GREMLIN Database
Y1533 - Putative dioxygenase SSO1533
UniProt: Q97Y16 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 384 (368)
Sequences: 1240 (562)
Seq/√Len: 29.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_K245_A4.8091.00
272_D277_T4.7081.00
146_D245_A4.4911.00
274_V277_T4.4641.00
272_D279_V4.1491.00
14_R288_Q4.1341.00
274_V279_V4.0091.00
133_F148_L3.9971.00
114_F232_F3.8061.00
304_I323_I3.7071.00
367_I371_E3.5551.00
275_V279_V3.4401.00
40_S137_F3.3811.00
149_V244_F3.2641.00
126_V166_L3.1141.00
130_E161_K3.0381.00
276_C279_V3.0071.00
359_T363_V2.8541.00
272_D275_V2.8261.00
339_V343_L2.7701.00
123_I275_V2.6681.00
117_N122_E2.6651.00
143_K249_Y2.6131.00
214_L227_L2.5050.99
213_K224_L2.4850.99
6_R22_G2.4850.99
85_D113_L2.4670.99
19_M344_N2.4480.99
137_F154_T2.3890.99
132_L141_E2.3360.99
145_G353_V2.3250.99
92_A102_S2.3110.99
142_V148_L2.2270.98
29_V154_T2.2060.98
272_D276_C2.1420.98
134_K157_T2.1180.98
132_L139_E2.0780.98
229_T233_D2.0510.97
94_I363_V2.0390.97
88_L113_L2.0230.97
273_F277_T2.0230.97
125_Y357_V2.0190.97
146_D199_K2.0120.97
255_T285_Y1.9650.96
252_E257_K1.9560.96
57_W215_V1.9490.96
118_A216_I1.9450.96
46_N233_D1.9410.96
90_R168_I1.9190.96
140_I200_L1.9160.96
200_L242_Y1.8910.96
340_E344_N1.8780.95
125_Y308_S1.8360.95
145_G249_Y1.8230.95
113_L213_K1.8060.94
249_Y353_V1.7970.94
73_H374_D1.7970.94
114_F212_Y1.7810.94
216_I225_V1.7290.93
256_G286_H1.7210.93
142_V164_A1.7200.93
316_R338_A1.7130.93
99_L359_T1.7020.92
12_K250_D1.6850.92
101_I357_V1.6720.92
173_Q270_A1.6500.91
55_G224_L1.6450.91
305_I312_F1.6440.91
131_I142_V1.6340.91
134_K232_F1.5990.90
112_K210_G1.5880.89
69_E378_P1.5850.89
101_I363_V1.5790.89
157_T232_F1.5700.89
77_T93_L1.5490.88
109_G160_F1.5450.88
112_K208_E1.5310.88
74_K322_D1.4960.86
60_N63_G1.4940.86
206_Y230_H1.4910.86
326_H377_Y1.4880.86
326_H334_P1.4840.86
31_G241_L1.4820.86
308_S353_V1.4680.85
211_N226_E1.4600.85
123_I149_V1.4530.85
273_F279_V1.4410.84
48_P155_T1.4390.84
109_G159_S1.4290.84
267_T277_T1.4240.83
259_H281_R1.4230.83
10_L236_G1.4200.83
56_E221_G1.4190.83
42_L137_F1.4020.82
334_P377_Y1.3970.82
83_S107_D1.3890.82
266_T269_A1.3830.81
46_N209_N1.3760.81
94_I304_I1.3750.81
183_E195_N1.3460.80
307_Y352_E1.3440.80
273_F276_C1.3360.79
29_V41_L1.3100.78
167_F357_V1.2990.77
254_I260_Q1.2920.77
260_Q264_A1.2870.76
53_K379_L1.2810.76
124_Y168_I1.2800.76
171_G270_A1.2790.76
73_H373_D1.2600.75
84_S107_D1.2360.73
282_L285_Y1.2310.73
5_H200_L1.2230.73
19_M288_Q1.2190.72
177_P271_D1.2190.72
362_R365_V1.2160.72
92_A100_I1.2120.72
116_R155_T1.1970.71
283_F313_M1.1890.71
112_K213_K1.1870.70
305_I314_S1.1850.70
312_F354_A1.1810.70
20_K23_K1.1770.70
147_Y248_V1.1700.69
109_G137_F1.1640.69
26_R339_V1.1540.68
116_R216_I1.1490.68
136_V155_T1.1440.67
160_F164_A1.1400.67
256_G260_Q1.1370.67
174_I270_A1.1290.66
134_K159_S1.1200.66
349_Y352_E1.1180.66
205_T209_N1.1160.66
121_D175_E1.1130.65
75_L323_I1.1120.65
256_G283_F1.1120.65
255_T283_F1.1040.65
42_L234_V1.1040.65
379_L382_Y1.0990.64
38_R154_T1.0950.64
248_V353_V1.0880.64
307_Y354_A1.0810.63
92_A366_S1.0540.61
139_E204_R1.0530.61
143_K199_K1.0440.60
91_I368_Y1.0420.60
15_H238_D1.0400.60
169_I276_C1.0380.60
305_I354_A1.0350.60
128_S162_K1.0260.59
51_I69_E1.0200.58
150_I295_Y1.0100.58
21_D323_I1.0100.58
84_S108_E1.0090.58
99_L363_V1.0080.58
130_E160_F1.0070.57
75_L93_L1.0070.57
215_V224_L1.0050.57
194_Y197_D1.0000.57
143_K245_A0.9990.57
101_I304_I0.9910.56
157_T212_Y0.9890.56
66_K370_K0.9880.56
97_D361_K0.9880.56
337_S341_A0.9760.55
122_E133_F0.9760.55
205_T208_E0.9680.54
99_L169_I0.9620.54
196_R238_D0.9600.54
75_L365_V0.9600.54
184_Y195_N0.9530.53
20_K26_R0.9440.53
295_Y339_V0.9440.53
218_T362_R0.9440.53
13_K197_D0.9420.52
16_T255_T0.9370.52
348_T351_D0.9360.52
216_I378_P0.9300.51
131_I164_A0.9270.51
175_E270_A0.9270.51
117_N232_F0.9270.51
314_S380_S0.9260.51
378_P382_Y0.9260.51
253_P265_Y0.9250.51
314_S334_P0.9220.51
17_V24_L0.9200.51
290_V343_L0.9190.51
124_Y150_I0.9140.50
125_Y306_F0.9080.50
31_G39_Y0.9080.50
213_K226_E0.9050.50
106_V164_A0.9000.49
121_D294_Y0.9000.49
316_R341_A0.8960.49
134_K204_R0.8930.49
119_D217_K0.8930.49
125_Y147_Y0.8890.48
78_S107_D0.8890.48
130_E143_K0.8840.48
133_F158_L0.8840.48
169_I275_V0.8820.48
114_F210_G0.8810.48
10_L25_M0.8810.48
14_R19_M0.8720.47
86_V166_L0.8690.47
39_Y190_G0.8680.47
124_Y158_L0.8640.46
55_G228_D0.8640.46
247_S250_D0.8630.46
151_P200_L0.8570.46
62_I90_R0.8550.46
315_R326_H0.8550.46
132_L159_S0.8540.46
150_I342_S0.8520.45
75_L373_D0.8500.45
82_K87_F0.8500.45
301_A359_T0.8490.45
114_F214_L0.8490.45
133_F142_V0.8420.45
52_M226_E0.8410.45
283_F350_N0.8390.44
102_S168_I0.8370.44
376_T379_L0.8360.44
306_F355_I0.8320.44
28_E189_E0.8260.43
192_F238_D0.8260.43
83_S108_E0.8230.43
252_E260_Q0.8230.43
113_L215_V0.8180.43
322_D374_D0.8170.43
215_V222_F0.8140.42
227_L232_F0.8130.42
9_E22_G0.8110.42
176_V181_R0.8060.42
326_H354_A0.8030.42
65_W219_V0.8020.42
154_T241_L0.8020.42
81_R128_S0.8000.41
219_V362_R0.7990.41
199_K250_D0.7960.41
287_P300_D0.7960.41
28_E39_Y0.7930.41
104_S126_V0.7910.41
15_H192_F0.7910.41
124_Y166_L0.7890.41
317_G334_P0.7890.41
150_I244_F0.7880.40
194_Y257_K0.7860.40
85_D88_L0.7830.40
155_T331_I0.7800.40
121_D151_P0.7790.40
118_A200_L0.7780.40
73_H76_S0.7770.40
41_L190_G0.7770.40
120_F123_I0.7770.40
104_S164_A0.7740.39
48_P300_D0.7720.39
63_G367_I0.7720.39
328_G362_R0.7710.39
15_H31_G0.7710.39
131_I148_L0.7690.39
128_S163_N0.7660.39
99_L273_F0.7660.39
327_R374_D0.7640.39
99_L235_V0.7620.38
49_T69_E0.7600.38
93_L369_A0.7540.38
92_A99_L0.7530.38
133_F140_I0.7470.37
373_D376_T0.7460.37
117_N299_I0.7440.37
95_F120_F0.7420.37
81_R93_L0.7420.37
130_E144_E0.7410.37
189_E255_T0.7410.37
93_L214_L0.7400.37
182_N240_Y0.7390.37
198_L244_F0.7390.37
64_E367_I0.7390.37
113_L156_Y0.7390.37
312_F324_T0.7340.36
335_Q338_A0.7340.36
175_E272_D0.7340.36
68_A71_R0.7340.36
70_Y354_A0.7330.36
217_K331_I0.7320.36
260_Q313_M0.7320.36
148_L245_A0.7320.36
239_G262_P0.7310.36
252_E256_G0.7300.36
280_P370_K0.7300.36
124_Y156_Y0.7300.36
317_G324_T0.7290.36
50_R382_Y0.7290.36
6_R10_L0.7290.36
16_T40_S0.7290.36
368_Y371_E0.7290.36
305_I320_K0.7280.36
209_N228_D0.7260.36
75_L91_I0.7260.36
341_A353_V0.7250.36
56_E87_F0.7230.36
71_R74_K0.7210.35
307_Y312_F0.7170.35
114_F134_K0.7160.35
134_K139_E0.7160.35
52_M378_P0.7130.35
314_S335_Q0.7090.35
314_S326_H0.7060.34
98_N362_R0.7060.34
172_K220_N0.7050.34
253_P257_K0.7040.34
17_V288_Q0.7040.34
70_Y157_T0.7030.34
121_D171_G0.7020.34
133_F213_K0.7020.34
191_S289_S0.6990.34
266_T300_D0.6960.34
116_R330_H0.6940.34
257_K330_H0.6930.34
40_S301_A0.6930.34
266_T276_C0.6930.34
248_V277_T0.6860.33
132_L212_Y0.6850.33
256_G300_D0.6840.33
165_E197_D0.6830.33
252_E374_D0.6820.33
127_H164_A0.6800.33
315_R334_P0.6780.32
31_G192_F0.6770.32
312_F335_Q0.6770.32
104_S166_L0.6760.32
68_A378_P0.6760.32
97_D100_I0.6760.32
153_G243_P0.6760.32
229_T374_D0.6750.32
317_G326_H0.6750.32
194_Y285_Y0.6740.32
40_S118_A0.6720.32
283_F348_T0.6700.32
305_I315_R0.6680.32
69_E216_I0.6680.32
377_Y381_W0.6650.32
295_Y338_A0.6630.31
86_V321_G0.6630.31
105_K165_E0.6630.31
119_D136_V0.6630.31
51_I331_I0.6620.31
64_E365_V0.6610.31
148_L164_A0.6570.31
47_P217_K0.6560.31
281_R358_E0.6530.31
69_E338_A0.6510.31
137_F151_P0.6490.30
117_N244_F0.6490.30
45_L207_D0.6480.30
62_I232_F0.6470.30
267_T312_F0.6470.30
20_K339_V0.6460.30
266_T285_Y0.6440.30
295_Y316_R0.6440.30
46_N92_A0.6430.30
28_E294_Y0.6420.30
283_F349_Y0.6410.30
340_E343_L0.6410.30
233_D363_V0.6400.30
128_S142_V0.6380.30
210_G226_E0.6380.30
98_N150_I0.6370.30
96_N270_A0.6370.30
326_H356_M0.6350.30
32_L308_S0.6350.30
48_P256_G0.6340.30
123_I172_K0.6310.29
85_D108_E0.6300.29
205_T361_K0.6300.29
115_Y124_Y0.6290.29
26_R47_P0.6290.29
42_L241_L0.6250.29
189_E294_Y0.6250.29
184_Y192_F0.6250.29
51_I155_T0.6250.29
6_R9_E0.6240.29
187_L192_F0.6210.29
368_Y372_I0.6170.28
49_T267_T0.6170.28
15_H335_Q0.6160.28
182_N238_D0.6150.28
314_S317_G0.6150.28
59_S124_Y0.6150.28
20_K28_E0.6140.28
43_Y238_D0.6130.28
25_M29_V0.6130.28
98_N361_K0.6120.28
64_E364_K0.6110.28
53_K378_P0.6110.28
176_V273_F0.6100.28
14_R299_I0.6100.28
315_R356_M0.6070.28
48_P226_E0.6060.28
62_I117_N0.6040.28
9_E18_F0.6020.27
330_H362_R0.6000.27
45_L241_L0.5990.27
109_G288_Q0.5980.27
91_I148_L0.5970.27
108_E202_V0.5960.27
5_H152_R0.5950.27
103_F367_I0.5950.27
97_D172_K0.5940.27
9_E21_D0.5930.27
282_L286_H0.5920.27
259_H358_E0.5920.27
112_K212_Y0.5920.27
56_E265_Y0.5910.27
218_T359_T0.5880.27
195_N240_Y0.5880.27
59_S63_G0.5860.26
216_I253_P0.5830.26
56_E350_N0.5820.26
93_L103_F0.5810.26
58_K61_T0.5800.26
327_R363_V0.5800.26
86_V156_Y0.5770.26
78_S84_S0.5750.26
60_N222_F0.5730.26
266_T287_P0.5720.26
114_F227_L0.5720.26
25_M47_P0.5710.26
51_I72_H0.5700.26
239_G303_E0.5700.26
66_K70_Y0.5700.26
12_K288_Q0.5700.26
205_T271_D0.5690.25
96_N361_K0.5690.25
152_R260_Q0.5680.25
154_T242_Y0.5680.25
312_F356_M0.5680.25
326_H335_Q0.5670.25
311_Q337_S0.5660.25
61_T111_T0.5660.25
66_K69_E0.5650.25
95_F172_K0.5640.25
55_G213_K0.5640.25
88_L156_Y0.5630.25
227_L299_I0.5630.25
101_I323_I0.5620.25
133_F159_S0.5620.25
151_P250_D0.5610.25
96_N145_G0.5610.25
46_N229_T0.5580.25
32_L175_E0.5580.25
30_F42_L0.5580.25
151_P237_W0.5580.25
369_A373_D0.5580.25
171_G232_F0.5580.25
34_G250_D0.5560.25
345_K365_V0.5550.25
152_R187_L0.5540.25
337_S340_E0.5530.25
217_K221_G0.5530.25
15_H187_L0.5520.24
106_V160_F0.5520.24
321_G356_M0.5520.24
181_R342_S0.5510.24
306_F318_I0.5500.24
81_R163_N0.5480.24
122_E156_Y0.5470.24
57_W87_F0.5450.24
48_P266_T0.5450.24
349_Y363_V0.5450.24
11_P197_D0.5440.24
327_R360_Q0.5440.24
132_L161_K0.5430.24
262_P303_E0.5430.24
77_T84_S0.5420.24
160_F219_V0.5410.24
145_G363_V0.5400.24
356_M381_W0.5400.24
327_R358_E0.5390.24
249_Y340_E0.5390.24
139_E206_Y0.5370.24
28_E32_L0.5370.24
57_W60_N0.5360.24
254_I264_A0.5350.23
198_L264_A0.5350.23
354_A377_Y0.5350.23
100_I172_K0.5340.23
181_R205_T0.5340.23
111_T159_S0.5330.23
60_N143_K0.5330.23
13_K257_K0.5330.23
169_I304_I0.5330.23
208_E212_Y0.5320.23
259_H334_P0.5310.23
55_G295_Y0.5300.23
265_Y355_I0.5300.23
87_F109_G0.5290.23
203_L206_Y0.5290.23
74_K317_G0.5280.23
324_T356_M0.5270.23
47_P74_K0.5260.23
61_T91_I0.5250.23
75_L159_S0.5250.23
253_P286_H0.5230.23
120_F156_Y0.5220.23
252_E287_P0.5210.23
326_H381_W0.5210.23
151_P243_P0.5210.23
111_T127_H0.5210.23
263_T266_T0.5200.23
57_W61_T0.5200.23
136_V188_V0.5200.23
128_S160_F0.5180.23
55_G64_E0.5180.23
86_V142_V0.5170.22
141_E212_Y0.5170.22
366_S369_A0.5160.22
249_Y257_K0.5160.22
310_G324_T0.5150.22
334_P354_A0.5150.22
216_I336_P0.5150.22
67_D72_H0.5140.22
83_S371_E0.5130.22
93_L368_Y0.5130.22
38_R175_E0.5120.22
163_N211_N0.5120.22
59_S99_L0.5120.22
50_R233_D0.5120.22
265_Y336_P0.5110.22
140_I148_L0.5100.22
161_K349_Y0.5100.22
63_G157_T0.5090.22
36_N315_R0.5090.22
28_E242_Y0.5080.22
319_N353_V0.5080.22
168_I364_K0.5070.22
256_G299_I0.5070.22
21_D31_G0.5070.22
100_I220_N0.5060.22
156_Y242_Y0.5050.22
50_R228_D0.5050.22
59_S88_L0.5040.22
305_I355_I0.5030.22
312_F352_E0.5020.22
246_L251_L0.5020.22
63_G84_S0.5020.22
89_D317_G0.5010.22
252_E331_I0.5010.22
147_Y329_G0.5000.22
28_E255_T0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1eybA 5 0.9349 100 0.101 Contact Map
3zdsA 6 0.9766 100 0.111 Contact Map
3qacA 3 0.7656 98.3 0.938 Contact Map
1juhA 3 0.7682 98.1 0.94 Contact Map
4lejA 3 0.763 98.1 0.941 Contact Map
3d82A 2 0.2656 98 0.942 Contact Map
2e9qA 6 0.763 98 0.942 Contact Map
2i45A 2 0.2578 98 0.943 Contact Map
2vqaA 3 0.7734 97.8 0.944 Contact Map
1yhfA 2 0.2969 97.7 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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