GREMLIN Database
Q97Y04 - Uncharacterized protein
UniProt: Q97Y04 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 342 (286)
Sequences: 11890 (9055)
Seq/√Len: 535.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
137_K154_D4.1641.00
26_F111_Y3.9791.00
50_K90_F3.5111.00
161_I196_Y3.2991.00
85_I120_I2.8051.00
45_T48_M2.5411.00
266_C285_C2.5341.00
54_L90_F2.4491.00
141_D151_P2.4341.00
115_I162_Q2.3981.00
48_M300_E2.3751.00
25_N109_N2.3231.00
139_A185_S2.3181.00
51_R55_F2.3151.00
54_L94_I2.2561.00
162_Q165_N2.2191.00
281_K295_S2.2041.00
16_I56_L2.1561.00
46_S86_D2.1391.00
281_K298_H2.1131.00
92_N127_K2.0911.00
119_K123_E2.0811.00
185_S188_K1.9921.00
134_D144_R1.9621.00
136_Y139_A1.9311.00
136_Y185_S1.9031.00
85_I117_K1.8871.00
23_W43_I1.8841.00
53_K91_T1.8811.00
119_K168_D1.8691.00
153_F192_L1.8521.00
49_T87_I1.8401.00
82_K86_D1.8371.00
90_F93_S1.8371.00
176_S189_F1.8331.00
57_E94_I1.7591.00
154_D158_E1.7081.00
46_S50_K1.6961.00
153_F157_F1.6861.00
110_G131_V1.6831.00
89_D120_I1.6701.00
192_L196_Y1.6591.00
25_N112_L1.6571.00
277_R281_K1.6491.00
191_D195_N1.6491.00
303_G306_V1.6411.00
68_V102_I1.6331.00
174_I193_A1.6201.00
120_I123_E1.6181.00
117_K120_I1.6071.00
72_W91_T1.6051.00
158_E161_I1.5961.00
114_D158_E1.5921.00
46_S82_K1.5901.00
180_P228_K1.5871.00
30_Y134_D1.5821.00
187_K235_E1.5791.00
86_D89_D1.5721.00
161_I165_N1.5661.00
277_R283_F1.5651.00
155_K158_E1.5641.00
161_I164_R1.5561.00
302_D306_V1.5541.00
135_G139_A1.5491.00
120_I124_K1.5431.00
48_M51_R1.5351.00
70_I91_T1.5161.00
78_L106_I1.5151.00
137_K151_P1.5121.00
14_F68_V1.5041.00
142_K181_D1.4931.00
29_V142_K1.4891.00
298_H301_E1.4861.00
50_K86_D1.4711.00
50_K54_L1.4631.00
114_D117_K1.4481.00
89_D93_S1.4481.00
225_E228_K1.4331.00
137_K141_D1.4291.00
122_L168_D1.4261.00
131_V160_L1.4131.00
90_F94_I1.4041.00
115_I165_N1.3961.00
92_N124_K1.3941.00
92_N104_G1.3921.00
118_F162_Q1.3781.00
131_V159_N1.3551.00
188_K191_D1.3461.00
311_K315_W1.3341.00
20_P72_W1.3211.00
162_Q168_D1.3011.00
57_E101_D1.2951.00
137_K153_F1.2951.00
80_D87_I1.2831.00
164_R197_F1.2711.00
89_D124_K1.2581.00
156_I159_N1.2571.00
191_D236_L1.2561.00
55_F303_G1.2521.00
118_F159_N1.2491.00
43_I80_D1.2491.00
18_I49_T1.2491.00
107_I130_Q1.2261.00
78_L112_L1.2181.00
88_M126_V1.2131.00
231_E235_E1.2111.00
157_F161_I1.2101.00
136_Y188_K1.2081.00
140_H156_I1.1991.00
158_E162_Q1.1981.00
140_H152_T1.1961.00
230_M234_Q1.1871.00
141_D152_T1.1791.00
129_F163_T1.1751.00
139_A184_D1.1731.00
191_D239_Y1.1721.00
313_N317_K1.1611.00
157_F192_L1.1591.00
91_T104_G1.1461.00
305_I309_E1.1451.00
164_R196_Y1.1411.00
72_W88_M1.1341.00
46_S90_F1.1161.00
103_I128_I1.1141.00
44_T48_M1.1101.00
86_D90_F1.1041.00
88_M124_K1.0981.00
72_W104_G1.0931.00
139_A142_K1.0921.00
20_P84_I1.0881.00
231_E234_Q1.0751.00
176_S201_R1.0691.00
18_I276_I1.0431.00
164_R198_S1.0381.00
143_L179_M1.0321.00
227_K231_E1.0251.00
78_L84_I1.0231.00
164_R172_M1.0231.00
84_I88_M1.0161.00
282_L307_L1.0101.00
118_F122_L1.0071.00
22_S278_N1.0041.00
191_D194_S1.0021.00
304_S308_D1.0011.00
42_M279_D1.0001.00
187_K191_D0.9991.00
69_H103_I0.9981.00
138_D142_K0.9961.00
21_S43_I0.9961.00
159_N162_Q0.9961.00
157_F196_Y0.9961.00
228_K231_E0.9931.00
53_K94_I0.9921.00
25_N76_E0.9911.00
235_E238_M0.9881.00
152_T155_K0.9881.00
69_H105_E0.9841.00
117_K121_L0.9751.00
50_K94_I0.9751.00
135_G153_F0.9631.00
85_I89_D0.9611.00
52_I276_I0.9591.00
236_L240_A0.9591.00
295_S298_H0.9581.00
115_I168_D0.9501.00
311_K314_R0.9441.00
193_A198_S0.9411.00
51_R300_E0.9381.00
16_I276_I0.9341.00
189_F193_A0.9341.00
174_I198_S0.9311.00
325_R328_P0.9271.00
233_I236_L0.9261.00
14_F272_F0.9221.00
249_D252_T0.9191.00
235_E239_Y0.9181.00
30_Y143_L0.9171.00
44_T49_T0.9151.00
234_Q238_M0.9101.00
78_L117_K0.9091.00
114_D162_Q0.9081.00
50_K93_S0.9081.00
300_E303_G0.9071.00
113_L118_F0.9051.00
25_N111_Y0.9001.00
84_I106_I0.8991.00
165_N168_D0.8991.00
302_D307_L0.8881.00
103_I127_K0.8881.00
239_Y242_Q0.8871.00
163_T172_M0.8851.00
85_I123_E0.8781.00
283_F295_S0.8771.00
20_P80_D0.8741.00
26_F152_T0.8721.00
160_L172_M0.8711.00
160_L174_I0.8691.00
87_I91_T0.8691.00
131_V163_T0.8671.00
56_L70_I0.8661.00
178_V186_I0.8661.00
20_P87_I0.8581.00
245_L249_D0.8511.00
51_R54_L0.8491.00
130_Q175_R0.8471.00
109_N112_L0.8421.00
155_K159_N0.8401.00
53_K70_I0.8361.00
315_W318_Y0.8271.00
54_L58_N0.8271.00
310_S313_N0.8221.00
119_K122_L0.8191.00
119_K162_Q0.8171.00
297_G307_L0.8151.00
85_I124_K0.8141.00
113_L159_N0.8111.00
187_K239_Y0.8111.00
314_R318_Y0.8041.00
46_S87_I0.7981.00
106_I121_L0.7941.00
29_V143_L0.7931.00
133_I174_I0.7921.00
154_D157_F0.7891.00
159_N163_T0.7791.00
192_L195_N0.7771.00
193_A196_Y0.7761.00
76_E109_N0.7751.00
250_K253_L0.7721.00
207_F213_S0.7721.00
106_I129_F0.7721.00
18_I53_K0.7711.00
46_S80_D0.7701.00
19_I278_N0.7681.00
122_L169_N0.7661.00
312_I315_W0.7651.00
18_I52_I0.7621.00
88_M104_G0.7611.00
16_I274_I0.7591.00
19_I73_Y0.7591.00
49_T80_D0.7581.00
226_P230_M0.7581.00
57_E102_I0.7551.00
104_G126_V0.7531.00
55_F58_N0.7521.00
56_L67_K0.7501.00
308_D317_K0.7491.00
118_F168_D0.7481.00
21_S80_D0.7481.00
149_G152_T0.7481.00
113_L131_V0.7431.00
193_A201_R0.7421.00
78_L159_N0.7411.00
312_I316_A0.7401.00
171_F199_R0.7401.00
32_Y73_Y0.7381.00
106_I126_V0.7361.00
190_L194_S0.7351.00
132_T177_N0.7341.00
55_F305_I0.7311.00
88_M120_I0.7311.00
274_I308_D0.7301.00
19_I275_I0.7301.00
76_E79_L0.7291.00
274_I304_S0.7271.00
141_D150_K0.7241.00
233_I237_Y0.7231.00
244_G253_L0.7211.00
82_K87_I0.7211.00
160_L198_S0.7201.00
44_T52_I0.7201.00
108_T131_V0.7201.00
163_T170_F0.7181.00
113_L121_L0.7181.00
85_I88_M0.7151.00
52_I56_L0.7131.00
141_D153_F0.7091.00
30_Y144_R0.7081.00
128_I171_F0.7061.00
128_I173_F0.7041.00
135_G185_S0.7021.00
140_H144_R0.7001.00
174_I201_R0.6981.00
72_W87_I0.6951.00
205_F209_P0.6941.00
135_G140_H0.6931.00
325_R329_R0.6911.00
47_E50_K0.6901.00
89_D123_E0.6881.00
229_R233_I0.6861.00
71_R105_E0.6831.00
73_Y107_I0.6821.00
229_R232_I0.6811.00
238_M242_Q0.6801.00
236_L239_Y0.6791.00
140_H153_F0.6791.00
310_S315_W0.6791.00
136_Y184_D0.6791.00
133_I153_F0.6741.00
17_T273_S0.6741.00
49_T53_K0.6721.00
71_R107_I0.6651.00
129_F170_F0.6641.00
164_R199_R0.6621.00
92_N125_G0.6561.00
237_Y241_T0.6551.00
115_I119_K0.6531.00
187_K190_L0.6531.00
238_M241_T0.6531.00
226_P259_V0.6521.00
91_T102_I0.6511.00
199_R253_L0.6501.00
245_L250_K0.6481.00
185_S189_F0.6451.00
229_R236_L0.6411.00
230_M233_I0.6411.00
81_F117_K0.6411.00
107_I286_P0.6391.00
81_F85_I0.6391.00
220_N223_V0.6371.00
78_L121_L0.6361.00
141_D144_R0.6351.00
122_L127_K0.6341.00
101_D104_G0.6341.00
114_D159_N0.6331.00
130_Q173_F0.6311.00
33_E73_Y0.6301.00
133_I156_I0.6281.00
245_L248_P0.6221.00
113_L163_T0.6201.00
249_D253_L0.6171.00
189_F201_R0.6161.00
17_T286_P0.6141.00
80_D84_I0.6131.00
105_E128_I0.6131.00
26_F140_H0.6121.00
182_N185_S0.6111.00
247_I250_K0.6101.00
122_L170_F0.6081.00
118_F129_F0.6071.00
54_L57_E0.6031.00
296_V313_N0.6031.00
80_D86_D0.6011.00
176_S193_A0.5991.00
73_Y286_P0.5981.00
27_R149_G0.5981.00
118_F163_T0.5971.00
49_T52_I0.5921.00
111_Y155_K0.5890.99
276_I282_L0.5890.99
107_I175_R0.5880.99
70_I104_G0.5830.99
209_P212_R0.5810.99
133_I157_F0.5800.99
25_N79_L0.5800.99
140_H151_P0.5800.99
183_L228_K0.5790.99
94_I101_D0.5790.99
297_G302_D0.5770.99
237_Y240_A0.5760.99
24_C28_C0.5750.99
326_G329_R0.5740.99
55_F304_S0.5740.99
23_W41_N0.5730.99
172_M198_S0.5730.99
264_D268_A0.5700.99
112_L115_I0.5700.99
310_S314_R0.5690.99
303_G307_L0.5670.99
246_N249_D0.5650.99
227_K230_M0.5640.99
186_I189_F0.5620.99
92_N101_D0.5610.99
302_D310_S0.5590.99
275_I286_P0.5590.99
28_C31_C0.5580.99
263_D266_C0.5570.99
190_L201_R0.5550.99
16_I67_K0.5520.99
114_D155_K0.5520.99
58_N305_I0.5510.99
94_I102_I0.5490.99
248_P252_T0.5480.99
13_I308_D0.5460.99
137_K150_K0.5460.99
48_M52_I0.5450.99
189_F192_L0.5430.99
17_T73_Y0.5420.99
34_N149_G0.5410.99
135_G144_R0.5410.99
70_I102_I0.5380.99
141_D149_G0.5370.99
15_S69_H0.5370.99
79_L112_L0.5360.99
27_R34_N0.5350.99
47_E90_F0.5350.99
311_K317_K0.5350.99
53_K72_W0.5350.99
131_V156_I0.5340.99
53_K57_E0.5340.99
47_E51_R0.5340.99
151_P154_D0.5340.99
24_C31_C0.5330.99
208_F211_T0.5330.99
176_S203_Y0.5300.99
111_Y159_N0.5270.99
264_D267_Q0.5260.99
78_L113_L0.5250.99
234_Q237_Y0.5230.99
46_S49_T0.5220.99
180_P183_L0.5210.99
280_G298_H0.5190.99
52_I55_F0.5190.99
250_K254_L0.5170.99
282_L304_S0.5160.99
283_F289_V0.5160.99
246_N251_D0.5160.99
67_K101_D0.5150.99
297_G301_E0.5150.99
17_T275_I0.5130.99
297_G300_E0.5120.99
240_A246_N0.5100.99
144_R151_P0.5100.99
76_E108_T0.5100.99
222_K226_P0.5090.99
232_I235_E0.5090.99
138_D141_D0.5060.98
205_F210_V0.5030.98
158_E165_N0.5030.98
186_I232_I0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.9327 100 0.274 Contact Map
4m7tA 1 0.693 100 0.458 Contact Map
1tv8A 2 0.8684 100 0.46 Contact Map
4rtbA 2 0.8655 100 0.547 Contact Map
3c8fA 1 0.6637 100 0.594 Contact Map
4wcxA 1 0.9064 100 0.594 Contact Map
2yx0A 1 0.7485 99.9 0.619 Contact Map
2qgqA 1 0.7281 99.9 0.635 Contact Map
2a5hA 4 0.807 99.9 0.636 Contact Map
2z2uA 1 0.6491 99.9 0.641 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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