GREMLIN Database
Q97Y20 - Dihydrolipoamide S-acetyltransferase, amino-end (PdhC)
UniProt: Q97Y20 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 211 (207)
Sequences: 8187 (6623)
Seq/√Len: 460.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_L77_G3.9921.00
26_E58_K3.3741.00
24_K34_E3.3031.00
62_K65_E3.2931.00
58_K75_Y3.1531.00
179_E182_R3.1141.00
126_K151_L2.8921.00
4_E72_I2.7791.00
23_K35_D2.7371.00
60_Y75_Y2.6751.00
4_E75_Y2.6401.00
129_D132_K2.5851.00
61_A71_Q2.5671.00
16_K66_E2.4961.00
31_Q53_S2.4781.00
29_R55_I2.4521.00
21_Q63_E2.4251.00
24_K56_L2.4071.00
176_I180_I2.3431.00
122_L148_I2.2851.00
25_K28_D2.2441.00
144_E148_I2.2001.00
183_R186_Q2.1481.00
21_Q38_I2.1251.00
56_L74_A2.1181.00
186_Q190_T2.0851.00
31_Q34_E2.0811.00
177_R180_I2.0761.00
68_P71_Q2.0761.00
121_R125_E2.0021.00
60_Y72_I1.9861.00
204_S207_K1.9681.00
179_E183_R1.9531.00
132_K150_E1.9341.00
19_I37_V1.9131.00
32_E53_S1.9121.00
123_A130_L1.9041.00
185_V189_Q1.9021.00
56_L59_I1.8991.00
188_L193_Q1.8761.00
61_A67_V1.8701.00
37_V73_I1.8561.00
122_L147_V1.8321.00
182_R186_Q1.7471.00
148_I152_E1.6081.00
115_A130_L1.5881.00
38_I47_T1.5681.00
23_K38_I1.5201.00
203_N207_K1.5181.00
145_D149_R1.4831.00
25_K59_I1.4661.00
35_D47_T1.4341.00
5_V74_A1.4211.00
122_L126_K1.4061.00
6_L72_I1.4051.00
55_I77_G1.3741.00
202_A205_L1.3711.00
180_I184_M1.3421.00
145_D148_I1.3401.00
20_V45_T1.3221.00
30_V50_S1.3221.00
118_R144_E1.3141.00
135_G142_I1.3051.00
55_I80_G1.2961.00
207_K210_M1.2871.00
188_L195_T1.2531.00
26_E62_K1.2491.00
52_V76_I1.2371.00
61_A65_E1.2271.00
16_K68_P1.2161.00
135_G141_M1.1901.00
26_E59_I1.1711.00
188_L191_M1.1641.00
126_K148_I1.1521.00
149_R153_N1.1271.00
128_I133_I1.1081.00
24_K28_D1.1081.00
30_V56_L1.1001.00
7_M17_G1.0991.00
36_L50_S1.0921.00
22_W59_I1.0801.00
123_A133_I1.0661.00
134_R150_E1.0651.00
188_L192_A1.0571.00
119_A144_E1.0551.00
185_V191_M1.0541.00
26_E57_L1.0491.00
36_L74_A1.0401.00
9_K12_L1.0291.00
14_M17_G1.0261.00
123_A142_I1.0251.00
137_G146_D1.0151.00
10_L17_G1.0101.00
33_G49_K1.0081.00
187_S193_Q0.9851.00
57_L75_Y0.9831.00
5_V76_I0.9821.00
185_V188_L0.9781.00
123_A147_V0.9681.00
151_L154_I0.9671.00
19_I61_A0.9601.00
123_A128_I0.9601.00
115_A123_A0.9581.00
18_K66_E0.9571.00
113_V142_I0.9521.00
178_Q182_R0.9491.00
15_T68_P0.9461.00
18_K64_G0.9461.00
175_V178_Q0.9411.00
29_R53_S0.9401.00
25_K63_E0.9391.00
39_I48_V0.9321.00
130_L142_I0.9281.00
6_L70_G0.9271.00
147_V150_E0.9271.00
115_A119_A0.9191.00
90_P93_A0.9061.00
7_M39_I0.9011.00
149_R152_E0.8991.00
152_E155_E0.8961.00
67_V71_Q0.8931.00
19_I73_I0.8891.00
20_V64_G0.8601.00
119_A147_V0.8581.00
136_T140_G0.8461.00
92_L95_Q0.8421.00
201_N204_S0.8401.00
135_G140_G0.8251.00
136_T146_D0.8241.00
159_K162_A0.8231.00
50_S53_S0.8211.00
10_L13_T0.8151.00
119_A123_A0.8131.00
155_E158_M0.8091.00
176_I179_E0.8021.00
94_T97_Q0.7951.00
122_L144_E0.7941.00
35_D49_K0.7911.00
185_V192_A0.7901.00
22_W61_A0.7771.00
4_E60_Y0.7751.00
150_E154_I0.7721.00
136_T143_T0.7711.00
37_V48_V0.7691.00
89_K92_L0.7661.00
35_D38_I0.7611.00
137_G140_G0.7601.00
5_V36_L0.7601.00
84_P87_P0.7481.00
113_V131_S0.7461.00
55_I79_I0.7441.00
164_G167_V0.7431.00
187_S191_M0.7421.00
10_L48_V0.7381.00
123_A129_D0.7371.00
154_I157_G0.7321.00
115_A142_I0.7301.00
30_V76_I0.7291.00
88_T92_L0.7281.00
32_E50_S0.7271.00
17_G44_I0.7221.00
163_T168_K0.7221.00
163_T166_R0.7201.00
23_K47_T0.7191.00
118_R122_L0.7181.00
38_I45_T0.7121.00
23_K26_E0.7111.00
158_M161_T0.7101.00
40_E175_V0.7061.00
79_I82_Q0.7041.00
41_T44_I0.7041.00
177_R181_S0.6991.00
50_S76_I0.6981.00
11_G14_M0.6971.00
133_I142_I0.6911.00
19_I59_I0.6871.00
11_G46_T0.6861.00
22_W37_V0.6821.00
87_P90_P0.6821.00
137_G143_T0.6811.00
133_I146_D0.6741.00
6_L69_V0.6721.00
14_M69_V0.6701.00
130_L133_I0.6671.00
20_V23_K0.6631.00
187_S190_T0.6631.00
59_I62_K0.6591.00
86_S90_P0.6531.00
17_G39_I0.6511.00
174_S180_I0.6501.00
89_K93_A0.6491.00
19_I51_P0.6441.00
57_L79_I0.6421.00
29_R79_I0.6411.00
85_P89_K0.6360.99
133_I150_E0.6360.99
11_G16_K0.6360.99
7_M46_T0.6320.99
7_M67_V0.6300.99
156_K159_K0.6290.99
93_A96_Q0.6270.99
90_P94_T0.6260.99
205_L209_K0.6250.99
116_S143_T0.6240.99
105_E108_K0.6220.99
93_A99_A0.6210.99
122_L128_I0.6190.99
138_P141_M0.6170.99
18_K41_T0.6170.99
154_I158_M0.6160.99
120_R123_A0.6160.99
40_E45_T0.6140.99
128_I147_V0.6140.99
17_G41_T0.6110.99
172_P175_V0.6100.99
174_S177_R0.6090.99
86_S89_K0.6090.99
78_E81_E0.6050.99
18_K45_T0.6040.99
10_L39_I0.6030.99
5_V30_V0.6020.99
29_R56_L0.6010.99
114_R141_M0.5970.99
60_Y74_A0.5940.99
165_L168_K0.5900.99
151_L155_E0.5880.99
102_I105_E0.5850.99
142_I147_V0.5840.99
157_G160_F0.5830.99
19_I67_V0.5820.99
107_V110_I0.5800.99
170_V173_M0.5790.99
126_K152_E0.5790.99
119_A142_I0.5790.99
171_I174_S0.5780.99
91_A94_T0.5780.99
185_V190_T0.5780.99
9_K13_T0.5760.99
128_I151_L0.5760.99
86_S96_Q0.5750.99
103_R108_K0.5740.99
12_L15_T0.5740.99
78_E82_Q0.5700.99
140_G146_D0.5680.99
32_E52_V0.5670.99
135_G146_D0.5660.99
33_G53_S0.5650.99
57_L78_E0.5630.99
99_A102_I0.5620.99
158_M162_A0.5620.99
12_L16_K0.5610.99
154_I159_K0.5610.99
117_P120_R0.5600.99
59_I65_E0.5570.99
77_G80_G0.5570.99
22_W73_I0.5560.99
18_K175_V0.5560.99
98_Q103_R0.5550.99
87_P91_A0.5550.99
9_K46_T0.5540.99
132_K154_I0.5510.99
97_Q104_T0.5490.99
18_K65_E0.5460.98
12_L51_P0.5450.98
18_K40_E0.5440.98
100_Q104_T0.5430.98
148_I151_L0.5410.98
128_I146_D0.5410.98
99_A103_R0.5400.98
98_Q101_P0.5380.98
26_E75_Y0.5370.98
36_L48_V0.5370.98
5_V51_P0.5360.98
72_I75_Y0.5320.98
97_Q101_P0.5310.98
147_V151_L0.5310.98
18_K44_I0.5300.98
14_M41_T0.5290.98
58_K72_I0.5280.98
7_M73_I0.5280.98
113_V130_L0.5280.98
10_L42_E0.5270.98
191_M194_V0.5270.98
10_L44_I0.5270.98
128_I150_E0.5260.98
83_P107_V0.5260.98
105_E109_V0.5240.98
91_A95_Q0.5230.98
22_W62_K0.5230.98
100_Q105_E0.5220.98
176_I181_S0.5210.98
10_L14_M0.5200.98
11_G69_V0.5200.98
133_I137_G0.5170.98
186_Q189_Q0.5150.98
83_P89_K0.5140.98
9_K37_V0.5130.98
116_S122_L0.5120.98
93_A97_Q0.5120.98
164_G168_K0.5120.98
157_G162_A0.5110.98
14_M49_K0.5090.98
173_M195_T0.5080.98
143_T147_V0.5080.98
118_R121_R0.5070.98
84_P88_T0.5050.97
96_Q104_T0.5030.97
116_S141_M0.5010.97
96_Q99_A0.5000.97
120_R130_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dvaI 1 0.1991 100 0.153 Contact Map
1zy8K 1 0.2085 100 0.39 Contact Map
1y8oB 1 0.4408 99.8 0.669 Contact Map
1pmrA 1 0.3791 99.7 0.691 Contact Map
3crkC 1 0.3886 99.7 0.697 Contact Map
2dneA 1 0.4834 99.7 0.71 Contact Map
1ghjA 1 0.3744 99.7 0.71 Contact Map
2dncA 1 0.436 99.7 0.711 Contact Map
3va7A 1 0.346 99.7 0.711 Contact Map
1qjoA 1 0.3791 99.6 0.721 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0082 seconds.