Q97Y23 - SULSO - GREMLIN Contacts

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Q97Y23 - Pyruvate dehydrogenase, alpha subunit (Lipoamide). (PdhA-2)

UniProt:	Q97Y23	Sequences: MFQDIPKSKLLDMYKKMLLIRYHELTAKELFASGKIPGFVHLYVGEEAVAVGVMSTLRDDDYITSTHRGHGHCIAKGLDVKRMLAEIMGKKTGVCKGKGGSMHIFDYSKGMLGANGIVGGGAPHAVGAALAFKLKGLDRVAVAFIGDGAMNQGVVLESLNLSAIWKLPVIFVVEDNMYAMSTRSLVPGKLQPRHSAAKSYVERALGFGIPAVEVDGMDVLAVYEVAKEAVDRARRGGGPSLLHCKTYRFFGHFEGDPLVYRDKEEEEMWRKRDPITLFRDKLVSNNIINSEELDKIDREAKAEIEQALKFAEESPYPEVEEALTDVFTDNSY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	332 (314)
Sequences:	5144 (2899)
Seq/√Len:	163.6

BACSU - ACOA ODPA ODBA
HALSA - Q9HN77 Q9HNV6
SULSO - Q97Y23 Q97YF6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
15_K	299_E	4.275	1.00
289_N	292_E	3.530	1.00
156_L	207_F	3.497	1.00
170_I	233_A	3.185	1.00
230_V	234_R	3.009	1.00
145_I	173_V	2.844	1.00
212_V	228_E	2.707	1.00
290_S	294_D	2.705	1.00
231_D	235_R	2.701	1.00
53_V	144_F	2.602	1.00
81_K	310_F	2.598	1.00
140_V	230_V	2.517	1.00
213_E	245_K	2.468	1.00
35_K	312_E	2.442	1.00
166_K	196_A	2.427	1.00
283_V	290_S	2.396	1.00
20_I	71_G	2.375	1.00
19_L	303_E	2.329	1.00
126_V	158_S	2.321	1.00
232_R	237_G	2.301	1.00
64_T	128_A	2.287	1.00
132_F	141_A	2.242	1.00
279_R	283_V	2.225	1.00
321_E	324_T	2.218	1.00
232_R	240_S	2.196	1.00
81_K	306_Q	2.152	1.00
288_I	293_L	2.146	1.00
6_P	9_K	2.084	1.00
309_K	313_E	2.053	1.00
279_R	297_D	2.043	1.00
268_M	271_K	2.037	1.00
132_F	137_L	2.013	1.00
122_A	155_V	2.008	1.00
58_R	138_D	2.003	1.00
53_V	226_A	2.000	1.00
280_D	284_S	1.960	1.00
204_A	211_A	1.948	1.00
155_V	159_L	1.907	1.00
295_K	299_E	1.898	1.00
302_A	306_Q	1.876	1.00
218_D	221_A	1.874	1.00
279_R	293_L	1.835	1.00
233_A	240_S	1.807	1.00
60_D	139_R	1.805	1.00
126_V	171_F	1.803	1.00
214_V	225_V	1.750	1.00
12_D	16_K	1.734	1.00
172_V	244_C	1.722	1.00
53_V	142_V	1.706	1.00
217_M	249_F	1.699	1.00
132_F	139_R	1.696	1.00
173_V	200_Y	1.677	1.00
148_G	179_A	1.673	1.00
92_T	314_S	1.659	1.00
283_V	293_L	1.628	1.00
210_P	232_R	1.614	1.00
7_K	292_E	1.605	1.00
212_V	225_V	1.580	1.00
53_V	172_V	1.541	1.00
122_A	158_S	1.524	1.00
292_E	295_K	1.521	1.00
129_A	169_V	1.517	1.00
13_M	219_V	1.501	1.00
175_D	243_H	1.501	1.00
210_P	238_G	1.498	1.00
310_F	314_S	1.472	1.00
229_A	240_S	1.471	1.00
10_L	282_L	1.463	1.00
13_M	55_S	1.458	1.00
130_L	134_L	1.446	1.00
96_K	325_D	1.444	1.00
145_I	149_A	1.439	1.00
281_K	285_N	1.431	1.00
18_L	300_A	1.422	1.00
306_Q	310_F	1.415	1.00
79_D	82_R	1.404	1.00
11_L	292_E	1.402	1.00
227_K	231_D	1.385	1.00
299_E	303_E	1.377	1.00
298_R	302_A	1.368	1.00
202_E	205_L	1.345	1.00
226_A	242_L	1.330	1.00
142_V	170_I	1.326	1.00
225_V	242_L	1.325	1.00
7_K	11_L	1.324	1.00
159_L	209_I	1.321	1.00
7_K	287_I	1.317	1.00
264_E	267_E	1.316	1.00
217_M	246_T	1.312	1.00
307_A	311_A	1.305	1.00
73_C	111_M	1.292	1.00
25_L	44_V	1.291	1.00
173_V	241_L	1.288	1.00
9_K	12_D	1.287	1.00
276_T	280_D	1.284	1.00
49_V	244_C	1.278	1.00
62_Y	132_F	1.256	1.00
177_M	245_K	1.250	1.00
106_D	109_K	1.249	1.00
269_W	272_R	1.241	1.00
172_V	226_A	1.235	1.00
52_G	222_V	1.224	1.00
166_K	238_G	1.223	1.00
140_V	233_A	1.217	1.00
11_L	288_I	1.217	1.00
199_S	202_E	1.215	1.00
291_E	295_K	1.213	1.00
263_K	267_E	1.210	1.00
201_V	213_E	1.203	1.00
22_Y	301_K	1.196	1.00
291_E	294_D	1.196	1.00
85_A	92_T	1.185	1.00
214_V	221_A	1.181	1.00
16_K	55_S	1.177	1.00
18_L	297_D	1.170	1.00
153_G	157_E	1.163	1.00
267_E	270_R	1.161	1.00
14_Y	18_L	1.160	1.00
309_K	312_E	1.156	1.00
223_Y	227_K	1.138	1.00
294_D	298_R	1.136	1.00
267_E	271_K	1.117	1.00
163_A	209_I	1.113	1.00
318_E	321_E	1.112	1.00
59_D	109_K	1.110	1.00
57_L	142_V	1.108	1.00
19_L	80_V	1.105	1.00
26_T	305_E	1.102	1.00
49_V	172_V	1.098	1.00
52_G	219_V	1.097	1.00
128_A	141_A	1.092	1.00
305_E	309_K	1.092	1.00
151_N	203_R	1.090	1.00
56_T	227_K	1.088	1.00
115_N	120_G	1.087	1.00
228_E	231_D	1.082	1.00
126_V	169_V	1.080	1.00
277_L	281_K	1.076	0.99
293_L	297_D	1.074	0.99
10_L	220_L	1.072	0.99
142_V	226_A	1.071	0.99
57_L	230_V	1.069	0.99
140_V	170_I	1.068	0.99
117_I	120_G	1.068	0.99
163_A	208_G	1.063	0.99
212_V	240_S	1.052	0.99
56_T	223_Y	1.050	0.99
7_K	285_N	1.048	0.99
10_L	278_F	1.046	0.99
303_E	307_A	1.045	0.99
91_K	315_P	1.044	0.99
220_L	278_F	1.040	0.99
247_Y	269_W	1.039	0.99
22_Y	304_I	1.039	0.99
22_Y	297_D	1.035	0.99
142_V	172_V	1.035	0.99
161_L	165_W	1.034	0.99
249_F	270_R	1.034	0.99
60_D	76_K	1.030	0.99
56_T	230_V	1.028	0.99
90_K	316_Y	1.023	0.99
151_N	194_H	1.022	0.99
64_T	112_L	1.021	0.99
80_V	303_E	1.021	0.99
27_A	87_I	1.019	0.99
18_L	275_I	1.016	0.99
183_R	192_P	1.008	0.99
122_A	145_I	1.006	0.99
211_A	241_L	1.005	0.99
140_V	234_R	1.004	0.99
300_A	304_I	0.997	0.99
55_S	223_Y	0.991	0.99
166_K	237_G	0.988	0.99
30_L	308_L	0.987	0.99
18_L	22_Y	0.985	0.99
133_K	166_K	0.978	0.99
12_D	55_S	0.978	0.99
16_K	51_V	0.977	0.99
251_G	257_P	0.974	0.99
215_D	221_A	0.971	0.99
278_F	282_L	0.970	0.99
178_Y	265_E	0.968	0.99
26_T	29_E	0.961	0.99
14_Y	296_I	0.957	0.99
170_I	230_V	0.953	0.99
57_L	63_I	0.951	0.99
204_A	209_I	0.949	0.99
15_K	19_L	0.947	0.99
17_M	275_I	0.944	0.99
212_V	242_L	0.944	0.99
62_Y	112_L	0.943	0.99
229_A	233_A	0.942	0.99
22_Y	25_L	0.941	0.99
288_I	292_E	0.940	0.99
13_M	223_Y	0.940	0.99
279_R	290_S	0.939	0.99
26_T	308_L	0.939	0.99
195_S	200_Y	0.935	0.99
82_R	108_S	0.934	0.99
224_E	228_E	0.924	0.98
60_D	138_D	0.922	0.98
261_R	265_E	0.919	0.98
125_A	169_V	0.913	0.98
145_I	150_M	0.913	0.98
264_E	268_M	0.907	0.98
218_D	277_L	0.904	0.98
159_L	241_L	0.903	0.98
14_Y	279_R	0.903	0.98
17_M	48_A	0.900	0.98
302_A	305_E	0.895	0.98
126_V	167_L	0.887	0.98
119_G	155_V	0.881	0.98
31_F	254_E	0.880	0.98
221_A	224_E	0.880	0.98
247_Y	265_E	0.880	0.98
197_A	202_E	0.880	0.98
19_L	300_A	0.879	0.98
138_D	235_R	0.879	0.98
163_A	196_A	0.875	0.98
9_K	223_Y	0.874	0.98
125_A	143_A	0.872	0.98
39_F	253_F	0.862	0.98
158_S	171_F	0.860	0.97
280_D	283_V	0.860	0.97
81_K	314_S	0.856	0.97
263_K	266_E	0.849	0.97
222_V	244_C	0.848	0.97
215_D	277_L	0.848	0.97
150_M	155_V	0.848	0.97
30_L	88_M	0.844	0.97
300_A	303_E	0.842	0.97
43_Y	71_G	0.842	0.97
119_G	149_A	0.840	0.97
129_A	168_P	0.839	0.97
282_L	287_I	0.838	0.97
306_Q	309_K	0.838	0.97
91_K	96_K	0.835	0.97
81_K	307_A	0.835	0.97
163_A	166_K	0.833	0.97
150_M	200_Y	0.832	0.97
303_E	306_Q	0.830	0.97
14_Y	297_D	0.825	0.97
199_S	213_E	0.821	0.97
48_A	52_G	0.817	0.97
23_H	84_L	0.815	0.97
203_R	206_G	0.812	0.96
278_F	281_K	0.808	0.96
225_V	229_A	0.801	0.96
12_D	15_K	0.791	0.96
63_I	72_H	0.785	0.96
229_A	232_R	0.783	0.96
125_A	141_A	0.782	0.96
39_F	254_E	0.780	0.96
73_C	78_L	0.777	0.95
170_I	226_A	0.775	0.95
288_I	296_I	0.770	0.95
10_L	287_I	0.770	0.95
85_A	314_S	0.768	0.95
110_G	139_R	0.765	0.95
164_I	194_H	0.762	0.95
43_Y	50_A	0.760	0.95
232_R	236_G	0.758	0.95
8_S	12_D	0.755	0.95
250_F	254_E	0.752	0.95
199_S	245_K	0.751	0.95
52_G	56_T	0.749	0.94
232_R	238_G	0.747	0.94
15_K	296_I	0.745	0.94
11_L	15_K	0.745	0.94
266_E	270_R	0.745	0.94
9_K	227_K	0.745	0.94
58_R	230_V	0.744	0.94
268_M	272_R	0.741	0.94
220_L	281_K	0.740	0.94
16_K	75_A	0.739	0.94
221_A	225_V	0.736	0.94
72_H	144_F	0.735	0.94
294_D	297_D	0.735	0.94
170_I	240_S	0.734	0.94
229_A	242_L	0.729	0.94
11_L	282_L	0.729	0.94
217_M	277_L	0.725	0.93
74_I	83_M	0.725	0.93
28_K	32_A	0.723	0.93
51_V	219_V	0.721	0.93
84_L	308_L	0.718	0.93
237_G	240_S	0.717	0.93
94_V	104_I	0.717	0.93
44_V	250_F	0.715	0.93
82_R	94_V	0.713	0.93
301_K	305_E	0.712	0.93
295_K	298_R	0.712	0.93
226_A	230_V	0.710	0.93
46_E	174_E	0.709	0.93
179_A	194_H	0.709	0.93
249_F	273_D	0.708	0.93
297_D	301_K	0.706	0.93
85_A	90_K	0.705	0.93
258_L	266_E	0.701	0.92
22_Y	300_A	0.699	0.92
272_R	277_L	0.698	0.92
283_V	288_I	0.696	0.92
155_V	241_L	0.695	0.92
119_G	122_A	0.693	0.92
180_M	253_F	0.692	0.92
92_T	315_P	0.691	0.92
145_I	171_F	0.690	0.92
28_K	254_E	0.689	0.92
118_V	152_Q	0.689	0.92
218_D	281_K	0.688	0.92
129_A	167_L	0.688	0.92
123_P	154_V	0.687	0.92
214_V	242_L	0.684	0.91
54_M	144_F	0.681	0.91
293_L	296_I	0.680	0.91
58_R	139_R	0.680	0.91
49_V	246_T	0.677	0.91
74_I	80_V	0.676	0.91
144_F	172_V	0.673	0.91
80_V	304_I	0.671	0.91
299_E	302_A	0.668	0.90
210_P	240_S	0.666	0.90
26_T	30_L	0.666	0.90
177_M	192_P	0.665	0.90
52_G	226_A	0.664	0.90
23_H	83_M	0.663	0.90
261_R	266_E	0.662	0.90
247_Y	266_E	0.662	0.90
38_G	253_F	0.651	0.89
13_M	220_L	0.649	0.89
204_A	241_L	0.647	0.89
78_L	109_K	0.643	0.89
78_L	94_V	0.642	0.89
129_A	141_A	0.641	0.88
85_A	310_F	0.639	0.88
81_K	85_A	0.638	0.88
18_L	296_I	0.636	0.88
96_K	321_E	0.635	0.88
43_Y	70_H	0.634	0.88
315_P	318_E	0.633	0.88
138_D	230_V	0.632	0.88
15_K	303_E	0.631	0.88
13_M	51_V	0.630	0.88
215_D	272_R	0.629	0.88
184_S	195_S	0.629	0.88
224_E	227_K	0.628	0.87
24_E	31_F	0.626	0.87
180_M	255_G	0.624	0.87
118_V	149_A	0.622	0.87
283_V	289_N	0.621	0.87
42_L	250_F	0.620	0.87
296_I	300_A	0.620	0.87
64_T	124_H	0.619	0.87
120_G	124_H	0.618	0.87
99_G	102_M	0.616	0.86
14_Y	293_L	0.616	0.86
119_G	152_Q	0.616	0.86
101_S	113_G	0.614	0.86
27_A	84_L	0.614	0.86
225_V	228_E	0.612	0.86
91_K	321_E	0.608	0.86
201_V	211_A	0.605	0.85
183_R	193_R	0.603	0.85
217_M	247_Y	0.603	0.85
281_K	287_I	0.602	0.85
64_T	125_A	0.602	0.85
67_H	121_G	0.601	0.85
276_T	279_R	0.601	0.85
14_Y	275_I	0.598	0.85
9_K	55_S	0.598	0.85
310_F	313_E	0.597	0.85
54_M	76_K	0.597	0.85
28_K	44_V	0.597	0.85
213_E	243_H	0.594	0.84
122_A	159_L	0.594	0.84
279_R	288_I	0.593	0.84
129_A	132_F	0.591	0.84
44_V	249_F	0.591	0.84
170_I	242_L	0.589	0.84
63_I	111_M	0.589	0.84
305_E	308_L	0.588	0.84
177_M	184_S	0.588	0.84
180_M	254_E	0.587	0.84
67_H	180_M	0.586	0.84
214_V	244_C	0.585	0.84
181_S	254_E	0.584	0.83
64_T	121_G	0.583	0.83
86_E	93_G	0.583	0.83
14_Y	288_I	0.583	0.83
141_A	169_V	0.580	0.83
209_I	239_P	0.578	0.83
16_K	19_L	0.578	0.83
60_D	137_L	0.577	0.83
214_V	222_V	0.575	0.82
88_M	312_E	0.575	0.82
147_D	200_Y	0.573	0.82
320_E	324_T	0.573	0.82
209_I	241_L	0.571	0.82
162_S	171_F	0.571	0.82
251_G	258_L	0.567	0.82
19_L	74_I	0.565	0.81
197_A	203_R	0.565	0.81
200_Y	241_L	0.564	0.81
175_D	184_S	0.562	0.81
112_L	128_A	0.559	0.81
307_A	310_F	0.558	0.81
60_D	110_G	0.558	0.81
210_P	228_E	0.555	0.80
163_A	207_F	0.553	0.80
28_K	250_F	0.553	0.80
46_E	66_T	0.552	0.80
11_L	287_I	0.551	0.80
65_S	69_G	0.551	0.80
197_A	208_G	0.550	0.80
19_L	304_I	0.550	0.80
277_L	280_D	0.550	0.80
149_A	173_V	0.550	0.80
65_S	111_M	0.550	0.80
102_M	118_V	0.548	0.79
53_V	72_H	0.546	0.79
151_N	195_S	0.546	0.79
17_M	278_F	0.543	0.79
23_H	70_H	0.543	0.79
99_G	113_G	0.543	0.79
282_L	288_I	0.541	0.79
20_I	51_V	0.540	0.78
67_H	253_F	0.540	0.78
197_A	200_Y	0.539	0.78
15_K	300_A	0.539	0.78
76_K	109_K	0.537	0.78
107_Y	110_G	0.534	0.78
31_F	39_F	0.533	0.77
28_K	42_L	0.532	0.77
132_F	138_D	0.532	0.77
195_S	203_R	0.528	0.77
142_V	230_V	0.526	0.77
317_P	325_D	0.526	0.77
30_L	33_S	0.525	0.76
172_V	222_V	0.524	0.76
178_Y	249_F	0.524	0.76
86_E	116_G	0.523	0.76
302_A	309_K	0.523	0.76
128_A	131_A	0.522	0.76
62_Y	139_R	0.520	0.76
62_Y	110_G	0.518	0.75
158_S	169_V	0.518	0.75
72_H	142_V	0.515	0.75
220_L	224_E	0.515	0.75
232_R	235_R	0.514	0.75
55_S	75_A	0.513	0.75
63_I	76_K	0.512	0.75
58_R	234_R	0.512	0.75
46_E	157_E	0.512	0.75
112_L	115_N	0.512	0.75
19_L	307_A	0.511	0.75
66_T	121_G	0.509	0.74
88_M	311_A	0.508	0.74
143_A	169_V	0.508	0.74
42_L	251_G	0.507	0.74
63_I	144_F	0.506	0.74
23_H	27_A	0.506	0.74
174_E	246_T	0.506	0.74
100_G	117_I	0.505	0.74
184_S	200_Y	0.504	0.74
64_T	143_A	0.503	0.73
62_Y	128_A	0.502	0.73
53_V	170_I	0.501	0.73
156_L	206_G	0.501	0.73
115_N	121_G	0.501	0.73
311_A	314_S	0.501	0.73
38_G	100_G	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1qs0A	2	0.9759	100	0.274	Contact Map
1umdA	2	0.9759	100	0.28	Contact Map
2bfdA	2	0.9096	100	0.284	Contact Map
2ozlA	2	0.9669	100	0.303	Contact Map
1w85A	2	0.9488	100	0.325	Contact Map
2xt6A	2	0.8946	100	0.414	Contact Map
2yicA	2	0.9006	100	0.419	Contact Map
2jgdA	2	0.8765	100	0.442	Contact Map
5c4iC	2	0.7771	100	0.652	Contact Map
1itzA	2	0.9096	100	0.675	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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