GREMLIN Database
Q97Y06 - Partial transposase ISC1229
UniProt: Q97Y06 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 251 (237)
Sequences: 4001 (3004)
Seq/√Len: 195.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_R121_M3.3991.00
217_H220_K3.0201.00
50_Q112_R2.9301.00
103_V114_E2.8351.00
150_V162_F2.5961.00
162_F235_A2.5791.00
166_C192_L2.5581.00
134_T247_P2.4361.00
157_P161_S2.4011.00
106_R114_E2.3891.00
49_V52_K2.2171.00
211_L215_E2.2051.00
131_V247_P2.2041.00
49_V56_R2.1501.00
158_R161_S2.1451.00
110_Q114_E2.0901.00
138_I143_A1.9991.00
57_L108_L1.9831.00
43_Y119_R1.9831.00
146_I238_V1.9541.00
49_V107_T1.9511.00
222_K225_K1.9081.00
184_I228_T1.9001.00
47_K115_L1.8821.00
50_Q115_L1.8741.00
168_L231_A1.8671.00
44_L194_S1.8481.00
41_S149_I1.8381.00
13_T172_V1.8171.00
107_T114_E1.7891.00
216_A220_K1.7641.00
121_M124_G1.7551.00
232_R236_R1.7541.00
132_L238_V1.7511.00
174_R179_E1.7341.00
126_V133_L1.7231.00
156_F165_Y1.7211.00
23_N27_K1.6851.00
105_A109_L1.6821.00
241_V247_P1.6731.00
51_T55_N1.6641.00
142_A195_L1.6381.00
135_I238_V1.6361.00
135_I241_V1.6241.00
198_F201_E1.6231.00
194_S198_F1.6131.00
240_S244_N1.5991.00
107_T110_Q1.5901.00
221_L225_K1.5811.00
145_I195_L1.5691.00
116_K119_R1.5641.00
106_R113_E1.5311.00
131_V134_T1.5251.00
71_S74_R1.5231.00
43_Y47_K1.5221.00
46_M115_L1.5201.00
239_W243_Y1.5031.00
74_R77_K1.4971.00
103_V117_E1.4861.00
199_L234_L1.4781.00
214_Y230_L1.4761.00
78_F82_D1.4251.00
166_C235_A1.4211.00
47_K50_Q1.4101.00
200_A234_L1.4031.00
106_R110_Q1.3921.00
163_V232_R1.3911.00
200_A231_A1.3901.00
57_L101_I1.3891.00
132_L143_A1.3621.00
75_L78_F1.3581.00
82_D85_D1.3431.00
210_L237_I1.3301.00
50_Q108_L1.3301.00
204_Y214_Y1.3201.00
218_K224_R1.3101.00
131_V241_V1.3021.00
42_L46_M1.2841.00
110_Q113_E1.2701.00
133_L140_K1.2691.00
213_F233_K1.2691.00
218_K223_G1.2681.00
81_G85_D1.2571.00
175_S179_E1.2561.00
197_Y231_A1.2451.00
108_L112_R1.2281.00
45_F56_R1.2281.00
78_F83_F1.2191.00
149_I189_N1.2151.00
135_I234_L1.2131.00
80_K84_S1.2071.00
78_F81_G1.2051.00
208_P212_K1.2041.00
53_Q57_L1.2001.00
210_L230_L1.1971.00
213_F217_H1.1921.00
48_D52_K1.1721.00
126_V129_D1.1521.00
123_E140_K1.1481.00
215_E219_D1.1451.00
153_I242_W1.1441.00
142_A199_L1.1371.00
240_S243_Y1.1351.00
35_P94_T1.1331.00
49_V53_Q1.1321.00
197_Y228_T1.1311.00
121_M125_N1.1301.00
78_F85_D1.1201.00
163_V169_D1.1171.00
44_L191_Y1.1121.00
217_H226_L1.1121.00
40_V191_Y1.1101.00
19_E23_N1.1021.00
196_F235_A1.0881.00
119_R123_E1.0861.00
127_P245_N1.0811.00
132_L242_W1.0741.00
112_R116_K1.0681.00
200_A230_L1.0681.00
40_V122_I1.0611.00
213_F230_L1.0511.00
43_Y115_L1.0461.00
224_R227_Y1.0341.00
95_G121_M1.0291.00
186_K193_R1.0271.00
201_E224_R1.0171.00
80_K83_F1.0161.00
77_K80_K1.0131.00
241_V246_K1.0071.00
79_S82_D1.0051.00
24_M28_A1.0001.00
201_E204_Y0.9981.00
208_P211_L0.9901.00
146_I192_L0.9840.99
217_H222_K0.9820.99
237_I241_V0.9810.99
213_F229_A0.9800.99
76_E80_K0.9790.99
103_V121_M0.9760.99
50_Q54_E0.9730.99
53_Q107_T0.9670.99
44_L48_D0.9660.99
98_L102_Q0.9640.99
76_E79_S0.9630.99
53_Q104_L0.9570.99
217_H221_L0.9530.99
54_E108_L0.9500.99
39_L118_V0.9420.99
216_A219_D0.9330.99
37_K149_I0.9210.99
161_S164_A0.9190.99
138_I238_V0.9140.99
43_Y141_L0.9090.99
96_T121_M0.9070.99
113_E117_E0.9040.99
210_L234_L0.8990.99
12_K17_D0.8970.99
46_M118_V0.8970.99
99_R103_V0.8910.99
138_I142_A0.8880.99
74_R78_F0.8880.99
200_A227_Y0.8850.99
14_D175_S0.8830.99
135_I138_I0.8780.99
99_R102_Q0.8770.99
53_Q108_L0.8680.99
79_S85_D0.8670.99
40_V144_G0.8670.99
52_K55_N0.8630.99
109_L113_E0.8540.99
74_R85_D0.8510.99
74_R81_G0.8500.98
47_K51_T0.8460.98
158_R239_W0.8430.98
70_L74_R0.8380.98
184_I193_R0.8380.98
222_K226_L0.8370.98
150_V153_I0.8370.98
164_A169_D0.8360.98
66_D71_S0.8330.98
138_I234_L0.8170.98
79_S83_F0.8110.98
213_F216_A0.8090.98
126_V144_G0.8080.98
40_V145_I0.8060.98
11_K172_V0.8040.98
30_E33_N0.7970.98
114_E117_E0.7970.98
46_M114_E0.7960.98
169_D185_S0.7940.98
77_K81_G0.7930.98
201_E227_Y0.7870.98
197_Y201_E0.7860.98
8_V11_K0.7780.97
128_Q245_N0.7740.97
67_E70_L0.7720.97
10_G187_R0.7700.97
172_V179_E0.7690.97
185_S193_R0.7680.97
72_E76_E0.7640.97
65_S68_E0.7630.97
64_V67_E0.7630.97
100_E103_V0.7590.97
152_D155_R0.7490.97
58_R62_F0.7430.96
188_G193_R0.7420.96
212_K216_A0.7410.96
16_Y20_K0.7360.96
21_L24_M0.7360.96
73_E77_K0.7350.96
169_D193_R0.7330.96
131_V245_N0.7290.96
196_F231_A0.7240.96
47_K119_R0.7160.96
215_E218_K0.7150.96
111_T115_L0.7120.96
212_K215_E0.7120.96
117_E121_M0.7110.96
73_E83_F0.7100.95
77_K82_D0.7080.95
218_K226_L0.7070.95
171_V185_S0.7070.95
169_D172_V0.7060.95
50_Q111_T0.7050.95
42_L100_E0.7000.95
160_E232_R0.6950.95
184_I229_A0.6950.95
236_R239_W0.6930.95
45_F49_V0.6900.95
65_S69_K0.6900.95
96_T99_R0.6880.95
154_K243_Y0.6880.95
196_F238_V0.6880.95
138_I146_I0.6870.95
85_D91_L0.6840.94
75_L82_D0.6840.94
41_S189_N0.6810.94
65_S70_L0.6770.94
68_E71_S0.6700.94
67_E71_S0.6690.94
149_I191_Y0.6690.94
201_E231_A0.6670.94
34_N38_E0.6630.94
191_Y194_S0.6610.93
41_S191_Y0.6610.93
169_D186_K0.6610.93
22_E26_N0.6570.93
129_D133_L0.6550.93
38_E97_V0.6530.93
107_T111_T0.6510.93
38_E100_E0.6500.93
123_E133_L0.6500.93
55_N59_R0.6500.93
11_K16_Y0.6470.93
35_P95_G0.6460.93
39_L121_M0.6440.93
99_R110_Q0.6410.92
145_I191_Y0.6380.92
115_L119_R0.6370.92
217_H229_A0.6370.92
42_L118_V0.6370.92
78_F84_S0.6360.92
204_Y227_Y0.6360.92
53_Q111_T0.6360.92
112_R115_L0.6360.92
159_P239_W0.6340.92
200_A203_Q0.6340.92
225_K229_A0.6300.92
145_I149_I0.6290.92
104_L107_T0.6210.91
66_D70_L0.6210.91
71_S81_G0.6200.91
75_L85_D0.6190.91
74_R82_D0.6160.91
70_L79_S0.6140.91
119_R122_I0.6130.91
168_L196_F0.6130.91
53_Q56_R0.6120.91
42_L103_V0.6120.91
202_T206_R0.6100.90
30_E34_N0.6080.90
168_L232_R0.6060.90
69_K72_E0.6060.90
172_V181_R0.6060.90
16_Y21_L0.6040.90
233_K236_R0.6010.90
9_R169_D0.5970.89
103_V107_T0.5960.89
73_E82_D0.5940.89
71_S85_D0.5930.89
102_Q106_R0.5920.89
163_V236_R0.5900.89
119_R141_L0.5890.89
193_R228_T0.5860.89
138_I199_L0.5850.88
75_L79_S0.5840.88
71_S84_S0.5830.88
46_M111_T0.5820.88
207_N248_Y0.5800.88
9_R19_E0.5760.88
126_V143_A0.5730.87
153_I239_W0.5700.87
29_R34_N0.5670.87
23_N26_N0.5670.87
81_G84_S0.5640.87
42_L45_F0.5630.87
204_Y218_K0.5620.86
45_F52_K0.5610.86
167_G176_G0.5600.86
42_L104_L0.5590.86
159_P236_R0.5560.86
134_T147_I0.5530.86
221_L224_R0.5520.85
243_Y246_K0.5510.85
203_Q207_N0.5500.85
174_R178_I0.5470.85
134_T241_V0.5460.85
106_R117_E0.5440.85
185_S188_G0.5430.85
56_R59_R0.5420.84
195_L199_L0.5410.84
146_I162_F0.5410.84
120_K124_G0.5380.84
42_L107_T0.5370.84
22_E28_A0.5370.84
129_D147_I0.5330.83
201_E205_S0.5330.83
32_V35_P0.5320.83
36_L144_G0.5300.83
162_F238_V0.5290.83
207_N211_L0.5280.83
113_E116_K0.5280.83
70_L73_E0.5260.83
182_K185_S0.5190.82
203_Q210_L0.5190.82
68_E74_R0.5180.82
128_Q131_V0.5180.82
124_G128_Q0.5180.82
70_L82_D0.5170.82
137_G202_T0.5170.82
213_F220_K0.5150.81
45_F48_D0.5130.81
69_K74_R0.5120.81
36_L125_N0.5110.81
45_F107_T0.5100.81
239_W244_N0.5100.81
75_L81_G0.5090.81
38_E60_A0.5070.80
168_L193_R0.5060.80
203_Q234_L0.5050.80
218_K221_L0.5040.80
183_G225_K0.5040.80
40_V148_G0.5030.80
109_L112_R0.5030.80
103_V106_R0.5000.79
35_P96_T0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1keaA 2 0.7888 92.2 0.912 Contact Map
3fhfA 1 0.7689 89 0.918 Contact Map
2abkA 1 0.7649 84.5 0.924 Contact Map
1pu6A 1 0.7689 81.2 0.927 Contact Map
3fhgA 2 0.8008 81.1 0.927 Contact Map
2a1jB 2 0.3068 80.5 0.927 Contact Map
4ofaA 1 0.5219 79.4 0.928 Contact Map
1kftA 1 0.2151 78.7 0.928 Contact Map
1z00A 1 0.3267 78.2 0.929 Contact Map
3n0uA 1 0.7849 77.4 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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