Q97Y34 - SULSO - GREMLIN Contacts

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Q97Y34 - Transposase ISC1217

UniProt:	Q97Y34	Sequences: MTKELTREEYYKALEKAVNEVILSMTGTRKDVAKRLVLGAVVGRNATEIAQEAEMDYETVLNNLDKAAQAKLIEVVKKLVGDHPVLLIVDDTHDHKLYARAMPVSRNGAQIFYCRAHKRFESAIQLLVIGVKDLVNNQIYVIHIIAYIPRKVEEELKRRGEEVKFKTKIDALLEFLSSLSGLNVKSKVFDSWYVNSRTLQGNTVGELKANARVVEGGRSVPVGEFPQGEYLVEYLGTPIKLLVIDDYKGYGRRYFFSTDLNDTAEDIITTWENRWDIEVLIRELKALGLEGGSFLTWVRNSGFVALKALSLLVVQYFKYSTGLRLGAKRLARLIKSIYHEVGGIKKLFKRRRKP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	354 (296)
Sequences:	1045 (798)
Seq/√Len:	46.4

SULSO - Q97Y34 Q97ZD8 Q97XR1 Q97YE4 Q97XK5 Q97VQ0 Q7LYK0 Q7LX51

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
155_E	158_R	5.633	1.00
154_E	158_R	4.853	1.00
154_E	157_K	4.456	1.00
189_F	205_G	3.510	1.00
129_I	179_L	3.332	1.00
155_E	159_R	3.169	1.00
153_E	158_R	3.126	1.00
156_L	159_R	3.089	1.00
89_V	172_L	2.977	1.00
155_E	160_G	2.948	1.00
154_E	160_G	2.912	1.00
145_I	178_S	2.852	1.00
36_L	303_F	2.777	1.00
287_L	307_K	2.749	1.00
166_K	174_E	2.704	1.00
91_D	192_W	2.529	1.00
87_L	179_L	2.440	1.00
90_D	274_R	2.380	1.00
89_V	187_K	2.330	1.00
154_E	159_R	2.325	1.00
143_H	178_S	2.210	1.00
214_V	219_S	2.166	1.00
90_D	278_E	2.144	1.00
204_V	271_W	2.142	1.00
128_V	281_I	2.138	1.00
127_L	193_Y	2.098	1.00
153_E	157_K	2.077	1.00
88_I	132_K	2.058	1.00
153_E	160_G	2.037	0.99
274_R	278_E	1.950	0.99
142_I	182_L	1.888	0.99
222_V	228_G	1.810	0.99
85_V	131_V	1.796	0.99
91_D	168_K	1.771	0.98
143_H	175_F	1.757	0.98
224_E	228_G	1.752	0.98
278_E	285_K	1.752	0.98
130_G	139_I	1.739	0.98
26_T	30_K	1.730	0.98
294_F	299_R	1.728	0.98
22_I	25_M	1.723	0.98
32_V	59_T	1.715	0.98
153_E	159_R	1.709	0.98
153_E	156_L	1.709	0.98
91_D	193_Y	1.696	0.98
222_V	226_P	1.690	0.98
62_N	65_D	1.649	0.98
145_I	174_E	1.619	0.97
240_K	244_I	1.588	0.97
293_S	299_R	1.584	0.97
275_W	278_E	1.566	0.97
145_I	301_S	1.563	0.97
220_V	223_G	1.548	0.96
228_G	232_V	1.541	0.96
90_D	285_K	1.537	0.96
222_V	229_E	1.510	0.96
147_Y	165_F	1.508	0.96
168_K	193_Y	1.474	0.95
193_Y	274_R	1.474	0.95
22_I	30_K	1.456	0.95
64_L	306_L	1.442	0.95
95_H	117_H	1.439	0.95
91_D	275_W	1.411	0.94
93_H	121_E	1.406	0.94
240_K	243_V	1.399	0.94
93_H	114_C	1.398	0.94
194_V	205_G	1.394	0.94
295_L	303_F	1.385	0.93
211_A	256_F	1.372	0.93
194_V	200_Q	1.367	0.93
86_L	270_T	1.355	0.93
242_L	267_I	1.353	0.93
89_V	129_I	1.341	0.92
206_E	253_R	1.335	0.92
114_C	121_E	1.325	0.92
243_V	246_D	1.322	0.92
221_P	227_Q	1.319	0.92
130_G	281_I	1.317	0.92
222_V	227_Q	1.311	0.91
274_R	285_K	1.309	0.91
63_N	292_G	1.287	0.91
221_P	226_P	1.286	0.91
157_K	160_G	1.283	0.90
202_N	258_T	1.275	0.90
156_L	160_G	1.256	0.89
303_F	310_S	1.251	0.89
296_T	307_K	1.248	0.89
279_V	283_E	1.245	0.89
193_Y	285_K	1.234	0.89
115_R	192_W	1.222	0.88
90_D	275_W	1.218	0.88
33_A	37_V	1.205	0.87
240_K	245_D	1.204	0.87
167_T	170_D	1.203	0.87
275_W	285_K	1.203	0.87
109_A	122_S	1.187	0.87
170_D	173_L	1.182	0.86
94_D	102_M	1.177	0.86
92_T	278_E	1.176	0.86
103_P	300_N	1.166	0.86
224_E	227_Q	1.163	0.85
304_V	307_K	1.154	0.85
93_H	112_F	1.153	0.85
108_G	148_I	1.151	0.85
21_V	24_S	1.146	0.85
292_G	300_N	1.145	0.85
220_V	229_E	1.138	0.84
141_V	312_L	1.136	0.84
28_T	33_A	1.135	0.84
129_I	175_F	1.135	0.84
102_M	124_I	1.108	0.83
230_Y	233_E	1.105	0.82
49_I	52_E	1.102	0.82
31_D	236_G	1.094	0.82
19_N	23_L	1.093	0.82
77_K	80_V	1.093	0.82
69_Q	302_G	1.091	0.82
24_S	71_K	1.088	0.81
204_V	257_S	1.076	0.81
190_D	278_E	1.074	0.81
297_W	301_S	1.072	0.80
225_F	228_G	1.071	0.80
155_E	161_E	1.046	0.79
203_T	258_T	1.043	0.79
249_G	257_S	1.040	0.78
188_V	270_T	1.033	0.78
275_W	314_V	1.032	0.78
189_F	194_V	1.032	0.78
186_S	270_T	1.029	0.78
211_A	254_Y	1.027	0.77
33_A	36_L	1.026	0.77
156_L	161_E	1.023	0.77
90_D	277_I	1.021	0.77
220_V	226_P	1.021	0.77
276_D	311_L	1.020	0.77
26_T	29_R	1.011	0.76
130_G	280_L	1.011	0.76
127_L	172_L	1.009	0.76
241_L	254_Y	1.008	0.76
29_R	67_A	1.000	0.76
223_G	230_Y	0.998	0.75
145_I	171_A	0.996	0.75
82_D	136_N	0.992	0.75
110_Q	151_K	0.991	0.75
48_E	293_S	0.987	0.75
96_K	109_A	0.985	0.74
274_R	281_I	0.981	0.74
285_K	314_V	0.977	0.74
22_I	29_R	0.976	0.74
126_L	304_V	0.976	0.74
63_N	67_A	0.974	0.74
103_P	297_W	0.969	0.73
20_E	25_M	0.969	0.73
39_G	49_I	0.967	0.73
306_L	310_S	0.958	0.72
150_R	154_E	0.954	0.72
277_I	285_K	0.951	0.72
139_I	276_D	0.950	0.72
205_G	256_F	0.946	0.71
36_L	40_A	0.945	0.71
108_G	288_G	0.943	0.71
90_D	168_K	0.936	0.71
86_L	188_V	0.931	0.70
40_A	45_N	0.924	0.70
21_V	27_G	0.918	0.69
126_L	300_N	0.917	0.69
221_P	224_E	0.916	0.69
91_D	281_I	0.914	0.69
207_L	278_E	0.910	0.68
77_K	182_L	0.910	0.68
70_A	74_E	0.902	0.68
57_Y	61_L	0.901	0.68
207_L	256_F	0.900	0.68
281_I	285_K	0.900	0.68
94_D	126_L	0.897	0.67
88_I	188_V	0.897	0.67
72_L	76_V	0.897	0.67
171_A	175_F	0.896	0.67
114_C	125_Q	0.896	0.67
75_V	80_V	0.895	0.67
34_K	38_L	0.894	0.67
128_V	141_V	0.893	0.67
124_I	300_N	0.890	0.67
240_K	257_S	0.883	0.66
21_V	25_M	0.883	0.66
63_N	69_Q	0.878	0.66
112_F	115_R	0.875	0.65
127_L	168_K	0.874	0.65
141_V	280_L	0.874	0.65
38_L	41_V	0.873	0.65
90_D	193_Y	0.871	0.65
139_I	280_L	0.870	0.65
244_I	247_Y	0.870	0.65
16_K	19_N	0.870	0.65
199_L	205_G	0.870	0.65
28_T	31_D	0.866	0.65
26_T	32_V	0.863	0.64
127_L	171_A	0.863	0.64
189_F	192_W	0.863	0.64
220_V	228_G	0.861	0.64
200_Q	205_G	0.859	0.64
48_E	51_Q	0.857	0.64
102_M	292_G	0.853	0.63
141_V	311_L	0.852	0.63
94_D	128_V	0.850	0.63
58_E	62_N	0.848	0.63
92_T	275_W	0.846	0.63
246_D	249_G	0.843	0.62
115_R	121_E	0.840	0.62
224_E	229_E	0.839	0.62
223_G	227_Q	0.839	0.62
223_G	228_G	0.835	0.62
18_V	21_V	0.829	0.61
28_T	36_L	0.828	0.61
94_D	304_V	0.828	0.61
70_A	178_S	0.827	0.61
207_L	211_A	0.822	0.60
25_M	29_R	0.817	0.60
92_T	274_R	0.814	0.60
127_L	145_I	0.814	0.60
102_M	146_A	0.811	0.59
255_F	268_I	0.810	0.59
103_P	124_I	0.810	0.59
111_I	122_S	0.809	0.59
112_F	124_I	0.806	0.59
277_I	287_L	0.803	0.59
112_F	121_E	0.800	0.58
29_R	33_A	0.799	0.58
195_N	210_N	0.798	0.58
159_R	162_E	0.794	0.58
299_R	303_F	0.790	0.57
129_I	187_K	0.789	0.57
18_V	34_K	0.788	0.57
193_Y	275_W	0.787	0.57
117_H	121_E	0.784	0.57
75_V	79_L	0.784	0.57
74_E	265_E	0.784	0.57
21_V	34_K	0.784	0.57
92_T	285_K	0.782	0.57
68_A	302_G	0.780	0.56
189_F	208_K	0.779	0.56
91_D	277_I	0.778	0.56
255_F	271_W	0.776	0.56
168_K	192_W	0.775	0.56
114_C	275_W	0.772	0.56
92_T	289_L	0.772	0.56
239_I	248_K	0.772	0.56
18_V	37_V	0.771	0.56
74_E	210_N	0.767	0.55
319_Y	322_G	0.763	0.55
159_R	163_V	0.762	0.55
87_L	184_V	0.759	0.54
157_K	162_E	0.754	0.54
224_E	230_Y	0.753	0.54
191_S	207_L	0.752	0.54
150_R	187_K	0.751	0.54
154_E	164_K	0.750	0.53
37_V	309_L	0.749	0.53
98_Y	109_A	0.748	0.53
39_G	60_V	0.747	0.53
278_E	281_I	0.744	0.53
114_C	120_F	0.744	0.53
32_V	35_R	0.740	0.53
101_A	129_I	0.737	0.52
21_V	213_V	0.736	0.52
193_Y	278_E	0.736	0.52
239_I	243_V	0.729	0.51
93_H	120_F	0.729	0.51
191_S	208_K	0.729	0.51
17_A	20_E	0.727	0.51
281_I	284_L	0.724	0.51
64_L	302_G	0.723	0.51
231_L	234_Y	0.718	0.50
245_D	251_G	0.717	0.50
179_L	182_L	0.717	0.50
122_S	149_P	0.716	0.50
192_W	208_K	0.715	0.50
208_K	212_R	0.714	0.50
124_I	148_I	0.713	0.50
316_Y	322_G	0.713	0.50
94_D	303_F	0.713	0.50
129_I	176_L	0.713	0.50
279_V	282_R	0.712	0.50
278_E	314_V	0.711	0.50
92_T	304_V	0.700	0.49
162_E	165_F	0.696	0.48
45_N	291_G	0.693	0.48
147_Y	168_K	0.691	0.48
220_V	224_E	0.689	0.47
95_H	121_E	0.688	0.47
115_R	120_F	0.688	0.47
98_Y	295_L	0.686	0.47
225_F	230_Y	0.685	0.47
221_P	228_G	0.684	0.47
17_A	21_V	0.683	0.47
125_Q	168_K	0.682	0.47
20_E	24_S	0.682	0.47
271_W	274_R	0.681	0.47
23_L	30_K	0.680	0.47
302_G	305_A	0.678	0.46
142_I	179_L	0.677	0.46
168_K	194_V	0.677	0.46
184_V	282_R	0.676	0.46
145_I	166_K	0.672	0.46
40_A	284_L	0.672	0.46
27_G	31_D	0.670	0.46
275_W	281_I	0.670	0.46
111_I	121_E	0.670	0.46
239_I	242_L	0.668	0.45
178_S	195_N	0.667	0.45
114_C	117_H	0.667	0.45
296_T	308_A	0.665	0.45
71_K	74_E	0.664	0.45
93_H	125_Q	0.664	0.45
102_M	126_L	0.662	0.45
199_L	256_F	0.656	0.44
120_F	308_A	0.655	0.44
102_M	300_N	0.655	0.44
289_L	304_V	0.654	0.44
111_I	253_R	0.654	0.44
45_N	50_A	0.654	0.44
111_I	120_F	0.652	0.44
225_F	232_V	0.649	0.44
284_L	289_L	0.648	0.43
37_V	142_I	0.645	0.43
85_V	185_K	0.643	0.43
190_D	274_R	0.640	0.43
132_K	273_N	0.637	0.42
192_W	278_E	0.635	0.42
16_K	20_E	0.635	0.42
25_M	30_K	0.635	0.42
192_W	275_W	0.633	0.42
37_V	306_L	0.632	0.42
220_V	232_V	0.632	0.42
288_G	291_G	0.629	0.42
69_Q	98_Y	0.624	0.41
116_A	290_E	0.622	0.41
259_D	299_R	0.621	0.41
127_L	192_W	0.619	0.41
69_Q	305_A	0.619	0.41
36_L	293_S	0.617	0.40
96_K	102_M	0.615	0.40
156_L	162_E	0.615	0.40
62_N	299_R	0.614	0.40
166_K	177_S	0.614	0.40
32_V	63_N	0.613	0.40
160_G	165_F	0.612	0.40
168_K	171_A	0.611	0.40
257_S	267_I	0.607	0.40
73_I	144_I	0.607	0.40
298_V	302_G	0.605	0.39
72_L	80_V	0.603	0.39
127_L	147_Y	0.602	0.39
57_Y	275_W	0.600	0.39
159_R	164_K	0.598	0.39
295_L	310_S	0.597	0.39
266_D	269_T	0.596	0.39
127_L	274_R	0.596	0.39
102_M	118_K	0.594	0.38
102_M	293_S	0.594	0.38
67_A	131_V	0.593	0.38
46_A	195_N	0.592	0.38
318_K	322_G	0.591	0.38
72_L	75_V	0.590	0.38
131_V	189_F	0.587	0.38
21_V	182_L	0.587	0.38
40_A	303_F	0.586	0.38
29_R	296_T	0.586	0.38
112_F	125_Q	0.585	0.37
124_I	303_F	0.585	0.37
170_D	234_Y	0.584	0.37
38_L	46_A	0.583	0.37
300_N	304_V	0.583	0.37
97_L	121_E	0.583	0.37
39_G	108_G	0.583	0.37
41_V	100_R	0.582	0.37
226_P	229_E	0.581	0.37
36_L	46_A	0.579	0.37
112_F	149_P	0.578	0.37
307_K	318_K	0.578	0.37
72_L	309_L	0.578	0.37
40_A	306_L	0.577	0.37
148_I	152_V	0.577	0.37
83_H	233_E	0.577	0.37
257_S	293_S	0.573	0.36
76_V	80_V	0.572	0.36
135_V	138_Q	0.571	0.36
17_A	31_D	0.569	0.36
58_E	292_G	0.568	0.36
181_G	185_K	0.566	0.36
18_V	33_A	0.566	0.36
263_T	266_D	0.565	0.36
41_V	196_S	0.565	0.36
114_C	271_W	0.564	0.36
274_R	277_I	0.563	0.35
263_T	270_T	0.562	0.35
260_L	263_T	0.561	0.35
88_I	276_D	0.561	0.35
18_V	22_I	0.560	0.35
282_R	285_K	0.553	0.35
125_Q	149_P	0.552	0.34
233_E	237_T	0.551	0.34
21_V	33_A	0.550	0.34
82_D	263_T	0.549	0.34
98_Y	283_E	0.549	0.34
44_R	48_E	0.548	0.34
103_P	301_S	0.546	0.34
160_G	163_V	0.543	0.34
79_L	240_K	0.543	0.34
244_I	272_E	0.542	0.34
243_V	247_Y	0.542	0.34
188_V	273_N	0.540	0.33
149_P	187_K	0.540	0.33
102_M	303_F	0.535	0.33
252_R	309_L	0.535	0.33
172_L	187_K	0.533	0.33
240_K	247_Y	0.527	0.32
19_N	34_K	0.523	0.32
48_E	52_E	0.523	0.32
113_Y	183_N	0.520	0.32
88_I	135_V	0.519	0.32
86_L	272_E	0.519	0.32
168_K	274_R	0.518	0.32
98_Y	108_G	0.517	0.31
300_N	307_K	0.516	0.31
117_H	219_S	0.515	0.31
118_K	152_V	0.514	0.31
292_G	303_F	0.513	0.31
168_K	191_S	0.512	0.31
91_D	191_S	0.510	0.31
160_G	174_E	0.510	0.31
67_A	302_G	0.509	0.31
299_R	306_L	0.506	0.30
296_T	311_L	0.506	0.30
167_T	177_S	0.506	0.30
196_S	290_E	0.506	0.30
197_R	251_G	0.505	0.30
22_I	26_T	0.505	0.30
160_G	164_K	0.504	0.30
90_D	190_D	0.504	0.30
147_Y	193_Y	0.504	0.30
65_D	299_R	0.501	0.30
109_A	292_G	0.501	0.30
151_K	166_K	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.9209	99.9	0.716	Contact Map
2kkoA	2	0.3023	25.6	0.963	Contact Map
2zkzA	2	0.2514	12.6	0.968	Contact Map
3cuoA	2	0.2768	12.3	0.968	Contact Map
3hdeA	2	0.2712	10.1	0.969	Contact Map
1r1tA	2	0.2768	9.3	0.97	Contact Map
1qgpA	1	0.2034	8.5	0.97	Contact Map
4i2oA	2	0.2486	8.2	0.971	Contact Map
3qfiA	1	0.2542	7.8	0.971	Contact Map
3hdfA	1	0.2684	6.8	0.972	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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