GREMLIN Database
Q97XZ9 - First ORF in transposon ISC1491
UniProt: Q97XZ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 245 (219)
Sequences: 2976 (2342)
Seq/√Len: 158.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_I114_F5.7391.00
22_A107_A3.5181.00
176_E216_K3.2011.00
94_L110_L3.1621.00
63_G84_Y3.1181.00
145_K148_Q2.9021.00
18_K42_E2.8931.00
96_E99_G2.6321.00
64_I110_L2.6061.00
21_V53_L2.6031.00
139_R143_M2.5351.00
145_K152_E2.4711.00
146_I219_E2.4371.00
228_M231_S2.2921.00
147_T151_N2.2441.00
10_F23_K2.1221.00
24_A111_A2.0771.00
46_D49_G1.9731.00
12_I19_L1.9491.00
217_S221_M1.9411.00
212_V216_K1.8841.00
12_I75_L1.8841.00
213_D220_A1.8821.00
24_A115_I1.8741.00
78_E82_K1.8631.00
136_T229_I1.8561.00
189_R193_K1.8201.00
210_Q221_M1.8141.00
41_R56_F1.7771.00
65_M86_V1.7621.00
10_F57_L1.7481.00
92_L96_E1.7221.00
138_Y142_L1.7211.00
22_A108_Q1.7121.00
32_K36_E1.7081.00
213_D221_M1.6931.00
148_Q151_N1.6871.00
143_M146_I1.6571.00
77_E130_R1.6561.00
153_I208_L1.6391.00
196_L200_L1.6321.00
206_L228_M1.5981.00
16_R158_E1.5931.00
44_K49_G1.5731.00
15_S18_K1.5471.00
20_T42_E1.5101.00
226_E229_I1.4991.00
223_K226_E1.4931.00
195_K199_S1.4921.00
65_M76_H1.4921.00
150_K167_F1.4801.00
214_L221_M1.4661.00
146_I150_K1.4421.00
214_L217_S1.4201.00
62_E87_T1.4051.00
188_E200_L1.4041.00
15_S20_T1.4011.00
211_L214_L1.3731.00
164_I171_G1.3661.00
145_K149_V1.3551.00
194_E198_R1.3191.00
186_K189_R1.3131.00
95_K98_F1.3121.00
188_E191_E1.3021.00
181_G184_L1.2901.00
19_L45_Y1.2811.00
149_V152_E1.2771.00
41_R52_E1.2431.00
224_E228_M1.2361.00
11_A111_A1.2251.00
20_T40_V1.2171.00
222_V226_E1.2151.00
72_F88_L1.2001.00
139_R226_E1.1991.00
206_L209_K1.1931.00
43_F49_G1.1831.00
52_E55_K1.1781.00
196_L199_S1.1771.00
11_A79_L1.1611.00
193_K196_L1.1591.00
57_L63_G1.1481.00
188_E193_K1.1471.00
40_V108_Q1.1281.00
9_G115_I1.1261.00
48_E52_E1.1151.00
219_E223_K1.1131.00
12_I53_L1.1061.00
188_E192_L1.1041.00
40_V104_K1.1011.00
10_F21_V1.0960.99
181_G185_S1.0860.99
153_I215_L1.0840.99
228_M232_K1.0700.99
43_F56_F1.0700.99
143_M222_V1.0680.99
213_D217_S1.0670.99
213_D224_E1.0630.99
112_K116_L1.0620.99
15_S19_L1.0610.99
76_H86_V1.0540.99
144_R148_Q1.0510.99
50_I75_L1.0470.99
168_D171_G1.0470.99
209_K224_E1.0430.99
76_H88_L1.0370.99
170_R173_A1.0350.99
165_E171_G1.0220.99
49_G52_E1.0200.99
54_I82_K1.0120.99
64_I89_I1.0100.99
108_Q112_K1.0040.99
47_N51_E1.0020.99
210_Q224_E0.9970.99
210_Q213_D0.9780.99
208_L215_L0.9780.99
208_L212_V0.9780.99
132_L229_I0.9680.99
167_F171_G0.9640.99
110_L113_A0.9640.99
67_S88_L0.9620.99
218_L222_V0.9600.99
35_V38_N0.9570.99
89_I94_L0.9530.99
216_K223_K0.9520.99
191_E194_E0.9510.99
218_L221_M0.9500.99
173_A177_K0.9480.99
63_G79_L0.9470.99
146_I215_L0.9290.98
15_S72_F0.9240.98
14_V65_M0.9240.98
221_M224_E0.9200.98
68_T71_Y0.9130.98
62_E85_K0.9070.98
141_S152_E0.9060.98
97_V113_A0.8980.98
166_P171_G0.8910.98
193_K197_G0.8890.98
206_L210_Q0.8870.98
227_D230_I0.8850.98
33_R36_E0.8850.98
227_D231_S0.8800.98
93_H100_K0.8800.98
204_E211_L0.8790.98
21_V41_R0.8790.98
224_E232_K0.8710.97
143_M147_T0.8640.97
179_S182_E0.8610.97
12_I21_V0.8570.97
32_K35_V0.8540.97
193_K200_L0.8530.97
223_K227_D0.8520.97
50_I78_E0.8500.97
216_K219_E0.8400.97
41_R49_G0.8370.97
190_D194_E0.8370.97
150_K215_L0.8360.97
152_E155_K0.8350.97
62_E114_F0.8310.97
178_L181_G0.8270.96
209_K213_D0.8200.96
19_L75_L0.8180.96
142_L222_V0.8130.96
8_R23_K0.8100.96
214_L218_L0.8100.96
64_I119_V0.8090.96
98_F109_R0.8070.96
189_R196_L0.8030.96
188_E199_S0.8010.96
216_K220_A0.7950.96
195_K198_R0.7920.96
187_E193_K0.7910.95
71_Y90_N0.7910.95
43_F50_I0.7820.95
50_I74_Y0.7800.95
23_K39_E0.7770.95
55_K82_K0.7740.95
153_I212_V0.7700.95
174_L181_G0.7700.95
175_L212_V0.7640.95
217_S220_A0.7630.95
23_K60_Y0.7630.95
64_I94_L0.7630.95
190_D193_K0.7520.94
193_K199_S0.7510.94
226_E230_I0.7500.94
194_E197_G0.7490.94
140_E144_R0.7460.94
169_K173_A0.7430.94
52_E56_F0.7390.94
51_E55_K0.7360.93
201_N212_V0.7340.93
14_V19_L0.7330.93
146_I222_V0.7310.93
178_L184_L0.7290.93
126_T129_I0.7280.93
145_K214_L0.7270.93
70_P158_E0.7240.93
142_L146_I0.7190.93
32_K38_N0.7170.92
179_S183_G0.7150.92
138_Y141_S0.7140.92
112_K115_I0.7140.92
54_I58_G0.7120.92
11_A107_A0.7110.92
215_L219_E0.7080.92
209_K212_V0.7050.92
101_K106_D0.7040.92
210_Q228_M0.7020.92
187_E191_E0.7000.92
126_T130_R0.6990.92
130_R134_E0.6970.91
172_I176_E0.6960.91
95_K99_G0.6950.91
173_A195_K0.6940.91
141_S144_R0.6930.91
67_S91_P0.6850.91
58_G84_Y0.6840.91
97_V100_K0.6770.90
174_L178_L0.6770.90
187_E192_L0.6770.90
55_K59_E0.6730.90
10_F79_L0.6720.90
21_V43_F0.6700.90
54_I84_Y0.6690.90
43_F53_L0.6690.90
75_L79_L0.6680.90
19_L43_F0.6660.89
94_L105_L0.6640.89
149_V153_I0.6630.89
172_I179_S0.6630.89
174_L179_S0.6600.89
12_I18_K0.6540.89
80_T124_I0.6520.88
197_G203_A0.6480.88
78_E81_E0.6480.88
89_I119_V0.6450.88
20_T104_K0.6440.88
9_G114_F0.6390.87
173_A194_E0.6380.87
83_G231_S0.6330.87
49_G53_L0.6320.87
83_G220_A0.6280.87
195_K200_L0.6230.86
80_T121_G0.6220.86
212_V219_E0.6200.86
67_S102_T0.6160.85
187_E200_L0.6120.85
110_L115_I0.6110.85
178_L182_E0.6100.85
22_A40_V0.6060.85
138_Y149_V0.6030.84
21_V56_F0.5960.84
209_K227_D0.5950.83
213_D219_E0.5940.83
180_R183_G0.5930.83
153_I211_L0.5880.83
207_A210_Q0.5880.83
118_A153_I0.5870.83
189_R199_S0.5860.83
14_V71_Y0.5830.82
149_V214_L0.5800.82
180_R185_S0.5790.82
208_L211_L0.5780.82
141_S145_K0.5680.81
22_A111_A0.5670.80
170_R174_L0.5640.80
94_L113_A0.5640.80
187_E194_E0.5640.80
68_T90_N0.5630.80
21_V57_L0.5620.80
201_N204_E0.5610.80
217_S227_D0.5610.80
165_E172_I0.5600.80
17_D202_D0.5600.80
219_E224_E0.5590.80
54_I78_E0.5550.79
157_L175_L0.5540.79
57_L61_K0.5540.79
96_E100_K0.5530.79
186_K190_D0.5520.79
139_R222_V0.5500.78
94_L98_F0.5490.78
177_K195_K0.5480.78
89_I110_L0.5440.78
186_K200_L0.5430.78
34_E39_E0.5430.78
167_F170_R0.5420.77
67_S72_F0.5400.77
177_K231_S0.5370.77
12_I65_M0.5370.77
15_S89_I0.5360.77
54_I79_L0.5350.77
213_D216_K0.5350.77
67_S137_R0.5340.76
158_E163_K0.5330.76
219_E230_I0.5320.76
188_E194_E0.5320.76
205_K209_K0.5310.76
189_R192_L0.5300.76
167_F174_L0.5290.76
220_A231_S0.5280.76
209_K230_I0.5280.76
174_L177_K0.5260.75
173_A176_E0.5210.75
210_Q225_V0.5210.75
141_S147_T0.5190.74
113_A119_V0.5190.74
202_D228_M0.5190.74
224_E227_D0.5160.74
22_A37_V0.5140.74
165_E168_D0.5140.74
217_S228_M0.5130.74
141_S148_Q0.5130.74
182_E186_K0.5130.74
58_G144_R0.5120.73
34_E37_V0.5110.73
222_V229_I0.5090.73
76_H124_I0.5070.73
58_G82_K0.5060.73
219_E222_V0.5060.73
113_A117_G0.5050.72
49_G56_F0.5050.72
8_R60_Y0.5040.72
190_D198_R0.5020.72
177_K181_G0.5020.72
211_L228_M0.5020.72
45_Y50_I0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hjrA 2 0.4408 94.2 0.895 Contact Map
4ep4A 2 0.5469 91.6 0.904 Contact Map
1nu0A 1 0.4286 84.3 0.915 Contact Map
1vhxA 2 0.449 77.2 0.921 Contact Map
3cpeA 1 0.6735 67.7 0.927 Contact Map
3id6A 2 0.8571 66.2 0.928 Contact Map
3ifrA 2 0.6939 65.2 0.928 Contact Map
3c6aA 1 0.6367 64.5 0.928 Contact Map
1iv0A 1 0.3347 64.4 0.928 Contact Map
3plaA 2 0.8939 53.6 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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