GREMLIN Database
Q97Y10 - Uncharacterized protein
UniProt: Q97Y10 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 282 (265)
Sequences: 1748 (1142)
Seq/√Len: 70.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_I177_V4.6871.00
75_R78_D4.0421.00
135_I279_S3.9441.00
2_K173_G3.3481.00
27_S253_I3.0921.00
210_G273_S3.0831.00
85_F116_M2.8791.00
86_E123_Y2.8411.00
44_A106_S2.8361.00
35_G224_C2.6271.00
14_T142_R2.6201.00
13_Y121_W2.5891.00
227_A252_T2.5111.00
171_K215_N2.4611.00
12_G138_Y2.2991.00
226_V265_V2.2981.00
62_N89_V2.2931.00
118_T121_W2.2851.00
24_V65_V2.2491.00
82_M119_P2.1171.00
178_V280_I2.1171.00
25_I211_V2.1121.00
83_K126_M2.0531.00
250_V273_S2.0521.00
52_R224_C2.0491.00
120_D124_N2.0381.00
174_V212_V2.0221.00
229_S266_I2.0201.00
166_E169_N2.0151.00
9_K28_E1.9691.00
45_T49_D1.9671.00
54_K224_C1.9641.00
216_S265_V1.9281.00
174_V273_S1.9121.00
5_I171_K1.8491.00
124_N128_N1.8151.00
219_N222_D1.7961.00
176_S210_G1.7481.00
83_K87_L1.7211.00
28_E31_N1.7061.00
12_G158_S1.6841.00
8_I255_T1.6751.00
190_E193_V1.6550.99
184_I238_I1.6500.99
65_V76_V1.6440.99
212_V269_T1.5950.99
75_R79_A1.5930.99
45_T103_V1.5750.99
233_G270_Y1.5710.99
176_S273_S1.5710.99
210_G250_V1.5670.99
92_K95_Q1.5650.99
208_T277_V1.5390.99
36_I48_T1.5380.99
174_V272_A1.5160.99
234_F277_V1.4960.99
133_I160_Q1.4930.99
218_L226_V1.4900.99
65_V80_V1.4870.99
65_V122_G1.4710.99
124_N127_S1.4660.99
217_K259_E1.4650.99
232_N242_N1.4620.99
105_A251_F1.4570.99
146_V180_S1.4250.98
218_L265_V1.4250.98
67_T106_S1.4160.98
158_S175_I1.4110.98
18_S115_I1.3820.98
82_M123_Y1.3680.98
83_K127_S1.3510.98
147_G180_S1.3380.98
178_V208_T1.3370.98
35_G223_A1.3300.98
234_F273_S1.3220.97
77_V104_S1.3190.97
83_K123_Y1.3160.97
14_T138_Y1.3150.97
103_V209_L1.2870.97
38_Q49_D1.2820.97
75_R119_P1.2810.97
30_E257_E1.2690.97
123_Y126_M1.2640.97
170_L216_S1.2630.97
13_Y124_N1.2600.97
232_N235_S1.2600.97
71_V81_L1.2540.96
10_V213_I1.2450.96
162_Y213_I1.2380.96
236_S270_Y1.2380.96
140_A177_V1.2370.96
146_V178_V1.2310.96
225_R228_S1.2260.96
72_F98_K1.2230.96
19_K142_R1.2110.96
24_V126_M1.2090.96
223_A254_A1.2040.96
49_D52_R1.1970.95
231_E242_N1.1940.95
68_G112_D1.1740.95
28_E32_N1.1680.95
8_I27_S1.1680.95
8_I213_I1.1650.95
87_L126_M1.1640.95
10_V175_I1.1590.94
6_N171_K1.1460.94
39_R231_E1.1450.94
24_V80_V1.1410.94
212_V230_A1.1320.94
56_R244_S1.1310.94
158_S161_G1.1280.94
14_T121_W1.1230.94
48_T100_P1.1050.93
5_I213_I1.0990.93
105_A177_V1.0940.93
78_D119_P1.0870.92
244_S263_D1.0850.92
223_A252_T1.0850.92
185_Y267_A1.0850.92
88_G91_F1.0700.92
50_L101_I1.0630.92
170_L215_N1.0590.91
123_Y127_S1.0570.91
73_G77_V1.0530.91
61_V253_I1.0520.91
35_G220_N1.0440.91
158_S177_V1.0350.90
39_R242_N1.0230.90
26_L126_M1.0210.90
83_K86_E1.0180.90
66_L209_L1.0140.89
12_G133_I1.0100.89
172_I265_V1.0080.89
189_G193_V1.0040.89
135_I160_Q1.0040.89
186_D190_E0.9890.88
12_G134_P0.9870.88
210_G234_F0.9840.88
47_G50_L0.9750.88
14_T134_P0.9730.87
147_G240_P0.9720.87
119_P123_Y0.9680.87
191_L194_G0.9670.87
60_S101_I0.9640.87
26_L83_K0.9620.87
215_N258_M0.9580.87
170_L217_K0.9550.86
181_I245_L0.9540.86
58_N101_I0.9410.86
34_A61_V0.9350.85
226_V269_T0.9350.85
189_G194_G0.9320.85
82_M115_I0.9300.85
37_S228_S0.9300.85
8_I253_I0.9280.85
135_I275_E0.9250.85
56_R245_L0.9230.85
213_I253_I0.9220.84
91_F95_Q0.9200.84
219_N223_A0.9200.84
22_V117_P0.9170.84
3_I8_I0.9140.84
22_V65_V0.9130.84
79_A119_P0.9060.83
175_I211_V0.9000.83
18_S116_M0.8960.83
152_I161_G0.8960.83
5_I173_G0.8900.82
144_A177_V0.8880.82
25_I253_I0.8840.82
64_I253_I0.8790.82
97_L113_N0.8790.82
22_V27_S0.8660.81
33_T223_A0.8630.80
194_G278_L0.8620.80
36_I51_L0.8550.80
176_S250_V0.8470.79
64_I211_V0.8460.79
225_R244_S0.8410.79
27_S32_N0.8410.79
10_V23_T0.8380.78
230_A273_S0.8380.78
93_I108_F0.8350.78
186_D189_G0.8280.77
225_R229_S0.8280.77
92_K98_K0.8280.77
51_L249_T0.8260.77
218_L223_A0.8210.77
49_D55_H0.8160.76
152_I160_Q0.8140.76
230_A233_G0.8130.76
93_I99_I0.8090.76
45_T105_A0.8070.76
77_V100_P0.8060.76
232_N270_Y0.8050.75
36_I49_D0.8020.75
73_G100_P0.8010.75
209_L250_V0.7990.75
78_D81_L0.7970.75
275_E279_S0.7960.75
267_A271_E0.7940.74
3_I135_I0.7910.74
268_L272_A0.7880.74
13_Y79_A0.7810.73
230_A250_V0.7780.73
59_Q222_D0.7760.73
234_F241_Y0.7750.73
79_A126_M0.7730.72
82_M86_E0.7710.72
201_K204_T0.7710.72
27_S213_I0.7710.72
194_G274_R0.7690.72
146_V280_I0.7680.72
78_D82_M0.7660.72
137_R142_R0.7610.71
176_S208_T0.7610.71
55_H228_S0.7530.70
87_L127_S0.7510.70
211_V253_I0.7510.70
145_T148_K0.7480.70
262_V266_I0.7440.70
85_F113_N0.7440.70
33_T219_N0.7440.70
37_S231_E0.7380.69
37_S250_V0.7360.69
224_C228_S0.7350.69
235_S241_Y0.7230.67
109_D145_T0.7220.67
26_L129_L0.7220.67
238_I241_Y0.7220.67
233_G237_V0.7190.67
48_T73_G0.7170.67
226_V266_I0.7130.66
187_E194_G0.7130.66
174_V269_T0.7120.66
182_G185_Y0.7120.66
6_N215_N0.7110.66
62_N100_P0.7100.66
165_I169_N0.7100.66
237_V274_R0.7040.65
222_D262_V0.7020.65
176_S252_T0.6970.65
2_K213_I0.6970.65
231_E250_V0.6970.65
147_G237_V0.6970.65
4_G162_Y0.6950.64
25_I175_I0.6940.64
162_Y173_G0.6920.64
103_V251_F0.6890.64
12_G175_I0.6860.63
10_V211_V0.6850.63
76_V102_V0.6830.63
133_I138_Y0.6820.63
71_V99_I0.6790.63
273_S276_S0.6790.63
32_N253_I0.6780.62
86_E126_M0.6740.62
65_V104_S0.6720.62
132_D173_G0.6720.62
84_L98_K0.6710.62
152_I162_Y0.6710.62
33_T220_N0.6680.61
229_S241_Y0.6650.61
131_Y134_P0.6620.61
2_K25_I0.6610.60
186_D193_V0.6580.60
237_V277_V0.6530.60
236_S274_R0.6530.60
240_P243_L0.6510.59
19_K111_Y0.6460.59
4_G10_V0.6460.59
172_I272_A0.6450.59
212_V273_S0.6450.59
266_I270_Y0.6440.58
109_D182_G0.6430.58
11_G125_A0.6390.58
171_K213_I0.6370.58
23_T175_I0.6350.57
34_A51_L0.6340.57
79_A122_G0.6340.57
3_I133_I0.6310.57
36_I251_F0.6300.57
22_V67_T0.6280.57
132_D236_S0.6280.57
137_R280_I0.6280.57
217_K257_E0.6260.56
213_I255_T0.6250.56
48_T251_F0.6230.56
152_I158_S0.6230.56
17_K124_N0.6220.56
79_A123_Y0.6190.55
168_N264_K0.6190.55
204_T243_L0.6170.55
10_V162_Y0.6150.55
4_G152_I0.6130.55
78_D115_I0.6130.55
217_K258_M0.6110.55
26_L32_N0.6100.54
134_P138_Y0.6090.54
174_V230_A0.6070.54
241_Y270_Y0.6060.54
72_F85_F0.6030.54
226_V262_V0.6030.54
108_F265_V0.5960.53
32_N60_S0.5950.53
46_L106_S0.5930.52
43_P47_G0.5920.52
90_G95_Q0.5910.52
88_G92_K0.5890.52
16_E142_R0.5890.52
14_T206_G0.5880.52
180_S184_I0.5870.52
166_E268_L0.5870.52
33_T254_A0.5870.52
41_G228_S0.5860.51
208_T238_I0.5850.51
15_D124_N0.5850.51
274_R278_L0.5850.51
233_G277_V0.5850.51
234_F238_I0.5840.51
3_I131_Y0.5840.51
80_V100_P0.5840.51
68_G71_V0.5820.51
234_F250_V0.5810.51
166_E171_K0.5810.51
56_R101_I0.5780.51
180_S238_I0.5770.50
70_S113_N0.5710.50
107_I144_A0.5710.50
41_G225_R0.5700.50
165_I168_N0.5690.49
201_K205_P0.5680.49
225_R266_I0.5670.49
55_H58_N0.5670.49
68_G111_Y0.5670.49
146_V151_G0.5670.49
73_G81_L0.5660.49
178_V238_I0.5660.49
105_A144_A0.5660.49
242_N248_D0.5640.49
148_K182_G0.5620.49
39_R232_N0.5620.49
175_I213_I0.5580.48
45_T251_F0.5570.48
38_Q52_R0.5570.48
24_V125_A0.5520.47
233_G273_S0.5520.47
47_G51_L0.5510.47
163_Y268_L0.5510.47
97_L108_F0.5480.47
241_Y267_A0.5480.47
47_G55_H0.5460.47
70_S81_L0.5450.47
131_Y138_Y0.5440.46
41_G106_S0.5440.46
2_K12_G0.5430.46
272_A275_E0.5420.46
6_N167_N0.5420.46
48_T77_V0.5390.46
170_L258_M0.5380.46
182_G240_P0.5370.46
53_P99_I0.5370.46
163_Y279_S0.5350.45
188_K193_V0.5340.45
12_G160_Q0.5340.45
148_K183_N0.5340.45
137_R149_L0.5330.45
149_L183_N0.5320.45
9_K130_G0.5320.45
42_S97_L0.5310.45
30_E128_N0.5310.45
111_Y229_S0.5270.44
24_V63_A0.5250.44
46_L55_H0.5250.44
152_I275_E0.5240.44
109_D234_F0.5230.44
81_L84_L0.5220.44
77_V81_L0.5220.44
168_N258_M0.5210.44
52_R55_H0.5200.44
75_R122_G0.5180.43
59_Q219_N0.5180.43
107_I140_A0.5170.43
187_E190_E0.5160.43
148_K161_G0.5140.43
104_S223_A0.5130.43
46_L50_L0.5120.43
35_G54_K0.5110.42
176_S280_I0.5100.42
89_V92_K0.5070.42
47_G251_F0.5070.42
94_S97_L0.5060.42
15_D18_S0.5020.41
73_G147_G0.5020.41
42_S99_I0.5020.41
150_K158_S0.5020.41
135_I162_Y0.5020.41
174_V227_A0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4iheA 4 0.9752 100 0.112 Contact Map
3axgA 4 0.9362 100 0.135 Contact Map
3n2wA 4 0.9504 100 0.172 Contact Map
1b65A 4 0.9433 100 0.173 Contact Map
2drhA 4 0.9362 100 0.186 Contact Map
1vraB 2 0.2695 91.2 0.945 Contact Map
2v4iB 2 0.266 90.8 0.945 Contact Map
3it4B 2 0.2695 89.7 0.946 Contact Map
1vz6A 2 0.8369 88 0.948 Contact Map
1tdjA 2 0.8759 12.2 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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