Q97Y14 - SULSO - GREMLIN Contacts

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Q97Y14 - Uncharacterized protein

UniProt:	Q97Y14	Sequences: MEKLSLISADLVHPDCWTERTEKYLVNVKLLSQQFSDDKFFVSKVLILGKDSRNLIDELKNFKGVKINKLYCLDEDSFVMDFIYPRYNSVSSLFYDTNSIVISHRIVDGIEKWKIIASSSMVSHILEKLENTTNLIDFKEINLKKLERLLDKLTDRNLSFLKIAHKQGLFDYPKRKTLLSLSKELGIKPNTLLYHIRKSESSLLEILIDEYYSLL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	215 (200)
Sequences:	1909 (1552)
Seq/√Len:	109.8

HALSA - Q9HSM9 Q9HR58 Q9HSR5 O54637 Q9HPS7 Q9HQD9 DMSR Q9HQU9
SULSO - Q97Y14 Q97YL7 Q97UD7 Q97WR0 Q97YT8 Q97X87 Q7LXI8 Q97ZB6 Q97UC0 Q97ZX5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
176_K	181_L	4.167	1.00
170_F	200_E	3.993	1.00
163_I	167_Q	3.906	1.00
94_F	99_S	3.736	1.00
160_F	185_L	3.190	1.00
191_T	195_H	3.154	1.00
167_Q	181_L	3.127	1.00
99_S	117_A	3.118	1.00
188_K	191_T	3.000	1.00
167_Q	184_E	2.919	1.00
171_D	175_R	2.871	1.00
165_H	205_E	2.817	1.00
156_R	195_H	2.799	1.00
176_K	180_S	2.782	1.00
163_I	181_L	2.685	1.00
137_D	140_E	2.604	1.00
177_T	180_S	2.587	1.00
22_E	109_G	2.404	1.00
178_L	192_L	2.335	1.00
156_R	160_F	2.305	1.00
172_Y	193_L	2.186	1.00
46_L	82_F	2.171	1.00
10_D	110_I	2.157	1.00
187_I	192_L	2.048	1.00
156_R	159_S	2.028	1.00
56_I	80_M	1.889	1.00
178_L	193_L	1.883	1.00
158_L	162_K	1.843	1.00
136_I	140_E	1.808	1.00
189_P	193_L	1.799	1.00
51_D	54_N	1.775	1.00
102_I	116_I	1.760	1.00
161_L	204_L	1.723	1.00
48_L	55_L	1.710	1.00
160_F	195_H	1.671	1.00
21_T	62_F	1.594	1.00
141_I	144_K	1.547	1.00
195_H	198_K	1.539	1.00
33_Q	47_I	1.529	1.00
176_K	184_E	1.520	1.00
181_L	192_L	1.505	1.00
204_L	207_L	1.499	1.00
161_L	170_F	1.497	1.00
52_S	55_L	1.465	1.00
9_A	115_I	1.454	1.00
174_K	197_R	1.446	1.00
183_K	186_G	1.423	1.00
180_S	183_K	1.419	1.00
150_L	207_L	1.398	1.00
165_H	208_I	1.395	1.00
165_H	170_F	1.395	1.00
160_F	181_L	1.363	1.00
71_Y	74_D	1.361	1.00
194_Y	198_K	1.346	1.00
7_I	122_V	1.332	1.00
178_L	195_H	1.327	1.00
32_S	46_L	1.326	1.00
124_H	127_E	1.287	0.99
160_F	187_I	1.275	0.99
167_Q	176_K	1.264	0.99
17_W	21_T	1.264	0.99
195_H	202_S	1.256	0.99
52_S	56_I	1.253	0.99
204_L	208_I	1.228	0.99
203_L	207_L	1.226	0.99
191_T	194_Y	1.220	0.99
191_T	199_S	1.219	0.99
71_Y	76_D	1.206	0.99
168_G	175_R	1.203	0.99
129_L	134_N	1.200	0.99
170_F	196_I	1.176	0.99
160_F	192_L	1.169	0.99
49_G	77_S	1.144	0.99
172_Y	194_Y	1.144	0.99
78_F	81_D	1.141	0.98
22_E	110_I	1.118	0.98
153_L	199_S	1.114	0.98
190_N	194_Y	1.113	0.98
169_L	174_K	1.107	0.98
172_Y	190_N	1.082	0.98
156_R	194_Y	1.070	0.98
30_L	48_L	1.064	0.98
201_S	205_E	1.054	0.97
54_N	58_E	1.047	0.97
182_S	192_L	1.044	0.97
172_Y	195_H	1.033	0.97
83_I	189_P	1.026	0.97
169_L	178_L	1.024	0.97
97_T	128_K	1.004	0.97
104_H	170_F	1.002	0.97
170_F	178_L	1.000	0.97
179_L	189_P	0.996	0.96
160_F	199_S	0.996	0.96
178_L	189_P	0.993	0.96
157_N	202_S	0.980	0.96
181_L	185_L	0.973	0.96
123_S	126_L	0.969	0.96
74_D	124_H	0.968	0.96
191_T	196_I	0.967	0.96
70_L	74_D	0.966	0.96
15_D	187_I	0.959	0.96
185_L	192_L	0.951	0.95
172_Y	201_S	0.945	0.95
163_I	185_L	0.927	0.95
52_S	78_F	0.923	0.95
64_G	154_T	0.914	0.94
196_I	200_E	0.912	0.94
172_Y	179_L	0.909	0.94
140_E	144_K	0.906	0.94
116_I	170_F	0.892	0.94
101_V	115_I	0.891	0.93
92_S	96_D	0.891	0.93
145_K	166_K	0.873	0.93
106_I	111_E	0.864	0.92
73_L	187_I	0.855	0.92
66_K	69_K	0.853	0.92
162_K	166_K	0.849	0.92
9_A	126_L	0.842	0.91
188_K	197_R	0.835	0.91
152_K	206_I	0.822	0.90
67_I	70_L	0.816	0.90
87_Y	124_H	0.810	0.90
16_C	19_E	0.802	0.89
178_L	191_T	0.802	0.89
135_L	138_F	0.800	0.89
89_S	92_S	0.796	0.89
98_N	128_K	0.792	0.89
203_L	206_I	0.791	0.89
49_G	54_N	0.790	0.89
99_S	103_S	0.790	0.89
161_L	208_I	0.788	0.88
85_P	88_N	0.778	0.88
171_D	201_S	0.774	0.88
140_E	143_L	0.773	0.88
7_I	10_D	0.761	0.87
12_V	202_S	0.758	0.86
151_D	207_L	0.758	0.86
48_L	58_E	0.754	0.86
93_L	125_I	0.753	0.86
172_Y	197_R	0.751	0.86
126_L	136_I	0.747	0.86
130_E	187_I	0.746	0.86
121_M	124_H	0.743	0.85
107_V	110_I	0.741	0.85
101_V	124_H	0.735	0.85
159_S	162_K	0.735	0.85
117_A	170_F	0.731	0.84
159_S	163_I	0.726	0.84
179_L	197_R	0.725	0.84
91_S	192_L	0.724	0.84
66_K	175_R	0.722	0.84
105_R	112_K	0.722	0.84
126_L	191_T	0.721	0.84
136_I	142_N	0.720	0.84
115_I	119_S	0.719	0.83
51_D	108_D	0.719	0.83
16_C	111_E	0.716	0.83
14_P	17_W	0.712	0.83
43_S	83_I	0.712	0.83
40_F	171_D	0.711	0.83
90_V	94_F	0.710	0.83
31_L	34_Q	0.709	0.83
189_P	198_K	0.708	0.83
127_E	131_N	0.706	0.82
54_N	183_K	0.702	0.82
191_T	207_L	0.701	0.82
100_I	116_I	0.700	0.82
199_S	204_L	0.696	0.81
11_L	16_C	0.695	0.81
156_R	200_E	0.693	0.81
16_C	22_E	0.693	0.81
72_C	77_S	0.692	0.81
139_K	142_N	0.689	0.81
17_W	20_R	0.689	0.81
129_L	133_T	0.688	0.81
125_I	189_P	0.685	0.80
20_R	64_G	0.685	0.80
136_I	139_K	0.684	0.80
43_S	110_I	0.675	0.79
87_Y	101_V	0.674	0.79
104_H	117_A	0.671	0.79
70_L	86_R	0.671	0.79
98_N	118_S	0.671	0.79
26_V	30_L	0.670	0.79
99_S	102_I	0.668	0.79
102_I	177_T	0.667	0.79
163_I	184_E	0.664	0.78
55_L	143_L	0.664	0.78
91_S	199_S	0.663	0.78
7_I	11_L	0.658	0.78
71_Y	119_S	0.657	0.78
10_D	137_D	0.654	0.77
92_S	98_N	0.654	0.77
36_S	39_K	0.654	0.77
38_D	124_H	0.652	0.77
162_K	208_I	0.651	0.77
47_I	126_L	0.645	0.76
167_Q	192_L	0.645	0.76
27_N	33_Q	0.644	0.76
145_K	148_R	0.644	0.76
36_S	124_H	0.643	0.76
95_Y	181_L	0.640	0.76
13_H	16_C	0.640	0.76
124_H	175_R	0.639	0.76
59_L	198_K	0.638	0.76
198_K	201_S	0.637	0.75
31_L	205_E	0.637	0.75
112_K	184_E	0.633	0.75
45_V	104_H	0.627	0.74
93_L	96_D	0.625	0.74
125_I	194_Y	0.624	0.74
161_L	200_E	0.623	0.74
13_H	18_T	0.622	0.74
22_E	95_Y	0.618	0.73
32_S	116_I	0.618	0.73
69_K	176_K	0.617	0.73
158_L	207_L	0.617	0.73
138_F	141_I	0.615	0.73
169_L	203_L	0.614	0.73
159_S	192_L	0.611	0.72
170_F	199_S	0.609	0.72
38_D	125_I	0.608	0.72
53_R	57_D	0.608	0.72
120_S	134_N	0.608	0.72
91_S	101_V	0.605	0.72
176_K	192_L	0.601	0.71
144_K	201_S	0.598	0.71
34_Q	199_S	0.594	0.70
28_V	59_L	0.592	0.70
13_H	17_W	0.591	0.70
103_S	170_F	0.590	0.70
9_A	136_I	0.589	0.70
144_K	148_R	0.588	0.69
36_S	122_V	0.586	0.69
17_W	189_P	0.584	0.69
119_S	205_E	0.579	0.68
169_L	194_Y	0.576	0.68
11_L	124_H	0.575	0.68
119_S	146_L	0.574	0.68
67_I	186_G	0.571	0.67
64_G	200_E	0.570	0.67
163_I	176_K	0.570	0.67
198_K	203_L	0.567	0.67
18_T	111_E	0.565	0.66
71_Y	108_D	0.565	0.66
30_L	39_K	0.564	0.66
77_S	80_M	0.564	0.66
64_G	102_I	0.564	0.66
35_F	170_F	0.563	0.66
82_F	172_Y	0.563	0.66
32_S	45_V	0.562	0.66
15_D	46_L	0.561	0.66
21_T	28_V	0.561	0.66
25_L	78_F	0.561	0.66
59_L	67_I	0.559	0.66
120_S	159_S	0.557	0.65
140_E	154_T	0.557	0.65
152_K	205_E	0.555	0.65
8_S	112_K	0.555	0.65
136_I	141_I	0.552	0.65
33_Q	100_I	0.551	0.65
181_L	186_G	0.550	0.64
187_I	190_N	0.550	0.64
165_H	204_L	0.550	0.64
91_S	94_F	0.547	0.64
133_T	191_T	0.547	0.64
44_K	85_P	0.543	0.63
30_L	198_K	0.541	0.63
16_C	90_V	0.541	0.63
54_N	57_D	0.541	0.63
177_T	192_L	0.538	0.63
12_V	19_E	0.538	0.63
57_D	61_N	0.537	0.63
81_D	187_I	0.537	0.63
15_D	112_K	0.536	0.62
147_E	171_D	0.536	0.62
16_C	113_W	0.536	0.62
169_L	196_I	0.535	0.62
43_S	100_I	0.534	0.62
69_K	74_D	0.534	0.62
77_S	155_D	0.534	0.62
89_S	125_I	0.533	0.62
134_N	198_K	0.532	0.62
25_L	61_N	0.531	0.62
88_N	125_I	0.531	0.62
168_G	193_L	0.527	0.61
130_E	133_T	0.526	0.61
185_L	193_L	0.525	0.61
16_C	42_V	0.525	0.61
191_T	198_K	0.521	0.60
142_N	209_D	0.521	0.60
46_L	209_D	0.515	0.59
168_G	171_D	0.510	0.59
149_L	198_K	0.509	0.58
122_V	159_S	0.505	0.58
111_E	195_H	0.504	0.58
102_I	209_D	0.502	0.57
30_L	78_F	0.502	0.57
25_L	55_L	0.501	0.57
41_F	75_E	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ku3A	1	0.2837	97.7	0.835	Contact Map
4wszA	2	0.2651	97.7	0.836	Contact Map
2rnjA	1	0.2651	97.4	0.844	Contact Map
1s7oA	3	0.3442	97.4	0.845	Contact Map
1x3uA	1	0.3163	97.3	0.846	Contact Map
1je8A	2	0.2698	97.3	0.847	Contact Map
2o8xA	7	0.2837	97.3	0.847	Contact Map
3c57A	2	0.2372	97.3	0.848	Contact Map
1xsvA	2	0.3395	97.3	0.848	Contact Map
3t72q	1	0.3674	97.2	0.849	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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