GREMLIN Database
Q97Y13 - Uncharacterized protein
UniProt: Q97Y13 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (223)
Sequences: 4584 (3364)
Seq/√Len: 225.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_I192_L5.7061.00
50_E55_V4.5631.00
133_E137_K4.0141.00
105_F130_I3.6861.00
133_E168_S3.5571.00
58_F109_S3.2131.00
128_D165_V2.9281.00
54_G105_F2.7501.00
132_H191_I2.7291.00
227_N230_E2.6731.00
99_K102_D2.6721.00
54_G104_H2.4731.00
55_V103_I2.3451.00
183_I190_S2.1601.00
55_V98_Y2.0961.00
179_E196_R2.0631.00
190_S207_G2.0221.00
173_E177_G2.0181.00
194_K202_N2.0061.00
94_K99_K2.0051.00
105_F128_D1.9931.00
58_F193_L1.9421.00
50_E98_Y1.9411.00
180_L193_L1.9391.00
184_G234_R1.9171.00
108_L119_L1.9141.00
107_I193_L1.8711.00
241_M245_P1.8611.00
196_R202_N1.8601.00
101_E123_K1.8511.00
173_E176_P1.8291.00
230_E233_T1.7741.00
109_S193_L1.7641.00
155_D159_L1.7571.00
55_V104_H1.7511.00
181_L194_K1.7451.00
178_V195_V1.7371.00
49_I58_F1.6721.00
209_F238_L1.6391.00
98_Y102_D1.5811.00
56_I105_F1.5761.00
135_E187_T1.5321.00
194_K204_I1.5281.00
179_E194_K1.5181.00
57_L103_I1.5151.00
91_N94_K1.4951.00
56_I178_V1.4651.00
236_R240_S1.4631.00
7_Y50_E1.4601.00
240_S244_L1.4491.00
242_Q249_I1.4401.00
90_E100_P1.4341.00
180_L191_I1.4101.00
233_T237_L1.4061.00
125_S128_D1.4001.00
194_K241_M1.3971.00
192_L204_I1.3921.00
198_Q201_N1.3781.00
156_L159_L1.3731.00
136_L166_P1.3661.00
6_I203_Y1.3601.00
119_L129_V1.3531.00
106_I129_V1.3501.00
48_V103_I1.3491.00
136_L140_L1.3491.00
111_L131_V1.3431.00
58_F205_F1.3361.00
109_S207_G1.3351.00
93_L98_Y1.3141.00
55_V102_D1.3081.00
153_L157_E1.3011.00
48_V98_Y1.2971.00
197_T201_N1.2921.00
101_E124_N1.2691.00
51_H54_G1.2561.00
155_D158_I1.2381.00
48_V57_L1.2341.00
157_E160_R1.2271.00
51_H56_I1.2071.00
51_H177_G1.1991.00
206_T249_I1.1911.00
201_N248_N1.1861.00
167_M191_I1.1411.00
9_L48_V1.1331.00
9_L92_Q1.1281.00
183_I234_R1.1271.00
137_K141_L1.1081.00
171_Y179_E1.1061.00
135_E139_A1.0861.00
92_Q95_K1.0821.00
94_K100_P1.0691.00
138_Y188_P1.0641.00
111_L116_T1.0441.00
181_L192_L1.0421.00
90_E121_L1.0361.00
232_Y236_R1.0351.00
47_A250_I1.0291.00
181_L204_I1.0251.00
205_F250_I1.0211.00
57_L60_T1.0131.00
58_F107_I1.0131.00
47_A205_F1.0101.00
130_I167_M1.0101.00
219_E236_R1.0011.00
15_S41_D1.0011.00
237_L241_M0.9971.00
233_T236_R0.9961.00
225_L235_I0.9931.00
60_T119_L0.9891.00
151_Y155_D0.9771.00
111_L139_A0.9761.00
106_I119_L0.9751.00
55_V93_L0.9751.00
49_I178_V0.9751.00
64_D91_N0.9741.00
192_L209_F0.9701.00
103_I122_F0.9701.00
154_R157_E0.9691.00
241_M247_T0.9651.00
130_I165_V0.9641.00
88_K91_N0.9621.00
202_N247_T0.9621.00
152_L156_L0.9551.00
151_Y159_L0.9481.00
49_I56_I0.9471.00
18_L23_P0.9451.00
221_K232_Y0.9431.00
181_L241_M0.9421.00
210_I251_I0.9371.00
204_I247_T0.9361.00
13_K41_D0.9231.00
242_Q247_T0.9181.00
85_E91_N0.9110.99
87_N95_K0.9080.99
48_V55_V0.9020.99
151_Y156_L0.8940.99
240_S243_K0.8920.99
118_S121_L0.8900.99
171_Y182_L0.8870.99
8_L45_M0.8850.99
206_T251_I0.8820.99
122_F125_S0.8680.99
184_G230_E0.8660.99
106_I122_F0.8650.99
87_N91_N0.8620.99
9_L96_I0.8590.99
192_L238_L0.8590.99
225_L228_A0.8590.99
209_F234_R0.8290.99
235_I239_K0.8270.99
153_L158_I0.8200.99
196_R200_D0.8150.99
105_F175_L0.8140.99
143_L146_N0.8110.99
8_L47_A0.8100.99
219_E239_K0.8100.99
231_Y235_I0.8100.99
65_N68_G0.8030.99
35_K38_N0.7940.99
48_V96_I0.7930.99
63_P118_S0.7870.98
134_K137_K0.7870.98
155_D160_R0.7870.98
167_M180_L0.7860.98
18_L22_L0.7850.98
212_V215_E0.7790.98
197_T200_D0.7710.98
150_P153_L0.7680.98
174_I177_G0.7660.98
15_S39_W0.7620.98
237_L240_S0.7610.98
17_D38_N0.7590.98
154_R158_I0.7570.98
108_L129_V0.7480.98
112_H115_H0.7470.98
107_I191_I0.7470.98
192_L234_R0.7450.98
153_L159_L0.7440.98
206_T210_I0.7350.98
100_P121_L0.7280.97
46_S89_M0.7270.97
111_L135_E0.7260.97
202_N245_P0.7260.97
203_Y250_I0.7260.97
171_Y177_G0.7210.97
195_V205_F0.7180.97
236_R239_K0.7170.97
134_K168_S0.7150.97
229_E233_T0.7140.97
144_W147_K0.7130.97
57_L106_I0.7120.97
205_F252_S0.7070.97
228_A232_Y0.7050.97
194_K247_T0.7050.97
120_E123_K0.6990.97
142_N145_L0.6960.97
20_W23_P0.6950.97
211_H216_L0.6930.97
137_K140_L0.6900.96
124_N128_D0.6900.96
93_L103_I0.6880.96
58_F207_G0.6880.96
229_E232_Y0.6850.96
108_L116_T0.6810.96
204_I242_Q0.6800.96
56_I107_I0.6800.96
12_G61_G0.6790.96
131_V136_L0.6780.96
103_I128_D0.6750.96
173_E179_E0.6750.96
107_I178_V0.6750.96
7_Y96_I0.6740.96
135_E189_G0.6730.96
18_L38_N0.6710.96
161_E164_I0.6700.96
16_A20_W0.6680.96
170_E182_L0.6670.96
178_V193_L0.6640.96
204_I238_L0.6630.96
17_D20_W0.6610.96
153_L156_L0.6600.95
19_A25_P0.6600.95
61_G108_L0.6560.95
172_L177_G0.6520.95
168_S172_L0.6460.95
21_F24_N0.6460.95
194_K245_P0.6420.95
206_T252_S0.6400.95
62_I66_V0.6390.95
152_L158_I0.6370.95
10_D13_K0.6360.95
230_E234_R0.6340.94
210_I215_E0.6330.94
131_V166_P0.6330.94
90_E94_K0.6320.94
173_E196_R0.6300.94
172_L175_L0.6300.94
177_G196_R0.6280.94
133_E166_P0.6250.94
60_T118_S0.6240.94
225_L231_Y0.6240.94
214_E218_F0.6230.94
172_L180_L0.6230.94
134_K184_G0.6220.94
16_A21_F0.6200.94
22_L25_P0.6200.94
156_L160_R0.6190.94
54_G175_L0.6160.94
47_A203_Y0.6130.93
16_A19_A0.6130.93
19_A23_P0.6130.93
68_G85_E0.6130.93
59_D253_H0.6120.93
142_N146_N0.6120.93
151_Y154_R0.6090.93
17_D21_F0.6070.93
132_H182_L0.6060.93
108_L111_L0.6060.93
131_V164_I0.6050.93
116_T119_L0.6010.93
47_A252_S0.6010.93
162_M166_P0.5960.92
152_L155_D0.5950.92
100_P125_S0.5940.92
181_L237_L0.5920.92
17_D24_N0.5890.92
63_P225_L0.5870.92
121_L129_V0.5870.92
17_D22_L0.5870.92
241_M246_R0.5850.92
97_G102_D0.5840.92
86_E91_N0.5840.92
10_D87_N0.5810.91
103_I125_S0.5790.91
91_N95_K0.5770.91
15_S21_F0.5760.91
211_H223_W0.5760.91
213_P216_L0.5730.91
47_A58_F0.5720.91
9_L12_G0.5720.91
8_L11_H0.5710.91
10_D88_K0.5710.91
9_L98_Y0.5690.91
152_L159_L0.5680.90
230_E237_L0.5680.90
114_D253_H0.5670.90
136_L160_R0.5660.90
218_F239_K0.5640.90
213_P254_D0.5620.90
188_P227_N0.5600.90
43_S211_H0.5590.90
60_T117_G0.5580.90
57_L93_L0.5550.89
197_T203_Y0.5540.89
61_G107_I0.5530.89
93_L96_I0.5510.89
18_L21_F0.5510.89
210_I254_D0.5500.89
198_Q202_N0.5500.89
48_V102_D0.5470.89
101_E128_D0.5470.89
64_D88_K0.5460.89
156_L213_P0.5430.88
222_G225_L0.5410.88
44_V86_E0.5370.88
113_L117_G0.5340.88
219_E232_Y0.5320.87
209_F226_G0.5320.87
203_Y248_N0.5300.87
151_Y158_I0.5280.87
16_A66_V0.5270.87
130_I180_L0.5260.87
174_I180_L0.5240.87
60_T108_L0.5230.87
135_E138_Y0.5220.86
206_T209_F0.5210.86
251_I254_D0.5200.86
153_L160_R0.5200.86
34_P246_R0.5200.86
183_I207_G0.5170.86
44_V62_I0.5170.86
215_E231_Y0.5150.86
19_A22_L0.5130.85
171_Y237_L0.5110.85
8_L250_I0.5090.85
152_L157_E0.5080.85
56_I175_L0.5060.85
200_D240_S0.5040.84
105_F125_S0.5040.84
135_E190_S0.5030.84
172_L176_P0.5010.84
223_W228_A0.5000.84
42_V212_V0.5000.84
18_L40_V0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3aj3A 2 0.9294 100 0.349 Contact Map
3dhaA 1 0.9182 100 0.365 Contact Map
2r2dA 5 0.9814 100 0.368 Contact Map
4le6A 4 0.7918 100 0.386 Contact Map
4zo2A 2 0.9219 100 0.402 Contact Map
3eshA 5 0.9554 100 0.406 Contact Map
1p9eA 3 0.9257 100 0.415 Contact Map
2zo4A 1 0.8141 100 0.506 Contact Map
1ztcA 4 0.7323 100 0.524 Contact Map
2cfuA 2 0.8959 100 0.535 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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