GREMLIN Database
Q97Y24 - Dihydrolipoamide dehydrogenase (PdhD-2)
UniProt: Q97Y24 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 412 (388)
Sequences: 18488 (12367)
Seq/√Len: 627.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_V231_G4.3861.00
259_D263_R3.6901.00
151_K174_E3.4521.00
35_R102_N3.4121.00
176_H208_Y3.0871.00
174_E206_K2.6931.00
197_T201_S2.6821.00
360_A374_I2.6801.00
109_M116_S2.5931.00
7_K29_K2.5561.00
6_M31_T2.5411.00
138_F141_D2.5281.00
141_D145_T2.4671.00
20_S123_L2.4501.00
129_R243_N2.4031.00
129_R245_E2.3811.00
208_Y227_Q2.3731.00
31_T99_I2.3671.00
217_D222_T2.3571.00
33_I117_L2.3401.00
373_L392_M2.3031.00
131_E241_K2.2631.00
121_K268_N2.2451.00
215_K222_T2.2441.00
6_M97_E2.2191.00
8_V24_L2.2171.00
111_H114_N2.1741.00
134_G215_K2.1701.00
119_A122_V2.1681.00
249_E257_Y2.1501.00
355_N385_K2.1331.00
107_S266_I2.1331.00
260_E301_E2.1311.00
153_V178_I2.0901.00
106_R109_M2.0861.00
322_T327_C2.0571.00
356_R381_Q2.0491.00
111_H116_S2.0391.00
9_V117_L2.0341.00
151_K232_D2.0281.00
9_V33_I1.9611.00
291_A295_M1.9421.00
148_D173_K1.9221.00
16_A272_A1.9011.00
190_R325_G1.9001.00
7_K120_D1.8901.00
180_K212_K1.8861.00
182_D210_G1.8811.00
377_L382_I1.8791.00
123_L295_M1.8421.00
141_D144_Y1.8421.00
222_T228_K1.8381.00
140_E145_T1.8291.00
251_P255_Y1.8181.00
152_V173_K1.8051.00
162_I177_L1.8041.00
129_R241_K1.7711.00
109_M118_A1.7671.00
212_K224_E1.7621.00
214_S224_E1.7431.00
214_S222_T1.7281.00
263_R267_P1.7261.00
169_K174_E1.7211.00
109_M112_A1.7081.00
270_Y294_N1.7071.00
104_F108_S1.7041.00
152_V168_M1.6741.00
153_V221_V1.6741.00
211_K225_D1.6711.00
142_L145_T1.6631.00
208_Y211_K1.6481.00
139_T145_T1.6341.00
138_F142_L1.6121.00
176_H206_K1.6111.00
104_F107_S1.6111.00
362_A367_A1.6051.00
29_K97_E1.6031.00
251_P257_Y1.6031.00
35_R103_G1.5861.00
9_V110_V1.5791.00
169_K205_I1.5671.00
139_T143_A1.5631.00
99_I115_T1.5621.00
138_F145_T1.5581.00
68_S71_T1.5521.00
140_E144_Y1.5481.00
9_V119_A1.5371.00
183_L193_S1.5131.00
121_K295_M1.5071.00
383_S386_D1.4941.00
124_V275_I1.4861.00
126_T275_I1.4531.00
350_I360_A1.4421.00
261_Y294_N1.4371.00
9_V31_T1.4321.00
23_T293_K1.4231.00
8_V123_L1.4111.00
199_F202_Q1.4071.00
123_L272_A1.4051.00
7_K31_T1.4001.00
190_R194_E1.3851.00
150_N232_D1.3731.00
216_I234_V1.3651.00
71_T74_E1.3651.00
197_T207_L1.3571.00
189_D349_K1.3571.00
195_I363_F1.3441.00
140_E143_A1.3421.00
327_C351_C1.3381.00
31_T117_L1.3281.00
104_F111_H1.3201.00
99_I117_L1.3191.00
262_L276_I1.3111.00
88_E100_H1.3111.00
198_N201_S1.3101.00
263_R268_N1.2901.00
138_F144_Y1.2901.00
178_I229_I1.2901.00
11_I124_V1.2891.00
139_T144_Y1.2811.00
112_A117_L1.2801.00
27_H293_K1.2771.00
183_L190_R1.2751.00
288_G292_A1.2681.00
170_K203_I1.2661.00
256_I275_I1.2651.00
162_I313_I1.2591.00
292_A296_L1.2581.00
151_K230_S1.2571.00
104_F122_V1.2531.00
11_I103_G1.2361.00
152_V233_A1.2331.00
316_Q368_E1.2251.00
197_T209_L1.2241.00
380_Y386_D1.2211.00
121_K270_Y1.2201.00
324_N349_K1.2141.00
16_A284_A1.2121.00
150_N174_E1.2111.00
211_K227_Q1.2051.00
151_K176_H1.2041.00
157_G184_L1.2041.00
293_K298_E1.2021.00
198_N202_Q1.2001.00
179_D209_L1.1941.00
89_H93_S1.1911.00
217_D228_K1.1881.00
141_D146_N1.1831.00
191_T329_T1.1661.00
88_E92_N1.1561.00
266_I269_I1.1521.00
261_Y301_E1.1471.00
262_L291_A1.1461.00
139_T142_L1.1401.00
78_T82_T1.1371.00
24_L292_A1.1301.00
155_V234_V1.1291.00
105_L116_S1.1291.00
317_I363_F1.1271.00
140_E146_N1.1261.00
194_E197_T1.1241.00
39_L98_V1.1201.00
208_Y229_I1.1181.00
157_G179_D1.1171.00
142_L146_N1.1171.00
201_S206_K1.1141.00
107_S269_I1.1051.00
183_L197_T1.1041.00
49_I52_K1.1001.00
134_G137_K1.0781.00
199_F203_I1.0701.00
6_M99_I1.0611.00
372_S393_P1.0601.00
223_L229_I1.0591.00
33_I112_A1.0561.00
69_L73_R1.0551.00
211_K224_E1.0521.00
219_T230_S1.0521.00
23_T27_H1.0511.00
188_I309_K1.0501.00
138_F143_A1.0401.00
263_R294_N1.0401.00
382_I386_D1.0391.00
188_I319_Y1.0381.00
253_E277_G1.0371.00
10_I21_A1.0321.00
272_A291_A1.0301.00
249_E265_Q1.0221.00
374_I401_I1.0191.00
90_L94_H1.0171.00
73_R77_L1.0151.00
143_A146_N1.0131.00
291_A294_N1.0111.00
33_I99_I1.0101.00
81_N85_K1.0051.00
13_A34_E1.0051.00
257_Y265_Q1.0001.00
348_L362_A0.9991.00
332_T364_M0.9951.00
155_V236_V0.9901.00
74_E78_T0.9891.00
51_T54_I0.9851.00
293_K300_R0.9841.00
162_I200_L0.9821.00
192_L347_F0.9771.00
263_R270_Y0.9761.00
184_L197_T0.9731.00
77_L81_N0.9721.00
139_T146_N0.9721.00
318_A371_I0.9711.00
256_I271_A0.9651.00
192_L363_F0.9631.00
348_L400_A0.9601.00
355_N384_L0.9581.00
182_D190_R0.9541.00
153_V229_I0.9521.00
366_Y369_D0.9501.00
23_T26_K0.9491.00
50_P53_S0.9461.00
350_I374_I0.9441.00
166_W170_K0.9361.00
258_V271_A0.9361.00
179_D186_Q0.9351.00
27_H296_L0.9341.00
123_L291_A0.9301.00
151_K173_K0.9301.00
261_Y299_K0.9271.00
372_S398_L0.9231.00
108_S268_N0.9211.00
131_E238_F0.9201.00
322_T326_N0.9201.00
101_A112_A0.9181.00
258_V276_I0.9171.00
181_N186_Q0.9121.00
177_L207_L0.9111.00
336_T339_I0.9111.00
178_I211_K0.9091.00
73_R76_A0.9081.00
310_V393_P0.9051.00
263_R266_I0.9041.00
195_I198_N0.9041.00
105_L111_H0.9041.00
196_V363_F0.8981.00
155_V238_F0.8981.00
97_E115_T0.8941.00
309_K319_Y0.8901.00
87_L91_L0.8891.00
192_L361_V0.8881.00
176_H231_G0.8841.00
184_L209_L0.8811.00
169_K203_I0.8811.00
195_I199_F0.8801.00
154_I161_G0.8771.00
155_V213_V0.8761.00
50_P54_I0.8761.00
79_S83_I0.8751.00
51_T55_L0.8741.00
290_I302_F0.8721.00
87_L90_L0.8721.00
6_M121_K0.8711.00
264_T271_A0.8701.00
89_H92_N0.8651.00
161_G179_D0.8651.00
6_M29_K0.8621.00
20_S291_A0.8591.00
202_Q345_E0.8581.00
320_V378_I0.8561.00
196_V317_I0.8551.00
242_P255_Y0.8541.00
178_I208_Y0.8531.00
188_I317_I0.8531.00
323_T326_N0.8511.00
337_R340_V0.8501.00
20_S288_G0.8441.00
122_V269_I0.8441.00
23_T292_A0.8431.00
78_T81_N0.8431.00
22_L94_H0.8431.00
252_H257_Y0.8431.00
306_G378_I0.8421.00
191_T349_K0.8421.00
290_I294_N0.8421.00
194_E198_N0.8411.00
52_K55_L0.8401.00
9_V122_V0.8391.00
152_V235_F0.8341.00
20_S272_A0.8331.00
91_L98_V0.8331.00
25_S30_V0.8321.00
271_A275_I0.8301.00
165_G177_L0.8251.00
32_L91_L0.8251.00
258_V262_L0.8211.00
373_L376_V0.8191.00
43_C48_C0.8151.00
286_Y289_I0.8141.00
128_T240_R0.8141.00
99_I102_N0.8141.00
165_G205_I0.8131.00
112_A115_T0.8091.00
206_K227_Q0.8081.00
35_R243_N0.8071.00
33_I103_G0.8061.00
23_T289_I0.8051.00
211_K223_L0.7991.00
151_K231_G0.7971.00
20_S292_A0.7931.00
79_S82_T0.7931.00
329_T347_F0.7931.00
10_I20_S0.7911.00
310_V368_E0.7911.00
132_R236_V0.7911.00
199_F345_E0.7901.00
19_Y285_I0.7891.00
324_N351_C0.7881.00
357_V374_I0.7881.00
180_K186_Q0.7871.00
31_T97_E0.7861.00
82_T85_K0.7851.00
27_H298_E0.7821.00
178_I223_L0.7811.00
86_S90_L0.7801.00
13_A32_L0.7801.00
200_L207_L0.7791.00
245_E248_E0.7781.00
244_I250_I0.7741.00
183_L325_G0.7741.00
132_R138_F0.7741.00
76_A79_S0.7711.00
13_A39_L0.7711.00
335_L338_T0.7691.00
104_F110_V0.7681.00
57_Q72_L0.7631.00
382_I387_T0.7621.00
270_Y295_M0.7611.00
7_K117_L0.7601.00
377_L387_T0.7601.00
320_V360_A0.7571.00
107_S268_N0.7521.00
105_L108_S0.7511.00
189_D361_V0.7501.00
57_Q75_Y0.7491.00
85_K88_E0.7491.00
376_V380_Y0.7481.00
379_R389_D0.7471.00
18_V32_L0.7451.00
183_L194_E0.7421.00
184_L207_L0.7361.00
335_L339_I0.7281.00
24_L296_L0.7271.00
81_N84_S0.7261.00
147_E233_A0.7251.00
331_N334_N0.7251.00
38_K84_S0.7241.00
75_Y79_S0.7231.00
37_E46_Y0.7231.00
133_L236_V0.7221.00
164_L235_F0.7201.00
262_L294_N0.7191.00
136_V236_V0.7191.00
262_L290_I0.7181.00
37_E100_H0.7161.00
138_F146_N0.7161.00
376_V382_I0.7161.00
199_F363_F0.7151.00
24_L295_M0.7141.00
303_I379_R0.7131.00
356_R383_S0.7121.00
125_S272_A0.7111.00
25_S96_I0.7101.00
154_I235_F0.7091.00
8_V295_M0.7091.00
384_L388_I0.7081.00
49_I53_S0.7081.00
316_Q366_Y0.7071.00
289_I293_K0.7061.00
318_A367_A0.7041.00
34_E38_K0.7031.00
6_M9_V0.7021.00
386_D389_D0.7001.00
102_N115_T0.7001.00
196_V313_I0.6981.00
21_A96_I0.6941.00
40_G44_V0.6941.00
142_L168_M0.6921.00
360_A378_I0.6921.00
22_L26_K0.6901.00
91_L95_G0.6861.00
357_V378_I0.6841.00
159_A311_I0.6831.00
91_L96_I0.6821.00
166_W203_I0.6801.00
272_A288_G0.6801.00
223_L227_Q0.6781.00
122_V268_N0.6751.00
249_E252_H0.6711.00
244_I275_I0.6681.00
76_A80_I0.6671.00
77_L80_I0.6671.00
102_N246_G0.6671.00
184_L193_S0.6631.00
10_I17_G0.6621.00
327_C358_I0.6621.00
376_V390_L0.6611.00
375_S379_R0.6611.00
97_E100_H0.6601.00
283_E287_A0.6581.00
154_I165_G0.6521.00
24_L30_V0.6511.00
323_T361_V0.6501.00
119_A266_I0.6481.00
102_N113_S0.6481.00
108_S266_I0.6461.00
256_I264_T0.6451.00
17_G21_A0.6451.00
244_I255_Y0.6431.00
161_G180_K0.6421.00
55_L167_M0.6421.00
344_S365_P0.6391.00
106_R116_S0.6351.00
37_E101_A0.6341.00
283_E307_I0.6331.00
374_I378_I0.6331.00
58_L170_K0.6291.00
253_E257_Y0.6291.00
192_L317_I0.6281.00
54_I73_R0.6281.00
200_L205_I0.6281.00
71_T75_Y0.6271.00
49_I54_I0.6261.00
379_R390_L0.6261.00
74_E77_L0.6261.00
67_M72_L0.6241.00
91_L94_H0.6231.00
213_V221_V0.6211.00
376_V387_T0.6201.00
104_F119_A0.6201.00
286_Y302_F0.6161.00
8_V292_A0.6151.00
352_E358_I0.6141.00
82_T339_I0.6131.00
167_M171_L0.6121.00
152_V175_V0.6121.00
85_K89_H0.6101.00
332_T400_A0.6101.00
26_K94_H0.6091.00
251_P277_G0.6081.00
279_F307_I0.6071.00
272_A295_M0.6051.00
101_A113_S0.6051.00
75_Y78_T0.6051.00
124_V247_F0.6041.00
223_L226_N0.6031.00
151_K169_K0.6031.00
270_Y291_A0.6031.00
230_S233_A0.6031.00
250_I256_I0.6021.00
185_L196_V0.5981.00
193_S197_T0.5981.00
360_A371_I0.5981.00
33_I101_A0.5961.00
252_H255_Y0.5961.00
161_G237_T0.5951.00
394_H399_E0.5941.00
162_I184_L0.5931.00
195_I347_F0.5921.00
170_K314_Y0.5911.00
99_I103_G0.5911.00
21_A32_L0.5901.00
192_L195_I0.5901.00
100_H103_G0.5901.00
106_R111_H0.5891.00
132_R137_K0.5881.00
45_L84_S0.5881.00
126_T247_F0.5881.00
316_Q397_Y0.5831.00
191_T347_F0.5831.00
320_V375_S0.5821.00
369_D398_L0.5821.00
70_N74_E0.5811.00
150_N173_K0.5801.00
83_I87_L0.5791.00
314_Y365_P0.5781.00
70_N73_R0.5781.00
307_I311_I0.5771.00
7_K118_A0.5771.00
70_N146_N0.5761.00
44_V48_C0.5751.00
41_G44_V0.5751.00
153_V234_V0.5751.00
216_I236_V0.5731.00
362_A370_V0.5731.00
176_H229_I0.5721.00
206_K209_L0.5711.00
80_I83_I0.5701.00
376_V392_M0.5691.00
90_L93_S0.5691.00
8_V30_V0.5681.00
16_A125_S0.5671.00
39_L88_E0.5671.00
84_S88_E0.5651.00
354_D381_Q0.5651.00
328_V352_E0.5641.00
385_K389_D0.5621.00
347_F350_I0.5621.00
20_S24_L0.5591.00
332_T335_L0.5591.00
319_Y361_V0.5581.00
274_D284_A0.5581.00
323_T351_C0.5581.00
38_K46_Y0.5571.00
133_L238_F0.5561.00
124_V246_G0.5551.00
53_S56_S0.5541.00
264_T269_I0.5541.00
203_I313_I0.5531.00
104_F124_V0.5521.00
180_K238_F0.5511.00
287_A304_V0.5511.00
244_I247_F0.5511.00
29_K120_D0.5511.00
216_I221_V0.5471.00
335_L340_V0.5471.00
48_C51_T0.5451.00
159_A309_K0.5441.00
293_K299_K0.5430.99
293_K297_G0.5410.99
164_L167_M0.5410.99
334_N337_R0.5410.99
168_M173_K0.5410.99
336_T340_V0.5390.99
136_V216_I0.5390.99
40_G43_C0.5370.99
166_W200_L0.5360.99
162_I207_L0.5350.99
360_A401_I0.5350.99
203_I314_Y0.5350.99
322_T358_I0.5350.99
328_V331_N0.5340.99
105_L109_M0.5320.99
51_T164_L0.5310.99
25_S95_G0.5300.99
251_P265_Q0.5300.99
341_E348_L0.5300.99
373_L398_L0.5290.99
151_K233_A0.5280.99
370_V397_Y0.5280.99
188_I311_I0.5280.99
47_G50_P0.5260.99
271_A276_I0.5250.99
74_E146_N0.5230.99
8_V20_S0.5230.99
52_K56_S0.5220.99
378_I382_I0.5220.99
249_E254_K0.5210.99
80_I84_S0.5210.99
191_T194_E0.5210.99
286_Y402_T0.5210.99
119_A268_N0.5180.99
206_K229_I0.5180.99
88_E98_V0.5170.99
8_V121_K0.5140.99
46_Y140_E0.5140.99
178_I231_G0.5100.99
15_P281_A0.5100.99
332_T339_I0.5100.99
95_G103_G0.5090.99
306_G375_S0.5090.99
333_L339_I0.5090.99
364_M367_A0.5080.99
372_S375_S0.5070.99
371_I393_P0.5060.99
132_R136_V0.5050.99
48_C52_K0.5050.99
375_S390_L0.5040.99
201_S207_L0.5040.99
10_I30_V0.5030.99
22_L90_L0.5030.99
69_L72_L0.5020.99
20_S295_M0.5020.99
190_R193_S0.5010.99
120_D268_N0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ojtA 2 1 100 0.231 Contact Map
3urhA 2 0.9879 100 0.241 Contact Map
3ladA 2 0.9951 100 0.242 Contact Map
1zmdA 4 1 100 0.243 Contact Map
1lvlA 2 0.9927 100 0.246 Contact Map
2qaeA 2 0.9879 100 0.25 Contact Map
1dxlA 2 0.9951 100 0.254 Contact Map
1v59A 2 1 100 0.257 Contact Map
4jq9A 3 0.9951 100 0.257 Contact Map
4dnaA 2 0.9903 100 0.258 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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