GREMLIN Database
Q97Y22 - Pyruvate dehydrogenase, beta subunit (Lipoamide). (PdhB-2)
UniProt: Q97Y22 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (301)
Sequences: 13927 (7980)
Seq/√Len: 460.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
226_E320_K4.5551.00
19_E47_K3.7341.00
222_Q316_V3.3141.00
311_D314_K2.9301.00
195_A245_T2.8321.00
204_V319_V2.8031.00
67_A79_V2.7541.00
217_L232_V2.4631.00
199_R220_A2.4121.00
15_R47_K2.3831.00
202_D229_S2.3191.00
199_R221_E2.2621.00
220_A232_V2.1811.00
146_V157_L2.1681.00
15_R48_F2.1671.00
222_Q312_S2.1541.00
218_E312_S2.0941.00
312_S316_V2.0901.00
243_K275_I2.0611.00
205_T253_T1.9981.00
204_V230_V1.9931.00
306_Q311_D1.9721.00
76_R110_K1.9031.00
70_A75_L1.8831.00
215_H312_S1.8821.00
224_S229_S1.8601.00
289_K321_S1.8601.00
247_I275_I1.8501.00
203_D254_G1.8181.00
68_V98_M1.7861.00
98_M113_L1.7831.00
222_Q225_K1.7661.00
64_I98_M1.7541.00
199_R224_S1.7521.00
264_D292_T1.7441.00
289_K318_T1.7391.00
203_D229_S1.7361.00
231_E252_K1.7361.00
19_E48_F1.7261.00
231_E249_S1.7011.00
216_S259_V1.6941.00
270_S274_S1.6661.00
135_S262_D1.6631.00
231_E253_T1.6471.00
108_Q142_G1.6391.00
144_K164_D1.6381.00
222_Q313_K1.6281.00
206_V216_S1.6281.00
208_G216_S1.6161.00
278_D290_R1.6081.00
197_I231_E1.6041.00
247_I279_E1.6001.00
243_K279_E1.5961.00
138_A271_W1.5881.00
317_N321_S1.5801.00
16_Q155_K1.5801.00
200_E231_E1.5771.00
316_V320_K1.5761.00
143_L169_V1.5651.00
25_I70_A1.5631.00
218_E221_E1.5411.00
64_I113_L1.5401.00
112_P161_S1.5371.00
303_P306_Q1.5371.00
17_E159_I1.5331.00
144_K166_N1.5141.00
215_H218_E1.5131.00
273_S288_I1.5051.00
78_V162_I1.5011.00
161_S168_V1.4761.00
8_E36_G1.4551.00
248_K253_T1.4531.00
138_A274_S1.4471.00
318_T321_S1.4441.00
214_W218_E1.4401.00
208_G213_V1.4221.00
221_E225_K1.4071.00
64_I79_V1.3961.00
207_I235_V1.3861.00
314_K318_T1.3851.00
233_I245_T1.3741.00
137_F169_V1.3651.00
306_Q313_K1.3591.00
219_A316_V1.3551.00
191_P194_K1.3531.00
13_A155_K1.3521.00
215_H315_I1.3471.00
13_A159_I1.3401.00
206_V319_V1.3391.00
222_Q226_E1.3281.00
21_D76_R1.3191.00
196_E234_D1.3111.00
17_E163_R1.2981.00
195_A235_V1.2981.00
159_I163_R1.2971.00
144_K237_S1.2941.00
14_L78_V1.2901.00
110_K166_N1.2821.00
235_V268_F1.2731.00
43_G46_E1.2701.00
17_E24_V1.2651.00
64_I90_A1.2651.00
153_D234_D1.2641.00
76_R112_P1.2601.00
27_I67_A1.2551.00
18_M44_L1.2541.00
197_I200_E1.2531.00
257_V322_I1.2481.00
146_V237_S1.2451.00
8_E12_E1.2361.00
205_T249_S1.2281.00
94_I143_L1.2251.00
160_S192_L1.2191.00
233_I249_S1.2131.00
221_E224_S1.2101.00
23_S75_L1.2081.00
257_V319_V1.2021.00
110_K165_D1.1861.00
273_S277_A1.1821.00
248_K252_K1.1791.00
241_F246_V1.1781.00
27_I56_T1.1731.00
244_E248_K1.1731.00
17_E162_I1.1681.00
153_D236_R1.1661.00
247_I280_A1.1661.00
190_I193_G1.1651.00
207_I256_V1.1631.00
26_L41_T1.1631.00
12_E155_K1.1611.00
149_S213_V1.1571.00
260_D269_A1.1541.00
206_V230_V1.1291.00
149_S234_D1.1291.00
230_V319_V1.1231.00
281_F286_A1.1231.00
198_R213_V1.1121.00
199_R229_S1.1101.00
247_I251_K1.1081.00
17_E20_R1.1061.00
25_I75_L1.0981.00
9_A151_P1.0911.00
146_V168_V1.0841.00
201_G229_S1.0801.00
16_Q159_I1.0781.00
195_A233_I1.0751.00
135_S139_H1.0741.00
314_K317_N1.0681.00
256_V276_I1.0641.00
21_D24_V1.0641.00
274_S290_R1.0621.00
13_A16_Q1.0611.00
212_T215_H1.0471.00
250_V276_I1.0451.00
12_E16_Q1.0391.00
216_S260_D1.0361.00
197_I245_T1.0351.00
243_K247_I1.0351.00
194_K244_E1.0271.00
277_A288_I1.0251.00
257_V291_I1.0241.00
259_V315_I1.0211.00
20_R159_I1.0211.00
98_M111_V1.0141.00
91_M136_I1.0111.00
18_M24_V1.0111.00
273_S290_R1.0101.00
282_E287_P1.0091.00
71_A77_P1.0031.00
85_D133_L1.0001.00
134_Y209_I1.0001.00
299_P307_Y0.9901.00
16_Q20_R0.9821.00
249_S252_K0.9771.00
21_D162_I0.9751.00
275_I279_E0.9751.00
15_R19_E0.9741.00
239_V295_N0.9741.00
61_A93_Q0.9641.00
197_I233_I0.9621.00
12_E43_G0.9601.00
67_A111_V0.9561.00
84_V171_L0.9531.00
26_L31_I0.9501.00
209_I238_I0.9471.00
258_I269_A0.9461.00
144_K168_V0.9451.00
76_R165_D0.9451.00
226_E316_V0.9451.00
289_K322_I0.9411.00
205_T231_E0.9351.00
42_K46_E0.9321.00
219_A315_I0.9261.00
99_A140_V0.9211.00
43_G47_K0.9201.00
146_V192_L0.9131.00
8_E11_N0.9131.00
135_S266_C0.9121.00
313_K317_N0.9121.00
205_T233_I0.9121.00
144_K240_P0.9051.00
291_I318_T0.9031.00
149_S196_E0.9001.00
309_L314_K0.8981.00
134_Y171_L0.8951.00
293_T308_I0.8931.00
56_T66_A0.8931.00
16_Q19_E0.8891.00
32_G53_V0.8821.00
94_I137_F0.8751.00
223_L319_V0.8751.00
255_R287_P0.8731.00
108_Q166_N0.8701.00
259_V282_E0.8651.00
63_F79_V0.8651.00
158_L170_F0.8641.00
100_K126_A0.8621.00
134_Y262_D0.8521.00
23_S76_R0.8481.00
131_Q293_T0.8471.00
216_S232_V0.8441.00
281_F321_S0.8421.00
265_R295_N0.8421.00
8_E176_L0.8391.00
25_I54_I0.8331.00
248_K251_K0.8281.00
66_A70_A0.8261.00
160_S191_P0.8231.00
35_G80_E0.8201.00
154_A172_E0.8171.00
245_T249_S0.8121.00
228_I320_K0.8091.00
27_I54_I0.8061.00
29_E35_G0.8041.00
143_L167_P0.8031.00
303_P307_Y0.8031.00
48_F52_R0.8031.00
235_V238_I0.8031.00
87_F137_F0.8021.00
45_I48_F0.7991.00
204_V257_V0.7991.00
220_A224_S0.7981.00
241_F275_I0.7951.00
138_A238_I0.7941.00
255_R322_I0.7891.00
88_G91_M0.7881.00
159_I187_E0.7871.00
26_L78_V0.7851.00
147_V209_I0.7841.00
112_P168_V0.7831.00
13_A17_E0.7831.00
120_G305_E0.7811.00
319_V322_I0.7811.00
223_L316_V0.7801.00
98_M167_P0.7791.00
203_D228_I0.7761.00
62_G66_A0.7741.00
144_K192_L0.7731.00
215_H311_D0.7701.00
246_V275_I0.7701.00
208_G212_T0.7641.00
207_I233_I0.7631.00
218_E222_Q0.7621.00
84_V137_F0.7611.00
224_S230_V0.7561.00
215_H305_E0.7561.00
160_S163_R0.7551.00
116_R172_E0.7521.00
151_P179_I0.7521.00
242_D275_I0.7521.00
136_I140_V0.7491.00
296_V307_Y0.7471.00
306_Q314_K0.7451.00
200_E252_K0.7451.00
99_A297_P0.7441.00
246_V276_I0.7411.00
193_G196_E0.7381.00
133_L171_L0.7371.00
268_F272_V0.7341.00
13_A158_L0.7301.00
45_I53_V0.7261.00
44_L53_V0.7251.00
10_I80_E0.7241.00
317_N320_K0.7231.00
156_G159_I0.7231.00
202_D231_E0.7211.00
87_F117_A0.7191.00
152_H184_P0.7181.00
178_G214_W0.7171.00
304_L308_I0.7161.00
71_A111_V0.7161.00
199_R217_L0.7151.00
144_K239_V0.7141.00
238_I242_D0.7141.00
276_I282_E0.7071.00
249_S253_T0.7031.00
123_I302_P0.7001.00
29_E63_F0.6981.00
173_H177_Y0.6951.00
27_I63_F0.6941.00
150_T198_R0.6921.00
14_L41_T0.6911.00
9_A13_A0.6911.00
265_R287_P0.6871.00
135_S263_Y0.6871.00
11_N15_R0.6851.00
138_A266_C0.6781.00
257_V289_K0.6771.00
269_A292_T0.6741.00
65_G93_Q0.6741.00
271_W274_S0.6731.00
247_I281_F0.6721.00
94_I115_L0.6711.00
219_A259_V0.6711.00
126_A129_H0.6701.00
71_A109_L0.6671.00
140_V143_L0.6671.00
156_G189_T0.6661.00
27_I66_A0.6641.00
157_L236_R0.6631.00
146_V160_S0.6611.00
160_S189_T0.6591.00
281_F318_T0.6591.00
318_T322_I0.6581.00
72_L109_L0.6581.00
32_G45_I0.6581.00
67_A80_E0.6571.00
264_D278_D0.6501.00
271_W275_I0.6501.00
242_D270_S0.6481.00
200_E248_K0.6471.00
134_Y145_V0.6471.00
203_D230_V0.6461.00
198_R217_L0.6441.00
294_P308_I0.6431.00
99_A143_L0.6421.00
264_D290_R0.6411.00
152_H156_G0.6401.00
194_K242_D0.6381.00
22_P52_R0.6360.99
146_V161_S0.6330.99
163_R187_E0.6300.99
209_I235_V0.6290.99
24_V162_I0.6290.99
197_I248_K0.6270.99
258_I261_E0.6260.99
94_I113_L0.6250.99
24_V78_V0.6240.99
278_D289_K0.6230.99
277_A280_A0.6220.99
95_Y140_V0.6210.99
11_N36_G0.6170.99
212_T259_V0.6170.99
250_V256_V0.6160.99
90_A94_I0.6110.99
219_A319_V0.6100.99
266_C270_S0.6090.99
84_V133_L0.6090.99
183_V186_E0.6090.99
92_D96_N0.6070.99
120_G304_L0.6060.99
88_G133_L0.6060.99
78_V158_L0.6060.99
156_G160_S0.6040.99
161_S170_F0.5980.99
243_K278_D0.5980.99
79_V113_L0.5980.99
258_I272_V0.5960.99
259_V291_I0.5940.99
197_I249_S0.5920.99
45_I50_S0.5900.99
54_I66_A0.5890.99
70_A77_P0.5870.99
258_I288_I0.5850.99
294_P314_K0.5850.99
159_I189_T0.5850.99
271_W290_R0.5840.99
101_L109_L0.5830.99
282_E286_A0.5810.99
138_A145_V0.5800.99
33_V55_D0.5790.99
43_G55_D0.5780.99
145_V169_V0.5770.99
205_T256_V0.5770.99
260_D267_G0.5770.99
10_I158_L0.5770.99
59_S62_G0.5740.99
255_R279_E0.5740.99
156_G187_E0.5730.99
267_G270_S0.5720.99
296_V308_I0.5710.99
310_P314_K0.5700.99
108_Q165_D0.5690.99
15_R53_V0.5680.99
138_A268_F0.5680.99
144_K193_G0.5640.99
91_M139_H0.5630.99
187_E190_I0.5630.99
131_Q263_Y0.5630.99
213_V232_V0.5600.99
112_P158_L0.5590.99
164_D168_V0.5590.99
147_V210_A0.5590.99
188_Y196_E0.5580.99
64_I81_L0.5570.99
72_L101_L0.5570.99
76_R162_I0.5570.99
31_I83_F0.5560.99
18_M53_V0.5560.99
152_H188_Y0.5550.99
257_V260_D0.5520.99
208_G235_V0.5520.99
8_E43_G0.5510.99
193_G237_S0.5490.99
223_L230_V0.5460.98
184_P188_Y0.5440.98
115_L169_V0.5420.98
149_S153_D0.5410.98
121_A124_S0.5410.98
88_G136_I0.5410.98
179_I214_W0.5400.98
182_E185_E0.5400.98
281_F287_P0.5390.98
219_A312_S0.5370.98
205_T252_K0.5360.98
291_I310_P0.5350.98
237_S240_P0.5350.98
18_M48_F0.5330.98
211_R215_H0.5320.98
155_K159_I0.5310.98
238_I268_F0.5300.98
269_A290_R0.5270.98
152_H179_I0.5260.98
195_A242_D0.5240.98
21_D163_R0.5240.98
112_P170_F0.5240.98
173_H211_R0.5210.98
205_T255_R0.5140.98
42_K45_I0.5130.98
44_L48_F0.5110.98
298_I308_I0.5100.98
204_V255_R0.5090.98
178_G218_E0.5080.98
205_T254_G0.5080.98
223_L228_I0.5080.98
15_R18_M0.5060.97
301_S304_L0.5050.97
196_E236_R0.5030.97
147_V211_R0.5030.97
12_E15_R0.5020.97
85_D131_Q0.5010.97
270_S290_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w85B 2 0.9877 100 0.214 Contact Map
1umdB 2 0.9846 100 0.216 Contact Map
1ik6A 3 0.8549 100 0.225 Contact Map
1qs0B 2 0.9846 100 0.235 Contact Map
2ozlB 2 0.9907 100 0.248 Contact Map
2o1xA 2 0.9321 100 0.254 Contact Map
2bfdB 2 0.9877 100 0.26 Contact Map
2o1sA 2 0.9259 100 0.264 Contact Map
4kxvA 2 0.9352 100 0.266 Contact Map
1gpuA 2 0.9105 100 0.309 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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