Q97Y36 - SULSO - GREMLIN Contacts

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Q97Y36 - Uncharacterized protein

UniProt:	Q97Y36	Sequences: MVPKYLVLAYAITPIHVGAGKSSTGVVDSPLVRDSIGYPIVYGSSLKGSLKSFLIAKNESLAKCVFGGKPEEENILTSKYVLTDLIPVFYPVSSIDEGYIYITTRYLINHIEDLMSRLGIGSLYKESKEKSEVRIFLGKISTELSLQLSDEVRSLGNLIKDKNRVYVLDNSIGLSAVESALTRVTRTELDDNTKTSKNIWSEEYIPQGTILLSGIFEREISNSYCEELNRNNVNIDNEFLKLIDNVSVFIGGKESIGKGLTKIKLKRVS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	269 (247)
Sequences:	399 (362)
Seq/√Len:	23.0

SULSO - Q97Y36 CMR4 Q97XK7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
185_T	201_S	6.796	1.00
205_I	211_L	6.337	1.00
204_Y	258_K	5.068	1.00
88_V	212_L	4.348	1.00
190_D	197_K	4.309	1.00
189_L	194_K	4.190	1.00
186_R	256_I	3.704	1.00
32_V	42_Y	3.510	1.00
90_Y	177_V	3.357	1.00
68_G	76_L	3.046	1.00
31_L	211_L	2.975	1.00
188_E	197_K	2.945	1.00
200_W	256_I	2.910	0.99
87_P	209_T	2.839	0.99
52_S	254_E	2.464	0.98
11_A	15_I	2.430	0.98
105_R	170_N	2.344	0.97
31_L	205_I	2.249	0.97
202_E	253_K	2.216	0.96
97_E	100_I	2.185	0.96
66_F	78_S	2.092	0.95
188_E	198_N	2.080	0.95
104_T	173_G	2.057	0.94
93_S	138_G	1.969	0.93
122_S	128_K	1.967	0.93
50_L	82_L	1.966	0.93
68_G	75_I	1.941	0.93
20_G	28_D	1.898	0.92
36_I	51_K	1.870	0.91
168_L	216_F	1.835	0.90
200_W	253_K	1.825	0.90
89_F	210_I	1.764	0.88
187_T	198_N	1.752	0.88
17_V	31_L	1.726	0.87
34_D	110_H	1.719	0.87
27_V	185_T	1.702	0.86
68_G	77_T	1.671	0.85
186_R	202_E	1.652	0.85
15_I	261_T	1.646	0.85
17_V	181_L	1.618	0.83
127_S	130_K	1.588	0.82
173_G	177_V	1.580	0.82
49_S	52_S	1.564	0.81
181_L	205_I	1.557	0.81
107_L	177_V	1.539	0.80
17_V	42_Y	1.537	0.80
51_K	78_S	1.521	0.79
41_V	250_I	1.491	0.78
34_D	208_G	1.490	0.78
168_L	172_I	1.488	0.78
200_W	208_G	1.479	0.77
85_L	213_S	1.475	0.77
104_T	170_N	1.468	0.77
83_T	216_F	1.445	0.76
249_F	253_K	1.440	0.75
10_Y	208_G	1.437	0.75
47_K	255_S	1.422	0.75
223_S	234_N	1.420	0.74
187_T	196_S	1.368	0.72
142_T	172_I	1.368	0.72
17_V	205_I	1.362	0.71
194_K	254_E	1.353	0.71
89_F	165_V	1.352	0.71
17_V	32_V	1.330	0.69
36_I	92_V	1.330	0.69
24_T	239_F	1.301	0.68
43_G	260_L	1.298	0.67
122_S	129_E	1.277	0.66
101_Y	204_Y	1.271	0.66
189_L	193_T	1.267	0.66
80_Y	236_D	1.266	0.65
9_A	85_L	1.244	0.64
154_S	157_N	1.242	0.64
185_T	200_W	1.210	0.62
8_L	82_L	1.210	0.62
122_S	125_K	1.192	0.61
146_L	150_D	1.167	0.59
85_L	132_E	1.167	0.59
34_D	173_G	1.158	0.58
20_G	199_I	1.153	0.58
31_L	189_L	1.151	0.58
12_I	164_R	1.148	0.58
190_D	193_T	1.148	0.58
42_Y	49_S	1.140	0.57
12_I	101_Y	1.129	0.56
150_D	223_S	1.127	0.56
236_D	240_L	1.121	0.56
25_G	78_S	1.119	0.56
43_G	211_L	1.118	0.56
104_T	218_R	1.116	0.56
95_I	189_L	1.099	0.54
94_S	202_E	1.084	0.53
145_S	152_V	1.083	0.53
124_Y	127_S	1.076	0.53
31_L	181_L	1.072	0.53
29_S	139_K	1.069	0.52
123_L	132_E	1.056	0.51
14_P	200_W	1.054	0.51
66_F	137_L	1.048	0.51
122_S	126_E	1.048	0.51
17_V	211_L	1.035	0.50
209_T	254_E	1.031	0.50
150_D	157_N	1.025	0.49
156_G	160_K	1.021	0.49
41_V	211_L	1.010	0.48
161_D	224_Y	1.007	0.48
182_T	207_Q	1.006	0.48
85_L	104_T	0.997	0.47
124_Y	166_Y	0.996	0.47
43_G	256_I	0.991	0.47
32_V	40_I	0.990	0.47
187_T	200_W	0.990	0.47
14_P	184_V	0.986	0.47
30_P	77_T	0.983	0.46
34_D	99_Y	0.982	0.46
121_G	150_D	0.981	0.46
131_S	157_N	0.980	0.46
14_P	207_Q	0.976	0.46
20_G	27_V	0.972	0.46
188_E	196_S	0.969	0.45
72_E	75_I	0.968	0.45
140_I	176_A	0.963	0.45
107_L	173_G	0.958	0.45
40_I	200_W	0.957	0.45
124_Y	133_V	0.954	0.44
97_E	182_T	0.953	0.44
152_V	160_K	0.951	0.44
87_P	167_V	0.950	0.44
64_C	210_I	0.949	0.44
87_P	211_L	0.947	0.44
120_I	150_D	0.931	0.43
185_T	189_L	0.920	0.42
6_L	214_G	0.918	0.42
27_V	201_S	0.913	0.42
102_I	191_D	0.907	0.41
139_K	202_E	0.906	0.41
29_S	200_W	0.900	0.41
13_T	139_K	0.900	0.41
122_S	132_E	0.898	0.41
98_G	213_S	0.897	0.40
102_I	168_L	0.896	0.40
7_V	213_S	0.878	0.39
27_V	99_Y	0.867	0.38
246_V	250_I	0.867	0.38
43_G	78_S	0.867	0.38
187_T	209_T	0.861	0.38
54_L	62_A	0.848	0.37
89_F	255_S	0.847	0.37
88_V	111_I	0.846	0.37
99_Y	182_T	0.846	0.37
235_I	240_L	0.843	0.37
126_E	132_E	0.842	0.37
102_I	111_I	0.840	0.37
68_G	218_R	0.836	0.36
87_P	107_L	0.832	0.36
83_T	214_G	0.831	0.36
37_G	178_E	0.829	0.36
38_Y	84_D	0.828	0.36
64_C	220_I	0.826	0.36
142_T	168_L	0.824	0.36
125_K	151_E	0.819	0.35
97_E	171_S	0.818	0.35
105_R	110_H	0.813	0.35
107_L	182_T	0.811	0.35
176_A	179_S	0.806	0.35
28_D	199_I	0.804	0.34
34_D	86_I	0.801	0.34
181_L	211_L	0.796	0.34
127_S	153_R	0.782	0.33
110_H	113_D	0.782	0.33
204_Y	253_K	0.782	0.33
59_E	155_L	0.776	0.33
201_S	207_Q	0.776	0.33
251_G	259_G	0.772	0.32
237_N	241_K	0.766	0.32
32_V	47_K	0.762	0.32
46_L	213_S	0.760	0.32
12_I	262_K	0.758	0.32
12_I	165_V	0.755	0.31
145_S	234_N	0.751	0.31
156_G	165_V	0.747	0.31
63_K	209_T	0.746	0.31
239_F	243_I	0.744	0.31
86_I	114_L	0.744	0.31
218_R	254_E	0.740	0.31
190_D	194_K	0.740	0.31
186_R	200_W	0.735	0.30
189_L	196_S	0.734	0.30
42_Y	45_S	0.731	0.30
108_I	187_T	0.730	0.30
102_I	131_S	0.729	0.30
92_V	176_A	0.727	0.30
24_T	189_L	0.725	0.30
13_T	202_E	0.723	0.30
90_Y	181_L	0.723	0.30
21_K	35_S	0.719	0.29
41_V	46_L	0.717	0.29
46_L	85_L	0.717	0.29
158_L	234_N	0.717	0.29
99_Y	168_L	0.716	0.29
182_T	185_T	0.716	0.29
11_A	253_K	0.715	0.29
73_E	132_E	0.715	0.29
71_E	156_G	0.707	0.29
215_I	239_F	0.703	0.28
208_G	256_I	0.702	0.28
172_I	186_R	0.698	0.28
219_E	234_N	0.694	0.28
41_V	180_A	0.694	0.28
184_V	256_I	0.692	0.28
111_I	213_S	0.692	0.28
81_V	216_F	0.688	0.28
25_G	113_D	0.685	0.27
86_I	212_L	0.681	0.27
71_E	134_R	0.681	0.27
30_P	34_D	0.681	0.27
22_S	186_R	0.680	0.27
107_L	181_L	0.678	0.27
38_Y	99_Y	0.678	0.27
19_A	256_I	0.677	0.27
55_I	191_D	0.675	0.27
101_Y	209_T	0.674	0.27
11_A	261_T	0.673	0.27
112_E	117_R	0.673	0.27
36_I	249_F	0.672	0.27
240_L	243_I	0.668	0.26
151_E	154_S	0.668	0.26
130_K	241_K	0.668	0.26
39_P	84_D	0.665	0.26
142_T	167_V	0.662	0.26
13_T	89_F	0.662	0.26
13_T	260_L	0.662	0.26
134_R	143_E	0.655	0.26
17_V	87_P	0.652	0.26
127_S	131_S	0.651	0.26
41_V	45_S	0.650	0.25
126_E	209_T	0.645	0.25
99_Y	212_L	0.644	0.25
42_Y	184_V	0.643	0.25
109_N	131_S	0.640	0.25
123_L	205_I	0.639	0.25
98_G	196_S	0.639	0.25
123_L	127_S	0.637	0.25
222_N	225_C	0.637	0.25
30_P	81_V	0.636	0.25
115_M	135_I	0.635	0.25
49_S	213_S	0.634	0.25
130_K	163_N	0.633	0.25
38_Y	107_L	0.632	0.25
31_L	166_Y	0.630	0.24
69_K	134_R	0.630	0.24
39_P	66_F	0.627	0.24
80_Y	217_E	0.626	0.24
104_T	159_I	0.624	0.24
22_S	81_V	0.623	0.24
38_Y	176_A	0.622	0.24
133_V	150_D	0.618	0.24
173_G	182_T	0.617	0.24
79_K	220_I	0.617	0.24
89_F	199_I	0.614	0.24
85_L	98_G	0.614	0.24
236_D	250_I	0.613	0.24
49_S	83_T	0.612	0.24
181_L	207_Q	0.610	0.23
123_L	130_K	0.606	0.23
136_F	142_T	0.606	0.23
43_G	248_V	0.605	0.23
40_I	185_T	0.604	0.23
126_E	130_K	0.602	0.23
178_E	258_K	0.599	0.23
204_Y	261_T	0.597	0.23
30_P	47_K	0.596	0.23
233_V	255_S	0.595	0.23
59_E	63_K	0.595	0.23
99_Y	207_Q	0.592	0.23
6_L	189_L	0.592	0.23
177_V	182_T	0.592	0.23
72_E	130_K	0.590	0.22
29_S	253_K	0.589	0.22
10_Y	113_D	0.588	0.22
157_N	237_N	0.588	0.22
131_S	153_R	0.587	0.22
101_Y	261_T	0.584	0.22
30_P	138_G	0.584	0.22
8_L	168_L	0.583	0.22
60_S	219_E	0.583	0.22
8_L	158_L	0.582	0.22
139_K	200_W	0.582	0.22
51_K	92_V	0.582	0.22
133_V	243_I	0.582	0.22
40_I	62_A	0.581	0.22
162_K	192_N	0.578	0.22
95_I	101_Y	0.578	0.22
186_R	194_K	0.577	0.22
131_S	159_I	0.577	0.22
177_V	204_Y	0.574	0.22
47_K	186_R	0.574	0.22
129_E	144_L	0.573	0.22
175_S	179_S	0.573	0.22
45_S	169_D	0.572	0.22
253_K	258_K	0.571	0.22
126_E	145_S	0.571	0.22
140_I	253_K	0.570	0.21
98_G	182_T	0.570	0.21
33_R	105_R	0.565	0.21
59_E	68_G	0.564	0.21
150_D	234_N	0.561	0.21
59_E	143_E	0.557	0.21
167_V	235_I	0.555	0.21
150_D	160_K	0.555	0.21
46_L	250_I	0.554	0.21
47_K	253_K	0.553	0.21
134_R	221_S	0.553	0.21
126_E	129_E	0.552	0.21
185_T	199_I	0.551	0.21
27_V	93_S	0.551	0.21
106_Y	113_D	0.550	0.21
19_A	35_S	0.548	0.20
33_R	91_P	0.547	0.20
58_N	121_G	0.544	0.20
140_I	173_G	0.544	0.20
105_R	137_L	0.544	0.20
35_S	249_F	0.543	0.20
251_G	257_G	0.543	0.20
234_N	240_L	0.542	0.20
10_Y	101_Y	0.541	0.20
32_V	49_S	0.540	0.20
206_P	251_G	0.539	0.20
77_T	205_I	0.537	0.20
115_M	241_K	0.535	0.20
140_I	155_L	0.534	0.20
40_I	186_R	0.534	0.20
180_A	204_Y	0.534	0.20
189_L	254_E	0.533	0.20
52_S	152_V	0.531	0.20
58_N	242_L	0.530	0.20
35_S	141_S	0.530	0.20
51_K	55_I	0.528	0.20
234_N	237_N	0.527	0.20
9_A	60_S	0.524	0.19
17_V	189_L	0.523	0.19
45_S	186_R	0.523	0.19
131_S	161_D	0.522	0.19
134_R	165_V	0.521	0.19
27_V	208_G	0.521	0.19
46_L	100_I	0.519	0.19
43_G	205_I	0.517	0.19
116_S	119_G	0.516	0.19
186_R	253_K	0.515	0.19
83_T	215_I	0.513	0.19
159_I	171_S	0.511	0.19
12_I	176_A	0.510	0.19
157_N	238_E	0.510	0.19
190_D	224_Y	0.509	0.19
49_S	98_G	0.509	0.19
59_E	241_K	0.507	0.19
62_A	191_D	0.507	0.19
179_S	253_K	0.507	0.19
104_T	108_I	0.506	0.19
9_A	49_S	0.505	0.19
204_Y	207_Q	0.505	0.19
81_V	214_G	0.505	0.19
180_A	213_S	0.505	0.19
127_S	223_S	0.504	0.19
44_S	258_K	0.503	0.19
99_Y	208_G	0.503	0.19
31_L	36_I	0.502	0.18
209_T	236_D	0.501	0.18
63_K	68_G	0.500	0.18
15_I	192_N	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3x1lC	3	0.9703	100	0.283	Contact Map
4w8wA	1	0.8699	100	0.308	Contact Map
4qtsC	1	0.5056	100	0.667	Contact Map
4n0lA	1	0.6989	99.9	0.71	Contact Map
3x1lH	1	0.5539	99.9	0.756	Contact Map
4w8vA	1	0.6729	99.9	0.758	Contact Map
4qtsA	1	0.7026	98.2	0.893	Contact Map
3x1lB	1	0.7695	97.4	0.912	Contact Map
4txdA	1	0.658	79.5	0.949	Contact Map
4l6uA	1	0.5428	40.2	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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