GREMLIN Database
Q97Y34 - Transposase ISC1217
UniProt: Q97Y34 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 354 (296)
Sequences: 1045 (798)
Seq/√Len: 46.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_E158_R5.6331.00
154_E158_R4.8531.00
154_E157_K4.4561.00
189_F205_G3.5101.00
129_I179_L3.3321.00
155_E159_R3.1691.00
153_E158_R3.1261.00
156_L159_R3.0891.00
89_V172_L2.9771.00
155_E160_G2.9481.00
154_E160_G2.9121.00
145_I178_S2.8521.00
36_L303_F2.7771.00
287_L307_K2.7491.00
166_K174_E2.7041.00
91_D192_W2.5291.00
87_L179_L2.4401.00
90_D274_R2.3801.00
89_V187_K2.3301.00
154_E159_R2.3251.00
143_H178_S2.2101.00
214_V219_S2.1661.00
90_D278_E2.1441.00
204_V271_W2.1421.00
128_V281_I2.1381.00
127_L193_Y2.0981.00
153_E157_K2.0771.00
88_I132_K2.0581.00
153_E160_G2.0370.99
274_R278_E1.9500.99
142_I182_L1.8880.99
222_V228_G1.8100.99
85_V131_V1.7960.99
91_D168_K1.7710.98
143_H175_F1.7570.98
224_E228_G1.7520.98
278_E285_K1.7520.98
130_G139_I1.7390.98
26_T30_K1.7300.98
294_F299_R1.7280.98
22_I25_M1.7230.98
32_V59_T1.7150.98
153_E159_R1.7090.98
153_E156_L1.7090.98
91_D193_Y1.6960.98
222_V226_P1.6900.98
62_N65_D1.6490.98
145_I174_E1.6190.97
240_K244_I1.5880.97
293_S299_R1.5840.97
275_W278_E1.5660.97
145_I301_S1.5630.97
220_V223_G1.5480.96
228_G232_V1.5410.96
90_D285_K1.5370.96
222_V229_E1.5100.96
147_Y165_F1.5080.96
168_K193_Y1.4740.95
193_Y274_R1.4740.95
22_I30_K1.4560.95
64_L306_L1.4420.95
95_H117_H1.4390.95
91_D275_W1.4110.94
93_H121_E1.4060.94
240_K243_V1.3990.94
93_H114_C1.3980.94
194_V205_G1.3940.94
295_L303_F1.3850.93
211_A256_F1.3720.93
194_V200_Q1.3670.93
86_L270_T1.3550.93
242_L267_I1.3530.93
89_V129_I1.3410.92
206_E253_R1.3350.92
114_C121_E1.3250.92
243_V246_D1.3220.92
221_P227_Q1.3190.92
130_G281_I1.3170.92
222_V227_Q1.3110.91
274_R285_K1.3090.91
63_N292_G1.2870.91
221_P226_P1.2860.91
157_K160_G1.2830.90
202_N258_T1.2750.90
156_L160_G1.2560.89
303_F310_S1.2510.89
296_T307_K1.2480.89
279_V283_E1.2450.89
193_Y285_K1.2340.89
115_R192_W1.2220.88
90_D275_W1.2180.88
33_A37_V1.2050.87
240_K245_D1.2040.87
167_T170_D1.2030.87
275_W285_K1.2030.87
109_A122_S1.1870.87
170_D173_L1.1820.86
94_D102_M1.1770.86
92_T278_E1.1760.86
103_P300_N1.1660.86
224_E227_Q1.1630.85
304_V307_K1.1540.85
93_H112_F1.1530.85
108_G148_I1.1510.85
21_V24_S1.1460.85
292_G300_N1.1450.85
220_V229_E1.1380.84
141_V312_L1.1360.84
28_T33_A1.1350.84
129_I175_F1.1350.84
102_M124_I1.1080.83
230_Y233_E1.1050.82
49_I52_E1.1020.82
31_D236_G1.0940.82
19_N23_L1.0930.82
77_K80_V1.0930.82
69_Q302_G1.0910.82
24_S71_K1.0880.81
204_V257_S1.0760.81
190_D278_E1.0740.81
297_W301_S1.0720.80
225_F228_G1.0710.80
155_E161_E1.0460.79
203_T258_T1.0430.79
249_G257_S1.0400.78
188_V270_T1.0330.78
275_W314_V1.0320.78
189_F194_V1.0320.78
186_S270_T1.0290.78
211_A254_Y1.0270.77
33_A36_L1.0260.77
156_L161_E1.0230.77
90_D277_I1.0210.77
220_V226_P1.0210.77
276_D311_L1.0200.77
26_T29_R1.0110.76
130_G280_L1.0110.76
127_L172_L1.0090.76
241_L254_Y1.0080.76
29_R67_A1.0000.76
223_G230_Y0.9980.75
145_I171_A0.9960.75
82_D136_N0.9920.75
110_Q151_K0.9910.75
48_E293_S0.9870.75
96_K109_A0.9850.74
274_R281_I0.9810.74
285_K314_V0.9770.74
22_I29_R0.9760.74
126_L304_V0.9760.74
63_N67_A0.9740.74
103_P297_W0.9690.73
20_E25_M0.9690.73
39_G49_I0.9670.73
306_L310_S0.9580.72
150_R154_E0.9540.72
277_I285_K0.9510.72
139_I276_D0.9500.72
205_G256_F0.9460.71
36_L40_A0.9450.71
108_G288_G0.9430.71
90_D168_K0.9360.71
86_L188_V0.9310.70
40_A45_N0.9240.70
21_V27_G0.9180.69
126_L300_N0.9170.69
221_P224_E0.9160.69
91_D281_I0.9140.69
207_L278_E0.9100.68
77_K182_L0.9100.68
70_A74_E0.9020.68
57_Y61_L0.9010.68
207_L256_F0.9000.68
281_I285_K0.9000.68
94_D126_L0.8970.67
88_I188_V0.8970.67
72_L76_V0.8970.67
171_A175_F0.8960.67
114_C125_Q0.8960.67
75_V80_V0.8950.67
34_K38_L0.8940.67
128_V141_V0.8930.67
124_I300_N0.8900.67
240_K257_S0.8830.66
21_V25_M0.8830.66
63_N69_Q0.8780.66
112_F115_R0.8750.65
127_L168_K0.8740.65
141_V280_L0.8740.65
38_L41_V0.8730.65
90_D193_Y0.8710.65
139_I280_L0.8700.65
244_I247_Y0.8700.65
16_K19_N0.8700.65
199_L205_G0.8700.65
28_T31_D0.8660.65
26_T32_V0.8630.64
127_L171_A0.8630.64
189_F192_W0.8630.64
220_V228_G0.8610.64
200_Q205_G0.8590.64
48_E51_Q0.8570.64
102_M292_G0.8530.63
141_V311_L0.8520.63
94_D128_V0.8500.63
58_E62_N0.8480.63
92_T275_W0.8460.63
246_D249_G0.8430.62
115_R121_E0.8400.62
224_E229_E0.8390.62
223_G227_Q0.8390.62
223_G228_G0.8350.62
18_V21_V0.8290.61
28_T36_L0.8280.61
94_D304_V0.8280.61
70_A178_S0.8270.61
207_L211_A0.8220.60
25_M29_R0.8170.60
92_T274_R0.8140.60
127_L145_I0.8140.60
102_M146_A0.8110.59
255_F268_I0.8100.59
103_P124_I0.8100.59
111_I122_S0.8090.59
112_F124_I0.8060.59
277_I287_L0.8030.59
112_F121_E0.8000.58
29_R33_A0.7990.58
195_N210_N0.7980.58
159_R162_E0.7940.58
299_R303_F0.7900.57
129_I187_K0.7890.57
18_V34_K0.7880.57
193_Y275_W0.7870.57
117_H121_E0.7840.57
75_V79_L0.7840.57
74_E265_E0.7840.57
21_V34_K0.7840.57
92_T285_K0.7820.57
68_A302_G0.7800.56
189_F208_K0.7790.56
91_D277_I0.7780.56
255_F271_W0.7760.56
168_K192_W0.7750.56
114_C275_W0.7720.56
92_T289_L0.7720.56
239_I248_K0.7720.56
18_V37_V0.7710.56
74_E210_N0.7670.55
319_Y322_G0.7630.55
159_R163_V0.7620.55
87_L184_V0.7590.54
157_K162_E0.7540.54
224_E230_Y0.7530.54
191_S207_L0.7520.54
150_R187_K0.7510.54
154_E164_K0.7500.53
37_V309_L0.7490.53
98_Y109_A0.7480.53
39_G60_V0.7470.53
278_E281_I0.7440.53
114_C120_F0.7440.53
32_V35_R0.7400.53
101_A129_I0.7370.52
21_V213_V0.7360.52
193_Y278_E0.7360.52
239_I243_V0.7290.51
93_H120_F0.7290.51
191_S208_K0.7290.51
17_A20_E0.7270.51
281_I284_L0.7240.51
64_L302_G0.7230.51
231_L234_Y0.7180.50
245_D251_G0.7170.50
179_L182_L0.7170.50
122_S149_P0.7160.50
192_W208_K0.7150.50
208_K212_R0.7140.50
124_I148_I0.7130.50
316_Y322_G0.7130.50
94_D303_F0.7130.50
129_I176_L0.7130.50
279_V282_R0.7120.50
278_E314_V0.7110.50
92_T304_V0.7000.49
162_E165_F0.6960.48
45_N291_G0.6930.48
147_Y168_K0.6910.48
220_V224_E0.6890.47
95_H121_E0.6880.47
115_R120_F0.6880.47
98_Y295_L0.6860.47
225_F230_Y0.6850.47
221_P228_G0.6840.47
17_A21_V0.6830.47
125_Q168_K0.6820.47
20_E24_S0.6820.47
271_W274_R0.6810.47
23_L30_K0.6800.47
302_G305_A0.6780.46
142_I179_L0.6770.46
168_K194_V0.6770.46
184_V282_R0.6760.46
145_I166_K0.6720.46
40_A284_L0.6720.46
27_G31_D0.6700.46
275_W281_I0.6700.46
111_I121_E0.6700.46
239_I242_L0.6680.45
178_S195_N0.6670.45
114_C117_H0.6670.45
296_T308_A0.6650.45
71_K74_E0.6640.45
93_H125_Q0.6640.45
102_M126_L0.6620.45
199_L256_F0.6560.44
120_F308_A0.6550.44
102_M300_N0.6550.44
289_L304_V0.6540.44
111_I253_R0.6540.44
45_N50_A0.6540.44
111_I120_F0.6520.44
225_F232_V0.6490.44
284_L289_L0.6480.43
37_V142_I0.6450.43
85_V185_K0.6430.43
190_D274_R0.6400.43
132_K273_N0.6370.42
192_W278_E0.6350.42
16_K20_E0.6350.42
25_M30_K0.6350.42
192_W275_W0.6330.42
37_V306_L0.6320.42
220_V232_V0.6320.42
288_G291_G0.6290.42
69_Q98_Y0.6240.41
116_A290_E0.6220.41
259_D299_R0.6210.41
127_L192_W0.6190.41
69_Q305_A0.6190.41
36_L293_S0.6170.40
96_K102_M0.6150.40
156_L162_E0.6150.40
62_N299_R0.6140.40
166_K177_S0.6140.40
32_V63_N0.6130.40
160_G165_F0.6120.40
168_K171_A0.6110.40
257_S267_I0.6070.40
73_I144_I0.6070.40
298_V302_G0.6050.39
72_L80_V0.6030.39
127_L147_Y0.6020.39
57_Y275_W0.6000.39
159_R164_K0.5980.39
295_L310_S0.5970.39
266_D269_T0.5960.39
127_L274_R0.5960.39
102_M118_K0.5940.38
102_M293_S0.5940.38
67_A131_V0.5930.38
46_A195_N0.5920.38
318_K322_G0.5910.38
72_L75_V0.5900.38
131_V189_F0.5870.38
21_V182_L0.5870.38
40_A303_F0.5860.38
29_R296_T0.5860.38
112_F125_Q0.5850.37
124_I303_F0.5850.37
170_D234_Y0.5840.37
38_L46_A0.5830.37
300_N304_V0.5830.37
97_L121_E0.5830.37
39_G108_G0.5830.37
41_V100_R0.5820.37
226_P229_E0.5810.37
36_L46_A0.5790.37
112_F149_P0.5780.37
307_K318_K0.5780.37
72_L309_L0.5780.37
40_A306_L0.5770.37
148_I152_V0.5770.37
83_H233_E0.5770.37
257_S293_S0.5730.36
76_V80_V0.5720.36
135_V138_Q0.5710.36
17_A31_D0.5690.36
58_E292_G0.5680.36
181_G185_K0.5660.36
18_V33_A0.5660.36
263_T266_D0.5650.36
41_V196_S0.5650.36
114_C271_W0.5640.36
274_R277_I0.5630.35
263_T270_T0.5620.35
260_L263_T0.5610.35
88_I276_D0.5610.35
18_V22_I0.5600.35
282_R285_K0.5530.35
125_Q149_P0.5520.34
233_E237_T0.5510.34
21_V33_A0.5500.34
82_D263_T0.5490.34
98_Y283_E0.5490.34
44_R48_E0.5480.34
103_P301_S0.5460.34
160_G163_V0.5430.34
79_L240_K0.5430.34
244_I272_E0.5420.34
243_V247_Y0.5420.34
188_V273_N0.5400.33
149_P187_K0.5400.33
102_M303_F0.5350.33
252_R309_L0.5350.33
172_L187_K0.5330.33
240_K247_Y0.5270.32
19_N34_K0.5230.32
48_E52_E0.5230.32
113_Y183_N0.5200.32
88_I135_V0.5190.32
86_L272_E0.5190.32
168_K274_R0.5180.32
98_Y108_G0.5170.31
300_N307_K0.5160.31
117_H219_S0.5150.31
118_K152_V0.5140.31
292_G303_F0.5130.31
168_K191_S0.5120.31
91_D191_S0.5100.31
160_G174_E0.5100.31
67_A302_G0.5090.31
299_R306_L0.5060.30
296_T311_L0.5060.30
167_T177_S0.5060.30
196_S290_E0.5060.30
197_R251_G0.5050.30
22_I26_T0.5050.30
160_G164_K0.5040.30
90_D190_D0.5040.30
147_Y193_Y0.5040.30
65_D299_R0.5010.30
109_A292_G0.5010.30
151_K166_K0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9209 99.9 0.716 Contact Map
2kkoA 2 0.3023 25.6 0.963 Contact Map
2zkzA 2 0.2514 12.6 0.968 Contact Map
3cuoA 2 0.2768 12.3 0.968 Contact Map
3hdeA 2 0.2712 10.1 0.969 Contact Map
1r1tA 2 0.2768 9.3 0.97 Contact Map
1qgpA 1 0.2034 8.5 0.97 Contact Map
4i2oA 2 0.2486 8.2 0.971 Contact Map
3qfiA 1 0.2542 7.8 0.971 Contact Map
3hdfA 1 0.2684 6.8 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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