GREMLIN Database
Q97Y18 - Alkyldihydroxyacetonephosphate synthase (Precursor)
UniProt: Q97Y18 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 451 (404)
Sequences: 18756 (14096)
Seq/√Len: 701.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_E207_K4.0241.00
53_T168_E3.8661.00
64_N441_N3.7191.00
147_I208_A3.3971.00
98_R112_E3.3451.00
165_L211_R3.2381.00
103_N106_D3.0111.00
67_Y441_N3.0091.00
168_E178_K2.9851.00
110_T209_K2.9261.00
110_T207_K2.9041.00
97_N119_D2.8721.00
228_N231_N2.8591.00
123_W126_K2.8401.00
48_L59_I2.7651.00
129_Y212_I2.6801.00
340_A343_K2.6261.00
169_V195_F2.5971.00
56_V206_T2.5261.00
166_W178_K2.4371.00
57_S176_A2.4001.00
171_L175_K2.3641.00
112_E207_K2.3611.00
51_S95_K2.3541.00
115_I120_L2.3331.00
166_W209_K2.3211.00
60_V70_I2.2461.00
104_E127_R2.2321.00
118_K122_E2.1341.00
62_L66_Y2.0941.00
172_P444_M2.0821.00
99_I115_I2.0661.00
347_K401_Q2.0501.00
125_N215_L2.0491.00
171_L177_V2.0021.00
116_K119_D2.0011.00
398_V401_Q1.9751.00
168_E176_A1.9451.00
53_T176_A1.9441.00
49_S95_K1.9441.00
54_E57_S1.9381.00
109_V120_L1.9331.00
230_H346_D1.9241.00
101_E110_T1.8961.00
53_T57_S1.8941.00
166_W180_G1.8911.00
169_V203_G1.8901.00
124_L212_I1.8761.00
56_V204_V1.8681.00
397_R401_Q1.8451.00
54_E58_N1.8231.00
53_T206_T1.8101.00
57_S61_K1.8071.00
108_S165_L1.8051.00
107_L129_Y1.8011.00
111_V143_I1.8001.00
108_S209_K1.7981.00
167_L195_F1.7961.00
96_L112_E1.7521.00
51_S55_E1.7431.00
93_L204_V1.7231.00
72_P204_V1.7181.00
91_L204_V1.7051.00
73_Y76_G1.7011.00
60_V444_M1.6961.00
52_T55_E1.6761.00
58_N61_K1.6641.00
433_L437_M1.6601.00
386_E390_R1.6541.00
286_I289_Q1.6511.00
107_L214_P1.6321.00
102_F123_W1.6281.00
194_L434_I1.6271.00
350_E354_S1.6181.00
436_R442_N1.6101.00
119_D122_E1.6021.00
148_A198_S1.5981.00
168_E206_T1.5891.00
123_W127_R1.5751.00
429_D432_L1.5671.00
63_A89_V1.5651.00
390_R394_T1.5471.00
147_I164_I1.5371.00
407_S410_H1.5311.00
347_K350_E1.5291.00
109_V210_L1.5291.00
429_D433_L1.5251.00
231_N234_K1.5011.00
148_A205_I1.4971.00
99_I123_W1.4891.00
93_L96_L1.4841.00
180_G187_M1.4761.00
56_V170_I1.4741.00
285_K289_Q1.4621.00
48_L89_V1.4581.00
288_R292_M1.4561.00
61_K64_N1.4531.00
170_I206_T1.4491.00
349_K353_N1.4461.00
397_R422_E1.4451.00
195_F203_G1.4291.00
29_P33_L1.4251.00
103_N108_S1.4241.00
147_I210_L1.4121.00
146_A160_I1.4111.00
421_K426_E1.4061.00
230_H234_K1.4021.00
60_V64_N1.3991.00
112_E115_I1.3951.00
111_V210_L1.3891.00
163_L213_F1.3871.00
62_L68_V1.3851.00
427_Q430_L1.3621.00
432_L436_R1.3521.00
354_S394_T1.3441.00
347_K398_V1.3401.00
56_V91_L1.3391.00
238_E242_R1.3371.00
60_V204_V1.3261.00
176_A206_T1.3101.00
172_P438_I1.3091.00
435_K442_N1.3051.00
179_V188_S1.3031.00
430_L433_L1.2921.00
234_K238_E1.2911.00
164_I167_L1.2891.00
250_V253_D1.2871.00
312_A315_Y1.2781.00
30_L33_L1.2681.00
347_K402_L1.2651.00
179_V192_V1.2591.00
285_K288_R1.2451.00
61_K65_K1.2451.00
355_M394_T1.2411.00
406_I409_H1.2401.00
343_K347_K1.2381.00
428_Y432_L1.2221.00
158_S162_N1.2151.00
393_E397_R1.2141.00
97_N112_E1.2121.00
311_F315_Y1.2101.00
49_S92_D1.2091.00
132_D163_L1.2061.00
350_E353_N1.2041.00
111_V120_L1.2031.00
346_D350_E1.2011.00
98_R115_I1.1971.00
313_R317_E1.1971.00
122_E126_K1.1931.00
60_V170_I1.1931.00
50_P55_E1.1901.00
384_D387_L1.1871.00
177_V188_S1.1841.00
50_P59_I1.1841.00
141_A146_A1.1821.00
59_I89_V1.1781.00
33_L36_H1.1771.00
63_A70_I1.1751.00
351_S354_S1.1731.00
170_I176_A1.1651.00
69_C88_C1.1641.00
57_S170_I1.1641.00
433_L436_R1.1581.00
109_V212_I1.1561.00
387_L390_R1.1501.00
304_I307_W1.1471.00
408_H411_G1.1471.00
292_M295_N1.1431.00
55_E58_N1.1421.00
284_E288_R1.1391.00
351_S394_T1.1231.00
64_N443_I1.1191.00
407_S412_V1.1161.00
398_V402_L1.1051.00
102_F129_Y1.0881.00
410_H413_G1.0821.00
366_T369_Y1.0771.00
254_K258_E1.0771.00
389_K393_E1.0751.00
373_A376_Y1.0721.00
383_Q386_E1.0721.00
102_F109_V1.0681.00
70_I91_L1.0661.00
109_V124_L1.0651.00
222_L226_F1.0631.00
320_T323_I1.0561.00
164_I196_I1.0511.00
74_G142_T1.0511.00
372_G376_Y1.0421.00
193_R430_L1.0381.00
171_L438_I1.0321.00
73_Y90_I1.0261.00
376_Y380_V1.0261.00
59_I91_L1.0251.00
147_I160_I1.0241.00
195_F205_I1.0181.00
337_T340_A1.0151.00
46_L89_V1.0111.00
119_D123_W1.0091.00
319_M323_I1.0081.00
49_S94_S1.0061.00
121_E133_Y1.0031.00
238_E293_R1.0021.00
373_A381_M1.0011.00
271_R274_G0.9971.00
279_L282_V0.9951.00
305_R309_E0.9881.00
169_V177_V0.9781.00
364_R367_H0.9771.00
167_L192_V0.9761.00
312_A316_E0.9761.00
390_R393_E0.9751.00
253_D256_S0.9751.00
67_Y443_I0.9691.00
144_G208_A0.9661.00
282_V285_K0.9621.00
45_L87_N0.9521.00
190_D193_R0.9431.00
248_R253_D0.9371.00
248_R252_H0.9361.00
129_Y214_P0.9331.00
235_F238_E0.9321.00
93_L113_V0.9301.00
365_V368_V0.9271.00
61_K175_K0.9251.00
289_Q292_M0.9241.00
394_T397_R0.9221.00
252_H255_E0.9221.00
373_A377_N0.9181.00
351_S398_V0.9171.00
32_I35_E0.9161.00
310_V315_Y0.9151.00
376_Y381_M0.9111.00
180_G186_S0.9101.00
305_R308_R0.9081.00
385_L389_K0.9081.00
53_T170_I0.9061.00
247_H250_V0.9061.00
306_S310_V0.9041.00
291_A296_A0.9031.00
58_N62_L0.9001.00
238_E241_L0.8991.00
363_S366_T0.8911.00
255_E258_E0.8911.00
420_V424_L0.8891.00
409_H412_V0.8881.00
406_I410_H0.8851.00
178_K209_K0.8831.00
167_L208_A0.8811.00
53_T112_E0.8781.00
426_E429_D0.8761.00
250_V254_K0.8751.00
181_S186_S0.8741.00
331_T334_L0.8721.00
118_K140_L0.8711.00
118_K139_Y0.8701.00
281_N285_K0.8671.00
143_I210_L0.8641.00
70_I443_I0.8611.00
237_R241_L0.8601.00
374_S377_N0.8591.00
194_L202_L0.8581.00
186_S189_P0.8581.00
289_Q293_R0.8581.00
311_F314_K0.8571.00
309_E313_R0.8561.00
344_L402_L0.8561.00
364_R368_V0.8561.00
74_G93_L0.8541.00
319_M322_I0.8501.00
165_L209_K0.8491.00
56_V96_L0.8481.00
409_H413_G0.8461.00
73_Y92_D0.8451.00
30_L43_K0.8411.00
403_G406_I0.8391.00
332_L335_G0.8391.00
227_P231_N0.8391.00
335_G405_T0.8381.00
236_T240_V0.8351.00
56_V93_L0.8341.00
234_K237_R0.8311.00
246_P249_I0.8301.00
179_V195_F0.8281.00
281_N284_E0.8261.00
246_P253_D0.8241.00
78_S82_G0.8231.00
68_V89_V0.8221.00
343_K346_D0.8221.00
245_P248_R0.8211.00
246_P255_E0.8181.00
132_D213_F0.8161.00
163_L211_R0.8151.00
307_W312_A0.8141.00
364_R369_Y0.8131.00
29_P32_I0.8131.00
74_G113_V0.8121.00
250_V255_E0.8121.00
352_L355_M0.8101.00
418_N421_K0.8081.00
108_S211_R0.8071.00
351_S355_M0.8061.00
397_R400_M0.8051.00
75_G142_T0.8051.00
97_N115_I0.8041.00
248_R251_V0.8021.00
383_Q387_L0.8011.00
343_K402_L0.8011.00
248_R255_E0.7981.00
115_I119_D0.7981.00
113_V208_A0.7971.00
189_P201_T0.7931.00
69_C445_N0.7931.00
178_K207_K0.7921.00
247_H251_V0.7871.00
222_L225_L0.7871.00
347_K351_S0.7861.00
325_Q328_W0.7831.00
50_P93_L0.7801.00
372_G380_V0.7801.00
190_D437_M0.7771.00
279_L283_N0.7771.00
404_G408_H0.7751.00
349_K352_L0.7751.00
71_V88_C0.7741.00
311_F316_E0.7731.00
377_N380_V0.7721.00
117_I146_A0.7701.00
376_Y379_V0.7701.00
272_V275_Y0.7611.00
30_L34_E0.7601.00
276_D281_N0.7581.00
377_N381_M0.7551.00
109_V123_W0.7541.00
32_I36_H0.7521.00
250_V256_S0.7501.00
261_L266_N0.7491.00
94_S142_T0.7491.00
365_V369_Y0.7481.00
374_S379_V0.7461.00
245_P249_I0.7461.00
315_Y318_Q0.7451.00
375_L380_V0.7441.00
307_W310_V0.7411.00
144_G148_A0.7361.00
373_A378_V0.7341.00
244_S247_H0.7341.00
308_R311_F0.7341.00
164_I208_A0.7341.00
340_A402_L0.7331.00
205_I208_A0.7331.00
269_L273_R0.7331.00
173_N177_V0.7311.00
198_S202_L0.7301.00
348_L352_L0.7301.00
318_Q321_K0.7281.00
372_G381_M0.7271.00
53_T96_L0.7261.00
223_S226_F0.7261.00
166_W207_K0.7261.00
117_I133_Y0.7251.00
251_V256_S0.7241.00
400_M422_E0.7231.00
53_T56_V0.7221.00
273_R276_D0.7221.00
45_L88_C0.7191.00
143_I208_A0.7171.00
247_H253_D0.7151.00
318_Q322_I0.7151.00
103_N110_T0.7141.00
54_E176_A0.7141.00
373_A379_V0.7091.00
310_V313_R0.7091.00
246_P251_V0.7091.00
246_P252_H0.7081.00
72_P93_L0.7081.00
310_V314_K0.7071.00
420_V428_Y0.7071.00
122_E125_N0.7061.00
378_V381_M0.7051.00
180_G188_S0.7041.00
270_I273_R0.7041.00
233_I237_R0.7031.00
317_E320_T0.6981.00
64_N173_N0.6971.00
407_S413_G0.6961.00
271_R275_Y0.6951.00
405_T408_H0.6931.00
344_L348_L0.6911.00
246_P250_V0.6901.00
309_E312_A0.6901.00
117_I120_L0.6901.00
34_E38_G0.6891.00
96_L206_T0.6871.00
190_D434_I0.6851.00
308_R312_A0.6841.00
29_P35_E0.6841.00
434_I438_I0.6821.00
396_A400_M0.6811.00
124_L127_R0.6811.00
178_K187_M0.6791.00
50_P95_K0.6771.00
251_V255_E0.6771.00
277_E281_N0.6761.00
120_L143_I0.6741.00
280_V284_E0.6721.00
99_I112_E0.6711.00
60_V172_P0.6711.00
167_L205_I0.6701.00
374_S378_V0.6691.00
372_G375_L0.6681.00
131_L212_I0.6671.00
268_A271_R0.6671.00
167_L179_V0.6651.00
300_D307_W0.6651.00
307_W316_E0.6641.00
232_A236_T0.6641.00
94_S116_K0.6621.00
47_V90_I0.6621.00
435_K445_N0.6611.00
106_D339_S0.6611.00
192_V196_I0.6591.00
419_W422_E0.6581.00
313_R316_E0.6581.00
130_T215_L0.6581.00
172_P443_I0.6571.00
147_I205_I0.6561.00
193_R196_I0.6551.00
249_I252_H0.6541.00
442_N445_N0.6541.00
324_S327_L0.6531.00
333_D337_T0.6521.00
78_S83_S0.6521.00
117_I141_A0.6501.00
386_E389_K0.6481.00
128_G215_L0.6471.00
355_M390_R0.6461.00
159_N162_N0.6441.00
420_V423_E0.6421.00
252_H257_S0.6421.00
309_E316_E0.6411.00
303_L307_W0.6401.00
255_E260_M0.6391.00
280_V283_N0.6391.00
238_E294_H0.6351.00
388_L392_W0.6341.00
251_V254_K0.6341.00
306_S309_E0.6331.00
306_S315_Y0.6331.00
35_E38_G0.6321.00
342_P346_D0.6311.00
103_N107_L0.6281.00
324_S328_W0.6271.00
244_S250_V0.6261.00
99_I111_V0.6251.00
373_A380_V0.6251.00
429_D436_R0.6241.00
253_D258_E0.6231.00
302_S307_W0.6221.00
346_D349_K0.6201.00
255_E259_M0.6191.00
328_W331_T0.6181.00
29_P36_H0.6181.00
57_S60_V0.6151.00
416_K420_V0.6151.00
284_E291_A0.6151.00
276_D279_L0.6131.00
107_L211_R0.6121.00
288_R291_A0.6071.00
248_R254_K0.6061.00
372_G378_V0.6061.00
246_P254_K0.6061.00
286_I291_A0.6051.00
324_S329_N0.6041.00
407_S411_G0.6041.00
226_F235_F0.6031.00
150_K159_N0.6031.00
403_G410_H0.6031.00
230_H342_P0.6021.00
325_Q329_N0.6021.00
274_G277_E0.6011.00
117_I143_I0.5991.00
230_H343_K0.5981.00
363_S367_H0.5971.00
428_Y431_L0.5961.00
267_I272_V0.5961.00
102_F127_R0.5961.00
267_I271_R0.5961.00
293_R296_A0.5951.00
302_S305_R0.5941.00
300_D303_L0.5921.00
50_P56_V0.5921.00
308_R316_E0.5891.00
37_L40_N0.5881.00
168_E209_K0.5871.00
252_H256_S0.5861.00
32_I49_S0.5841.00
320_T324_S0.5821.00
53_T207_K0.5821.00
271_R276_D0.5821.00
237_R240_V0.5811.00
202_L434_I0.5811.00
421_K428_Y0.5811.00
55_E59_I0.5801.00
120_L131_L0.5791.00
273_R277_E0.5791.00
102_F212_I0.5781.00
326_G329_N0.5771.00
372_G379_V0.5771.00
247_H252_H0.5761.00
85_H88_C0.5761.00
385_L388_L0.5761.00
249_I255_E0.5761.00
332_L336_A0.5751.00
362_L366_T0.5751.00
44_P90_I0.5751.00
165_L181_S0.5711.00
307_W314_K0.5691.00
261_L265_Y0.5681.00
33_L47_V0.5671.00
268_A272_V0.5661.00
329_N332_L0.5641.00
286_I290_L0.5641.00
333_D338_W0.5631.00
169_V179_V0.5631.00
188_S438_I0.5621.00
254_K257_S0.5621.00
309_E314_K0.5611.00
309_E315_Y0.5591.00
291_A294_H0.5571.00
275_Y279_L0.5561.00
391_V394_T0.5541.00
249_I254_K0.5541.00
375_L378_V0.5531.00
136_Q146_A0.5531.00
326_G332_L0.5521.00
406_I411_G0.5521.00
272_V287_I0.5511.00
175_K427_Q0.5501.00
30_L36_H0.5501.00
161_E363_S0.5501.00
138_F141_A0.5491.00
408_H412_V0.5471.00
101_E108_S0.5471.00
314_K317_E0.5461.00
272_V276_D0.5451.00
369_Y372_G0.5451.00
228_N232_A0.5431.00
283_N286_I0.5431.00
415_L418_N0.5431.00
75_G116_K0.5431.00
180_G189_P0.5421.00
405_T410_H0.5401.00
62_L89_V0.5401.00
412_V420_V0.5391.00
46_L68_V0.5391.00
172_P441_N0.5381.00
314_K318_Q0.5381.00
220_T281_N0.5371.00
414_I417_K0.5371.00
307_W311_F0.5361.00
121_E130_T0.5351.00
404_G407_S0.5341.00
375_L379_V0.5321.00
111_V115_I0.5321.00
330_D333_D0.5311.00
350_E355_M0.5291.00
393_E396_A0.5291.00
201_T435_K0.5291.00
292_M296_A0.5281.00
364_R375_L0.5271.00
253_D257_S0.5261.00
177_V430_L0.5251.00
403_G409_H0.5241.00
331_T335_G0.5231.00
280_V288_R0.5231.00
344_L347_K0.5231.00
294_H297_N0.5211.00
290_L294_H0.5211.00
71_V85_H0.5191.00
399_I402_L0.5181.00
101_E104_E0.5171.00
121_E124_L0.5171.00
248_R257_S0.5151.00
244_S249_I0.5140.99
362_L365_V0.5120.99
164_I210_L0.5120.99
256_S259_M0.5120.99
249_I253_D0.5090.99
50_P96_L0.5080.99
374_S381_M0.5080.99
384_D388_L0.5080.99
153_G156_S0.5070.99
269_L274_G0.5060.99
246_P257_S0.5060.99
270_I274_G0.5050.99
181_S196_I0.5050.99
118_K138_F0.5040.99
104_E107_L0.5040.99
33_L37_L0.5030.99
131_L210_L0.5030.99
372_G377_N0.5020.99
69_C446_P0.5020.99
191_L438_I0.5000.99
416_K419_W0.5000.99
254_K259_M0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pm9A 5 0.9734 100 0.303 Contact Map
2uuuA 2 0.9357 100 0.331 Contact Map
1f0xA 1 0.929 100 0.358 Contact Map
4bbyA 2 0.9845 100 0.359 Contact Map
1w1oA 1 0.9268 100 0.361 Contact Map
2bvfA 1 0.9335 100 0.365 Contact Map
1wvfA 2 0.9734 100 0.365 Contact Map
2exrA 1 0.9024 100 0.365 Contact Map
4xloA 2 0.9512 100 0.368 Contact Map
4ud8A 1 0.949 100 0.379 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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