GREMLIN Database
Q97Y36 - Uncharacterized protein
UniProt: Q97Y36 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (247)
Sequences: 399 (362)
Seq/√Len: 23.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
185_T201_S6.7961.00
205_I211_L6.3371.00
204_Y258_K5.0681.00
88_V212_L4.3481.00
190_D197_K4.3091.00
189_L194_K4.1901.00
186_R256_I3.7041.00
32_V42_Y3.5101.00
90_Y177_V3.3571.00
68_G76_L3.0461.00
31_L211_L2.9751.00
188_E197_K2.9451.00
200_W256_I2.9100.99
87_P209_T2.8390.99
52_S254_E2.4640.98
11_A15_I2.4300.98
105_R170_N2.3440.97
31_L205_I2.2490.97
202_E253_K2.2160.96
97_E100_I2.1850.96
66_F78_S2.0920.95
188_E198_N2.0800.95
104_T173_G2.0570.94
93_S138_G1.9690.93
122_S128_K1.9670.93
50_L82_L1.9660.93
68_G75_I1.9410.93
20_G28_D1.8980.92
36_I51_K1.8700.91
168_L216_F1.8350.90
200_W253_K1.8250.90
89_F210_I1.7640.88
187_T198_N1.7520.88
17_V31_L1.7260.87
34_D110_H1.7190.87
27_V185_T1.7020.86
68_G77_T1.6710.85
186_R202_E1.6520.85
15_I261_T1.6460.85
17_V181_L1.6180.83
127_S130_K1.5880.82
173_G177_V1.5800.82
49_S52_S1.5640.81
181_L205_I1.5570.81
107_L177_V1.5390.80
17_V42_Y1.5370.80
51_K78_S1.5210.79
41_V250_I1.4910.78
34_D208_G1.4900.78
168_L172_I1.4880.78
200_W208_G1.4790.77
85_L213_S1.4750.77
104_T170_N1.4680.77
83_T216_F1.4450.76
249_F253_K1.4400.75
10_Y208_G1.4370.75
47_K255_S1.4220.75
223_S234_N1.4200.74
187_T196_S1.3680.72
142_T172_I1.3680.72
17_V205_I1.3620.71
194_K254_E1.3530.71
89_F165_V1.3520.71
17_V32_V1.3300.69
36_I92_V1.3300.69
24_T239_F1.3010.68
43_G260_L1.2980.67
122_S129_E1.2770.66
101_Y204_Y1.2710.66
189_L193_T1.2670.66
80_Y236_D1.2660.65
9_A85_L1.2440.64
154_S157_N1.2420.64
185_T200_W1.2100.62
8_L82_L1.2100.62
122_S125_K1.1920.61
146_L150_D1.1670.59
85_L132_E1.1670.59
34_D173_G1.1580.58
20_G199_I1.1530.58
31_L189_L1.1510.58
12_I164_R1.1480.58
190_D193_T1.1480.58
42_Y49_S1.1400.57
12_I101_Y1.1290.56
150_D223_S1.1270.56
236_D240_L1.1210.56
25_G78_S1.1190.56
43_G211_L1.1180.56
104_T218_R1.1160.56
95_I189_L1.0990.54
94_S202_E1.0840.53
145_S152_V1.0830.53
124_Y127_S1.0760.53
31_L181_L1.0720.53
29_S139_K1.0690.52
123_L132_E1.0560.51
14_P200_W1.0540.51
66_F137_L1.0480.51
122_S126_E1.0480.51
17_V211_L1.0350.50
209_T254_E1.0310.50
150_D157_N1.0250.49
156_G160_K1.0210.49
41_V211_L1.0100.48
161_D224_Y1.0070.48
182_T207_Q1.0060.48
85_L104_T0.9970.47
124_Y166_Y0.9960.47
43_G256_I0.9910.47
32_V40_I0.9900.47
187_T200_W0.9900.47
14_P184_V0.9860.47
30_P77_T0.9830.46
34_D99_Y0.9820.46
121_G150_D0.9810.46
131_S157_N0.9800.46
14_P207_Q0.9760.46
20_G27_V0.9720.46
188_E196_S0.9690.45
72_E75_I0.9680.45
140_I176_A0.9630.45
107_L173_G0.9580.45
40_I200_W0.9570.45
124_Y133_V0.9540.44
97_E182_T0.9530.44
152_V160_K0.9510.44
87_P167_V0.9500.44
64_C210_I0.9490.44
87_P211_L0.9470.44
120_I150_D0.9310.43
185_T189_L0.9200.42
6_L214_G0.9180.42
27_V201_S0.9130.42
102_I191_D0.9070.41
139_K202_E0.9060.41
29_S200_W0.9000.41
13_T139_K0.9000.41
122_S132_E0.8980.41
98_G213_S0.8970.40
102_I168_L0.8960.40
7_V213_S0.8780.39
27_V99_Y0.8670.38
246_V250_I0.8670.38
43_G78_S0.8670.38
187_T209_T0.8610.38
54_L62_A0.8480.37
89_F255_S0.8470.37
88_V111_I0.8460.37
99_Y182_T0.8460.37
235_I240_L0.8430.37
126_E132_E0.8420.37
102_I111_I0.8400.37
68_G218_R0.8360.36
87_P107_L0.8320.36
83_T214_G0.8310.36
37_G178_E0.8290.36
38_Y84_D0.8280.36
64_C220_I0.8260.36
142_T168_L0.8240.36
125_K151_E0.8190.35
97_E171_S0.8180.35
105_R110_H0.8130.35
107_L182_T0.8110.35
176_A179_S0.8060.35
28_D199_I0.8040.34
34_D86_I0.8010.34
181_L211_L0.7960.34
127_S153_R0.7820.33
110_H113_D0.7820.33
204_Y253_K0.7820.33
59_E155_L0.7760.33
201_S207_Q0.7760.33
251_G259_G0.7720.32
237_N241_K0.7660.32
32_V47_K0.7620.32
46_L213_S0.7600.32
12_I262_K0.7580.32
12_I165_V0.7550.31
145_S234_N0.7510.31
156_G165_V0.7470.31
63_K209_T0.7460.31
239_F243_I0.7440.31
86_I114_L0.7440.31
218_R254_E0.7400.31
190_D194_K0.7400.31
186_R200_W0.7350.30
189_L196_S0.7340.30
42_Y45_S0.7310.30
108_I187_T0.7300.30
102_I131_S0.7290.30
92_V176_A0.7270.30
24_T189_L0.7250.30
13_T202_E0.7230.30
90_Y181_L0.7230.30
21_K35_S0.7190.29
41_V46_L0.7170.29
46_L85_L0.7170.29
158_L234_N0.7170.29
99_Y168_L0.7160.29
182_T185_T0.7160.29
11_A253_K0.7150.29
73_E132_E0.7150.29
71_E156_G0.7070.29
215_I239_F0.7030.28
208_G256_I0.7020.28
172_I186_R0.6980.28
219_E234_N0.6940.28
41_V180_A0.6940.28
184_V256_I0.6920.28
111_I213_S0.6920.28
81_V216_F0.6880.28
25_G113_D0.6850.27
86_I212_L0.6810.27
71_E134_R0.6810.27
30_P34_D0.6810.27
22_S186_R0.6800.27
107_L181_L0.6780.27
38_Y99_Y0.6780.27
19_A256_I0.6770.27
55_I191_D0.6750.27
101_Y209_T0.6740.27
11_A261_T0.6730.27
112_E117_R0.6730.27
36_I249_F0.6720.27
240_L243_I0.6680.26
151_E154_S0.6680.26
130_K241_K0.6680.26
39_P84_D0.6650.26
142_T167_V0.6620.26
13_T89_F0.6620.26
13_T260_L0.6620.26
134_R143_E0.6550.26
17_V87_P0.6520.26
127_S131_S0.6510.26
41_V45_S0.6500.25
126_E209_T0.6450.25
99_Y212_L0.6440.25
42_Y184_V0.6430.25
109_N131_S0.6400.25
123_L205_I0.6390.25
98_G196_S0.6390.25
123_L127_S0.6370.25
222_N225_C0.6370.25
30_P81_V0.6360.25
115_M135_I0.6350.25
49_S213_S0.6340.25
130_K163_N0.6330.25
38_Y107_L0.6320.25
31_L166_Y0.6300.24
69_K134_R0.6300.24
39_P66_F0.6270.24
80_Y217_E0.6260.24
104_T159_I0.6240.24
22_S81_V0.6230.24
38_Y176_A0.6220.24
133_V150_D0.6180.24
173_G182_T0.6170.24
79_K220_I0.6170.24
89_F199_I0.6140.24
85_L98_G0.6140.24
236_D250_I0.6130.24
49_S83_T0.6120.24
181_L207_Q0.6100.23
123_L130_K0.6060.23
136_F142_T0.6060.23
43_G248_V0.6050.23
40_I185_T0.6040.23
126_E130_K0.6020.23
178_E258_K0.5990.23
204_Y261_T0.5970.23
30_P47_K0.5960.23
233_V255_S0.5950.23
59_E63_K0.5950.23
99_Y207_Q0.5920.23
6_L189_L0.5920.23
177_V182_T0.5920.23
72_E130_K0.5900.22
29_S253_K0.5890.22
10_Y113_D0.5880.22
157_N237_N0.5880.22
131_S153_R0.5870.22
101_Y261_T0.5840.22
30_P138_G0.5840.22
8_L168_L0.5830.22
60_S219_E0.5830.22
8_L158_L0.5820.22
139_K200_W0.5820.22
51_K92_V0.5820.22
133_V243_I0.5820.22
40_I62_A0.5810.22
162_K192_N0.5780.22
95_I101_Y0.5780.22
186_R194_K0.5770.22
131_S159_I0.5770.22
177_V204_Y0.5740.22
47_K186_R0.5740.22
129_E144_L0.5730.22
175_S179_S0.5730.22
45_S169_D0.5720.22
253_K258_K0.5710.22
126_E145_S0.5710.22
140_I253_K0.5700.21
98_G182_T0.5700.21
33_R105_R0.5650.21
59_E68_G0.5640.21
150_D234_N0.5610.21
59_E143_E0.5570.21
167_V235_I0.5550.21
150_D160_K0.5550.21
46_L250_I0.5540.21
47_K253_K0.5530.21
134_R221_S0.5530.21
126_E129_E0.5520.21
185_T199_I0.5510.21
27_V93_S0.5510.21
106_Y113_D0.5500.21
19_A35_S0.5480.20
33_R91_P0.5470.20
58_N121_G0.5440.20
140_I173_G0.5440.20
105_R137_L0.5440.20
35_S249_F0.5430.20
251_G257_G0.5430.20
234_N240_L0.5420.20
10_Y101_Y0.5410.20
32_V49_S0.5400.20
206_P251_G0.5390.20
77_T205_I0.5370.20
115_M241_K0.5350.20
140_I155_L0.5340.20
40_I186_R0.5340.20
180_A204_Y0.5340.20
189_L254_E0.5330.20
52_S152_V0.5310.20
58_N242_L0.5300.20
35_S141_S0.5300.20
51_K55_I0.5280.20
234_N237_N0.5270.20
9_A60_S0.5240.19
17_V189_L0.5230.19
45_S186_R0.5230.19
131_S161_D0.5220.19
134_R165_V0.5210.19
27_V208_G0.5210.19
46_L100_I0.5190.19
43_G205_I0.5170.19
116_S119_G0.5160.19
186_R253_K0.5150.19
83_T215_I0.5130.19
159_I171_S0.5110.19
12_I176_A0.5100.19
157_N238_E0.5100.19
190_D224_Y0.5090.19
49_S98_G0.5090.19
59_E241_K0.5070.19
62_A191_D0.5070.19
179_S253_K0.5070.19
104_T108_I0.5060.19
9_A49_S0.5050.19
204_Y207_Q0.5050.19
81_V214_G0.5050.19
180_A213_S0.5050.19
127_S223_S0.5040.19
44_S258_K0.5030.19
99_Y208_G0.5030.19
31_L36_I0.5020.18
209_T236_D0.5010.18
63_K68_G0.5000.18
15_I192_N0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3x1lC 3 0.9703 100 0.283 Contact Map
4w8wA 1 0.8699 100 0.308 Contact Map
4qtsC 1 0.5056 100 0.667 Contact Map
4n0lA 1 0.6989 99.9 0.71 Contact Map
3x1lH 1 0.5539 99.9 0.756 Contact Map
4w8vA 1 0.6729 99.9 0.758 Contact Map
4qtsA 1 0.7026 98.2 0.893 Contact Map
3x1lB 1 0.7695 97.4 0.912 Contact Map
4txdA 1 0.658 79.5 0.949 Contact Map
4l6uA 1 0.5428 40.2 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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