8690.32
51_K74_I0.8670.32
196_D219_M0.8660.32
78_K228_T0.8660.32
84_S168_K0.8590.32
77_S120_E0.8580.32
83_W92_V0.8480.31
84_S145_N0.8420.31
157_Y170_E0.8410.31
48_N235_D0.8410.31
52_S213_K0.8250.30
160_I169_D0.8070.29
55_D58_E0.8060.29
50_I150_D0.8050.29
99_I161_T0.8030.29
78_K156_T0.7990.29
42_N105_I0.7980.29
61_L102_T0.7980.29
32_A39_N0.7980.29
82_G110_I0.7970.28
107_G161_T0.7950.28
75_T189_F0.7950.28
79_L223_W0.7920.28
82_G231_Y0.7900.28
80_L180_F0.7890.28
144_F160_I0.7870.28
89_I218_S0.7850.28
87_Y169_D0.7850.28
40_L193_L0.7820.28
100_L173_V0.7820.28
144_F192_Y0.7810.28
80_L89_I0.7750.27
82_G91_E0.7740.27
87_Y117_Y0.7740.27
110_I146_A0.7680.27
119_K123_S0.7640.27
89_I94_L0.7630.27
100_L145_N0.7610.27
156_T233_S0.7610.27
164_Y170_E0.7600.27
26_E29_Q0.7560.26
91_E106_A0.7490.26
120_E211_L0.7430.26
82_G101_D0.7430.26
162_P176_I0.7410.26
101_D173_V0.7370.26
36_T94_L0.7340.25
37_M40_L0.7320.25
34_D42_N0.7290.25
72_T155_L0.7250.25
75_T183_I0.7250.25
105_I231_Y0.7230.25
106_A148_P0.7170.25
78_K105_I0.7160.25
78_K191_T0.7150.25
37_M206_D0.7140.24
82_G92_V0.7100.24
101_D170_E0.7050.24
112_G222_G0.7050.24
92_V96_W0.7040.24
84_S180_F0.7030.24
153_N167_A0.7010.24
37_M42_N0.6990.24
78_K117_Y0.6910.23
50_I57_V0.6900.23
97_D117_Y0.6880.23
109_E126_K0.6820.23
84_S89_I0.6810.23
81_T89_I0.6780.23
103_P112_G0.6770.23
93_P96_W0.6740.23
70_K190_K0.6740.23
193_L211_L0.6720.23
93_P163_H0.6700.23
78_K185_K0.6680.22
92_V220_R0.6620.22
79_L232_G0.6600.22
68_Y131_L0.6590.22
180_F226_K0.6590.22
84_S91_E0.6580.22
33_K108_S0.6580.22
100_L195_F0.6550.22
78_K182_A0.6530.22
161_T208_L0.6510.22
36_T223_W0.6470.22
114_V141_V0.6430.21
93_P161_T0.6420.21
86_I166_G0.6420.21
50_I223_W0.6400.21
164_Y182_A0.6390.21
36_T41_V0.6370.21
101_D168_K0.6360.21
112_G230_G0.6340.21
211_L214_T0.6340.21
113_I225_R0.6310.21
109_E215_M0.6310.21
47_Y59_R0.6300.21
122_T155_L0.6260.21
96_W148_P0.6250.21
31_L35_N0.6250.21
155_L185_K0.6200.20
82_G175_P0.6200.20
86_I225_R0.6190.20
77_S233_S0.6180.20
53_Y122_T0.6170.20
104_Y147_Y0.6100.20
103_P232_G0.6080.20
180_F218_S0.6080.20
84_S171_Y0.6070.20
86_I229_R0.5990.20
132_Y226_K0.5990.20
219_M223_W0.5990.20
169_D178_I0.5990.20
157_Y229_R0.5970.20
148_P172_N0.5950.19
175_P231_Y0.5950.19
98_M101_D0.5910.19
169_D181_L0.5870.19
74_I233_S0.5870.19
193_L210_L0.5860.19
167_A226_K0.5860.19
157_Y161_T0.5860.19
165_N168_K0.5860.19
111_K225_R0.5850.19
31_L39_N0.5810.19
113_I218_S0.5800.19
52_S132_Y0.5800.19
84_S96_W0.5800.19
85_P93_P0.5770.19
85_P95_A0.5720.19
175_P181_L0.5690.18
82_G104_Y0.5680.18
83_W91_E0.5680.18
27_K39_N0.5680.18
116_N158_D0.5670.18
164_Y194_A0.5640.18
224_G232_G0.5640.18
97_D218_S0.5600.18
39_N43_F0.5580.18
37_M156_T0.5560.18
180_F231_Y0.5560.18
45_P59_R0.5560.18
71_I212_L0.5560.18
182_A229_R0.5530.18
58_E116_N0.5510.18
50_I164_Y0.5500.18
55_D150_D0.5480.18
96_W169_D0.5450.18
84_S163_H0.5440.18
87_Y90_T0.5430.17
79_L85_P0.5420.17
67_C158_D0.5410.17
46_R176_I0.5400.17
107_G118_F0.5400.17
91_E111_K0.5370.17
63_R188_T0.5370.17
157_Y179_K0.5360.17
207_S211_L0.5350.17
35_N42_N0.5300.17
178_I226_K0.5300.17
75_T214_T0.5280.17
198_K216_I0.5260.17
29_Q42_N0.5230.17
27_K33_K0.5230.17
52_S217_F0.5210.17
112_G232_G0.5200.17
99_I233_S0.5180.17
27_K30_K0.5140.16
46_R59_R0.5140.16
130_C199_E0.5130.16
28_G38_E0.5120.16
29_Q41_V0.5110.16
146_A219_M0.5100.16
142_I199_E0.5070.16
41_V183_I0.5040.16
107_G162_P0.5040.16
82_G100_L0.5040.16
53_Y57_V0.5040.16
69_V212_L0.5000.16
112_G224_G0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3x1lH 1 0.8496 100 0.413 Contact Map
4w8vA 1 0.687 100 0.486 Contact Map
4n0lA 1 0.6951 99.9 0.646 Contact Map
4qtsC 1 0.5813 99.9 0.654 Contact Map
4w8wA 1 0.6585 99.9 0.691 Contact Map
3x1lC 3 0.7317 99.8 0.705 Contact Map
4w8zA 1 0.6341 98.4 0.862 Contact Map
4l6uA 1 0.6179 98.2 0.868 Contact Map
4qtsA 1 0.5854 97 0.897 Contact Map
3i4hX 1 0.6829 74.5 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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