GREMLIN Database
Q97Y14 - Uncharacterized protein
UniProt: Q97Y14 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 215 (200)
Sequences: 1909 (1552)
Seq/√Len: 109.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_K181_L4.1671.00
170_F200_E3.9931.00
163_I167_Q3.9061.00
94_F99_S3.7361.00
160_F185_L3.1901.00
191_T195_H3.1541.00
167_Q181_L3.1271.00
99_S117_A3.1181.00
188_K191_T3.0001.00
167_Q184_E2.9191.00
171_D175_R2.8711.00
165_H205_E2.8171.00
156_R195_H2.7991.00
176_K180_S2.7821.00
163_I181_L2.6851.00
137_D140_E2.6041.00
177_T180_S2.5871.00
22_E109_G2.4041.00
178_L192_L2.3351.00
156_R160_F2.3051.00
172_Y193_L2.1861.00
46_L82_F2.1711.00
10_D110_I2.1571.00
187_I192_L2.0481.00
156_R159_S2.0281.00
56_I80_M1.8891.00
178_L193_L1.8831.00
158_L162_K1.8431.00
136_I140_E1.8081.00
189_P193_L1.7991.00
51_D54_N1.7751.00
102_I116_I1.7601.00
161_L204_L1.7231.00
48_L55_L1.7101.00
160_F195_H1.6711.00
21_T62_F1.5941.00
141_I144_K1.5471.00
195_H198_K1.5391.00
33_Q47_I1.5291.00
176_K184_E1.5201.00
181_L192_L1.5051.00
204_L207_L1.4991.00
161_L170_F1.4971.00
52_S55_L1.4651.00
9_A115_I1.4541.00
174_K197_R1.4461.00
183_K186_G1.4231.00
180_S183_K1.4191.00
150_L207_L1.3981.00
165_H208_I1.3951.00
165_H170_F1.3951.00
160_F181_L1.3631.00
71_Y74_D1.3611.00
194_Y198_K1.3461.00
7_I122_V1.3321.00
178_L195_H1.3271.00
32_S46_L1.3261.00
124_H127_E1.2870.99
160_F187_I1.2750.99
167_Q176_K1.2640.99
17_W21_T1.2640.99
195_H202_S1.2560.99
52_S56_I1.2530.99
204_L208_I1.2280.99
203_L207_L1.2260.99
191_T194_Y1.2200.99
191_T199_S1.2190.99
71_Y76_D1.2060.99
168_G175_R1.2030.99
129_L134_N1.2000.99
170_F196_I1.1760.99
160_F192_L1.1690.99
49_G77_S1.1440.99
172_Y194_Y1.1440.99
78_F81_D1.1410.98
22_E110_I1.1180.98
153_L199_S1.1140.98
190_N194_Y1.1130.98
169_L174_K1.1070.98
172_Y190_N1.0820.98
156_R194_Y1.0700.98
30_L48_L1.0640.98
201_S205_E1.0540.97
54_N58_E1.0470.97
182_S192_L1.0440.97
172_Y195_H1.0330.97
83_I189_P1.0260.97
169_L178_L1.0240.97
97_T128_K1.0040.97
104_H170_F1.0020.97
170_F178_L1.0000.97
179_L189_P0.9960.96
160_F199_S0.9960.96
178_L189_P0.9930.96
157_N202_S0.9800.96
181_L185_L0.9730.96
123_S126_L0.9690.96
74_D124_H0.9680.96
191_T196_I0.9670.96
70_L74_D0.9660.96
15_D187_I0.9590.96
185_L192_L0.9510.95
172_Y201_S0.9450.95
163_I185_L0.9270.95
52_S78_F0.9230.95
64_G154_T0.9140.94
196_I200_E0.9120.94
172_Y179_L0.9090.94
140_E144_K0.9060.94
116_I170_F0.8920.94
101_V115_I0.8910.93
92_S96_D0.8910.93
145_K166_K0.8730.93
106_I111_E0.8640.92
73_L187_I0.8550.92
66_K69_K0.8530.92
162_K166_K0.8490.92
9_A126_L0.8420.91
188_K197_R0.8350.91
152_K206_I0.8220.90
67_I70_L0.8160.90
87_Y124_H0.8100.90
16_C19_E0.8020.89
178_L191_T0.8020.89
135_L138_F0.8000.89
89_S92_S0.7960.89
98_N128_K0.7920.89
203_L206_I0.7910.89
49_G54_N0.7900.89
99_S103_S0.7900.89
161_L208_I0.7880.88
85_P88_N0.7780.88
171_D201_S0.7740.88
140_E143_L0.7730.88
7_I10_D0.7610.87
12_V202_S0.7580.86
151_D207_L0.7580.86
48_L58_E0.7540.86
93_L125_I0.7530.86
172_Y197_R0.7510.86
126_L136_I0.7470.86
130_E187_I0.7460.86
121_M124_H0.7430.85
107_V110_I0.7410.85
101_V124_H0.7350.85
159_S162_K0.7350.85
117_A170_F0.7310.84
159_S163_I0.7260.84
179_L197_R0.7250.84
91_S192_L0.7240.84
66_K175_R0.7220.84
105_R112_K0.7220.84
126_L191_T0.7210.84
136_I142_N0.7200.84
115_I119_S0.7190.83
51_D108_D0.7190.83
16_C111_E0.7160.83
14_P17_W0.7120.83
43_S83_I0.7120.83
40_F171_D0.7110.83
90_V94_F0.7100.83
31_L34_Q0.7090.83
189_P198_K0.7080.83
127_E131_N0.7060.82
54_N183_K0.7020.82
191_T207_L0.7010.82
100_I116_I0.7000.82
199_S204_L0.6960.81
11_L16_C0.6950.81
156_R200_E0.6930.81
16_C22_E0.6930.81
72_C77_S0.6920.81
139_K142_N0.6890.81
17_W20_R0.6890.81
129_L133_T0.6880.81
125_I189_P0.6850.80
20_R64_G0.6850.80
136_I139_K0.6840.80
43_S110_I0.6750.79
87_Y101_V0.6740.79
104_H117_A0.6710.79
70_L86_R0.6710.79
98_N118_S0.6710.79
26_V30_L0.6700.79
99_S102_I0.6680.79
102_I177_T0.6670.79
163_I184_E0.6640.78
55_L143_L0.6640.78
91_S199_S0.6630.78
7_I11_L0.6580.78
71_Y119_S0.6570.78
10_D137_D0.6540.77
92_S98_N0.6540.77
36_S39_K0.6540.77
38_D124_H0.6520.77
162_K208_I0.6510.77
47_I126_L0.6450.76
167_Q192_L0.6450.76
27_N33_Q0.6440.76
145_K148_R0.6440.76
36_S124_H0.6430.76
95_Y181_L0.6400.76
13_H16_C0.6400.76
124_H175_R0.6390.76
59_L198_K0.6380.76
198_K201_S0.6370.75
31_L205_E0.6370.75
112_K184_E0.6330.75
45_V104_H0.6270.74
93_L96_D0.6250.74
125_I194_Y0.6240.74
161_L200_E0.6230.74
13_H18_T0.6220.74
22_E95_Y0.6180.73
32_S116_I0.6180.73
69_K176_K0.6170.73
158_L207_L0.6170.73
138_F141_I0.6150.73
169_L203_L0.6140.73
159_S192_L0.6110.72
170_F199_S0.6090.72
38_D125_I0.6080.72
53_R57_D0.6080.72
120_S134_N0.6080.72
91_S101_V0.6050.72
176_K192_L0.6010.71
144_K201_S0.5980.71
34_Q199_S0.5940.70
28_V59_L0.5920.70
13_H17_W0.5910.70
103_S170_F0.5900.70
9_A136_I0.5890.70
144_K148_R0.5880.69
36_S122_V0.5860.69
17_W189_P0.5840.69
119_S205_E0.5790.68
169_L194_Y0.5760.68
11_L124_H0.5750.68
119_S146_L0.5740.68
67_I186_G0.5710.67
64_G200_E0.5700.67
163_I176_K0.5700.67
198_K203_L0.5670.67
18_T111_E0.5650.66
71_Y108_D0.5650.66
30_L39_K0.5640.66
77_S80_M0.5640.66
64_G102_I0.5640.66
35_F170_F0.5630.66
82_F172_Y0.5630.66
32_S45_V0.5620.66
15_D46_L0.5610.66
21_T28_V0.5610.66
25_L78_F0.5610.66
59_L67_I0.5590.66
120_S159_S0.5570.65
140_E154_T0.5570.65
152_K205_E0.5550.65
8_S112_K0.5550.65
136_I141_I0.5520.65
33_Q100_I0.5510.65
181_L186_G0.5500.64
187_I190_N0.5500.64
165_H204_L0.5500.64
91_S94_F0.5470.64
133_T191_T0.5470.64
44_K85_P0.5430.63
30_L198_K0.5410.63
16_C90_V0.5410.63
54_N57_D0.5410.63
177_T192_L0.5380.63
12_V19_E0.5380.63
57_D61_N0.5370.63
81_D187_I0.5370.63
15_D112_K0.5360.62
147_E171_D0.5360.62
16_C113_W0.5360.62
169_L196_I0.5350.62
43_S100_I0.5340.62
69_K74_D0.5340.62
77_S155_D0.5340.62
89_S125_I0.5330.62
134_N198_K0.5320.62
25_L61_N0.5310.62
88_N125_I0.5310.62
168_G193_L0.5270.61
130_E133_T0.5260.61
185_L193_L0.5250.61
16_C42_V0.5250.61
191_T198_K0.5210.60
142_N209_D0.5210.60
46_L209_D0.5150.59
168_G171_D0.5100.59
149_L198_K0.5090.58
122_V159_S0.5050.58
111_E195_H0.5040.58
102_I209_D0.5020.57
30_L78_F0.5020.57
25_L55_L0.5010.57
41_F75_E0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ku3A 1 0.2837 97.7 0.835 Contact Map
4wszA 2 0.2651 97.7 0.836 Contact Map
2rnjA 1 0.2651 97.4 0.844 Contact Map
1s7oA 3 0.3442 97.4 0.845 Contact Map
1x3uA 1 0.3163 97.3 0.846 Contact Map
1je8A 2 0.2698 97.3 0.847 Contact Map
2o8xA 7 0.2837 97.3 0.847 Contact Map
3c57A 2 0.2372 97.3 0.848 Contact Map
1xsvA 2 0.3395 97.3 0.848 Contact Map
3t72q 1 0.3674 97.2 0.849 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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