Q97Y20 - SULSO - GREMLIN Contacts

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Q97Y20 - Dihydrolipoamide S-acetyltransferase, amino-end (PdhC)

UniProt:	Q97Y20	Sequences: MGKEVLMPKLGLTMTKGKIVQWKKKEGDRVQEGEDLVIIETEKITTTVKSPVSGILLKIYAKEGEEVPVGQIIAYIGEIGEQPPPSPTKPALATQQQQAQPIRTEEVKVIGEVRASPRARRLAKEKGIDLSKIRGTGPGGMITEDDVIRELENIEKGMKFTATGLRVKEVIPMSVIRQEISRRMVQSLQTMAQVTLSIEINANSLVKMKMK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	211 (207)
Sequences:	8187 (6623)
Seq/√Len:	460.4

ECOLI - ODP2 ODO2
BACSU - ODP2 ACOC ODB2 ODO2
HALSA - Q9HN75
SULSO - Q97Y20

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
57_L	77_G	3.992	1.00
26_E	58_K	3.374	1.00
24_K	34_E	3.303	1.00
62_K	65_E	3.293	1.00
58_K	75_Y	3.153	1.00
179_E	182_R	3.114	1.00
126_K	151_L	2.892	1.00
4_E	72_I	2.779	1.00
23_K	35_D	2.737	1.00
60_Y	75_Y	2.675	1.00
4_E	75_Y	2.640	1.00
129_D	132_K	2.585	1.00
61_A	71_Q	2.567	1.00
16_K	66_E	2.496	1.00
31_Q	53_S	2.478	1.00
29_R	55_I	2.452	1.00
21_Q	63_E	2.425	1.00
24_K	56_L	2.407	1.00
176_I	180_I	2.343	1.00
122_L	148_I	2.285	1.00
25_K	28_D	2.244	1.00
144_E	148_I	2.200	1.00
183_R	186_Q	2.148	1.00
21_Q	38_I	2.125	1.00
56_L	74_A	2.118	1.00
186_Q	190_T	2.085	1.00
31_Q	34_E	2.081	1.00
177_R	180_I	2.076	1.00
68_P	71_Q	2.076	1.00
121_R	125_E	2.002	1.00
60_Y	72_I	1.986	1.00
204_S	207_K	1.968	1.00
179_E	183_R	1.953	1.00
132_K	150_E	1.934	1.00
19_I	37_V	1.913	1.00
32_E	53_S	1.912	1.00
123_A	130_L	1.904	1.00
185_V	189_Q	1.902	1.00
56_L	59_I	1.899	1.00
188_L	193_Q	1.876	1.00
61_A	67_V	1.870	1.00
37_V	73_I	1.856	1.00
122_L	147_V	1.832	1.00
182_R	186_Q	1.747	1.00
148_I	152_E	1.608	1.00
115_A	130_L	1.588	1.00
38_I	47_T	1.568	1.00
23_K	38_I	1.520	1.00
203_N	207_K	1.518	1.00
145_D	149_R	1.483	1.00
25_K	59_I	1.466	1.00
35_D	47_T	1.434	1.00
5_V	74_A	1.421	1.00
122_L	126_K	1.406	1.00
6_L	72_I	1.405	1.00
55_I	77_G	1.374	1.00
202_A	205_L	1.371	1.00
180_I	184_M	1.342	1.00
145_D	148_I	1.340	1.00
20_V	45_T	1.322	1.00
30_V	50_S	1.322	1.00
118_R	144_E	1.314	1.00
135_G	142_I	1.305	1.00
55_I	80_G	1.296	1.00
207_K	210_M	1.287	1.00
188_L	195_T	1.253	1.00
26_E	62_K	1.249	1.00
52_V	76_I	1.237	1.00
61_A	65_E	1.227	1.00
16_K	68_P	1.216	1.00
135_G	141_M	1.190	1.00
26_E	59_I	1.171	1.00
188_L	191_M	1.164	1.00
126_K	148_I	1.152	1.00
149_R	153_N	1.127	1.00
128_I	133_I	1.108	1.00
24_K	28_D	1.108	1.00
30_V	56_L	1.100	1.00
7_M	17_G	1.099	1.00
36_L	50_S	1.092	1.00
22_W	59_I	1.080	1.00
123_A	133_I	1.066	1.00
134_R	150_E	1.065	1.00
188_L	192_A	1.057	1.00
119_A	144_E	1.055	1.00
185_V	191_M	1.054	1.00
26_E	57_L	1.049	1.00
36_L	74_A	1.040	1.00
9_K	12_L	1.029	1.00
14_M	17_G	1.026	1.00
123_A	142_I	1.025	1.00
137_G	146_D	1.015	1.00
10_L	17_G	1.010	1.00
33_G	49_K	1.008	1.00
187_S	193_Q	0.985	1.00
57_L	75_Y	0.983	1.00
5_V	76_I	0.982	1.00
185_V	188_L	0.978	1.00
123_A	147_V	0.968	1.00
151_L	154_I	0.967	1.00
19_I	61_A	0.960	1.00
123_A	128_I	0.960	1.00
115_A	123_A	0.958	1.00
18_K	66_E	0.957	1.00
113_V	142_I	0.952	1.00
178_Q	182_R	0.949	1.00
15_T	68_P	0.946	1.00
18_K	64_G	0.946	1.00
175_V	178_Q	0.941	1.00
29_R	53_S	0.940	1.00
25_K	63_E	0.939	1.00
39_I	48_V	0.932	1.00
130_L	142_I	0.928	1.00
6_L	70_G	0.927	1.00
147_V	150_E	0.927	1.00
115_A	119_A	0.919	1.00
90_P	93_A	0.906	1.00
7_M	39_I	0.901	1.00
149_R	152_E	0.899	1.00
152_E	155_E	0.896	1.00
67_V	71_Q	0.893	1.00
19_I	73_I	0.889	1.00
20_V	64_G	0.860	1.00
119_A	147_V	0.858	1.00
136_T	140_G	0.846	1.00
92_L	95_Q	0.842	1.00
201_N	204_S	0.840	1.00
135_G	140_G	0.825	1.00
136_T	146_D	0.824	1.00
159_K	162_A	0.823	1.00
50_S	53_S	0.821	1.00
10_L	13_T	0.815	1.00
119_A	123_A	0.813	1.00
155_E	158_M	0.809	1.00
176_I	179_E	0.802	1.00
94_T	97_Q	0.795	1.00
122_L	144_E	0.794	1.00
35_D	49_K	0.791	1.00
185_V	192_A	0.790	1.00
22_W	61_A	0.777	1.00
4_E	60_Y	0.775	1.00
150_E	154_I	0.772	1.00
136_T	143_T	0.771	1.00
37_V	48_V	0.769	1.00
89_K	92_L	0.766	1.00
35_D	38_I	0.761	1.00
137_G	140_G	0.760	1.00
5_V	36_L	0.760	1.00
84_P	87_P	0.748	1.00
113_V	131_S	0.746	1.00
55_I	79_I	0.744	1.00
164_G	167_V	0.743	1.00
187_S	191_M	0.742	1.00
10_L	48_V	0.738	1.00
123_A	129_D	0.737	1.00
154_I	157_G	0.732	1.00
115_A	142_I	0.730	1.00
30_V	76_I	0.729	1.00
88_T	92_L	0.728	1.00
32_E	50_S	0.727	1.00
17_G	44_I	0.722	1.00
163_T	168_K	0.722	1.00
163_T	166_R	0.720	1.00
23_K	47_T	0.719	1.00
118_R	122_L	0.718	1.00
38_I	45_T	0.712	1.00
23_K	26_E	0.711	1.00
158_M	161_T	0.710	1.00
40_E	175_V	0.706	1.00
79_I	82_Q	0.704	1.00
41_T	44_I	0.704	1.00
177_R	181_S	0.699	1.00
50_S	76_I	0.698	1.00
11_G	14_M	0.697	1.00
133_I	142_I	0.691	1.00
19_I	59_I	0.687	1.00
11_G	46_T	0.686	1.00
22_W	37_V	0.682	1.00
87_P	90_P	0.682	1.00
137_G	143_T	0.681	1.00
133_I	146_D	0.674	1.00
6_L	69_V	0.672	1.00
14_M	69_V	0.670	1.00
130_L	133_I	0.667	1.00
20_V	23_K	0.663	1.00
187_S	190_T	0.663	1.00
59_I	62_K	0.659	1.00
86_S	90_P	0.653	1.00
17_G	39_I	0.651	1.00
174_S	180_I	0.650	1.00
89_K	93_A	0.649	1.00
19_I	51_P	0.644	1.00
57_L	79_I	0.642	1.00
29_R	79_I	0.641	1.00
85_P	89_K	0.636	0.99
133_I	150_E	0.636	0.99
11_G	16_K	0.636	0.99
7_M	46_T	0.632	0.99
7_M	67_V	0.630	0.99
156_K	159_K	0.629	0.99
93_A	96_Q	0.627	0.99
90_P	94_T	0.626	0.99
205_L	209_K	0.625	0.99
116_S	143_T	0.624	0.99
105_E	108_K	0.622	0.99
93_A	99_A	0.621	0.99
122_L	128_I	0.619	0.99
138_P	141_M	0.617	0.99
18_K	41_T	0.617	0.99
154_I	158_M	0.616	0.99
120_R	123_A	0.616	0.99
40_E	45_T	0.614	0.99
128_I	147_V	0.614	0.99
17_G	41_T	0.611	0.99
172_P	175_V	0.610	0.99
174_S	177_R	0.609	0.99
86_S	89_K	0.609	0.99
78_E	81_E	0.605	0.99
18_K	45_T	0.604	0.99
10_L	39_I	0.603	0.99
5_V	30_V	0.602	0.99
29_R	56_L	0.601	0.99
114_R	141_M	0.597	0.99
60_Y	74_A	0.594	0.99
165_L	168_K	0.590	0.99
151_L	155_E	0.588	0.99
102_I	105_E	0.585	0.99
142_I	147_V	0.584	0.99
157_G	160_F	0.583	0.99
19_I	67_V	0.582	0.99
107_V	110_I	0.580	0.99
170_V	173_M	0.579	0.99
126_K	152_E	0.579	0.99
119_A	142_I	0.579	0.99
171_I	174_S	0.578	0.99
91_A	94_T	0.578	0.99
185_V	190_T	0.578	0.99
9_K	13_T	0.576	0.99
128_I	151_L	0.576	0.99
86_S	96_Q	0.575	0.99
103_R	108_K	0.574	0.99
12_L	15_T	0.574	0.99
78_E	82_Q	0.570	0.99
140_G	146_D	0.568	0.99
32_E	52_V	0.567	0.99
135_G	146_D	0.566	0.99
33_G	53_S	0.565	0.99
57_L	78_E	0.563	0.99
99_A	102_I	0.562	0.99
158_M	162_A	0.562	0.99
12_L	16_K	0.561	0.99
154_I	159_K	0.561	0.99
117_P	120_R	0.560	0.99
59_I	65_E	0.557	0.99
77_G	80_G	0.557	0.99
22_W	73_I	0.556	0.99
18_K	175_V	0.556	0.99
98_Q	103_R	0.555	0.99
87_P	91_A	0.555	0.99
9_K	46_T	0.554	0.99
132_K	154_I	0.551	0.99
97_Q	104_T	0.549	0.99
18_K	65_E	0.546	0.98
12_L	51_P	0.545	0.98
18_K	40_E	0.544	0.98
100_Q	104_T	0.543	0.98
148_I	151_L	0.541	0.98
128_I	146_D	0.541	0.98
99_A	103_R	0.540	0.98
98_Q	101_P	0.538	0.98
26_E	75_Y	0.537	0.98
36_L	48_V	0.537	0.98
5_V	51_P	0.536	0.98
72_I	75_Y	0.532	0.98
97_Q	101_P	0.531	0.98
147_V	151_L	0.531	0.98
18_K	44_I	0.530	0.98
14_M	41_T	0.529	0.98
58_K	72_I	0.528	0.98
7_M	73_I	0.528	0.98
113_V	130_L	0.528	0.98
10_L	42_E	0.527	0.98
191_M	194_V	0.527	0.98
10_L	44_I	0.527	0.98
128_I	150_E	0.526	0.98
83_P	107_V	0.526	0.98
105_E	109_V	0.524	0.98
91_A	95_Q	0.523	0.98
22_W	62_K	0.523	0.98
100_Q	105_E	0.522	0.98
176_I	181_S	0.521	0.98
10_L	14_M	0.520	0.98
11_G	69_V	0.520	0.98
133_I	137_G	0.517	0.98
186_Q	189_Q	0.515	0.98
83_P	89_K	0.514	0.98
9_K	37_V	0.513	0.98
116_S	122_L	0.512	0.98
93_A	97_Q	0.512	0.98
164_G	168_K	0.512	0.98
157_G	162_A	0.511	0.98
14_M	49_K	0.509	0.98
173_M	195_T	0.508	0.98
143_T	147_V	0.508	0.98
118_R	121_R	0.507	0.98
84_P	88_T	0.505	0.97
96_Q	104_T	0.503	0.97
116_S	141_M	0.501	0.97
96_Q	99_A	0.500	0.97
120_R	130_L	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3dvaI	1	0.1991	100	0.153	Contact Map
1zy8K	1	0.2085	100	0.39	Contact Map
1y8oB	1	0.4408	99.8	0.669	Contact Map
1pmrA	1	0.3791	99.7	0.691	Contact Map
3crkC	1	0.3886	99.7	0.697	Contact Map
2dneA	1	0.4834	99.7	0.71	Contact Map
1ghjA	1	0.3744	99.7	0.71	Contact Map
2dncA	1	0.436	99.7	0.711	Contact Map
3va7A	1	0.346	99.7	0.711	Contact Map
1qjoA	1	0.3791	99.6	0.721	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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