GREMLIN Database
Q97Y17 - Uncharacterized protein
UniProt: Q97Y17 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 341 (292)
Sequences: 16548 (10396)
Seq/√Len: 608.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
242_F284_D4.8191.00
154_N159_K3.2821.00
36_E72_R3.2311.00
37_F320_I2.7221.00
77_R109_N2.5881.00
242_F281_G2.4851.00
37_F40_K2.4411.00
136_D192_K2.4331.00
39_E75_N2.3881.00
288_Q291_K2.3771.00
216_D220_Q2.3351.00
70_A104_S2.2861.00
66_L78_I2.2621.00
281_G284_D2.2351.00
263_A266_R2.2281.00
133_E156_K2.1971.00
242_F246_V2.1951.00
241_S244_D2.1671.00
140_D193_K2.1401.00
188_Y221_G2.1341.00
290_Y294_K2.1071.00
239_S244_D2.0611.00
35_I69_I1.9981.00
320_I324_E1.9881.00
32_A36_E1.9821.00
322_I326_V1.9811.00
29_E105_N1.9491.00
36_E40_K1.9481.00
217_S221_G1.9321.00
212_K216_D1.9281.00
215_T230_I1.9171.00
240_K325_K1.8921.00
243_H247_E1.8771.00
147_S174_Y1.8101.00
97_Y108_L1.7971.00
41_L323_R1.7921.00
191_G221_G1.7691.00
46_V76_I1.7661.00
33_K36_E1.7621.00
32_A72_R1.7611.00
70_A78_I1.7521.00
47_W79_G1.7471.00
250_K254_H1.7401.00
101_D106_G1.7291.00
222_L227_N1.7241.00
61_S96_E1.7181.00
213_P216_D1.7081.00
317_D320_I1.6831.00
278_L285_V1.6581.00
130_A156_K1.6381.00
222_L228_A1.6251.00
291_K295_L1.6021.00
133_E157_Y1.5991.00
212_K295_L1.5881.00
143_L174_Y1.5871.00
220_Q224_E1.5861.00
215_T219_K1.5841.00
37_F316_Q1.5611.00
97_Y110_L1.5591.00
181_V197_L1.5361.00
35_I46_V1.5351.00
317_D321_N1.5321.00
118_K122_A1.5241.00
37_F41_L1.5101.00
144_K151_V1.5061.00
268_L272_Y1.4871.00
284_D287_N1.4821.00
140_D144_K1.4771.00
152_S162_N1.4701.00
217_S220_Q1.4661.00
69_I78_I1.4511.00
33_K316_Q1.4451.00
101_D171_Q1.4341.00
232_L298_V1.4301.00
221_G224_E1.4291.00
283_E287_N1.4281.00
143_L193_K1.4011.00
152_S161_E1.3871.00
188_Y192_K1.3821.00
286_A290_Y1.3701.00
244_D248_E1.3581.00
32_A68_H1.3461.00
238_I285_V1.3441.00
143_L177_I1.3431.00
23_T26_E1.3381.00
188_Y217_S1.3351.00
40_K74_K1.3331.00
140_D153_V1.3311.00
68_H71_S1.3251.00
321_N325_K1.3191.00
187_A217_S1.3131.00
39_E73_T1.3091.00
184_A217_S1.3021.00
144_K148_G1.3001.00
68_H103_L1.2991.00
144_K149_E1.2931.00
213_P217_S1.2831.00
284_D288_Q1.2761.00
240_K317_D1.2701.00
290_Y293_W1.2691.00
150_S162_N1.2581.00
154_N161_E1.2521.00
48_I66_L1.2391.00
130_A133_E1.2311.00
61_S64_V1.2271.00
136_D193_K1.2171.00
238_I282_P1.2141.00
26_E30_Q1.2131.00
88_K96_E1.2111.00
35_I73_T1.2091.00
29_E33_K1.2071.00
287_N291_K1.2011.00
269_D273_N1.1891.00
188_Y224_E1.1841.00
60_P99_L1.1811.00
291_K294_K1.1771.00
229_E299_N1.1741.00
282_P321_N1.1721.00
39_E74_K1.1601.00
110_L142_I1.1531.00
239_S245_A1.1501.00
33_K37_F1.1481.00
93_V138_A1.1461.00
144_K153_V1.1451.00
244_D247_E1.1441.00
178_W231_S1.1311.00
105_N170_L1.1251.00
221_G225_N1.1251.00
41_L319_L1.1231.00
139_L193_K1.1211.00
247_E250_K1.1201.00
237_H248_E1.1151.00
143_L195_F1.1141.00
136_D140_D1.1111.00
222_L225_N1.1101.00
208_I295_L1.1081.00
79_G109_N1.1071.00
185_E188_Y1.1051.00
178_W196_N1.1021.00
122_A161_E1.0931.00
66_L80_P1.0861.00
141_I153_V1.0831.00
100_L108_L1.0811.00
35_I76_I1.0761.00
48_I69_I1.0741.00
240_K244_D1.0711.00
249_S253_L1.0601.00
63_S96_E1.0581.00
303_F322_I1.0541.00
124_F127_P1.0511.00
142_I146_M1.0501.00
278_L288_Q1.0421.00
247_E251_E1.0411.00
238_I321_N1.0391.00
64_V67_S1.0381.00
270_D273_N1.0341.00
267_T270_D1.0331.00
280_G285_V1.0301.00
68_H72_R1.0271.00
92_Q96_E1.0231.00
130_A157_Y1.0191.00
141_I158_F1.0161.00
269_D272_Y1.0151.00
137_E155_G1.0051.00
134_I137_E1.0041.00
210_D213_P0.9901.00
36_E74_K0.9881.00
191_G225_N0.9791.00
112_M139_L0.9771.00
22_L30_Q0.9751.00
40_K320_I0.9731.00
143_L147_S0.9721.00
246_V250_K0.9631.00
63_S83_A0.9551.00
268_L273_N0.9501.00
236_T303_F0.9451.00
141_I160_Y0.9421.00
234_F278_L0.9401.00
25_R29_E0.9391.00
64_V100_L0.9381.00
267_T274_S0.9351.00
136_D189_H0.9351.00
30_Q33_K0.9251.00
229_E300_R0.9201.00
198_M231_S0.9161.00
102_T170_L0.9151.00
268_L271_L0.9151.00
192_K225_N0.9121.00
189_H193_K0.9111.00
190_V197_L0.9071.00
160_Y163_I0.9061.00
318_I321_N0.9051.00
241_S245_A0.9051.00
43_Y323_R0.9041.00
133_E185_E0.9041.00
243_H246_V0.9021.00
239_S248_E0.8961.00
286_A326_V0.8901.00
141_I144_K0.8831.00
82_V180_A0.8791.00
45_G79_G0.8771.00
21_G24_K0.8701.00
267_T271_L0.8661.00
150_S164_K0.8641.00
153_V156_K0.8621.00
287_N290_Y0.8581.00
38_A319_L0.8521.00
130_A134_I0.8521.00
218_Y228_A0.8511.00
137_E156_K0.8451.00
305_V322_I0.8431.00
116_Y120_E0.8351.00
85_I138_A0.8351.00
33_K40_K0.8341.00
188_Y225_N0.8321.00
257_V260_R0.8311.00
70_A108_L0.8301.00
82_V113_G0.8141.00
29_E32_A0.8131.00
218_Y222_L0.8121.00
28_Y103_L0.8121.00
67_S71_S0.8101.00
146_M175_P0.8081.00
249_S279_L0.8081.00
219_K230_I0.8061.00
45_G300_R0.8061.00
240_K321_N0.8051.00
216_D297_E0.8041.00
187_A191_G0.8041.00
271_L274_S0.8001.00
134_I138_A0.7991.00
219_K223_K0.7971.00
238_I326_V0.7951.00
323_R327_A0.7941.00
319_L323_R0.7941.00
188_Y220_Q0.7921.00
211_V215_T0.7911.00
117_L120_E0.7891.00
40_K324_E0.7881.00
316_Q320_I0.7841.00
66_L70_A0.7831.00
137_E141_I0.7791.00
248_E321_N0.7741.00
258_F262_Y0.7721.00
98_S169_P0.7611.00
234_F289_I0.7561.00
145_L151_V0.7521.00
138_A142_I0.7511.00
251_E255_R0.7491.00
70_A100_L0.7461.00
85_I93_V0.7451.00
66_L100_L0.7451.00
179_I194_G0.7441.00
251_E254_H0.7401.00
90_P138_A0.7321.00
90_P141_I0.7311.00
102_T173_P0.7301.00
71_S104_S0.7301.00
115_G120_E0.7281.00
47_W81_A0.7281.00
132_R185_E0.7261.00
179_I186_A0.7241.00
248_E251_E0.7211.00
223_K226_T0.7211.00
119_H122_A0.7171.00
246_V249_S0.7121.00
27_Y30_Q0.7121.00
211_V214_V0.7071.00
28_Y68_H0.7051.00
187_A213_P0.7051.00
66_L108_L0.7051.00
32_A69_I0.7051.00
254_H258_F0.7051.00
192_K221_G0.7041.00
179_I190_V0.7041.00
50_E88_K0.7021.00
215_T218_Y0.7021.00
140_D192_K0.7011.00
136_D185_E0.7001.00
236_T322_I0.6991.00
224_E227_N0.6981.00
231_S300_R0.6951.00
84_T115_G0.6941.00
283_E286_A0.6901.00
184_A188_Y0.6901.00
255_R258_F0.6881.00
109_N178_W0.6851.00
269_D274_S0.6841.00
305_V319_L0.6841.00
93_V142_I0.6841.00
250_K253_L0.6831.00
52_H95_E0.6831.00
67_S100_L0.6811.00
34_E319_L0.6811.00
233_A302_M0.6801.00
45_G302_M0.6781.00
144_K147_S0.6771.00
219_K222_L0.6751.00
153_V158_F0.6731.00
210_D214_V0.6721.00
214_V217_S0.6711.00
289_I301_L0.6671.00
187_A197_L0.6651.00
293_W298_V0.6601.00
164_K168_L0.6591.00
218_Y221_G0.6561.00
171_Q175_P0.6551.00
129_E185_E0.6551.00
43_Y327_A0.6551.00
79_G178_W0.6521.00
114_S135_F0.6491.00
34_E316_Q0.6491.00
97_Y146_M0.6481.00
179_I189_H0.6481.00
48_I65_Y0.6461.00
88_K92_Q0.6421.00
78_I104_S0.6411.00
29_E74_K0.6401.00
181_V186_A0.6391.00
101_D169_P0.6381.00
253_L256_Y0.6371.00
80_P108_L0.6351.00
30_Q34_E0.6351.00
101_D174_Y0.6351.00
89_N92_Q0.6321.00
140_D143_L0.6301.00
208_I291_K0.6291.00
90_P158_F0.6271.00
223_K227_N0.6261.00
63_S97_Y0.6251.00
222_L226_T0.6231.00
148_G168_L0.6201.00
163_I167_V0.6191.00
101_D170_L0.6181.00
91_I145_L0.6171.00
257_V261_L0.6171.00
171_Q174_Y0.6161.00
77_R176_P0.6151.00
37_F323_R0.6151.00
208_I212_K0.6141.00
44_R75_N0.6121.00
134_I158_F0.6111.00
29_E71_S0.6041.00
32_A71_S0.6041.00
282_P325_K0.6031.00
141_I151_V0.6011.00
32_A35_I0.6011.00
246_V279_L0.5991.00
46_V69_I0.5981.00
230_I298_V0.5981.00
208_I211_V0.5971.00
209_D212_K0.5961.00
88_K93_V0.5961.00
192_K224_E0.5951.00
101_D104_S0.5951.00
26_E29_E0.5941.00
276_L288_Q0.5941.00
187_A218_Y0.5931.00
137_E140_D0.5931.00
137_E157_Y0.5921.00
114_S131_K0.5891.00
239_S242_F0.5881.00
98_S146_M0.5881.00
240_K282_P0.5881.00
214_V218_Y0.5871.00
187_A221_G0.5871.00
289_I303_F0.5871.00
82_V93_V0.5861.00
24_K27_Y0.5841.00
282_P324_E0.5821.00
237_H249_S0.5811.00
44_R77_R0.5811.00
77_R171_Q0.5801.00
270_D274_S0.5791.00
288_Q292_I0.5781.00
259_S262_Y0.5741.00
65_Y99_L0.5721.00
236_T278_L0.5691.00
168_L171_Q0.5671.00
127_P159_K0.5641.00
191_G222_L0.5631.00
203_A209_D0.5611.00
73_T107_R0.5601.00
138_A158_F0.5591.00
139_L179_I0.5581.00
38_A76_I0.5581.00
216_D219_K0.5571.00
22_L26_E0.5561.00
68_H104_S0.5490.99
255_R259_S0.5490.99
177_I194_G0.5490.99
39_E76_I0.5480.99
189_H192_K0.5480.99
64_V68_H0.5480.99
219_K297_E0.5470.99
101_D175_P0.5470.99
111_A180_A0.5460.99
81_A198_M0.5440.99
185_E189_H0.5430.99
166_N171_Q0.5430.99
154_N157_Y0.5420.99
242_F245_A0.5390.99
215_T298_V0.5360.99
28_Y32_A0.5320.99
112_M142_I0.5310.99
90_P142_I0.5310.99
127_P130_A0.5290.99
31_V34_E0.5270.99
67_S104_S0.5270.99
305_V318_I0.5240.99
53_F117_L0.5240.99
240_K324_E0.5230.99
267_T272_Y0.5220.99
73_T76_I0.5200.99
137_E153_V0.5190.99
164_K167_V0.5180.99
197_L214_V0.5180.99
170_L173_P0.5160.99
182_L200_I0.5130.99
139_L189_H0.5130.99
174_Y195_F0.5120.99
176_P229_E0.5120.99
256_Y260_R0.5120.99
85_I112_M0.5110.99
285_V288_Q0.5110.99
241_S281_G0.5100.99
109_N300_R0.5090.99
187_A214_V0.5090.99
213_P220_Q0.5080.99
83_A93_V0.5070.99
258_F261_L0.5070.99
94_A146_M0.5060.99
64_V99_L0.5060.99
62_T80_P0.5060.99
41_L316_Q0.5050.99
139_L143_L0.5020.99
128_Q131_K0.5010.99
146_M177_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lucA 1 0.9208 100 0.212 Contact Map
2wgkA 2 0.9531 100 0.221 Contact Map
1lucB 1 0.9208 100 0.231 Contact Map
2i7gA 2 0.9589 100 0.235 Contact Map
3sdoA 2 0.9619 100 0.247 Contact Map
3b9oA 2 0.9472 100 0.251 Contact Map
1tvlA 2 0.9267 100 0.257 Contact Map
3raoA 2 0.9413 100 0.257 Contact Map
1ezwA 3 0.8886 100 0.261 Contact Map
3c8nA 2 0.9062 100 0.265 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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