GREMLIN Database
Q97Y35 - Uncharacterized protein
UniProt: Q97Y35 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 156 (144)
Sequences: 140 (126)
Seq/√Len: 10.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_E144_K4.7001.00
40_K151_I3.7600.98
144_K148_D2.9660.93
7_K10_E2.6430.88
6_K9_K2.4200.83
43_I147_L2.4110.83
81_E85_A2.3170.80
116_N139_H2.1550.75
43_I65_T2.1470.75
96_L115_W2.1380.74
19_I118_A2.1300.74
113_N142_K2.1050.73
124_W130_K2.0890.72
66_A143_V1.9890.69
71_K128_E1.9870.69
51_K137_S1.9620.67
64_K67_E1.9340.66
70_V136_I1.8430.62
63_Y127_H1.8010.61
4_L148_D1.7620.59
43_I47_E1.6970.56
63_Y125_G1.6930.56
82_Y130_K1.6830.55
12_D15_I1.6220.52
4_L13_I1.5750.50
51_K136_I1.5410.49
97_A131_L1.5010.47
32_I89_G1.4780.46
59_S125_G1.4770.46
16_N20_I1.4740.45
6_K134_A1.4680.45
62_A70_V1.4440.44
110_W149_N1.4270.43
71_K96_L1.3980.42
105_K134_A1.3930.42
84_Q87_K1.3810.41
65_T147_L1.3620.40
18_L22_A1.3390.39
99_A127_H1.3250.39
66_A115_W1.3090.38
55_A125_G1.2880.37
38_L49_Y1.2600.36
63_Y67_E1.2480.35
128_E136_I1.2470.35
101_N132_S1.2270.34
35_R130_K1.2150.34
97_A130_K1.2150.34
71_K136_I1.2130.34
110_W145_E1.2110.34
63_Y68_E1.2040.33
109_D143_V1.1590.32
47_E51_K1.1560.31
82_Y85_A1.1500.31
16_N26_K1.1490.31
111_V151_I1.1400.31
35_R124_W1.1170.30
52_K152_N1.1140.30
68_E125_G1.1030.29
17_D29_K1.0880.29
13_I143_V1.0880.29
16_N21_D1.0850.29
64_K127_H1.0810.28
85_A120_I1.0810.28
38_L41_K1.0790.28
125_G131_L1.0780.28
135_D152_N1.0700.28
105_K140_L1.0540.27
8_A46_T1.0490.27
32_I84_Q1.0190.26
132_S137_S1.0110.26
149_N152_N1.0110.26
35_R49_Y1.0100.26
39_A68_E1.0070.26
5_I9_K1.0030.26
102_R145_E1.0010.25
45_E80_P0.9870.25
104_A132_S0.9860.25
46_T53_G0.9760.25
101_N135_D0.9680.24
64_K68_E0.9570.24
78_N107_L0.9520.24
25_R152_N0.9510.24
109_D154_I0.9490.24
5_I17_D0.9480.24
67_E127_H0.9460.24
69_I146_M0.9440.24
38_L42_Y0.9430.23
36_I103_L0.9430.23
51_K134_A0.9420.23
64_K125_G0.9400.23
148_D152_N0.9360.23
111_V146_M0.9320.23
95_W99_A0.9290.23
77_F106_D0.9250.23
35_R85_A0.9200.23
65_T144_K0.9160.23
67_E99_A0.9140.23
44_T53_G0.9110.22
13_I19_I0.8850.22
46_T103_L0.8780.21
100_V105_K0.8560.21
85_A130_K0.8530.21
35_R75_E0.8530.21
56_V73_L0.8500.20
128_E144_K0.8430.20
68_E124_W0.8390.20
68_E127_H0.8380.20
121_L131_L0.8270.20
101_N105_K0.8220.20
68_E99_A0.8200.20
120_I131_L0.8180.20
5_I20_I0.8160.19
4_L50_L0.8150.19
100_V119_Y0.8110.19
44_T83_Q0.8090.19
67_E125_G0.8000.19
127_H130_K0.8000.19
32_I44_T0.7980.19
88_E103_L0.7950.19
29_K48_D0.7930.19
23_I40_K0.7840.19
47_E147_L0.7760.18
53_G111_V0.7710.18
81_E99_A0.7620.18
17_D34_L0.7590.18
12_D65_T0.7510.18
69_I150_V0.7510.18
96_L128_E0.7490.18
39_A96_L0.7470.18
30_E66_A0.7410.17
50_L128_E0.7410.17
14_D67_E0.7380.17
116_N120_I0.7360.17
66_A119_Y0.7340.17
6_K10_E0.7330.17
21_D31_A0.7260.17
51_K154_I0.7250.17
39_A128_E0.7240.17
8_A37_E0.7240.17
16_N31_A0.7140.17
148_D151_I0.7050.16
35_R127_H0.7050.16
40_K44_T0.7040.16
7_K24_S0.6990.16
77_F124_W0.6960.16
75_E114_G0.6950.16
35_R64_K0.6910.16
4_L30_E0.6850.16
7_K11_Y0.6820.16
25_R52_K0.6800.16
42_Y49_Y0.6780.16
76_K103_L0.6710.16
75_E130_K0.6660.15
23_I153_I0.6510.15
18_L118_A0.6400.15
22_A31_A0.6390.15
66_A117_S0.6370.15
124_W129_A0.6360.15
132_S139_H0.6290.15
35_R68_E0.6290.15
58_A65_T0.6280.15
98_S132_S0.6270.14
41_K45_E0.6260.14
35_R55_A0.6230.14
67_E120_I0.6210.14
144_K150_V0.6200.14
103_L132_S0.6200.14
65_T74_A0.6180.14
59_S115_W0.6170.14
20_I44_T0.6110.14
39_A89_G0.6100.14
44_T48_D0.6070.14
50_L71_K0.6070.14
35_R63_Y0.6040.14
81_E95_W0.6030.14
30_E134_A0.5910.14
21_D133_T0.5890.14
13_I20_I0.5890.14
83_Q105_K0.5860.14
68_E130_K0.5770.13
17_D80_P0.5770.13
55_A75_E0.5720.13
63_Y119_Y0.5710.13
21_D153_I0.5690.13
71_K129_A0.5680.13
34_L101_N0.5680.13
144_K147_L0.5660.13
17_D137_S0.5650.13
42_Y105_K0.5640.13
105_K138_E0.5610.13
14_D112_L0.5590.13
81_E88_E0.5590.13
41_K76_K0.5560.13
71_K104_A0.5550.13
13_I18_L0.5530.13
111_V118_A0.5530.13
77_F147_L0.5510.13
81_E121_L0.5410.13
52_K135_D0.5400.13
135_D143_V0.5380.13
23_I137_S0.5360.13
7_K52_K0.5350.12
62_A143_V0.5330.12
68_E81_E0.5320.12
97_A119_Y0.5320.12
114_G131_L0.5320.12
6_K104_A0.5290.12
36_I40_K0.5210.12
109_D149_N0.5160.12
143_V154_I0.5150.12
80_P103_L0.5130.12
49_Y121_L0.5120.12
97_A139_H0.5070.12
16_N46_T0.5070.12
9_K12_D0.5030.12
55_A124_W0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jpuA 1 0.7885 100 0.365 Contact Map
2hsbA 2 0.7628 98.2 0.842 Contact Map
1wolA 1 0.7436 98.1 0.845 Contact Map
1ufbA 3 0.7436 97.3 0.87 Contact Map
3o10A 2 0.7821 97 0.876 Contact Map
1o3uA 2 0.6923 96.9 0.876 Contact Map
4nqfA 2 0.8462 95.8 0.89 Contact Map
1mntA 2 0.3205 68.9 0.93 Contact Map
2oo2A 2 0.4744 38.7 0.941 Contact Map
4ndwA 2 0.4679 32.1 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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