GREMLIN Database
Q97Y21 - Acetoin catabolism protein X homolog (AcoX)
UniProt: Q97Y21 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 339 (321)
Sequences: 155 (120)
Seq/√Len: 6.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
211_I225_A7.0491.00
4_V42_L3.7740.94
13_G31_K3.5850.92
176_N299_D3.3490.88
173_L187_L2.9540.81
19_L310_P2.9060.80
20_V201_W2.8330.78
198_R262_V2.7720.76
13_G310_P2.7500.76
31_K309_G2.6930.74
31_K310_P2.6050.72
13_G19_L2.5660.70
12_S143_E2.5490.70
19_L309_G2.5140.69
13_G309_G2.4780.68
26_V30_A2.3840.64
8_V12_S2.3780.64
33_D169_K2.2930.61
171_I303_V2.2670.60
19_L31_K2.1940.58
14_R104_V2.1690.57
138_L305_I2.1260.55
270_L276_V2.1090.54
129_G312_L2.0620.53
159_K318_S2.0470.52
107_S117_V2.0390.52
152_G258_L1.9600.49
23_A196_G1.9550.49
50_E77_S1.9260.48
13_G25_F1.9000.47
42_L149_M1.8990.47
31_K147_L1.8940.46
13_G26_V1.8740.46
268_S274_Q1.8670.45
138_L312_L1.8500.45
61_S78_T1.8240.44
26_V31_K1.8040.43
25_F31_K1.7990.43
23_A283_Y1.7690.42
147_L309_G1.7600.41
94_S98_I1.7560.41
236_D272_L1.7010.39
90_T240_M1.6870.39
119_K181_N1.6860.39
28_N31_K1.6780.38
25_F28_N1.6680.38
118_Y310_P1.6500.37
13_G147_L1.6300.37
275_E304_R1.6250.37
147_L310_P1.6240.37
13_G28_N1.6150.36
258_L264_I1.6070.36
45_T152_G1.6010.36
183_A286_A1.6000.36
137_V213_K1.5900.35
167_R309_G1.5800.35
97_M102_V1.5760.35
81_M92_N1.5740.35
231_I269_I1.5580.34
107_S114_L1.5360.34
241_V319_L1.5130.33
97_M231_I1.5020.32
118_Y309_G1.4850.32
268_S311_L1.4800.32
230_P233_F1.4750.32
31_K129_G1.4740.32
35_I315_I1.4710.31
188_T209_A1.4690.31
206_L221_I1.4680.31
272_L307_R1.4680.31
19_L25_F1.4530.31
168_I312_L1.4460.31
186_D286_A1.3950.29
146_V319_L1.3950.29
192_G205_S1.3930.29
176_N264_I1.3860.29
77_S123_D1.3820.29
210_F305_I1.3700.28
129_G309_G1.3660.28
39_L42_L1.3500.28
167_R310_P1.3490.28
21_A71_D1.3440.27
54_M211_I1.3410.27
171_I305_I1.3240.27
181_N287_F1.3230.27
117_V231_I1.3230.27
129_G310_P1.3050.26
90_T130_L1.3010.26
24_T30_A1.2990.26
137_V233_F1.2960.26
76_L224_I1.2900.26
24_T221_I1.2870.26
31_K318_S1.2860.26
19_L118_Y1.2850.26
38_F130_L1.2780.26
11_E147_L1.2770.25
212_S285_I1.2720.25
6_I12_S1.2710.25
197_A266_G1.2680.25
247_K263_F1.2670.25
103_D313_V1.2550.25
173_L315_I1.2520.25
4_V117_V1.2470.25
81_M93_A1.2470.25
48_V254_L1.2430.25
106_V262_V1.2400.24
309_G318_S1.2380.24
245_L263_F1.2330.24
37_R186_D1.2310.24
104_V107_S1.2210.24
213_K233_F1.2180.24
11_E31_K1.2100.24
55_P81_M1.2080.24
200_I321_Y1.2070.24
156_K159_K1.2060.24
4_V149_M1.2010.23
143_E149_M1.2010.23
60_I255_A1.1940.23
127_I242_K1.1830.23
25_F310_P1.1810.23
28_N58_Y1.1790.23
310_P318_S1.1730.23
228_I264_I1.1720.23
225_A239_L1.1710.23
188_T243_F1.1680.23
38_F273_G1.1640.22
27_S181_N1.1630.22
34_T60_I1.1590.22
189_F210_F1.1560.22
53_F61_S1.1560.22
190_M284_V1.1560.22
20_V313_V1.1500.22
131_S143_E1.1460.22
144_P147_L1.1430.22
206_L223_S1.1420.22
13_G129_G1.1390.22
187_L285_I1.1330.22
26_V138_L1.1060.21
227_L319_L1.0990.21
50_E167_R1.0890.21
224_I263_F1.0840.20
114_L117_V1.0820.20
195_V198_R1.0790.20
180_K293_M1.0740.20
31_K128_L1.0720.20
37_R97_M1.0640.20
90_T117_V1.0630.20
81_M102_V1.0600.20
38_F144_P1.0520.20
16_I115_R1.0500.20
76_L317_K1.0500.20
33_D221_I1.0480.20
169_K295_V1.0360.19
55_P93_A1.0350.19
175_V308_D1.0320.19
154_L165_V1.0310.19
37_R286_A1.0270.19
144_P310_P1.0250.19
99_E171_I1.0240.19
121_A320_N1.0230.19
108_A132_L1.0210.19
132_L139_G1.0190.19
39_L76_L1.0170.19
144_P188_T1.0120.19
48_V155_L1.0060.19
123_D206_L1.0020.18
155_L284_V1.0010.18
19_L28_N0.9980.18
9_N17_R0.9940.18
10_P17_R0.9940.18
10_P15_D0.9940.18
9_N15_D0.9940.18
101_G142_Y0.9940.18
114_L129_G0.9870.18
66_S137_V0.9860.18
23_A64_I0.9860.18
271_K324_S0.9790.18
95_K313_V0.9780.18
29_Y64_I0.9750.18
19_L147_L0.9740.18
44_I264_I0.9730.18
41_G237_L0.9680.18
216_L253_T0.9590.18
211_I239_L0.9530.17
141_L197_A0.9530.17
105_I182_L0.9460.17
210_F284_V0.9450.17
98_I122_G0.9430.17
251_A268_S0.9420.17
39_L59_G0.9400.17
132_L155_L0.9380.17
149_M305_I0.9340.17
128_L309_G0.9340.17
21_A256_P0.9320.17
14_R53_F0.9320.17
209_A224_I0.9300.17
48_V325_Y0.9290.17
116_A223_S0.9260.17
261_E300_E0.9260.17
26_V129_G0.9230.17
50_E303_V0.9230.17
116_A239_L0.9160.17
42_L54_M0.9120.17
42_L268_S0.9080.16
24_T165_V0.9050.16
28_N309_G0.9010.16
144_P221_I0.9000.16
186_D201_W0.8980.16
14_R23_A0.8960.16
44_I76_L0.8940.16
47_S97_M0.8910.16
222_P283_Y0.8910.16
241_V295_V0.8890.16
202_D240_M0.8880.16
137_V140_A0.8850.16
252_A322_I0.8850.16
172_K180_K0.8760.16
197_A253_T0.8760.16
3_A50_E0.8730.16
116_A143_E0.8720.16
25_F309_G0.8700.16
54_M81_M0.8700.16
27_S54_M0.8690.16
117_V211_I0.8670.16
26_V310_P0.8660.16
13_G318_S0.8620.15
102_V238_G0.8620.15
7_I94_S0.8610.15
210_F240_M0.8610.15
127_I284_V0.8530.15
51_V261_E0.8520.15
21_A312_L0.8490.15
41_G210_F0.8470.15
30_A141_L0.8470.15
37_R201_W0.8410.15
13_G27_S0.8390.15
99_E195_V0.8380.15
138_L212_S0.8350.15
90_T283_Y0.8340.15
13_G128_L0.8340.15
26_V309_G0.8340.15
117_V160_A0.8340.15
144_P294_V0.8320.15
189_F238_G0.8280.15
235_D317_K0.8270.15
10_P18_R0.8240.15
9_N18_R0.8240.15
15_D18_R0.8240.15
19_L167_R0.8110.15
128_L310_P0.8040.14
60_I243_F0.8030.14
242_K260_K0.7990.14
50_E75_K0.7980.14
95_K302_M0.7950.14
56_D146_V0.7910.14
187_L308_D0.7900.14
188_T286_A0.7900.14
237_L307_R0.7880.14
54_M93_A0.7820.14
138_L143_E0.7800.14
31_K118_Y0.7800.14
14_R29_Y0.7780.14
56_D219_I0.7780.14
251_A274_Q0.7760.14
75_K250_V0.7760.14
32_I209_A0.7730.14
127_I310_P0.7690.14
128_L147_L0.7680.14
28_N310_P0.7680.14
192_G319_L0.7650.14
5_G118_Y0.7620.14
54_M117_V0.7620.14
178_E244_G0.7600.14
105_I149_M0.7590.14
200_I269_I0.7560.14
13_G167_R0.7550.14
86_T99_E0.7540.13
34_T171_I0.7500.13
60_I78_T0.7500.13
245_L258_L0.7450.13
12_S48_V0.7430.13
242_K317_K0.7420.13
25_F30_A0.7410.13
183_A186_D0.7400.13
31_K167_R0.7400.13
229_R269_I0.7390.13
39_L117_V0.7390.13
84_E315_I0.7320.13
81_M258_L0.7320.13
189_F308_D0.7270.13
29_Y208_Y0.7250.13
34_T130_L0.7240.13
106_V314_S0.7240.13
45_T125_V0.7220.13
153_F323_N0.7220.13
56_D211_I0.7200.13
159_K263_F0.7190.13
203_E232_T0.7150.13
226_S291_K0.7100.13
14_R206_L0.7080.13
47_S305_I0.7070.13
171_I272_L0.7050.13
181_N188_T0.7040.13
144_P227_L0.7030.13
144_P309_G0.7030.13
26_V144_P0.6990.13
3_A259_V0.6980.13
48_V143_E0.6950.12
3_A75_K0.6950.12
120_G295_V0.6950.12
108_A139_G0.6950.12
54_M115_R0.6930.12
56_D225_A0.6930.12
120_G206_L0.6920.12
177_N225_A0.6900.12
80_D105_I0.6900.12
53_F204_Y0.6850.12
3_A285_I0.6830.12
79_L122_G0.6820.12
108_A292_E0.6810.12
81_M229_R0.6800.12
129_G147_L0.6790.12
128_L151_L0.6750.12
214_G230_P0.6740.12
190_M206_L0.6720.12
118_Y144_P0.6700.12
13_G118_Y0.6690.12
19_L26_V0.6690.12
143_E185_V0.6690.12
189_F277_H0.6680.12
27_S213_K0.6670.12
238_G305_I0.6640.12
12_S116_A0.6640.12
27_S31_K0.6640.12
245_L266_G0.6620.12
176_N235_D0.6610.12
76_L219_I0.6610.12
259_V313_V0.6540.12
80_D297_S0.6540.12
61_S64_I0.6540.12
106_V248_I0.6540.12
130_L272_L0.6530.12
77_S275_E0.6510.12
41_G148_G0.6500.12
7_I80_D0.6480.12
11_E309_G0.6460.12
14_R63_D0.6450.12
90_T114_L0.6450.12
106_V261_E0.6430.12
30_A312_L0.6420.12
70_D159_K0.6410.12
88_D176_N0.6400.12
8_V322_I0.6400.12
8_V33_D0.6390.12
125_V313_V0.6370.12
115_R262_V0.6370.12
21_A201_W0.6360.12
114_L312_L0.6340.12
83_V324_S0.6340.12
201_W258_L0.6320.11
79_L93_A0.6320.11
20_V61_S0.6310.11
106_V151_L0.6300.11
64_I213_K0.6300.11
232_T235_D0.6280.11
32_I278_L0.6280.11
52_V207_R0.6270.11
12_S131_S0.6270.11
217_G223_S0.6250.11
127_I259_V0.6210.11
130_L185_V0.6210.11
20_V147_L0.6200.11
247_K303_V0.6200.11
94_S170_T0.6200.11
6_I143_E0.6150.11
28_N141_L0.6140.11
50_E278_L0.6140.11
251_A311_L0.6120.11
49_D60_I0.6100.11
19_L318_S0.6080.11
83_V225_A0.6080.11
204_Y307_R0.6060.11
19_L27_S0.6050.11
76_L202_D0.6050.11
52_V100_S0.6040.11
65_I104_V0.6030.11
5_G9_N0.6020.11
5_G17_R0.6020.11
5_G10_P0.6020.11
5_G15_D0.6020.11
53_F208_Y0.6010.11
211_I270_L0.5980.11
251_A319_L0.5960.11
37_R138_L0.5960.11
32_I187_L0.5940.11
215_E284_V0.5930.11
143_E186_D0.5920.11
37_R185_V0.5900.11
130_L254_L0.5880.11
101_G273_G0.5860.11
140_A250_V0.5840.11
29_Y137_V0.5840.11
230_P323_N0.5830.11
34_T254_L0.5820.11
14_R64_I0.5820.11
173_L197_A0.5810.11
154_L164_V0.5800.11
63_D67_D0.5780.11
122_G207_R0.5770.11
214_G267_I0.5750.11
300_E324_S0.5740.11
102_V117_V0.5730.11
44_I171_I0.5730.11
196_G203_E0.5710.11
116_A254_L0.5700.11
90_T303_V0.5700.11
14_R59_G0.5700.11
268_S273_G0.5690.11
52_V243_F0.5680.11
195_V278_L0.5680.11
45_T83_V0.5670.11
51_V59_G0.5650.11
65_I76_L0.5640.10
23_A119_K0.5640.10
127_I309_G0.5620.10
283_Y295_V0.5620.10
97_M195_V0.5610.10
7_I38_F0.5610.10
172_K304_R0.5580.10
181_N286_A0.5580.10
195_V287_F0.5580.10
25_F147_L0.5580.10
215_E221_I0.5570.10
51_V303_V0.5560.10
52_V102_V0.5540.10
239_L316_P0.5540.10
55_P211_I0.5510.10
64_I151_L0.5500.10
44_I223_S0.5500.10
27_S309_G0.5470.10
169_K286_A0.5470.10
44_I165_V0.5450.10
170_T266_G0.5450.10
34_T94_S0.5440.10
242_K279_P0.5440.10
128_L252_A0.5430.10
154_L212_S0.5370.10
43_N52_V0.5370.10
69_K261_E0.5370.10
80_D296_N0.5350.10
114_L168_I0.5340.10
234_Q304_R0.5330.10
167_R311_L0.5330.10
26_V312_L0.5320.10
208_Y225_A0.5300.10
245_L324_S0.5300.10
228_I239_L0.5290.10
8_V143_E0.5290.10
44_I250_V0.5260.10
149_M152_G0.5260.10
144_P151_L0.5250.10
152_G245_L0.5230.10
106_V316_P0.5230.10
64_I146_V0.5210.10
68_I159_K0.5210.10
268_S318_S0.5200.10
97_M210_F0.5180.10
11_E310_P0.5180.10
118_Y318_S0.5150.10
16_I20_V0.5140.10
48_V52_V0.5130.10
188_T195_V0.5120.10
188_T221_I0.5090.10
153_F236_D0.5090.10
80_D147_L0.5080.10
93_A188_T0.5080.10
125_V159_K0.5050.10
68_I105_I0.5050.10
19_L128_L0.5050.10
223_S284_V0.5030.10
120_G304_R0.5030.10
79_L254_L0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yt5A 4 0.6991 99.7 0.87 Contact Map
1z0sA 4 0.6873 99.7 0.87 Contact Map
2an1A 4 0.764 99.7 0.872 Contact Map
1u0tA 4 0.7463 99.6 0.881 Contact Map
2i2cA 3 0.708 99.6 0.887 Contact Map
3afoA 4 0.8112 99.5 0.89 Contact Map
2qv7A 2 0.7758 99.1 0.912 Contact Map
4werA 2 0.7404 99 0.916 Contact Map
3s40A 3 0.7581 98.9 0.919 Contact Map
3pfnA 4 0.7788 98.7 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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