GREMLIN Database
Q97Y23 - Pyruvate dehydrogenase, alpha subunit (Lipoamide). (PdhA-2)
UniProt: Q97Y23 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 332 (314)
Sequences: 5144 (2899)
Seq/√Len: 163.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_K299_E4.2751.00
289_N292_E3.5301.00
156_L207_F3.4971.00
170_I233_A3.1851.00
230_V234_R3.0091.00
145_I173_V2.8441.00
212_V228_E2.7071.00
290_S294_D2.7051.00
231_D235_R2.7011.00
53_V144_F2.6021.00
81_K310_F2.5981.00
140_V230_V2.5171.00
213_E245_K2.4681.00
35_K312_E2.4421.00
166_K196_A2.4271.00
283_V290_S2.3961.00
20_I71_G2.3751.00
19_L303_E2.3291.00
126_V158_S2.3211.00
232_R237_G2.3011.00
64_T128_A2.2871.00
132_F141_A2.2421.00
279_R283_V2.2251.00
321_E324_T2.2181.00
232_R240_S2.1961.00
81_K306_Q2.1521.00
288_I293_L2.1461.00
6_P9_K2.0841.00
309_K313_E2.0531.00
279_R297_D2.0431.00
268_M271_K2.0371.00
132_F137_L2.0131.00
122_A155_V2.0081.00
58_R138_D2.0031.00
53_V226_A2.0001.00
280_D284_S1.9601.00
204_A211_A1.9481.00
155_V159_L1.9071.00
295_K299_E1.8981.00
302_A306_Q1.8761.00
218_D221_A1.8741.00
279_R293_L1.8351.00
233_A240_S1.8071.00
60_D139_R1.8051.00
126_V171_F1.8031.00
214_V225_V1.7501.00
12_D16_K1.7341.00
172_V244_C1.7221.00
53_V142_V1.7061.00
217_M249_F1.6991.00
132_F139_R1.6961.00
173_V200_Y1.6771.00
148_G179_A1.6731.00
92_T314_S1.6591.00
283_V293_L1.6281.00
210_P232_R1.6141.00
7_K292_E1.6051.00
212_V225_V1.5801.00
53_V172_V1.5411.00
122_A158_S1.5241.00
292_E295_K1.5211.00
129_A169_V1.5171.00
13_M219_V1.5011.00
175_D243_H1.5011.00
210_P238_G1.4981.00
310_F314_S1.4721.00
229_A240_S1.4711.00
10_L282_L1.4631.00
13_M55_S1.4581.00
130_L134_L1.4461.00
96_K325_D1.4441.00
145_I149_A1.4391.00
281_K285_N1.4311.00
18_L300_A1.4221.00
306_Q310_F1.4151.00
79_D82_R1.4041.00
11_L292_E1.4021.00
227_K231_D1.3851.00
299_E303_E1.3771.00
298_R302_A1.3681.00
202_E205_L1.3451.00
226_A242_L1.3301.00
142_V170_I1.3261.00
225_V242_L1.3251.00
7_K11_L1.3241.00
159_L209_I1.3211.00
7_K287_I1.3171.00
264_E267_E1.3161.00
217_M246_T1.3121.00
307_A311_A1.3051.00
73_C111_M1.2921.00
25_L44_V1.2911.00
173_V241_L1.2881.00
9_K12_D1.2871.00
276_T280_D1.2841.00
49_V244_C1.2781.00
62_Y132_F1.2561.00
177_M245_K1.2501.00
106_D109_K1.2491.00
269_W272_R1.2411.00
172_V226_A1.2351.00
52_G222_V1.2241.00
166_K238_G1.2231.00
140_V233_A1.2171.00
11_L288_I1.2171.00
199_S202_E1.2151.00
291_E295_K1.2131.00
263_K267_E1.2101.00
201_V213_E1.2031.00
22_Y301_K1.1961.00
291_E294_D1.1961.00
85_A92_T1.1851.00
214_V221_A1.1811.00
16_K55_S1.1771.00
18_L297_D1.1701.00
153_G157_E1.1631.00
267_E270_R1.1611.00
14_Y18_L1.1601.00
309_K312_E1.1561.00
223_Y227_K1.1381.00
294_D298_R1.1361.00
267_E271_K1.1171.00
163_A209_I1.1131.00
318_E321_E1.1121.00
59_D109_K1.1101.00
57_L142_V1.1081.00
19_L80_V1.1051.00
26_T305_E1.1021.00
49_V172_V1.0981.00
52_G219_V1.0971.00
128_A141_A1.0921.00
305_E309_K1.0921.00
151_N203_R1.0901.00
56_T227_K1.0881.00
115_N120_G1.0871.00
228_E231_D1.0821.00
126_V169_V1.0801.00
277_L281_K1.0760.99
293_L297_D1.0740.99
10_L220_L1.0720.99
142_V226_A1.0710.99
57_L230_V1.0690.99
140_V170_I1.0680.99
117_I120_G1.0680.99
163_A208_G1.0630.99
212_V240_S1.0520.99
56_T223_Y1.0500.99
7_K285_N1.0480.99
10_L278_F1.0460.99
303_E307_A1.0450.99
91_K315_P1.0440.99
220_L278_F1.0400.99
247_Y269_W1.0390.99
22_Y304_I1.0390.99
22_Y297_D1.0350.99
142_V172_V1.0350.99
161_L165_W1.0340.99
249_F270_R1.0340.99
60_D76_K1.0300.99
56_T230_V1.0280.99
90_K316_Y1.0230.99
151_N194_H1.0220.99
64_T112_L1.0210.99
80_V303_E1.0210.99
27_A87_I1.0190.99
18_L275_I1.0160.99
183_R192_P1.0080.99
122_A145_I1.0060.99
211_A241_L1.0050.99
140_V234_R1.0040.99
300_A304_I0.9970.99
55_S223_Y0.9910.99
166_K237_G0.9880.99
30_L308_L0.9870.99
18_L22_Y0.9850.99
133_K166_K0.9780.99
12_D55_S0.9780.99
16_K51_V0.9770.99
251_G257_P0.9740.99
215_D221_A0.9710.99
278_F282_L0.9700.99
178_Y265_E0.9680.99
26_T29_E0.9610.99
14_Y296_I0.9570.99
170_I230_V0.9530.99
57_L63_I0.9510.99
204_A209_I0.9490.99
15_K19_L0.9470.99
17_M275_I0.9440.99
212_V242_L0.9440.99
62_Y112_L0.9430.99
229_A233_A0.9420.99
22_Y25_L0.9410.99
288_I292_E0.9400.99
13_M223_Y0.9400.99
279_R290_S0.9390.99
26_T308_L0.9390.99
195_S200_Y0.9350.99
82_R108_S0.9340.99
224_E228_E0.9240.98
60_D138_D0.9220.98
261_R265_E0.9190.98
125_A169_V0.9130.98
145_I150_M0.9130.98
264_E268_M0.9070.98
218_D277_L0.9040.98
159_L241_L0.9030.98
14_Y279_R0.9030.98
17_M48_A0.9000.98
302_A305_E0.8950.98
126_V167_L0.8870.98
119_G155_V0.8810.98
31_F254_E0.8800.98
221_A224_E0.8800.98
247_Y265_E0.8800.98
197_A202_E0.8800.98
19_L300_A0.8790.98
138_D235_R0.8790.98
163_A196_A0.8750.98
9_K223_Y0.8740.98
125_A143_A0.8720.98
39_F253_F0.8620.98
158_S171_F0.8600.97
280_D283_V0.8600.97
81_K314_S0.8560.97
263_K266_E0.8490.97
222_V244_C0.8480.97
215_D277_L0.8480.97
150_M155_V0.8480.97
30_L88_M0.8440.97
300_A303_E0.8420.97
43_Y71_G0.8420.97
119_G149_A0.8400.97
129_A168_P0.8390.97
282_L287_I0.8380.97
306_Q309_K0.8380.97
91_K96_K0.8350.97
81_K307_A0.8350.97
163_A166_K0.8330.97
150_M200_Y0.8320.97
303_E306_Q0.8300.97
14_Y297_D0.8250.97
199_S213_E0.8210.97
48_A52_G0.8170.97
23_H84_L0.8150.97
203_R206_G0.8120.96
278_F281_K0.8080.96
225_V229_A0.8010.96
12_D15_K0.7910.96
63_I72_H0.7850.96
229_A232_R0.7830.96
125_A141_A0.7820.96
39_F254_E0.7800.96
73_C78_L0.7770.95
170_I226_A0.7750.95
288_I296_I0.7700.95
10_L287_I0.7700.95
85_A314_S0.7680.95
110_G139_R0.7650.95
164_I194_H0.7620.95
43_Y50_A0.7600.95
232_R236_G0.7580.95
8_S12_D0.7550.95
250_F254_E0.7520.95
199_S245_K0.7510.95
52_G56_T0.7490.94
232_R238_G0.7470.94
15_K296_I0.7450.94
11_L15_K0.7450.94
266_E270_R0.7450.94
9_K227_K0.7450.94
58_R230_V0.7440.94
268_M272_R0.7410.94
220_L281_K0.7400.94
16_K75_A0.7390.94
221_A225_V0.7360.94
72_H144_F0.7350.94
294_D297_D0.7350.94
170_I240_S0.7340.94
229_A242_L0.7290.94
11_L282_L0.7290.94
217_M277_L0.7250.93
74_I83_M0.7250.93
28_K32_A0.7230.93
51_V219_V0.7210.93
84_L308_L0.7180.93
237_G240_S0.7170.93
94_V104_I0.7170.93
44_V250_F0.7150.93
82_R94_V0.7130.93
301_K305_E0.7120.93
295_K298_R0.7120.93
226_A230_V0.7100.93
46_E174_E0.7090.93
179_A194_H0.7090.93
249_F273_D0.7080.93
297_D301_K0.7060.93
85_A90_K0.7050.93
258_L266_E0.7010.92
22_Y300_A0.6990.92
272_R277_L0.6980.92
283_V288_I0.6960.92
155_V241_L0.6950.92
119_G122_A0.6930.92
180_M253_F0.6920.92
92_T315_P0.6910.92
145_I171_F0.6900.92
28_K254_E0.6890.92
118_V152_Q0.6890.92
218_D281_K0.6880.92
129_A167_L0.6880.92
123_P154_V0.6870.92
214_V242_L0.6840.91
54_M144_F0.6810.91
293_L296_I0.6800.91
58_R139_R0.6800.91
49_V246_T0.6770.91
74_I80_V0.6760.91
144_F172_V0.6730.91
80_V304_I0.6710.91
299_E302_A0.6680.90
210_P240_S0.6660.90
26_T30_L0.6660.90
177_M192_P0.6650.90
52_G226_A0.6640.90
23_H83_M0.6630.90
261_R266_E0.6620.90
247_Y266_E0.6620.90
38_G253_F0.6510.89
13_M220_L0.6490.89
204_A241_L0.6470.89
78_L109_K0.6430.89
78_L94_V0.6420.89
129_A141_A0.6410.88
85_A310_F0.6390.88
81_K85_A0.6380.88
18_L296_I0.6360.88
96_K321_E0.6350.88
43_Y70_H0.6340.88
315_P318_E0.6330.88
138_D230_V0.6320.88
15_K303_E0.6310.88
13_M51_V0.6300.88
215_D272_R0.6290.88
184_S195_S0.6290.88
224_E227_K0.6280.87
24_E31_F0.6260.87
180_M255_G0.6240.87
118_V149_A0.6220.87
283_V289_N0.6210.87
42_L250_F0.6200.87
296_I300_A0.6200.87
64_T124_H0.6190.87
120_G124_H0.6180.87
99_G102_M0.6160.86
14_Y293_L0.6160.86
119_G152_Q0.6160.86
101_S113_G0.6140.86
27_A84_L0.6140.86
225_V228_E0.6120.86
91_K321_E0.6080.86
201_V211_A0.6050.85
183_R193_R0.6030.85
217_M247_Y0.6030.85
281_K287_I0.6020.85
64_T125_A0.6020.85
67_H121_G0.6010.85
276_T279_R0.6010.85
14_Y275_I0.5980.85
9_K55_S0.5980.85
310_F313_E0.5970.85
54_M76_K0.5970.85
28_K44_V0.5970.85
213_E243_H0.5940.84
122_A159_L0.5940.84
279_R288_I0.5930.84
129_A132_F0.5910.84
44_V249_F0.5910.84
170_I242_L0.5890.84
63_I111_M0.5890.84
305_E308_L0.5880.84
177_M184_S0.5880.84
180_M254_E0.5870.84
67_H180_M0.5860.84
214_V244_C0.5850.84
181_S254_E0.5840.83
64_T121_G0.5830.83
86_E93_G0.5830.83
14_Y288_I0.5830.83
141_A169_V0.5800.83
209_I239_P0.5780.83
16_K19_L0.5780.83
60_D137_L0.5770.83
214_V222_V0.5750.82
88_M312_E0.5750.82
147_D200_Y0.5730.82
320_E324_T0.5730.82
209_I241_L0.5710.82
162_S171_F0.5710.82
251_G258_L0.5670.82
19_L74_I0.5650.81
197_A203_R0.5650.81
200_Y241_L0.5640.81
175_D184_S0.5620.81
112_L128_A0.5590.81
307_A310_F0.5580.81
60_D110_G0.5580.81
210_P228_E0.5550.80
163_A207_F0.5530.80
28_K250_F0.5530.80
46_E66_T0.5520.80
11_L287_I0.5510.80
65_S69_G0.5510.80
197_A208_G0.5500.80
19_L304_I0.5500.80
277_L280_D0.5500.80
149_A173_V0.5500.80
65_S111_M0.5500.80
102_M118_V0.5480.79
53_V72_H0.5460.79
151_N195_S0.5460.79
17_M278_F0.5430.79
23_H70_H0.5430.79
99_G113_G0.5430.79
282_L288_I0.5410.79
20_I51_V0.5400.78
67_H253_F0.5400.78
197_A200_Y0.5390.78
15_K300_A0.5390.78
76_K109_K0.5370.78
107_Y110_G0.5340.78
31_F39_F0.5330.77
28_K42_L0.5320.77
132_F138_D0.5320.77
195_S203_R0.5280.77
142_V230_V0.5260.77
317_P325_D0.5260.77
30_L33_S0.5250.76
172_V222_V0.5240.76
178_Y249_F0.5240.76
86_E116_G0.5230.76
302_A309_K0.5230.76
128_A131_A0.5220.76
62_Y139_R0.5200.76
62_Y110_G0.5180.75
158_S169_V0.5180.75
72_H142_V0.5150.75
220_L224_E0.5150.75
232_R235_R0.5140.75
55_S75_A0.5130.75
63_I76_K0.5120.75
58_R234_R0.5120.75
46_E157_E0.5120.75
112_L115_N0.5120.75
19_L307_A0.5110.75
66_T121_G0.5090.74
88_M311_A0.5080.74
143_A169_V0.5080.74
42_L251_G0.5070.74
63_I144_F0.5060.74
23_H27_A0.5060.74
174_E246_T0.5060.74
100_G117_I0.5050.74
184_S200_Y0.5040.74
64_T143_A0.5030.73
62_Y128_A0.5020.73
53_V170_I0.5010.73
156_L206_G0.5010.73
115_N121_G0.5010.73
311_A314_S0.5010.73
38_G100_G0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qs0A 2 0.9759 100 0.274 Contact Map
1umdA 2 0.9759 100 0.28 Contact Map
2bfdA 2 0.9096 100 0.284 Contact Map
2ozlA 2 0.9669 100 0.303 Contact Map
1w85A 2 0.9488 100 0.325 Contact Map
2xt6A 2 0.8946 100 0.414 Contact Map
2yicA 2 0.9006 100 0.419 Contact Map
2jgdA 2 0.8765 100 0.442 Contact Map
5c4iC 2 0.7771 100 0.652 Contact Map
1itzA 2 0.9096 100 0.675 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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