Q97Y22 - SULSO - GREMLIN Contacts

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Q97Y22 - Pyruvate dehydrogenase, beta subunit (Lipoamide). (PdhB-2)

UniProt:	Q97Y22	Sequences: MRQITFTEAINEALRQEMERDPSVILIGEDIGVYGGAFGVTKGLIEKFGSDRVIDTPISEAGFIGAAVGAALAGLRPVVELMFVDFFGVAMDQIYNQMAKLRYMSGGQLKVPLTLRAPIGAGISAAAQHSQTLYSIFAHVPGLKVVVPSTPHDAKGLLISSIRDDNPVVFLEHKVLYGIKGEVPEEEYTIPLGKAEIRREGDDVTVIGIARTVWHSLEAAEQLSKESISVEVIDVRSIVPFDKETVIKSVKKTGRVVIVDEDYDRCGFASWVSSIIADEAFEYLDAPIKRITTPNVPIPFSPPLEQYILPDSKKIVNTVKSILG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	324 (301)
Sequences:	13927 (7980)
Seq/√Len:	460.0

ECOLI - DXS TKT1 TKT2
BACSU - ODBB ODPB ACOB DXS TKT
HALSA - Q9HN76
SULSO - Q97Y22 Q97YF5 Q980J2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
226_E	320_K	4.555	1.00
19_E	47_K	3.734	1.00
222_Q	316_V	3.314	1.00
311_D	314_K	2.930	1.00
195_A	245_T	2.832	1.00
204_V	319_V	2.803	1.00
67_A	79_V	2.754	1.00
217_L	232_V	2.463	1.00
199_R	220_A	2.412	1.00
15_R	47_K	2.383	1.00
202_D	229_S	2.319	1.00
199_R	221_E	2.262	1.00
220_A	232_V	2.181	1.00
146_V	157_L	2.168	1.00
15_R	48_F	2.167	1.00
222_Q	312_S	2.154	1.00
218_E	312_S	2.094	1.00
312_S	316_V	2.090	1.00
243_K	275_I	2.061	1.00
205_T	253_T	1.998	1.00
204_V	230_V	1.993	1.00
306_Q	311_D	1.972	1.00
76_R	110_K	1.903	1.00
70_A	75_L	1.883	1.00
215_H	312_S	1.882	1.00
224_S	229_S	1.860	1.00
289_K	321_S	1.860	1.00
247_I	275_I	1.850	1.00
203_D	254_G	1.818	1.00
68_V	98_M	1.786	1.00
98_M	113_L	1.783	1.00
222_Q	225_K	1.766	1.00
64_I	98_M	1.754	1.00
199_R	224_S	1.752	1.00
264_D	292_T	1.744	1.00
289_K	318_T	1.739	1.00
203_D	229_S	1.736	1.00
231_E	252_K	1.736	1.00
19_E	48_F	1.726	1.00
231_E	249_S	1.701	1.00
216_S	259_V	1.694	1.00
270_S	274_S	1.666	1.00
135_S	262_D	1.663	1.00
231_E	253_T	1.647	1.00
108_Q	142_G	1.639	1.00
144_K	164_D	1.638	1.00
222_Q	313_K	1.628	1.00
206_V	216_S	1.628	1.00
208_G	216_S	1.616	1.00
278_D	290_R	1.608	1.00
197_I	231_E	1.604	1.00
247_I	279_E	1.600	1.00
243_K	279_E	1.596	1.00
138_A	271_W	1.588	1.00
317_N	321_S	1.580	1.00
16_Q	155_K	1.580	1.00
200_E	231_E	1.577	1.00
316_V	320_K	1.576	1.00
143_L	169_V	1.565	1.00
25_I	70_A	1.563	1.00
218_E	221_E	1.541	1.00
64_I	113_L	1.540	1.00
112_P	161_S	1.537	1.00
303_P	306_Q	1.537	1.00
17_E	159_I	1.533	1.00
144_K	166_N	1.514	1.00
215_H	218_E	1.513	1.00
273_S	288_I	1.505	1.00
78_V	162_I	1.501	1.00
161_S	168_V	1.476	1.00
8_E	36_G	1.455	1.00
248_K	253_T	1.453	1.00
138_A	274_S	1.447	1.00
318_T	321_S	1.444	1.00
214_W	218_E	1.440	1.00
208_G	213_V	1.422	1.00
221_E	225_K	1.407	1.00
64_I	79_V	1.396	1.00
207_I	235_V	1.386	1.00
314_K	318_T	1.385	1.00
233_I	245_T	1.374	1.00
137_F	169_V	1.365	1.00
306_Q	313_K	1.359	1.00
219_A	316_V	1.355	1.00
191_P	194_K	1.353	1.00
13_A	155_K	1.352	1.00
215_H	315_I	1.347	1.00
13_A	159_I	1.340	1.00
206_V	319_V	1.339	1.00
222_Q	226_E	1.328	1.00
21_D	76_R	1.319	1.00
196_E	234_D	1.311	1.00
17_E	163_R	1.298	1.00
195_A	235_V	1.298	1.00
159_I	163_R	1.297	1.00
144_K	237_S	1.294	1.00
14_L	78_V	1.290	1.00
110_K	166_N	1.282	1.00
235_V	268_F	1.273	1.00
43_G	46_E	1.270	1.00
17_E	24_V	1.265	1.00
64_I	90_A	1.265	1.00
153_D	234_D	1.264	1.00
76_R	112_P	1.260	1.00
27_I	67_A	1.255	1.00
18_M	44_L	1.254	1.00
197_I	200_E	1.253	1.00
257_V	322_I	1.248	1.00
146_V	237_S	1.245	1.00
8_E	12_E	1.236	1.00
205_T	249_S	1.228	1.00
94_I	143_L	1.225	1.00
160_S	192_L	1.219	1.00
233_I	249_S	1.213	1.00
221_E	224_S	1.210	1.00
23_S	75_L	1.208	1.00
257_V	319_V	1.202	1.00
110_K	165_D	1.186	1.00
273_S	277_A	1.182	1.00
248_K	252_K	1.179	1.00
241_F	246_V	1.178	1.00
27_I	56_T	1.173	1.00
244_E	248_K	1.173	1.00
17_E	162_I	1.168	1.00
153_D	236_R	1.166	1.00
247_I	280_A	1.166	1.00
190_I	193_G	1.165	1.00
207_I	256_V	1.163	1.00
26_L	41_T	1.163	1.00
12_E	155_K	1.161	1.00
149_S	213_V	1.157	1.00
260_D	269_A	1.154	1.00
206_V	230_V	1.129	1.00
149_S	234_D	1.129	1.00
230_V	319_V	1.123	1.00
281_F	286_A	1.123	1.00
198_R	213_V	1.112	1.00
199_R	229_S	1.110	1.00
247_I	251_K	1.108	1.00
17_E	20_R	1.106	1.00
25_I	75_L	1.098	1.00
9_A	151_P	1.091	1.00
146_V	168_V	1.084	1.00
201_G	229_S	1.080	1.00
16_Q	159_I	1.078	1.00
195_A	233_I	1.075	1.00
135_S	139_H	1.074	1.00
314_K	317_N	1.068	1.00
256_V	276_I	1.064	1.00
21_D	24_V	1.064	1.00
274_S	290_R	1.062	1.00
13_A	16_Q	1.061	1.00
212_T	215_H	1.047	1.00
250_V	276_I	1.045	1.00
12_E	16_Q	1.039	1.00
216_S	260_D	1.036	1.00
197_I	245_T	1.035	1.00
243_K	247_I	1.035	1.00
194_K	244_E	1.027	1.00
277_A	288_I	1.025	1.00
257_V	291_I	1.024	1.00
259_V	315_I	1.021	1.00
20_R	159_I	1.021	1.00
98_M	111_V	1.014	1.00
91_M	136_I	1.011	1.00
18_M	24_V	1.011	1.00
273_S	290_R	1.010	1.00
282_E	287_P	1.009	1.00
71_A	77_P	1.003	1.00
85_D	133_L	1.000	1.00
134_Y	209_I	1.000	1.00
299_P	307_Y	0.990	1.00
16_Q	20_R	0.982	1.00
249_S	252_K	0.977	1.00
21_D	162_I	0.975	1.00
275_I	279_E	0.975	1.00
15_R	19_E	0.974	1.00
239_V	295_N	0.974	1.00
61_A	93_Q	0.964	1.00
197_I	233_I	0.962	1.00
12_E	43_G	0.960	1.00
67_A	111_V	0.956	1.00
84_V	171_L	0.953	1.00
26_L	31_I	0.950	1.00
209_I	238_I	0.947	1.00
258_I	269_A	0.946	1.00
144_K	168_V	0.945	1.00
76_R	165_D	0.945	1.00
226_E	316_V	0.945	1.00
289_K	322_I	0.941	1.00
205_T	231_E	0.935	1.00
42_K	46_E	0.932	1.00
219_A	315_I	0.926	1.00
99_A	140_V	0.921	1.00
43_G	47_K	0.920	1.00
146_V	192_L	0.913	1.00
8_E	11_N	0.913	1.00
135_S	266_C	0.912	1.00
313_K	317_N	0.912	1.00
205_T	233_I	0.912	1.00
144_K	240_P	0.905	1.00
291_I	318_T	0.903	1.00
149_S	196_E	0.900	1.00
309_L	314_K	0.898	1.00
134_Y	171_L	0.895	1.00
293_T	308_I	0.893	1.00
56_T	66_A	0.893	1.00
16_Q	19_E	0.889	1.00
32_G	53_V	0.882	1.00
94_I	137_F	0.875	1.00
223_L	319_V	0.875	1.00
255_R	287_P	0.873	1.00
108_Q	166_N	0.870	1.00
259_V	282_E	0.865	1.00
63_F	79_V	0.865	1.00
158_L	170_F	0.864	1.00
100_K	126_A	0.862	1.00
134_Y	262_D	0.852	1.00
23_S	76_R	0.848	1.00
131_Q	293_T	0.847	1.00
216_S	232_V	0.844	1.00
281_F	321_S	0.842	1.00
265_R	295_N	0.842	1.00
8_E	176_L	0.839	1.00
25_I	54_I	0.833	1.00
248_K	251_K	0.828	1.00
66_A	70_A	0.826	1.00
160_S	191_P	0.823	1.00
35_G	80_E	0.820	1.00
154_A	172_E	0.817	1.00
245_T	249_S	0.812	1.00
228_I	320_K	0.809	1.00
27_I	54_I	0.806	1.00
29_E	35_G	0.804	1.00
143_L	167_P	0.803	1.00
303_P	307_Y	0.803	1.00
48_F	52_R	0.803	1.00
235_V	238_I	0.803	1.00
87_F	137_F	0.802	1.00
45_I	48_F	0.799	1.00
204_V	257_V	0.799	1.00
220_A	224_S	0.798	1.00
241_F	275_I	0.795	1.00
138_A	238_I	0.794	1.00
255_R	322_I	0.789	1.00
88_G	91_M	0.788	1.00
159_I	187_E	0.787	1.00
26_L	78_V	0.785	1.00
147_V	209_I	0.784	1.00
112_P	168_V	0.783	1.00
13_A	17_E	0.783	1.00
120_G	305_E	0.781	1.00
319_V	322_I	0.781	1.00
223_L	316_V	0.780	1.00
98_M	167_P	0.779	1.00
203_D	228_I	0.776	1.00
62_G	66_A	0.774	1.00
144_K	192_L	0.773	1.00
215_H	311_D	0.770	1.00
246_V	275_I	0.770	1.00
208_G	212_T	0.764	1.00
207_I	233_I	0.763	1.00
218_E	222_Q	0.762	1.00
84_V	137_F	0.761	1.00
224_S	230_V	0.756	1.00
215_H	305_E	0.756	1.00
160_S	163_R	0.755	1.00
116_R	172_E	0.752	1.00
151_P	179_I	0.752	1.00
242_D	275_I	0.752	1.00
136_I	140_V	0.749	1.00
296_V	307_Y	0.747	1.00
306_Q	314_K	0.745	1.00
200_E	252_K	0.745	1.00
99_A	297_P	0.744	1.00
246_V	276_I	0.741	1.00
193_G	196_E	0.738	1.00
133_L	171_L	0.737	1.00
268_F	272_V	0.734	1.00
13_A	158_L	0.730	1.00
45_I	53_V	0.726	1.00
44_L	53_V	0.725	1.00
10_I	80_E	0.724	1.00
317_N	320_K	0.723	1.00
156_G	159_I	0.723	1.00
202_D	231_E	0.721	1.00
87_F	117_A	0.719	1.00
152_H	184_P	0.718	1.00
178_G	214_W	0.717	1.00
304_L	308_I	0.716	1.00
71_A	111_V	0.716	1.00
199_R	217_L	0.715	1.00
144_K	239_V	0.714	1.00
238_I	242_D	0.714	1.00
276_I	282_E	0.707	1.00
249_S	253_T	0.703	1.00
123_I	302_P	0.700	1.00
29_E	63_F	0.698	1.00
173_H	177_Y	0.695	1.00
27_I	63_F	0.694	1.00
150_T	198_R	0.692	1.00
14_L	41_T	0.691	1.00
9_A	13_A	0.691	1.00
265_R	287_P	0.687	1.00
135_S	263_Y	0.687	1.00
11_N	15_R	0.685	1.00
138_A	266_C	0.678	1.00
257_V	289_K	0.677	1.00
269_A	292_T	0.674	1.00
65_G	93_Q	0.674	1.00
271_W	274_S	0.673	1.00
247_I	281_F	0.672	1.00
94_I	115_L	0.671	1.00
219_A	259_V	0.671	1.00
126_A	129_H	0.670	1.00
71_A	109_L	0.667	1.00
140_V	143_L	0.667	1.00
156_G	189_T	0.666	1.00
27_I	66_A	0.664	1.00
157_L	236_R	0.663	1.00
146_V	160_S	0.661	1.00
160_S	189_T	0.659	1.00
281_F	318_T	0.659	1.00
318_T	322_I	0.658	1.00
72_L	109_L	0.658	1.00
32_G	45_I	0.658	1.00
67_A	80_E	0.657	1.00
264_D	278_D	0.650	1.00
271_W	275_I	0.650	1.00
242_D	270_S	0.648	1.00
200_E	248_K	0.647	1.00
134_Y	145_V	0.647	1.00
203_D	230_V	0.646	1.00
198_R	217_L	0.644	1.00
294_P	308_I	0.643	1.00
99_A	143_L	0.642	1.00
264_D	290_R	0.641	1.00
152_H	156_G	0.640	1.00
194_K	242_D	0.638	1.00
22_P	52_R	0.636	0.99
146_V	161_S	0.633	0.99
163_R	187_E	0.630	0.99
209_I	235_V	0.629	0.99
24_V	162_I	0.629	0.99
197_I	248_K	0.627	0.99
258_I	261_E	0.626	0.99
94_I	113_L	0.625	0.99
24_V	78_V	0.624	0.99
278_D	289_K	0.623	0.99
277_A	280_A	0.622	0.99
95_Y	140_V	0.621	0.99
11_N	36_G	0.617	0.99
212_T	259_V	0.617	0.99
250_V	256_V	0.616	0.99
90_A	94_I	0.611	0.99
219_A	319_V	0.610	0.99
266_C	270_S	0.609	0.99
84_V	133_L	0.609	0.99
183_V	186_E	0.609	0.99
92_D	96_N	0.607	0.99
120_G	304_L	0.606	0.99
88_G	133_L	0.606	0.99
78_V	158_L	0.606	0.99
156_G	160_S	0.604	0.99
161_S	170_F	0.598	0.99
243_K	278_D	0.598	0.99
79_V	113_L	0.598	0.99
258_I	272_V	0.596	0.99
259_V	291_I	0.594	0.99
197_I	249_S	0.592	0.99
45_I	50_S	0.590	0.99
54_I	66_A	0.589	0.99
70_A	77_P	0.587	0.99
258_I	288_I	0.585	0.99
294_P	314_K	0.585	0.99
159_I	189_T	0.585	0.99
271_W	290_R	0.584	0.99
101_L	109_L	0.583	0.99
282_E	286_A	0.581	0.99
138_A	145_V	0.580	0.99
33_V	55_D	0.579	0.99
43_G	55_D	0.578	0.99
145_V	169_V	0.577	0.99
205_T	256_V	0.577	0.99
260_D	267_G	0.577	0.99
10_I	158_L	0.577	0.99
59_S	62_G	0.574	0.99
255_R	279_E	0.574	0.99
156_G	187_E	0.573	0.99
267_G	270_S	0.572	0.99
296_V	308_I	0.571	0.99
310_P	314_K	0.570	0.99
108_Q	165_D	0.569	0.99
15_R	53_V	0.568	0.99
138_A	268_F	0.568	0.99
144_K	193_G	0.564	0.99
91_M	139_H	0.563	0.99
187_E	190_I	0.563	0.99
131_Q	263_Y	0.563	0.99
213_V	232_V	0.560	0.99
112_P	158_L	0.559	0.99
164_D	168_V	0.559	0.99
147_V	210_A	0.559	0.99
188_Y	196_E	0.558	0.99
64_I	81_L	0.557	0.99
72_L	101_L	0.557	0.99
76_R	162_I	0.557	0.99
31_I	83_F	0.556	0.99
18_M	53_V	0.556	0.99
152_H	188_Y	0.555	0.99
257_V	260_D	0.552	0.99
208_G	235_V	0.552	0.99
8_E	43_G	0.551	0.99
193_G	237_S	0.549	0.99
223_L	230_V	0.546	0.98
184_P	188_Y	0.544	0.98
115_L	169_V	0.542	0.98
149_S	153_D	0.541	0.98
121_A	124_S	0.541	0.98
88_G	136_I	0.541	0.98
179_I	214_W	0.540	0.98
182_E	185_E	0.540	0.98
281_F	287_P	0.539	0.98
219_A	312_S	0.537	0.98
205_T	252_K	0.536	0.98
291_I	310_P	0.535	0.98
237_S	240_P	0.535	0.98
18_M	48_F	0.533	0.98
211_R	215_H	0.532	0.98
155_K	159_I	0.531	0.98
238_I	268_F	0.530	0.98
269_A	290_R	0.527	0.98
152_H	179_I	0.526	0.98
195_A	242_D	0.524	0.98
21_D	163_R	0.524	0.98
112_P	170_F	0.524	0.98
173_H	211_R	0.521	0.98
205_T	255_R	0.514	0.98
42_K	45_I	0.513	0.98
44_L	48_F	0.511	0.98
298_I	308_I	0.510	0.98
204_V	255_R	0.509	0.98
178_G	218_E	0.508	0.98
205_T	254_G	0.508	0.98
223_L	228_I	0.508	0.98
15_R	18_M	0.506	0.97
301_S	304_L	0.505	0.97
196_E	236_R	0.503	0.97
147_V	211_R	0.503	0.97
12_E	15_R	0.502	0.97
85_D	131_Q	0.501	0.97
270_S	290_R	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1w85B	2	0.9877	100	0.214	Contact Map
1umdB	2	0.9846	100	0.216	Contact Map
1ik6A	3	0.8549	100	0.225	Contact Map
1qs0B	2	0.9846	100	0.235	Contact Map
2ozlB	2	0.9907	100	0.248	Contact Map
2o1xA	2	0.9321	100	0.254	Contact Map
2bfdB	2	0.9877	100	0.26	Contact Map
2o1sA	2	0.9259	100	0.264	Contact Map
4kxvA	2	0.9352	100	0.266	Contact Map
1gpuA	2	0.9105	100	0.309	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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