Q97Y08 - SULSO - GREMLIN Contacts

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Q97Y08 - Uncharacterized protein

UniProt:	Q97Y08	Sequences: MLFDTSPKDNRKDFFDREKEIEKLKGLRAPITLVLGLRRTGKSSIIKIGINELNLPYIYLDLRKFEERNYISYKDFLLELQKEINKLVKRLPSLLKALKNIQGIVIMGNEIKFNWNRKDRLSFANLLESFEQASKDNVIIVLDEAQELVKLRGVNLLPALAYAYDNLKRIKFIMSGSEMGLLYDYLRVEDPESPLFGRAFSTVELKPFSREEAIEFLRRGFQEADIDFKDYEVVYEKIGGIPGWLTYFGFIYLDNKNLDFAINQTLEYAKKLILKEFENFLHGREIARKRYLNIMRTLSKCGKWSDVKRALELEEGIEISDSEIYNYLTQLTKHSWIIKEGEKYCPSEPLISLAFS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	356 (307)
Sequences:	9250 (8001)
Seq/√Len:	456.7

ECOLI - MALT
SULSO - Q97Y08 Q97X15 Q7LX94 Q7LX62 Q97VA4 Q97X37

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
213_A	245_L	4.928	1.00
209_S	212_E	4.099	1.00
171_K	177_S	3.483	1.00
288_R	330_Q	3.295	1.00
24_L	49_G	3.248	1.00
291_Y	330_Q	3.030	1.00
44_S	48_I	2.923	1.00
171_K	175_S	2.870	1.00
291_Y	331_L	2.821	1.00
210_R	232_E	2.733	1.00
48_I	51_N	2.715	1.00
170_I	177_S	2.687	1.00
46_I	141_V	2.570	1.00
50_I	141_V	2.534	1.00
23_K	201_S	2.404	1.00
298_L	303_K	2.394	1.00
214_I	231_Y	2.361	1.00
35_L	202_T	2.347	1.00
18_E	212_E	2.294	1.00
217_L	249_G	2.272	1.00
36_G	40_T	2.265	1.00
24_L	32_T	2.251	1.00
213_A	235_Y	2.218	1.00
46_I	175_S	2.187	1.00
292_L	296_R	2.162	1.00
149_V	156_L	2.156	1.00
143_D	177_S	2.093	1.00
304_W	307_V	2.059	1.00
212_E	215_E	1.986	1.00
21_I	48_I	1.960	1.00
295_M	331_L	1.941	1.00
16_D	212_E	1.918	1.00
288_R	291_Y	1.905	1.00
119_D	122_S	1.900	1.00
247_Y	250_F	1.848	1.00
173_I	177_S	1.835	1.00
46_I	177_S	1.831	1.00
14_F	48_I	1.823	1.00
294_I	327_Y	1.755	1.00
148_L	157_L	1.743	1.00
119_D	131_E	1.729	1.00
34_V	46_I	1.719	1.00
210_R	235_Y	1.686	1.00
234_V	245_L	1.679	1.00
210_R	214_I	1.672	1.00
145_A	176_G	1.671	1.00
40_T	242_P	1.668	1.00
349_P	353_L	1.666	1.00
15_F	219_R	1.640	1.00
338_I	345_C	1.637	1.00
14_F	44_S	1.634	1.00
37_L	40_T	1.632	1.00
122_S	131_E	1.629	1.00
56_P	64_K	1.609	1.00
35_L	204_E	1.603	1.00
48_I	52_E	1.589	1.00
340_E	345_C	1.578	1.00
191_P	194_P	1.561	1.00
22_E	25_K	1.559	1.00
233_V	236_E	1.547	1.00
218_R	231_Y	1.535	1.00
126_L	131_E	1.524	1.00
20_E	203_V	1.499	1.00
120_R	123_F	1.490	1.00
122_S	126_L	1.481	1.00
298_L	346_P	1.457	1.00
262_I	265_T	1.454	1.00
170_I	175_S	1.448	1.00
59_Y	64_K	1.439	1.00
232_E	236_E	1.436	1.00
174_M	177_S	1.424	1.00
298_L	337_I	1.402	1.00
233_V	237_K	1.389	1.00
247_Y	284_R	1.387	1.00
44_S	246_T	1.378	1.00
56_P	59_Y	1.372	1.00
143_D	146_Q	1.362	1.00
170_I	176_G	1.355	1.00
329_T	333_K	1.349	1.00
124_A	131_E	1.346	1.00
19_K	22_E	1.345	1.00
259_D	263_N	1.328	1.00
305_S	309_R	1.327	1.00
336_W	351_I	1.305	1.00
58_I	136_D	1.296	1.00
290_R	327_Y	1.296	1.00
227_D	230_D	1.288	1.00
76_F	156_L	1.287	1.00
214_I	218_R	1.283	1.00
18_E	22_E	1.282	1.00
161_A	165_D	1.282	1.00
238_I	248_F	1.258	1.00
18_E	215_E	1.257	1.00
208_F	212_E	1.257	1.00
332_T	337_I	1.246	1.00
171_K	176_G	1.231	1.00
167_L	172_F	1.221	1.00
116_N	119_D	1.215	1.00
120_R	124_A	1.209	1.00
118_K	122_S	1.203	1.00
76_F	79_E	1.201	1.00
30_P	201_S	1.200	1.00
20_E	206_K	1.199	1.00
46_I	50_I	1.199	1.00
47_K	61_D	1.199	1.00
303_K	344_Y	1.196	1.00
24_L	45_I	1.196	1.00
332_T	339_K	1.190	1.00
45_I	205_L	1.180	1.00
119_D	123_F	1.179	1.00
125_N	129_S	1.171	1.00
210_R	236_E	1.170	1.00
34_V	203_V	1.162	1.00
129_S	132_Q	1.155	1.00
21_I	49_G	1.146	1.00
79_E	83_E	1.136	1.00
349_P	352_S	1.129	1.00
293_N	296_R	1.128	1.00
216_F	245_L	1.128	1.00
173_I	176_G	1.127	1.00
215_E	219_R	1.124	1.00
27_L	53_L	1.118	1.00
76_F	159_A	1.118	1.00
120_R	126_L	1.118	1.00
231_Y	235_Y	1.117	1.00
308_K	311_L	1.114	1.00
215_E	218_R	1.110	1.00
320_S	323_E	1.108	1.00
259_D	262_I	1.097	1.00
123_F	127_L	1.091	1.00
179_M	183_Y	1.090	1.00
122_S	125_N	1.087	1.00
119_D	127_L	1.084	1.00
179_M	182_L	1.081	1.00
124_A	128_E	1.074	1.00
238_I	245_L	1.071	1.00
143_D	175_S	1.069	1.00
115_W	118_K	1.066	1.00
49_G	53_L	1.064	1.00
303_K	308_K	1.063	1.00
303_K	307_V	1.053	1.00
19_K	23_K	1.051	1.00
38_R	144_E	1.050	1.00
209_S	213_A	1.044	1.00
159_A	163_A	1.038	1.00
93_S	99_K	1.034	1.00
192_E	195_L	1.030	1.00
13_D	44_S	1.028	1.00
127_L	131_E	1.018	1.00
330_Q	334_H	1.017	1.00
294_I	328_L	1.016	1.00
312_E	319_I	1.014	1.00
226_I	230_D	1.004	1.00
338_I	347_S	1.001	1.00
122_S	129_S	0.993	1.00
119_D	126_L	0.993	1.00
290_R	323_E	0.987	1.00
182_L	186_L	0.986	1.00
261_A	266_L	0.983	1.00
259_D	266_L	0.980	1.00
34_V	205_L	0.980	1.00
38_R	177_S	0.971	1.00
57_Y	62_L	0.965	1.00
54_N	57_Y	0.964	1.00
214_I	232_E	0.961	1.00
291_Y	334_H	0.961	1.00
260_F	263_N	0.954	1.00
258_L	261_A	0.953	1.00
263_N	267_E	0.952	1.00
20_E	45_I	0.952	1.00
191_P	195_L	0.951	1.00
31_I	164_Y	0.942	1.00
281_L	284_R	0.939	1.00
31_I	200_F	0.935	1.00
309_R	321_D	0.934	1.00
60_L	68_R	0.924	1.00
26_G	201_S	0.913	1.00
145_A	148_L	0.912	1.00
23_K	26_G	0.909	1.00
217_L	234_V	0.904	1.00
162_Y	165_D	0.902	1.00
262_I	267_E	0.902	1.00
62_L	67_E	0.901	1.00
73_Y	155_N	0.897	1.00
263_N	266_L	0.895	1.00
15_F	212_E	0.894	1.00
62_L	66_E	0.894	1.00
40_T	241_I	0.891	1.00
62_L	65_F	0.890	1.00
297_T	312_E	0.887	1.00
56_P	136_D	0.885	1.00
169_R	177_S	0.883	1.00
271_K	274_L	0.881	1.00
29_A	164_Y	0.869	1.00
276_E	284_R	0.868	1.00
328_L	344_Y	0.864	1.00
235_Y	238_I	0.864	1.00
290_R	293_N	0.863	1.00
247_Y	276_E	0.863	1.00
282_H	285_E	0.860	1.00
121_L	124_A	0.860	1.00
260_F	265_T	0.859	1.00
43_S	47_K	0.858	1.00
193_S	202_T	0.857	1.00
63_R	66_E	0.856	1.00
329_T	332_T	0.855	1.00
56_P	60_L	0.854	1.00
57_Y	63_R	0.853	1.00
167_L	170_I	0.851	1.00
213_A	249_G	0.847	1.00
75_D	148_L	0.846	1.00
299_S	346_P	0.841	1.00
277_F	284_R	0.838	1.00
302_G	343_K	0.831	1.00
13_D	219_R	0.828	1.00
50_I	61_D	0.827	1.00
125_N	128_E	0.826	1.00
143_D	349_P	0.823	1.00
116_N	120_R	0.823	1.00
258_L	263_N	0.822	1.00
237_K	353_L	0.821	1.00
127_L	130_F	0.821	1.00
273_I	276_E	0.820	1.00
32_T	201_S	0.820	1.00
319_I	323_E	0.819	1.00
31_I	174_M	0.817	1.00
259_D	264_Q	0.815	1.00
169_R	175_S	0.814	1.00
308_K	312_E	0.813	1.00
261_A	265_T	0.811	1.00
339_K	344_Y	0.811	1.00
258_L	265_T	0.811	1.00
40_T	205_L	0.809	1.00
43_S	143_D	0.807	1.00
116_N	122_S	0.805	1.00
279_N	283_G	0.804	1.00
118_K	123_F	0.803	1.00
74_K	78_L	0.799	1.00
158_P	161_A	0.798	1.00
37_L	207_P	0.792	1.00
44_S	47_K	0.792	1.00
167_L	171_K	0.791	1.00
217_L	245_L	0.790	1.00
75_D	156_L	0.786	1.00
150_K	155_N	0.783	1.00
65_F	68_R	0.781	1.00
49_G	175_S	0.780	1.00
75_D	79_E	0.779	1.00
23_K	203_V	0.778	1.00
128_E	132_Q	0.778	1.00
279_N	282_H	0.777	1.00
303_K	337_I	0.776	1.00
16_D	209_S	0.774	1.00
60_L	64_K	0.770	1.00
264_Q	267_E	0.770	1.00
222_Q	225_D	0.769	1.00
161_A	191_P	0.769	1.00
122_S	127_L	0.768	1.00
243_G	247_Y	0.765	1.00
225_D	228_F	0.762	1.00
262_I	266_L	0.762	1.00
280_F	284_R	0.759	1.00
77_L	81_Q	0.755	1.00
216_F	246_T	0.753	1.00
20_E	205_L	0.750	1.00
57_Y	64_K	0.749	1.00
179_M	184_D	0.748	1.00
178_E	183_Y	0.747	1.00
171_K	174_M	0.743	1.00
208_F	216_F	0.743	1.00
217_L	231_Y	0.740	1.00
33_L	176_G	0.738	1.00
243_G	348_E	0.735	1.00
210_R	238_I	0.735	1.00
115_W	119_D	0.734	1.00
278_E	281_L	0.733	1.00
81_Q	85_N	0.732	1.00
50_I	139_I	0.730	1.00
211_E	214_I	0.729	1.00
167_L	177_S	0.728	1.00
294_I	308_K	0.727	1.00
145_A	174_M	0.727	1.00
120_R	131_E	0.726	1.00
190_D	193_S	0.726	1.00
207_P	239_G	0.724	1.00
157_L	161_A	0.724	1.00
55_L	59_Y	0.723	1.00
347_S	351_I	0.722	1.00
179_M	185_Y	0.721	1.00
21_I	52_E	0.720	1.00
169_R	176_G	0.720	1.00
58_I	64_K	0.716	1.00
291_Y	327_Y	0.713	1.00
124_A	162_Y	0.711	1.00
34_V	45_I	0.708	1.00
267_E	270_K	0.706	1.00
46_I	143_D	0.705	1.00
58_I	61_D	0.704	1.00
260_F	264_Q	0.704	1.00
223_E	228_F	0.704	1.00
128_E	131_E	0.703	1.00
126_L	129_S	0.699	1.00
234_V	248_F	0.696	1.00
114_N	117_R	0.696	1.00
42_K	243_G	0.694	1.00
32_T	203_V	0.692	1.00
117_R	121_L	0.690	1.00
53_L	139_I	0.688	1.00
180_G	183_Y	0.687	1.00
304_W	343_K	0.687	1.00
38_R	348_E	0.686	1.00
166_N	177_S	0.686	1.00
62_L	79_E	0.683	1.00
207_P	238_I	0.683	1.00
46_I	173_I	0.680	1.00
141_V	177_S	0.680	1.00
241_I	244_W	0.679	1.00
27_L	139_I	0.679	1.00
351_I	354_A	0.677	1.00
225_D	229_K	0.674	1.00
120_R	128_E	0.672	1.00
309_R	324_I	0.671	1.00
208_F	242_P	0.671	1.00
123_F	126_L	0.670	1.00
26_G	30_P	0.670	1.00
56_P	62_L	0.668	1.00
304_W	308_K	0.667	1.00
162_Y	166_N	0.666	1.00
332_T	344_Y	0.663	1.00
60_L	63_R	0.663	1.00
294_I	324_I	0.661	1.00
235_Y	240_G	0.659	1.00
319_I	327_Y	0.658	1.00
220_G	249_G	0.656	1.00
25_K	52_E	0.654	1.00
323_E	326_N	0.653	1.00
340_E	343_K	0.647	1.00
119_D	129_S	0.645	1.00
319_I	324_I	0.644	1.00
285_E	292_L	0.643	1.00
118_K	126_L	0.643	1.00
124_A	127_L	0.641	1.00
281_L	351_I	0.640	1.00
327_Y	330_Q	0.640	1.00
321_D	325_Y	0.639	0.99
84_I	88_V	0.639	0.99
294_I	312_E	0.639	0.99
20_E	23_K	0.638	0.99
150_K	158_P	0.637	0.99
39_R	144_E	0.634	0.99
328_L	337_I	0.626	0.99
217_L	220_G	0.625	0.99
239_G	349_P	0.624	0.99
182_L	185_Y	0.622	0.99
57_Y	60_L	0.621	0.99
298_L	301_C	0.617	0.99
144_E	147_E	0.616	0.99
62_L	68_R	0.616	0.99
15_F	216_F	0.615	0.99
190_D	194_P	0.615	0.99
116_N	131_E	0.614	0.99
126_L	130_F	0.614	0.99
117_R	122_S	0.610	0.99
40_T	207_P	0.607	0.99
118_K	121_L	0.606	0.99
175_S	179_M	0.605	0.99
170_I	173_I	0.603	0.99
79_E	142_L	0.602	0.99
279_N	284_R	0.601	0.99
119_D	125_N	0.598	0.99
117_R	120_R	0.597	0.99
241_I	246_T	0.595	0.99
243_G	246_T	0.593	0.99
307_V	312_E	0.593	0.99
331_L	334_H	0.592	0.99
78_L	82_K	0.592	0.99
15_F	44_S	0.592	0.99
167_L	175_S	0.591	0.99
29_A	167_L	0.591	0.99
274_L	277_F	0.591	0.99
117_R	130_F	0.589	0.99
332_T	338_I	0.589	0.99
178_E	181_L	0.587	0.99
298_L	308_K	0.587	0.99
57_Y	139_I	0.587	0.99
171_K	178_E	0.586	0.99
36_G	39_R	0.586	0.99
123_F	130_F	0.585	0.99
276_E	279_N	0.585	0.99
79_E	140_I	0.585	0.99
14_F	212_E	0.584	0.99
42_K	348_E	0.581	0.99
58_I	62_L	0.579	0.99
24_L	34_V	0.579	0.99
331_L	337_I	0.578	0.99
295_M	336_W	0.578	0.99
277_F	281_L	0.577	0.99
64_K	148_L	0.577	0.99
326_N	330_Q	0.577	0.99
302_G	340_E	0.576	0.99
275_K	278_E	0.575	0.99
309_R	312_E	0.574	0.99
119_D	124_A	0.573	0.99
139_I	173_I	0.573	0.99
40_T	244_W	0.572	0.99
120_R	127_L	0.570	0.99
273_I	278_E	0.570	0.99
210_R	231_Y	0.569	0.99
33_L	200_F	0.568	0.99
259_D	265_T	0.567	0.99
166_N	170_I	0.567	0.99
213_A	240_G	0.565	0.99
124_A	129_S	0.565	0.99
120_R	125_N	0.563	0.99
302_G	345_C	0.563	0.99
305_S	344_Y	0.561	0.99
75_D	78_L	0.561	0.99
241_I	245_L	0.560	0.99
115_W	123_F	0.559	0.99
146_Q	149_V	0.559	0.99
158_P	162_Y	0.558	0.99
321_D	324_I	0.557	0.99
61_D	64_K	0.556	0.99
297_T	311_L	0.554	0.99
298_L	302_G	0.551	0.99
15_F	215_E	0.550	0.98
123_F	131_E	0.548	0.98
50_I	59_Y	0.547	0.98
71_I	74_K	0.547	0.98
247_Y	251_I	0.543	0.98
254_D	286_I	0.542	0.98
47_K	59_Y	0.541	0.98
77_L	83_E	0.541	0.98
183_Y	186_L	0.538	0.98
76_F	142_L	0.537	0.98
214_I	229_K	0.537	0.98
32_T	173_I	0.535	0.98
346_P	352_S	0.531	0.98
54_N	59_Y	0.529	0.98
123_F	129_S	0.528	0.98
53_L	57_Y	0.527	0.98
287_A	291_Y	0.524	0.98
323_E	327_Y	0.523	0.98
289_K	293_N	0.522	0.98
335_S	347_S	0.521	0.98
310_A	313_L	0.521	0.98
120_R	132_Q	0.520	0.98
61_D	65_F	0.513	0.98
181_L	186_L	0.513	0.98
183_Y	187_R	0.512	0.98
58_I	138_V	0.512	0.98
140_I	172_F	0.510	0.98
26_G	32_T	0.509	0.98
62_L	142_L	0.508	0.97
334_H	338_I	0.507	0.97
286_I	334_H	0.507	0.97
232_E	235_Y	0.504	0.97
276_E	281_L	0.503	0.97
137_N	171_K	0.501	0.97
115_W	122_S	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2fnaA	1	0.9803	100	0.343	Contact Map
2qenA	1	0.9494	100	0.371	Contact Map
1z6tA	1	0.8483	100	0.542	Contact Map
1w5sA	1	0.9017	99.9	0.607	Contact Map
2a5yB	2	0.8399	99.9	0.61	Contact Map
3sfzA	1	0.8483	99.9	0.615	Contact Map
1fnnA	1	0.8764	99.9	0.625	Contact Map
3pfiA	3	0.7584	99.9	0.626	Contact Map
2v1uA	1	0.8764	99.9	0.646	Contact Map
2qbyA	1	0.8876	99.9	0.648	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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