GREMLIN Database
Q97Y08 - Uncharacterized protein
UniProt: Q97Y08 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 356 (307)
Sequences: 9250 (8001)
Seq/√Len: 456.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
213_A245_L4.9281.00
209_S212_E4.0991.00
171_K177_S3.4831.00
288_R330_Q3.2951.00
24_L49_G3.2481.00
291_Y330_Q3.0301.00
44_S48_I2.9231.00
171_K175_S2.8701.00
291_Y331_L2.8211.00
210_R232_E2.7331.00
48_I51_N2.7151.00
170_I177_S2.6871.00
46_I141_V2.5701.00
50_I141_V2.5341.00
23_K201_S2.4041.00
298_L303_K2.3941.00
214_I231_Y2.3611.00
35_L202_T2.3471.00
18_E212_E2.2941.00
217_L249_G2.2721.00
36_G40_T2.2651.00
24_L32_T2.2511.00
213_A235_Y2.2181.00
46_I175_S2.1871.00
292_L296_R2.1621.00
149_V156_L2.1561.00
143_D177_S2.0931.00
304_W307_V2.0591.00
212_E215_E1.9861.00
21_I48_I1.9601.00
295_M331_L1.9411.00
16_D212_E1.9181.00
288_R291_Y1.9051.00
119_D122_S1.9001.00
247_Y250_F1.8481.00
173_I177_S1.8351.00
46_I177_S1.8311.00
14_F48_I1.8231.00
294_I327_Y1.7551.00
148_L157_L1.7431.00
119_D131_E1.7291.00
34_V46_I1.7191.00
210_R235_Y1.6861.00
234_V245_L1.6791.00
210_R214_I1.6721.00
145_A176_G1.6711.00
40_T242_P1.6681.00
349_P353_L1.6661.00
15_F219_R1.6401.00
338_I345_C1.6371.00
14_F44_S1.6341.00
37_L40_T1.6321.00
122_S131_E1.6291.00
56_P64_K1.6091.00
35_L204_E1.6031.00
48_I52_E1.5891.00
340_E345_C1.5781.00
191_P194_P1.5611.00
22_E25_K1.5591.00
233_V236_E1.5471.00
218_R231_Y1.5351.00
126_L131_E1.5241.00
20_E203_V1.4991.00
120_R123_F1.4901.00
122_S126_L1.4811.00
298_L346_P1.4571.00
262_I265_T1.4541.00
170_I175_S1.4481.00
59_Y64_K1.4391.00
232_E236_E1.4361.00
174_M177_S1.4241.00
298_L337_I1.4021.00
233_V237_K1.3891.00
247_Y284_R1.3871.00
44_S246_T1.3781.00
56_P59_Y1.3721.00
143_D146_Q1.3621.00
170_I176_G1.3551.00
329_T333_K1.3491.00
124_A131_E1.3461.00
19_K22_E1.3451.00
259_D263_N1.3281.00
305_S309_R1.3271.00
336_W351_I1.3051.00
58_I136_D1.2961.00
290_R327_Y1.2961.00
227_D230_D1.2881.00
76_F156_L1.2871.00
214_I218_R1.2831.00
18_E22_E1.2821.00
161_A165_D1.2821.00
238_I248_F1.2581.00
18_E215_E1.2571.00
208_F212_E1.2571.00
332_T337_I1.2461.00
171_K176_G1.2311.00
167_L172_F1.2211.00
116_N119_D1.2151.00
120_R124_A1.2091.00
118_K122_S1.2031.00
76_F79_E1.2011.00
30_P201_S1.2001.00
20_E206_K1.1991.00
46_I50_I1.1991.00
47_K61_D1.1991.00
303_K344_Y1.1961.00
24_L45_I1.1961.00
332_T339_K1.1901.00
45_I205_L1.1801.00
119_D123_F1.1791.00
125_N129_S1.1711.00
210_R236_E1.1701.00
34_V203_V1.1621.00
129_S132_Q1.1551.00
21_I49_G1.1461.00
79_E83_E1.1361.00
349_P352_S1.1291.00
293_N296_R1.1281.00
216_F245_L1.1281.00
173_I176_G1.1271.00
215_E219_R1.1241.00
27_L53_L1.1181.00
76_F159_A1.1181.00
120_R126_L1.1181.00
231_Y235_Y1.1171.00
308_K311_L1.1141.00
215_E218_R1.1101.00
320_S323_E1.1081.00
259_D262_I1.0971.00
123_F127_L1.0911.00
179_M183_Y1.0901.00
122_S125_N1.0871.00
119_D127_L1.0841.00
179_M182_L1.0811.00
124_A128_E1.0741.00
238_I245_L1.0711.00
143_D175_S1.0691.00
115_W118_K1.0661.00
49_G53_L1.0641.00
303_K308_K1.0631.00
303_K307_V1.0531.00
19_K23_K1.0511.00
38_R144_E1.0501.00
209_S213_A1.0441.00
159_A163_A1.0381.00
93_S99_K1.0341.00
192_E195_L1.0301.00
13_D44_S1.0281.00
127_L131_E1.0181.00
330_Q334_H1.0171.00
294_I328_L1.0161.00
312_E319_I1.0141.00
226_I230_D1.0041.00
338_I347_S1.0011.00
122_S129_S0.9931.00
119_D126_L0.9931.00
290_R323_E0.9871.00
182_L186_L0.9861.00
261_A266_L0.9831.00
259_D266_L0.9801.00
34_V205_L0.9801.00
38_R177_S0.9711.00
57_Y62_L0.9651.00
54_N57_Y0.9641.00
214_I232_E0.9611.00
291_Y334_H0.9611.00
260_F263_N0.9541.00
258_L261_A0.9531.00
263_N267_E0.9521.00
20_E45_I0.9521.00
191_P195_L0.9511.00
31_I164_Y0.9421.00
281_L284_R0.9391.00
31_I200_F0.9351.00
309_R321_D0.9341.00
60_L68_R0.9241.00
26_G201_S0.9131.00
145_A148_L0.9121.00
23_K26_G0.9091.00
217_L234_V0.9041.00
162_Y165_D0.9021.00
262_I267_E0.9021.00
62_L67_E0.9011.00
73_Y155_N0.8971.00
263_N266_L0.8951.00
15_F212_E0.8941.00
62_L66_E0.8941.00
40_T241_I0.8911.00
62_L65_F0.8901.00
297_T312_E0.8871.00
56_P136_D0.8851.00
169_R177_S0.8831.00
271_K274_L0.8811.00
29_A164_Y0.8691.00
276_E284_R0.8681.00
328_L344_Y0.8641.00
235_Y238_I0.8641.00
290_R293_N0.8631.00
247_Y276_E0.8631.00
282_H285_E0.8601.00
121_L124_A0.8601.00
260_F265_T0.8591.00
43_S47_K0.8581.00
193_S202_T0.8571.00
63_R66_E0.8561.00
329_T332_T0.8551.00
56_P60_L0.8541.00
57_Y63_R0.8531.00
167_L170_I0.8511.00
213_A249_G0.8471.00
75_D148_L0.8461.00
299_S346_P0.8411.00
277_F284_R0.8381.00
302_G343_K0.8311.00
13_D219_R0.8281.00
50_I61_D0.8271.00
125_N128_E0.8261.00
143_D349_P0.8231.00
116_N120_R0.8231.00
258_L263_N0.8221.00
237_K353_L0.8211.00
127_L130_F0.8211.00
273_I276_E0.8201.00
32_T201_S0.8201.00
319_I323_E0.8191.00
31_I174_M0.8171.00
259_D264_Q0.8151.00
169_R175_S0.8141.00
308_K312_E0.8131.00
261_A265_T0.8111.00
339_K344_Y0.8111.00
258_L265_T0.8111.00
40_T205_L0.8091.00
43_S143_D0.8071.00
116_N122_S0.8051.00
279_N283_G0.8041.00
118_K123_F0.8031.00
74_K78_L0.7991.00
158_P161_A0.7981.00
37_L207_P0.7921.00
44_S47_K0.7921.00
167_L171_K0.7911.00
217_L245_L0.7901.00
75_D156_L0.7861.00
150_K155_N0.7831.00
65_F68_R0.7811.00
49_G175_S0.7801.00
75_D79_E0.7791.00
23_K203_V0.7781.00
128_E132_Q0.7781.00
279_N282_H0.7771.00
303_K337_I0.7761.00
16_D209_S0.7741.00
60_L64_K0.7701.00
264_Q267_E0.7701.00
222_Q225_D0.7691.00
161_A191_P0.7691.00
122_S127_L0.7681.00
243_G247_Y0.7651.00
225_D228_F0.7621.00
262_I266_L0.7621.00
280_F284_R0.7591.00
77_L81_Q0.7551.00
216_F246_T0.7531.00
20_E205_L0.7501.00
57_Y64_K0.7491.00
179_M184_D0.7481.00
178_E183_Y0.7471.00
171_K174_M0.7431.00
208_F216_F0.7431.00
217_L231_Y0.7401.00
33_L176_G0.7381.00
243_G348_E0.7351.00
210_R238_I0.7351.00
115_W119_D0.7341.00
278_E281_L0.7331.00
81_Q85_N0.7321.00
50_I139_I0.7301.00
211_E214_I0.7291.00
167_L177_S0.7281.00
294_I308_K0.7271.00
145_A174_M0.7271.00
120_R131_E0.7261.00
190_D193_S0.7261.00
207_P239_G0.7241.00
157_L161_A0.7241.00
55_L59_Y0.7231.00
347_S351_I0.7221.00
179_M185_Y0.7211.00
21_I52_E0.7201.00
169_R176_G0.7201.00
58_I64_K0.7161.00
291_Y327_Y0.7131.00
124_A162_Y0.7111.00
34_V45_I0.7081.00
267_E270_K0.7061.00
46_I143_D0.7051.00
58_I61_D0.7041.00
260_F264_Q0.7041.00
223_E228_F0.7041.00
128_E131_E0.7031.00
126_L129_S0.6991.00
234_V248_F0.6961.00
114_N117_R0.6961.00
42_K243_G0.6941.00
32_T203_V0.6921.00
117_R121_L0.6901.00
53_L139_I0.6881.00
180_G183_Y0.6871.00
304_W343_K0.6871.00
38_R348_E0.6861.00
166_N177_S0.6861.00
62_L79_E0.6831.00
207_P238_I0.6831.00
46_I173_I0.6801.00
141_V177_S0.6801.00
241_I244_W0.6791.00
27_L139_I0.6791.00
351_I354_A0.6771.00
225_D229_K0.6741.00
120_R128_E0.6721.00
309_R324_I0.6711.00
208_F242_P0.6711.00
123_F126_L0.6701.00
26_G30_P0.6701.00
56_P62_L0.6681.00
304_W308_K0.6671.00
162_Y166_N0.6661.00
332_T344_Y0.6631.00
60_L63_R0.6631.00
294_I324_I0.6611.00
235_Y240_G0.6591.00
319_I327_Y0.6581.00
220_G249_G0.6561.00
25_K52_E0.6541.00
323_E326_N0.6531.00
340_E343_K0.6471.00
119_D129_S0.6451.00
319_I324_I0.6441.00
285_E292_L0.6431.00
118_K126_L0.6431.00
124_A127_L0.6411.00
281_L351_I0.6401.00
327_Y330_Q0.6401.00
321_D325_Y0.6390.99
84_I88_V0.6390.99
294_I312_E0.6390.99
20_E23_K0.6380.99
150_K158_P0.6370.99
39_R144_E0.6340.99
328_L337_I0.6260.99
217_L220_G0.6250.99
239_G349_P0.6240.99
182_L185_Y0.6220.99
57_Y60_L0.6210.99
298_L301_C0.6170.99
144_E147_E0.6160.99
62_L68_R0.6160.99
15_F216_F0.6150.99
190_D194_P0.6150.99
116_N131_E0.6140.99
126_L130_F0.6140.99
117_R122_S0.6100.99
40_T207_P0.6070.99
118_K121_L0.6060.99
175_S179_M0.6050.99
170_I173_I0.6030.99
79_E142_L0.6020.99
279_N284_R0.6010.99
119_D125_N0.5980.99
117_R120_R0.5970.99
241_I246_T0.5950.99
243_G246_T0.5930.99
307_V312_E0.5930.99
331_L334_H0.5920.99
78_L82_K0.5920.99
15_F44_S0.5920.99
167_L175_S0.5910.99
29_A167_L0.5910.99
274_L277_F0.5910.99
117_R130_F0.5890.99
332_T338_I0.5890.99
178_E181_L0.5870.99
298_L308_K0.5870.99
57_Y139_I0.5870.99
171_K178_E0.5860.99
36_G39_R0.5860.99
123_F130_F0.5850.99
276_E279_N0.5850.99
79_E140_I0.5850.99
14_F212_E0.5840.99
42_K348_E0.5810.99
58_I62_L0.5790.99
24_L34_V0.5790.99
331_L337_I0.5780.99
295_M336_W0.5780.99
277_F281_L0.5770.99
64_K148_L0.5770.99
326_N330_Q0.5770.99
302_G340_E0.5760.99
275_K278_E0.5750.99
309_R312_E0.5740.99
119_D124_A0.5730.99
139_I173_I0.5730.99
40_T244_W0.5720.99
120_R127_L0.5700.99
273_I278_E0.5700.99
210_R231_Y0.5690.99
33_L200_F0.5680.99
259_D265_T0.5670.99
166_N170_I0.5670.99
213_A240_G0.5650.99
124_A129_S0.5650.99
120_R125_N0.5630.99
302_G345_C0.5630.99
305_S344_Y0.5610.99
75_D78_L0.5610.99
241_I245_L0.5600.99
115_W123_F0.5590.99
146_Q149_V0.5590.99
158_P162_Y0.5580.99
321_D324_I0.5570.99
61_D64_K0.5560.99
297_T311_L0.5540.99
298_L302_G0.5510.99
15_F215_E0.5500.98
123_F131_E0.5480.98
50_I59_Y0.5470.98
71_I74_K0.5470.98
247_Y251_I0.5430.98
254_D286_I0.5420.98
47_K59_Y0.5410.98
77_L83_E0.5410.98
183_Y186_L0.5380.98
76_F142_L0.5370.98
214_I229_K0.5370.98
32_T173_I0.5350.98
346_P352_S0.5310.98
54_N59_Y0.5290.98
123_F129_S0.5280.98
53_L57_Y0.5270.98
287_A291_Y0.5240.98
323_E327_Y0.5230.98
289_K293_N0.5220.98
335_S347_S0.5210.98
310_A313_L0.5210.98
120_R132_Q0.5200.98
61_D65_F0.5130.98
181_L186_L0.5130.98
183_Y187_R0.5120.98
58_I138_V0.5120.98
140_I172_F0.5100.98
26_G32_T0.5090.98
62_L142_L0.5080.97
334_H338_I0.5070.97
286_I334_H0.5070.97
232_E235_Y0.5040.97
276_E281_L0.5030.97
137_N171_K0.5010.97
115_W122_S0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fnaA 1 0.9803 100 0.343 Contact Map
2qenA 1 0.9494 100 0.371 Contact Map
1z6tA 1 0.8483 100 0.542 Contact Map
1w5sA 1 0.9017 99.9 0.607 Contact Map
2a5yB 2 0.8399 99.9 0.61 Contact Map
3sfzA 1 0.8483 99.9 0.615 Contact Map
1fnnA 1 0.8764 99.9 0.625 Contact Map
3pfiA 3 0.7584 99.9 0.626 Contact Map
2v1uA 1 0.8764 99.9 0.646 Contact Map
2qbyA 1 0.8876 99.9 0.648 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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