GREMLIN Database
Q97Y19 - Dihydrolipoamide S-acetyltransferase, carboxy-end (PdhC)
UniProt: Q97Y19 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 177 (171)
Sequences: 6159 (3101)
Seq/√Len: 237.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_D161_E3.3161.00
61_K69_E3.2451.00
72_E76_K3.0991.00
128_V135_I2.8211.00
26_T35_I2.7221.00
75_D79_E2.6841.00
20_H161_E2.6291.00
124_R131_D2.6011.00
76_K86_E2.4871.00
124_R137_Y2.4331.00
69_E72_E2.3381.00
13_V92_F2.2991.00
10_V40_I2.2591.00
37_E57_N2.2391.00
128_V133_I2.2021.00
90_G113_Q2.0441.00
11_K15_K1.9621.00
126_P133_I1.9211.00
18_R59_D1.8881.00
41_G52_V1.8861.00
22_Y34_I1.8771.00
14_A38_V1.8441.00
129_V134_S1.8201.00
17_L92_F1.7421.00
9_L119_V1.7261.00
61_K65_E1.6521.00
92_F115_A1.6411.00
161_E164_E1.6301.00
28_E31_Q1.6291.00
15_K165_I1.6101.00
122_I137_Y1.5971.00
25_A34_I1.5951.00
107_P118_G1.5741.00
14_A58_A1.5521.00
48_Q80_N1.5441.00
37_E59_D1.5111.00
129_V132_N1.5091.00
62_P65_E1.4901.00
10_V42_I1.4871.00
22_Y154_T1.4811.00
42_I70_S1.4731.00
10_V94_I1.4651.00
163_T167_E1.4581.00
39_N56_R1.4451.00
13_V162_L1.4411.00
57_N60_T1.4381.00
28_E33_K1.4201.00
124_R135_I1.4161.00
10_V58_A1.4131.00
16_L162_L1.4121.00
70_S74_A1.4101.00
25_A149_V1.3761.00
77_A82_L1.3691.00
141_L162_L1.3601.00
114_T149_V1.3491.00
126_P135_I1.3481.00
20_H157_K1.2901.00
55_I69_E1.2741.00
153_H157_K1.2731.00
10_V70_S1.2711.00
129_V136_G1.2701.00
13_V158_F1.2691.00
23_L150_M1.2581.00
45_A153_H1.2511.00
97_L105_F1.2431.00
92_F117_L1.2261.00
145_F155_A1.2251.00
147_H152_G1.1991.00
161_E165_I1.1881.00
127_V138_I1.1881.00
160_K164_E1.1551.00
110_N113_Q1.1481.00
38_V59_D1.1411.00
127_V136_G1.1331.00
19_D165_I1.1251.00
45_A157_K1.1191.00
41_G113_Q1.1041.00
93_T113_Q1.1021.00
39_N57_N1.0911.00
23_L115_A1.0801.00
103_D123_R1.0771.00
74_A78_R1.0631.00
103_D140_W1.0441.00
24_N91_T1.0291.00
32_I149_V1.0281.00
117_L162_L1.0251.00
125_A138_I1.0211.00
45_A100_Y1.0211.00
5_Y122_I1.0061.00
64_T68_K0.9921.00
124_R128_V0.9911.00
103_D121_R0.9901.00
119_V139_M0.9671.00
41_G90_G0.9661.00
20_H154_T0.9641.00
39_N54_V0.9541.00
92_F158_F0.9481.00
55_I70_S0.9371.00
10_V55_I0.9361.00
143_L159_L0.9351.00
76_K82_L0.9261.00
54_V90_G0.9161.00
15_K18_R0.9091.00
56_R85_D0.9031.00
72_E75_D0.8971.00
84_P88_S0.8941.00
10_V66_I0.8910.99
82_L87_V0.8880.99
7_D70_S0.8860.99
85_D88_S0.8820.99
51_I87_V0.8780.99
76_K81_K0.8660.99
23_L158_F0.8600.99
57_N61_K0.8550.99
18_R38_V0.8530.99
76_K83_N0.8450.99
9_L166_L0.8370.99
104_S140_W0.8370.99
65_E68_K0.8230.99
7_D66_I0.8210.99
97_L118_G0.8210.99
12_V166_L0.8000.99
3_I7_D0.8000.99
13_V115_A0.7980.99
15_K19_D0.7970.99
117_L143_L0.7910.99
154_T157_K0.7910.99
164_E171_K0.7890.99
26_T33_K0.7820.99
83_N86_E0.7720.99
65_E69_E0.7710.99
168_D171_K0.7650.98
143_L155_A0.7580.98
17_L158_F0.7520.98
43_A50_L0.7460.98
16_L165_I0.7400.98
54_V89_G0.7390.98
72_E86_E0.7350.98
6_T42_I0.7350.98
124_R130_G0.7280.98
35_I91_T0.7250.98
162_L166_L0.7210.98
16_L161_E0.7200.98
17_L38_V0.7170.98
42_I94_I0.7130.98
44_V78_R0.7120.98
22_Y25_A0.7050.97
102_I156_A0.7030.97
6_T99_M0.7020.97
92_F143_L0.7020.97
119_V141_L0.7010.97
51_I82_L0.7010.97
46_L51_I0.6980.97
104_S142_S0.6980.97
125_A140_W0.6980.97
3_I8_I0.6970.97
9_L139_M0.6940.97
56_R86_E0.6930.97
61_K72_E0.6910.97
27_L149_V0.6870.97
158_F162_L0.6810.97
6_T70_S0.6790.97
40_I92_F0.6770.97
169_E172_L0.6760.97
145_F150_M0.6720.96
160_K163_T0.6680.96
9_L94_I0.6640.96
117_L141_L0.6630.96
23_L154_T0.6590.96
109_I112_P0.6590.96
37_E60_T0.6530.96
7_D67_A0.6500.96
120_G156_A0.6500.96
13_V117_L0.6470.96
46_L77_A0.6470.96
109_I144_T0.6460.96
23_L114_T0.6370.95
17_L23_L0.6360.95
141_L159_L0.6350.95
97_L102_I0.6320.95
165_I171_K0.6320.95
106_T145_F0.6300.95
157_K160_K0.6290.95
15_K172_L0.6280.95
54_V113_Q0.6270.95
120_G142_S0.6270.95
104_S107_P0.6270.95
7_D63_I0.6240.95
50_L116_I0.6210.95
128_V136_G0.6210.95
69_E76_K0.6180.94
115_A143_L0.6140.94
4_T67_A0.6130.94
39_N113_Q0.6110.94
39_N90_G0.6110.94
14_A40_I0.6080.94
14_A18_R0.6070.94
39_N52_V0.6060.94
105_F120_G0.6060.94
49_G151_D0.6050.94
11_K66_I0.6040.94
6_T94_I0.6030.94
129_V133_I0.6030.94
6_T9_L0.6020.94
53_P90_G0.6000.94
48_Q51_I0.6000.94
58_A66_I0.6000.94
25_A114_T0.5990.93
84_P87_V0.5960.93
44_V73_L0.5960.93
131_D135_I0.5940.93
126_P136_G0.5910.93
102_I105_F0.5910.93
26_T114_T0.5830.93
25_A32_I0.5830.93
55_I61_K0.5780.92
151_D154_T0.5770.92
26_T37_E0.5760.92
13_V16_L0.5740.92
124_R129_V0.5730.92
90_G110_N0.5690.92
97_L120_G0.5670.91
56_R69_E0.5660.91
39_N89_G0.5630.91
128_V131_D0.5600.91
114_T150_M0.5580.91
11_K63_I0.5570.91
141_L166_L0.5570.91
63_I67_A0.5480.90
90_G111_P0.5470.90
22_Y32_I0.5460.90
108_I144_T0.5420.90
128_V132_N0.5360.89
43_A152_G0.5310.89
105_F118_G0.5290.88
38_V58_A0.5280.88
103_D125_A0.5250.88
97_L156_A0.5230.88
125_A136_G0.5190.88
8_I12_V0.5190.88
11_K169_E0.5190.88
20_H23_L0.5190.88
38_V91_T0.5160.87
107_P116_I0.5150.87
68_K72_E0.5150.87
131_D137_Y0.5140.87
107_P144_T0.5130.87
60_T65_E0.5120.87
6_T96_N0.5100.87
100_Y156_A0.5050.86
44_V47_D0.5020.86
120_G139_M0.5010.86
71_H74_A0.5010.86
110_N116_I0.5010.86
101_D121_R0.5000.86
24_N38_V0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dvaI 1 0 100 0.083 Contact Map
1sczA 4 0.9944 100 0.096 Contact Map
2ii3A 4 1 100 0.106 Contact Map
4n72A 3 0.9831 100 0.109 Contact Map
1dpbA 4 0.9831 100 0.112 Contact Map
3maeA 3 1 100 0.116 Contact Map
3l60A 3 0.9944 100 0.124 Contact Map
3b8kA 1 0.9831 100 0.125 Contact Map
2xt6A 2 0.8927 100 0.148 Contact Map
3rqcA 4 0.9379 100 0.15 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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